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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Net ecosystem carbon exchange for Bermuda grass growing in mesocosms as affected by irrigation frequency

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Pedosphere 2022年第3期32卷 393-401页

作者： Yuan LI Gabriel *** Timothy J.CLOUGH John e.HUNT David whitehead Department of Soil and Physical Sciences Lincoln UniversityLincoln 7647(New Zealand) manaaki Whenua-Landcare Research P.O.Box 69040Lincoln 7640(New Zealand) State Key Laboratory of Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020(China) Soil Biology Group Wageningen University and ResearchP.O.Box 47Wageningen 6700 AA(The Netherlands)

Intensification of grazed grasslands following conversion from dryland to irrigated farming has the potential to alter ecosystem carbon(C)cycling and affect components of carbon dioxide(CO_(2))exchange that could lead to either net accumulation or loss of soil *** there are many studies on the effect of water availability on biomass production and soil C stocks,much less is known about the effect of the frequency of water inputs on the components of CO_(2)*** grew Bermuda grass(Cynodon dactylon L.)in mesocosms under irrigation frequencies of every day(I_(1) treatment,30 d),every two days(I_(2) treatment,12 d),every three days(I_(3) treatment,30 d),and every six days(I_(6) treatment,18 d,after I_(2) treatment).Rates of CO_(2)exchange for estimating net ecosystem CO_(2)exchange(F_(N)),ecosystem respiration(R_(e)),and soil respiration(R_(S))were measured,and gross C uptake by plants(F_(G))and respiration from leaves(R_(L))were calculated during two periods,1–12 and 13–30 d,of the 30-d *** the first 12 d,there were no significant differences in cumulative F_(N)(mean±standard deviation,61±30 g C m^(-2),n=4).During the subsequent 18 d,cumulative F_(N) decreased with decreasing irrigation frequency and increasing cumulative soil water deficit(W),with values of 70±22,60±16,and 18±12 g C m^(-2) for the I_(1),I_(3),and I_(6) treatments,*** were similar decreases in F_(G),R_(e),and R_(L) with increasing W,but differences in R_(S) were not *** of the C_(4) grass growing in a C_(3)-derived soil enabled partitioning of R_(S) into its autotrophic(R_(A))and heterotrophic(R_(H))components using a^(13)C natural abundance isotopic technique at the end of the experiment when differences in cumulative W between the treatments were the *** values of R_(H) and its percentage contributions to R_(S)(43%±8%,42%±8%,and 8%±5%for the I_(1),I_(3),and I_(6) treatments,respectively)suggested that R_(H) remained unaffected across a wide

关键词： ^(13)C natural abundance CO_(2)exchange N_(2)O emission soil heterotrophic respiration water deficit

Neuromodulation for fecal incontinence: An effective surgical intervention

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World Journal of Gastroenterology 2013年第41期19卷 7048-7054页

作者： Giuseppe Chiarioni Olafur S Palsson Corrado R Asteria William e whitehead Division of Gastroenterology of the University of Verona Valeggio s/M HospitalAzienda Ospedaliera Universitaria Integrata di Verona37067 Valeggio sul MincioVeronaItaly Division of Gastroenterology and Hepatology and Center for Functional Gastrointestinal and motility Disorders University of North Carolina at Chapel HillChapel HillNC 27516United States Department of Surgery and Orthopedics General Surgery UnitAzienda Ospedaliera Carlo Poma di MantovaAsola General Hospital46041 AsolaMantovaItaly

Fecal incontinence is a disabling symptom with medical and social implications,including fear,embarrassment,isolation and even *** patients live in seclusion and have to plan their life around the symptom,with secondary impairment of their quality of *** management and biofeedback therapy are reported to benefit a good percentage of those ***,surgery must be considered in the nonresponder ***,sacral nerve electrostimulation,lately named neuromodulation,has been reported to benefit patients with fecal incontinence in randomized controlled trials more than placebo stimulation and conservative management,by some unknown *** is a minimally invasive procedure with a low rate of adverse events and apparently favorable cost-efficacy *** review is intended to expand knowledge about this effective intervention among the non-surgically skilled community who deals with this disabled group of patients.

关键词： Fecal incontinence Neuromodulation Sacral nerve stimulation Biofeedback Anal sphincter

exploring the mass gap:Black holes in green pea galaxies

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Science China(Physics,mechanics & Astronomy) 2024年第10期67卷 170-171页

作者： james e.Rhoads School of earth and Space exploration Arizona State UniversityTempeAZ 85287USA

We know about black holes primarily on two mass scales(e.g.,see Figure 22 of ref.[1]).Supermassive black holes inhabit the centers of galaxies,where they sometimes power active galactic nuclei(AGN).Their populations can be probed through AGN surveys,tidal disruption event surveys,and(in the closest galaxies)stellar and gas dynamics in the innermost regions where the black hole dominates the gravitational potential.

关键词： galaxies tidal galactic

Design and analysis of extended depth of focus metalenses for achromatic computational imaging

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Photonics Research 2020年第10期8卷 1613-1623页

作者： LUOCHeNG HUANA james whitehead SHANe COLBURN ARKA mAJUmDAR Department of electrical and Computer engineering Urniversity of WashingtonSeattleWashington 98195USA Department of Physics University of WashingtonSeatteWashington 98195USA

metasurface optics have demonstrated vast potential for implementing traditional optical components in an ultracompact and lightweight form ***,however,suffer from severe chromatic aberrations,posing serious limitations on their practical *** approaches for circumventing this involving dispersion engineering are limited to small apertures and often entail multiple scatterers per unit cell with small feature ***,we prescnt an alternative technique to mitigatc chromatic aberration and demonstrate high-quality,full-color imaging using extended depth of focus(eDOF)metalenses and computational *** eDOF metalenses have relied on cubic phase masks,where the image quality suffers from asymmetric *** we demonstrate the use of rotationally symmetric masks,including logarithmic-aspherical,and shifted axicon masks,to mitigate this *** work will inspire further development in achromatic metalenses beyond dispersion engineering and hybrid optical-digital metasurface systems.

关键词： chromatic dispersion optics

Toward the Fourth Industrial Revolution on Real-Time Customization

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Journal of Systems Science and Systems engineering 2020年第2期29卷 127-142页

作者： james m.Tien College of engineering University of MiamiCoral GablesFlorida 33146USA

The outputs of a national economy can be partitioned into three sets of products:tangible goods(due to manufacturing,construction,extraction and agriculture),intangible services(due to an act of useful effort),and an integration of services and goods or,as initially defined by Tien(2012),***,these products can also be considered in terms of their relation to the first three Industrial Revolutions:the First Industrial Revolution(circa 1800)was primarily focused on the production of goods;the Second Industrial Revolution(circa 1900)was primarily focused on the mass production of goods;and the Third Industrial Revolution(circa 2000)has been primarily focused on the mass customization of goods,services or *** this follow-up paper,the Third Industrial Revolution of mass customization continues to accelerate in its evolution and,in many respects,is subsuming the earlier Industrial Revolutions of production and mass *** importantly,with the advent of real-time decision making,artificial intelligence,Internet of Things,mobile networks,and other advanced digital technologies,customization has been extensively enabled,thereby advancing mass customization into a Fourth Industrial Revolution of real-time ***,the moral,ethical,security and employment problems associated with both mass and real-time customization must be carefully assessed and mitigated,especially in regard to unintended *** ahead and with the advance of artificial general intelligence,this Fourth Industrial Revolution could be forthcoming in about the middle of the 21st Century;it would allow for multiple activities to be simultaneously tackled in real-time and in a customized manner.

关键词： Industrial revolutions big data goods services servgoods connected production mass customization real-time decision making Internet of Things artificial intelligence general

THe NeXT INDUSTRIAL ReVOLUTION:INTeGRATeD SeRVICeS AND GOODS

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Journal of Systems Science and Systems engineering 2012年第3期21卷 257-296页

作者： james m.TIeN College of engineering University of MiamiCoral GablesFlorida 33146USA

The outputs or products of an economy can be divided into services products ana gooas products （due to manufacturing, construction, agriculture and mining）. To date, the services and goods products have, for the most part, been separately mass produced. However, in contrast to the first and second industrial revolutions which respectively focused on the development and the mass production of goods, the next - or third - industrial revolution is focused on the integration of services and/or goods; it is beginning in this second decade of the 21st Century. The Third Industrial Revolution （TIR） is based on the confluence of three major technological enablers （i.e., big data analytics, adaptive services and digital manufacturing）; they underpin the integration or mass customization of services and/or goods. As detailed in an earlier paper, we regard mass customization as the simultaneous and real-time management of supply and demand chains, based on a taxonomy that can be defined in terms of its underpinning component and management foci. The benefits of real-time mass customization cannot be over-stated as goods and services become indistinguishable and are co-produced - as ＂servgoods＂ - in real-time, resulting in an overwhelming economic advantage to the industrialized countries where the consuming customers are at the same time the co-producing producers.

关键词： Big data decision analytics goods adaptive services digital manufacturing value chain supply chain demand chain mass production mass customization industrial revolution

Performance, emission and combustion characteristics of CI engine fuelled with diesel and hydrogen

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Frontiers in energy 2015年第4期9卷 486-494页

作者： R. Senthil KUmAR m. LOGANATHAN e. james GUNASeKARAN Department of mechanical engineering Annamalai University Chi- dambaram 608002 India

Hydrogen （H2） is being considered as a primary automotive fuel and as a replacement for conventional fuels. Some of the desirable properties, like high flame velocity, high calorific value motivate us to use hydrogen fuel as a dual fuel mode in diesel engine. In this experiment, hydrogen was inducted in the inlet manifold with intake air. The experiments were conducted on a four stroke, single cylinder, water cooled, direct injection （DI）, diesel engine at a speed of 1500r/min. Hydrogen was stored in a high pressure cylinder and supplied to the inlet manifold through a water-and-air-based flame arrestor. A pressure regulator was used to reduce the cylinder pressure from 140 bar to 2 bar. The hydrogen was inducted with a volume flow rate of 41 pm, 61 pm and 81 pm, respectively by a digital volume flow meter. The engine performance, emission and combustion parameters were analyzed at various flow rates of hydrogen and compared with diesel fuel operation. The brake thermal efficiency （BTe） was increased and brake specific fuel consumption （BSFC） decreased for the hydrogen flow rate of 81 pm as compared to the diesel and lower volume flow rates of hydrogen. The hydrocarbon （HC） and carbon monoxide （CO） were decreased and the oxides of nitrogen （NOx） increased for higher volume flow rates of hydrogen compared to diesel and lower volume flow rates of hydrogen. The heat release rate and cylinder pressure was increased for higher volume flow rates of hydrogen compared to diesel and lower volume flow rates of hydrogen.

关键词： hydrogen brake thermal efficiency crankangle compressed ignition (CI)

Omeprazole induces gastric transmucosal permeability to the peptide bradykinin

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World Journal of Gastroenterology 2010年第9期16卷 1097-1103页

作者： melissa Gabello mary Carmen Valenzano e Peter Zurbach james m mullin Lankenau Institute for medical Research 100 Lancaster AvenueWynnewoodPA 19096United States Department of Biology Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Department of Chemistry Saint Joseph's University5600 City AvenuePhiladelphiaPA 19131United States Division of Gastroenterology Lankenau Hospital100 Lancaster AvenueWynnewoodPA 19096United States

AIm:To investigate omeprazole-induced transepithelial gastric leak and its effects on the permeability of the peptides bradykinin and ***:Rat gastric corpus tissue was isolated and mounted in an Ussing chamber apparatus to evaluate the permeability of 3H-bradykinin,3H-oxytocin,and 14CeDTA in the presence or absence of *** chromatography was performed to identify any metabolic breakdown products of the peptides resulting from permeation through the gastric tissue,and thereby calculate the true flux of the ***:The flux rate ofintact 3H-bradykinin increased substantially after omeprazole addition (109.5%) compared to the DmSO vehicle control (14%).No corresponding change in flux ofintact 3H-oxytocin was observed under the same conditions (11.9% and 6.4% in the DmSO-and omeprazole-treated conditions,respectively).After exposure to omeprazole,the flux rate of 14C-eDTA also increased dramatically (122.3%) compared to the DmSO condition (36.3%).CONCLUSION:The omeprazole-induced gastric leak allows for transmucosal permeability to charged molecules as well as *** induced leak will allow certain peptides to permeate.

关键词： Proton pump inhibitor Paracellular Drug delivery Tight junction Transepithelial