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Fluorescein sodium use during spinal ependymoma resection

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Translational Neuroscience and Clinics 2017年第3期3卷 123-134页

作者： Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang james Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi Guihuai Wang Department of Neurosurgery Changgung Hospital Medical Center Tsinghua University Department of Nephrology Beijing Luhe Hospital Capital Medical University Department of Psychiatry Zaozhuang Mental Health Center Department of Neurosurgery The Fifth People's Hospital of DatongRegional Medical Center of Shanxi Province

Spinal ependymomas(SEs) are common adult intramedullary tumors; however,determining the absolute boundary between the tumor and the tumor residual may be difficult. We assessed outcomes following the use of fluorescein sodium(FS) during surgical removal of SEs. We performed a retrospective analysis of 112 patients with SEs who were treated at Beijing Tsinghua Changgung Hospital between December 2014 and December 2016. Each patient received intravenous FS(3–4 mg/kg) to determine the SE boundaries during surgery. Tumor removal efficiencies and tumor residuals were assessed using magnetic resonance imaging(MRI) at 10 days and 3 months after surgical recovery; McC ormick's spinal function classification was also performed at the 3-month follow-up. The complete tumor removal rate was 92%(103/112). Ninetyfour patients underwent tumor removal under fluorescent light, which provided distinctive tumor fluorescence. Tumor removal under white light was performed in18 patients; fluorescent images were invisible or indistinctive in these 18 patients. At the 3-month follow-up, sensory function(85.8%(91/106)) and movement(84.3%(86/102)) were improved in patients with pre-surgical dysfunction; urination and defecation functions were improved in 66.7%(16/24). The Mc Cormick spinal cord functional classifications, at the 3-month follow-up, showed significant differences in the percentages of patients with disease classified to each grade(I–IV), compared with preoperative classifications(each, P < 0.05). There was no MRI evidence of tumor relapse or residuals at the 3-month follow-up. FS use during the surgical treatment of SE enables complete tumor removal and detection of tumor residuals.

关键词： spinal tumor ependymoma fluorescein sodium neurosurgery

Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation

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Translational Neuroscience and Clinics 2017年第3期3卷 135-146页

作者： Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi james Wang Department of Neurosurgery Changgung Hospital Medical Center Tsinghua University Department of Nephrology Beijing Luhe Hospital Capital Medical University Department of Psychiatry Zaozhuang Mental Health Center Department of Neurosurgery The Fifth People's Hospital of DatongRegional Medical Center Of Shanxi Province

This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons.

关键词： O-arm navigation spinal fixation application

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行进车辆上的陀螺定向

飞航导弹 1987年第S2期 57-61页

作者：韩九如

本文介绍一种里程仪辅助的惯性测量装置(IMU)在行进车辆上进行连续定向的原理。其辅助功能是用卡尔曼滤波实现的。仿真试验结果证明,该原理是可行的。

关键词：陀螺定向仿真试验结果惯性测量装置陀螺漂移辅助功能计算机仿真仿真结果系统仿真航向角偏差角

Fibromodulin reduces scar formation in adult cutaneouswounds by eliciting a fetal-like phenotype

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Signal Transduction and Targeted Therapy 2017年第1期2卷 73-84页

作者： Zhong Zheng Aaron W james Chenshuang Li Wenlu Jiang Joyce Z Wang Grace X Chang Kevin S Lee feng Chen Emily A Berthiaume Yao Chen Hsin Chuan Pan Eric C Chen Weiming Li Zhihe Zhao Xinli Zhang Kang Ting Chia Soo Division of Growth and Development School of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA UCLA Division of Plastic and Reconstructive Surgery Department of Orthopaedic SurgeryThe Orthopaedic Hospital Research CenterUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21287USA State Key Laboratory of Oral Diseases Department of OrthodonticsWest China School of StomatologySichuan UniversityChengduSichuan 610041China Department of Emergency Medicine Highland General HospitalOaklandCA 94602USA David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095USA Central Laboratory School of StomatologyPeking UniversityBeijing 100081China Department of Orthopaedics the First Clinical Hospital of Harbin Medical UniversityHarbinHeilongjiang 150081China

Blocking transforming growth factor(TGF)β1 signal transduction has been a central strategy for scar reduction;however,this approach appears to be minimally effective.Here,we show that fibromodulin(FMOD),a 59-kD small leucine-rich proteoglycan critical for normal collagen fibrillogenesis,significantly reduces scar formation while simultaneously increasing scar strength in both adult rodent models and porcine wounds,which simulate human cutaneous scar repair.Mechanistically,FMOD uncouples promigration/contraction cellular signals from pro-fibrotic signaling by selectively enhancing SMAD3-mediated signal transduction,while reducing AP-1-mediated TGFβ1 auto-induction and fibrotic extracellular matrix accumulation.Consequently,FMOD accelerates TGFβ1-responsive adult fibroblast migration,myofibroblast conversion,and function.Furthermore,our findings strongly indicate that,by delicately orchestrating TGFβ1 activities rather than indiscriminately blocking TGFβ1,FMOD elicits fetal-like cellular and molecular phenotypes in adult dermal fibroblasts in vitro and adult cutaneous wounds in vivo,which is a unique response of living system undescribed previously.Taken together,this study illuminates the signal modulating activities of FMOD beyond its structural support functions,and highlights the potential for FMOD-based therapies to be used in cutaneous wound repair.

关键词： fetal scar cutaneous

Global, 30-m resolution continuous fields of tree cover: Landsat-based rescaling of MODIS vegetation continuous fields with lidar-based estimates of error

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International Journal of Digital Earth 2013年第5期6卷 427-448页

作者： Joseph O.Sexton Xiao-Peng Song Min feng Praveen Noojipady Anupam Anand Chengquan Huang Do-Hyung Kim Kathrine M.Collins Saurabh Channan Charlene DiMiceli John R.Townshend Global Land Cover Facility Department of Geographical SciencesUniversity of MarylandCollege ParkMDUSA Department of Geographical Sciences University of MarylandCollege ParkMDUSA

We developed a global,30-m resolution dataset of percent tree cover by rescaling the 250-m MOderate-resolution Imaging Spectroradiometer(MODIS)Vegetation Continuous Fields(VCF)Tree Cover layer using circa-2000 and 2005 Landsat images,incorporating the MODIS Cropland Layer to improve accuracy in agricultural areas.Resulting Landsat-based estimates maintained consistency with the MODIS VCF in both epochs(RMSE=8.6%in 2000 and 11.9%in 2005),but showed improved accuracy in agricultural areas and increased discrimination of small forest patches.Against lidar measurements,the Landsat-based estimates exhibited accuracy slightly less than that of the MODIS VCF(RMSE=16.8%for MODIS-based vs.17.4%for Landsat-based estimates),but RMSE of Landsat estimates was 3.3 percentage points lower than that of the MODIS data in an agricultural region.The Landsat data retained the saturation artifact of the MODIS VCF at greater than or equal to 80%tree cover but showed greater potential for removal of errors through calibration to lidar,with post-calibration RMSE of 9.4%compared to 13.5%in MODIS estimates.Provided for free download at the Global Land Cover Facility(GLCF)website(***),the 30-m resolution GLCF tree cover dataset is the highest-resolution multi=temporal depiction of Earth’s tree cover available to the Earth science community.

关键词： tree cover continuous fields Landsat MODIS lidar

理论视角下企业“探索型学习-利用型学习”的研究回顾

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三峡大学学报（人文社会科学版） 2023年第1期45卷 69-77,F0003页

作者：林枫美仁萨·穆萨魏雨馨冯静三峡大学经济与管理学院湖北宜昌443002 三峡大学实验室与资产管理处湖北宜昌443002

探索型学习和利用型学习是当前激烈、动荡竞争环境下各类企业保持生存和追求长远发展的重要基础,这两种类别的学习已成为管理学领域的一种新范式。基于理论视角的主线,回顾、总结了March自1991年以来有关这两类学习的主要研究成果,旨在... 详细信息

探索型学习和利用型学习是当前激烈、动荡竞争环境下各类企业保持生存和追求长远发展的重要基础,这两种类别的学习已成为管理学领域的一种新范式。基于理论视角的主线,回顾、总结了March自1991年以来有关这两类学习的主要研究成果,旨在理解这两类学习的知识结构和研究趋势,加深对该领域的洞见。

关键词：探索型学习利用型学习权变分析绩效

不同清洗剂对鲜切黄瓜杀菌效果和生理指标的影响

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北京农学院学报 2020年第3期35卷 111-116页

作者：李小卫李宜霖侯茂书谭锋 james MMonaghan 北京农学院食品科学与工程学院北京102206 北京农学院国际学院北京102206 Harper Adams University NewportShropshire TF10NB Britain

【目的】评价不同清洗剂对鲜切黄瓜的清洗效果。【方法】选用5种清洗剂对鲜切黄瓜进行清洗试验,在杀菌效果同为90%的清洗条件下,对比不同清洗剂对鲜切黄瓜生理指标以及货架期菌落总数的影响。【结果】各清洗剂杀菌效果达到90%时的清洗... 详细信息

【目的】评价不同清洗剂对鲜切黄瓜的清洗效果。【方法】选用5种清洗剂对鲜切黄瓜进行清洗试验,在杀菌效果同为90%的清洗条件下,对比不同清洗剂对鲜切黄瓜生理指标以及货架期菌落总数的影响。【结果】各清洗剂杀菌效果达到90%时的清洗条件分别为:5%柠檬酸(C6H8O7)清洗5 min、250 mg/L(有效氯质量浓度)次氯酸钠(NaClO)清洗10 min、50 mg/L液态二氧化氯(Liquid ClO2)清洗15 min、150 mg/L(有效氯质量浓度)氯化酸性电解水(Chlorinated acid electrolyzed water,CAEW)清洗5 min和200 mg/L过氧乙酸(CH3COOOH)清洗15 min。与对照组相比,柠檬酸(C6H8O7)使鲜切黄瓜叶绿素含量降低13.6%;次氯酸钠(NaClO)清洗后的鲜切黄瓜叶绿素与抗坏血酸分别减少11.5%和13.9%;液态二氧化氯(Liquid ClO2)处理后,叶绿素、抗坏血酸、细胞渗透率、可溶性蛋白和丙二醛分别改变24.8%、20.6%、14.7%、4.9%和9.6%;氯化酸性电解水(CAEW)使叶绿素、细胞渗透率、可溶性蛋白与丙二醛分别改变19.3%、11.4%、12.8%和8.6%;过氧乙酸(CH3COOOH)仅使抗坏血酸和可溶性蛋白分别减少8.5%和9.8%。【结论】过氧乙酸(CH3COOOH)比相同质量浓度的次氯酸钠(NaClO)的杀菌效果好,对鲜切黄瓜生理指标影响小,且能够显著抑制货架期菌落总数的增长。

关键词：清洗剂杀菌效果鲜切黄瓜生理指标

近代内地会传教士叶长青与川边社会--以《教务杂志》史料为中心的介绍探讨

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西藏研究 2010年第6期124卷 57-70页

作者：冯宪华中共山东省邹城市委党史研究室山东邹城273500

内地会(China Inland Mission)传教士叶长青(james.Huston Edgar,1872～1936年)是清末民国时期川边传教布道的重要人物,著述颇丰,在人类学、地理学、考古学、宗教学等方面有一定建树。他还对川边嘉绒藏族和白石崇拜宗教信仰进行过考察... 详细信息

内地会(China Inland Mission)传教士叶长青(james.Huston Edgar,1872～1936年)是清末民国时期川边传教布道的重要人物,著述颇丰,在人类学、地理学、考古学、宗教学等方面有一定建树。他还对川边嘉绒藏族和白石崇拜宗教信仰进行过考察。经研究考证,他的中文名字为叶长青,国籍为澳大利亚。从中华续行委办会调查特委会编《中华归主》第四章第五节"川边"内容的出处来源看,编辑存在有疏漏不当之处。

关键词：叶长青川边教务杂志

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国之忧患与地缘政治意识

海南大学学报（人文社会科学版） 2021年第1期39卷 1-8,F0002页

作者：刘小枫中国人民大学文学院北京100872

地理学这门学科在我国教育体制的现行学科分类中属于理科(自然科学),但地理学在诞生之时就具有政治性质,与国家的生存忧患紧密相关。随着中国的世界性崛起,我国的人文和社会科学学者越来越需要面对风云变幻的世界地缘政治局势,"地缘政治... 详细信息

地理学这门学科在我国教育体制的现行学科分类中属于理科(自然科学),但地理学在诞生之时就具有政治性质,与国家的生存忧患紧密相关。随着中国的世界性崛起,我国的人文和社会科学学者越来越需要面对风云变幻的世界地缘政治局势,"地缘政治"这个语词也随之成为学界和传媒中的时髦用语。可是,政治地理学作为地缘政治意识的基础,在我国的教育建制中迄今仍然处于身份不明的位置。从政治史的角度讲,如果我国学界没有自己的世界历史地理学,那么,我们的地缘政治意识难免平泛和空洞。

关键词：费尔格里夫人文地理学政治地理学历史地理学地缘政治意识