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Insm1:orche.trating ce.lular mimicry in the.thymus me.ulla

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Ce.lular & Mole.ular Immunology 2024年第4期21卷 414-416页

作者： K.D.james J.e.Cowan UCL Institute.of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The.thymus is the.primary production site.for a functional and se.f-tole.ant T-ce.l *** e.tablishme.t of immune.tole.ance.is me.iate. by the.ge.e.ation and pre.e.tation of tissue.re.tricte. se.f-antige.s(TRAs)by me.ullary thymic e.ithe.ial ce.ls(mTe.s),which scre.n T-ce.l re.e.tors for se.f-re.ctivity to e.iminate.autore.ctive.T *** studie. have.e.te.de. our unde.standing of mTe. he.e.oge.e.ty by e.amining the.me.hanisms by which mTe.s mimic the.pe.iphe.al se.f[1].

关键词： me.ullary e.iminate re.tricte.

A holistic approach to improving safe.y for batte.y e.e.gy storage.syste.s

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Journal of e.e.gy Che.istry 2024年第5期92卷 422-439页

作者： james Close.Jonathan e.Barnard Y.M.John Che. Se.ali Pe.e.a De.artme.t of Che.ical e.gine.ring Centre for DigitalManufacturing&DesignUniversity of BathBath BA27AYUK ioMosaic Inte.national Limite. 16-18 Queen SquareBath BA12HNUK

The.inte.ration of batte.y e.e.gy storage.syste.s(Be.S)throughout our e.e.gy chain pose. conce.ns re.arding safe.y,e.pe.ially since.batte.ie. have.high e.e.gy de.sity and nume.ous Be.S failure.e.e.ts have.*** spre.d adoption will only incre.se.the.pre.ale.ce.of the.e.failure.e.e.ts unle.s the.e.is a ste. change.in the.manage.e.t and de.ign of *** unde.stand the.cause. of failure.the.main challe.ge. of Be.S safe.y are.*** conse.ue.ce. and failure.e.e.ts are.discusse.,including spe.ific focus on the.chain of e.e.ts causing the.mal runaway,and a case.study of a Be.S e.plosion in Surprise.Arizona is *** on the.te.hnology and past e.e.ts,a paradigm shift is re.uire. to improve.Be.S *** this re.ie.,a holistic approach is *** combine. curre.tly adopte. approache. including batte.y ce.l te.ting,lumpe. ce.l mathe.atical mode.ling,and calorime.ry,alongside.additional me.sure. take. to e.sure.Be.S safe.y including the.re.uire.e.t for computational fluid dynamics and kine.ic mode.ling,asse.sme.t of installation le.e. te.ting of the.full Be.S syste. and not simply a single.ce.l batte.y te.t,hazard and laye.s of prote.tion analysis,gas chromatography,and composition *** holistic approach propose. in this study aims to addre.s challe.ge. of Be.S safe.y and form the.basis of a paradigm shift in the.safe.y manage.e.t and de.ign of the.e.syste.s.

关键词： e.e.gy storage.yste.s Proce.s safe.y Batte.y safe.y The.mal safe.y

How to fill the.biodive.sity data gap:Is it be.te. to inve.t in fie.dwork or curation?

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Plant Dive.sity 2024年第1期46卷 39-48页

作者： Carlos A.Vargas Marius Bottin Tiina Sarkine. james e.Richardson Marce.a Ce.is Boris Villanue.a Adriana Sanche. Programa de.Biología Facultad de Ciencias NaturalesUniversidad del RosarioBogotaD.C.Colombia Subdire.cion Cie.tífica Jardín Botanico de Bogota“Jose Celestino Mutis”BogotaD.C.Colombia Inde.e.de.t Re.e.rche. BogotaD.C.Colombia Tropical Dive.sity Se.tion Royal Botanic Garden EdinburghUK School of Biological Earth and Environmental SciencesUniversity College CorkCorkIreland De.artame.to de.Química y Biología Universidad del NorteKm.5 Vía Puerto ColombiaArea Metropolitana de Barranquilla 081007Colombia

Data gaps and biase. are.two important issue. that affe.t the.quality of biodive.sity information and downstre.m *** how be.t to fill e.isting gaps and account for biase. is ne.e.sary to improve.our curre.t information most *** curre.t main approache. for obtaining and improving data include.1)curation of biological colle.tions,and(2)***,the.comparative.e.fe.tive.e.s of the.e.approache. in improving biodive.sity data re.ains little.*** use. the.Flora de.Bogota proje.t to study the.magnitude.of change.in spe.ie. richne.s,spatial cove.age.and sample.cove.age.of plant re.ords base. on curation ve.sus *** proce.s of curation re.ulte. in a de.re.se.in spe.ie. richne.s(synonym and e.ror re.oval),but it significantly incre.se. the.numbe. of re.ords pe. *** contribute. to a slight incre.se.in spe.ie. richne.s,via accumulation of ne. ***,curation le. to incre.se. in spatial cove.age.spe.ie. obse.ve. by locality,the.numbe. of plant re.ords by spe.ie.,and localitie. by spe.ie. compare. to ***,curationwas more.e.ficie.t in producing ne. information compare. to fie.dwork,mainly be.ause.of the.large.numbe. of re.ords available.in *** re.omme.d inte.sive.curatorial work as the.first ste. in incre.sing biodive.sity data quality and quantity,to ide.tify bias and gaps at the.re.ional scale.that can the. be.targe.e. with *** ste.wise.strate.y would e.able.fie.dwork to be.planne. more.coste.fe.tive.y give. the.limite. re.ource. for biodive.sity e.ploration and characte.ization.

关键词： Colombia Flora de.Bogota Sample.cove.age Spe.ie. richne.s Tropical Ande.

A Validate. Mode. for the.Imaging Diagnosis of Cystic Lung Dise.se

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Lipid nanoparticle. de.ive. mRNA to the.blood-brain barrie.

Ope. Journal of Radiology（放射学期刊） 2023年第1期

作者： Wallace.T. Mille.1 Kare. C. Patte.son2 3 Shwe.a Sood2 james e. schmitt4 Arshad A. Wani2 Robe.t Borde.5 Maya Galpe.in-Aise.be.g4 Mary K. Porte.s2 Miche.le.L. He.shman4 Michae. He.itt4 Je.nife. Le.y4 Victor D. Babatunde. Te.iana Glushko6 Timothy J. Nie.e.4 Se.ge. Le.hchinskiy4 Karine.Sahakyan7 Ke.ur De.ai4 Je.nife. A. Gillman4 Sande.p Re.dy4 Michae. Shrive.4 Nathanie. B. Linna4 Abass M. Noor4 Ayse.ur Buz8 Matthe. e. Biron4 Scott Simpson4

来源：博看期刊评论

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Nano Re.e.rch 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakke. Randi Calkins Se.astian Rudde. Camille.Jone. Je.sie.Doan Bora Jang e.isa Schrade. e.he.e.ri Ryan Ze.hause.n Liming Lian David Loughre. Hannah e.Pe.k Rache.le.Wie.e.Dorothy Kove.l Philip J.Santange.o james e.Dahlman Ge.rge.C.Woodruff School of Me.hanical e.gine.ring Georgia Institute of TechnologyAtlantaGA 30332USA Parke. H.Pe.it Institute.for Bioe.gine.ring and Bioscie.ce. Georgia Institute of TechnologyAtlantaGA 30332USA Wallace.H.Coulte. De.artme.t of Biome.ical e.gine.ring Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticle.(LNPs)have.de.ive.e. RNA to he.atocyte. in patie.ts afte. intrave.ous *** clinical data support e.forts to de.ign LNPs that transfe.t ce.ls in the.ce.tral ne.vous syste.(CNS).Howe.e.,de.ive.y to the.CNS has be.n difficult,in large.part be.ause.quantifying on-targe. de.ive.y alongside.common off-targe. ce.l type. in adult mice.re.ains *** we.re.ort me.hods to isolate.diffe.e.t ce.l type. from the.CNS,and subse.ue.tly pre.e.t mRNA de.ive.y re.douts using a live.-de.arge.e. *** data sugge.t that LNPs without targe.ing ligands can transfe.t ce.e.ral e.dothe.ial ce.ls in mice.afte. intrave.ous *** the.difficulty of crossing the.blood-brain barrie.,the. also unde.score.the.value.of quantifying de.ive.y in the.CNS with ce.l-type.re.olution inste.d of whole.tissue.re.olution.

关键词： lipid nanoparticle mRNA nanome.icine ce.tral ne.vous syste. blood-brain barrie.

De.ision-Making and Manage.e.t of Se.f-Care.in Pe.sons with Traumatic Spinal Cord Injurie.: A Pre.iminary Study

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Journal of Be.avioral and Brain Scie.ce 2024年第2期14卷 47-63页

作者： Paul e. Plonski Jasmin Vassile.a Ryan Shahidi Paul B. Pe.rin William Carte. Lance.L. Goe.z Ambe. Broche.ti james M. Bjork Institute.for Drug and Alcohol Studie. Virginia Commonwealth University Richmond VA USA Richmond Ve.e.ans Affairs Me.ical Ce.te. Richmond VA USA De.artme.t of Psychiatry Virginia Commonwealth University Richmond VA USA De.artme.t of Psychology Virginia Commonwealth University Richmond VA USA De.artme.t of Physical Me.icine.and Re.abilitation Virginia Commonwealth University Richmond VA USA De.artme.t of Spinal Cord Injury Cleveland Veterans Affairs Medical Center Cleveland OH USA De.artme.t of Pharmacology and Toxicology Virginia Commonwealth University Richmond VA USA

Patie.ts and physicians unde.stand the.importance.of se.f-care.following spinal cord injury (SCI), ye. many individuals with SCI do not adhe.e.to re.omme.de. se.f-care.activitie. de.pite.logistical supports. Ne.robe.avioral de.e.minants of SCI se.f-care.be.avior, such as impulsivity, are.not wide.y studie., ye. unde.standing the. could inform e.forts to improve.SCI se.f-care. We.e.plore. associations be.we.n impulsivity and se.f-care.in an obse.vational study of 35 US adults age.18 - 50 who had traumatic SCI with paraple.ia at le.st six months be.ore.asse.sme.t. The.primary outcome.me.sure.was se.f-re.orte. se.f-care. In LASSO re.re.sion mode.s that include. all ne.robe.avioral me.sure. and de.ographics as pre.ictors of se.f-care. dispositional me.sure. of gre.te. impulsivity (ne.ative.urge.cy, lack of pre.e.itation, lack of pe.se.e.ance., and re.uce. mindfulne.s we.e.associate. with re.uce. se.f-care. Outcome.(magnitude. se.sitivity, a late.t de.ision-making parame.e. de.ive. from computationally mode.ing succe.sive.choice. in a gambling task, was also associate. with se.f-care.be.avior. The.e.re.ults are.pre.iminary;more.re.e.rch is ne.de. to de.onstrate.the.utility of the.e.findings in clinical se.tings. Information about associations be.we.n impulsivity and poor se.f-care.in pe.ple.with SCI could guide.the.de.e.opme.t of inte.ve.tions to improve.SCI se.f-care.and he.p patie.ts with e.e.ate. risks re.ate. to se.f-care.and se.ondary he.lth conditions.

关键词： Spinal Cord Injury Se.f-Care De.ision-Making Paraple.ia Impulsive.Be.avior He.lth Care

Facilitate. Pre.iction of Micropollutant De.radation via UV-AOPs in Various Wate.s by Combining Mode. Simulation and Portable.Me.sure.e.t

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e.gine.ring 2024年第6期37卷 87-95页

作者： Yanyan Huang Me.gkai Li Zhe.Sun We.tao Li james R.Bolton Zhimin Qiang Ke. Laboratory of Drinking Wate. Scie.ce.and Te.hnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing 100049China De.artme.t of Civil and e.vironme.tal e.gine.ring University of AlbertaEdmontonAB T6G 1H9Canada State.Ke. Laboratory of e.vironme.tal Aquatic Che.istry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The.de.radation of micropollutants in wate. via ultraviole.(UV)-base. advance. oxidation proce.se.(AOPs)is strongly de.e.de.t on the.wate. *** re.ctive.radicals(RRs)forme. in UV-AOPs have.diffe.e.t re.ction se.e.tivitie. toward wate. matrice. and de.radation e.ficie.cie. for targe. ***,proce.s se.e.tion and optimization are.*** study de.e.ope. a facilitate. pre.iction me.hod for the.photon flue.ce.base. rate.constant for micropollutant de.radation(K′_(p,MP))in various UV-AOPs by combining mode. simulation with portable.*** me.hods for me.suring the.scave.ging capacitie. of the.principal RRs(RRSCs)involve. in UV-AOPs(i.e.,HO^(·),SO_(4)^(·-),and Cl^(·))using a mini-fluidic photore.ction syste. we.e.*** simulation mode.s consiste. of photoche.ical,quantitative.structure.activity re.ationship,and radical conce.tration ste.dy-state.approximation *** RRSCs we.e.de.e.mine. in e.ght te.t wate.s,and a highe. RRSC was found to be.associate. with a more.comple. wate. ***,by taking sulfame.hazine.caffe.ne.and carbamaze.ine.as mode. micropollutants,the.k′_(p,MP) value. in various UV-AOPs we.e.pre.icte. and furthe. ve.ifie. e.pe.ime.tally.A lowe. k′_(p,MP) was found to be.associate. with a highe. RRSC for a stronge. RR compe.ition;for e.ample.k′_(p,MP) value. of 130.9 and 332.5 m^(2) e.nste.n^(–1),re.pe.tive.y,we.e.obtaine. for carbamaze.ine.de.radation by UV/H_(2)O_(2) in the.raw wate.(RRSC=9.47×10^(4) s^(-1))and sand-filte.e. e.flue.t(RRSC=2.87×10^(4) s^(-1))of a drinking wate. tre.tme.t *** de.e.ope. me.hod facilitate. proce.s se.e.tion and optimization for UV-AOPs,which is e.se.tial for incre.sing the.e.ficie.cy and cost-e.fe.tive.e.s of wate. tre.tme.t.

关键词： UV-AOPs Micropollutant de.radation Re.ctive.radicals Wate. matrix Mode. simulation

Barosinusitis due.to routine.we.the. change.:A cross-se.tional analysis of public we.site.

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World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2024年第1期10卷 18-23页

作者： james C.Campbe.l Julia e.Canick Philip G.Che. Ralph Abi Hache. David W.Jang De.artme.t of He.d and Ne.k Surge.y&Communication Scie.ce. Duke University School of MedicineDurhamNorth CarolinaUSA Duke.Unive.sity School of Me.icine DurhamNorth CarolinaUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y University of Texas Health Science Center San AntonioSan AntonioTexasUSA

Background:Sinusitis is a common diagnosis that can be.e.rone.usly associate. with routine.we.the.‐re.ate. barome.ric pre.sure.*** actuality,the.e.pre.sure.change. like.y e.ace.bate.migraine.he.dache.,which can cause.facial pain and pre.sure.rathe. than true.sinus ***:The.pre.e.t study sought to characte.ize.the.re.re.e.tation of both sinusitis and migraine.in association with barome.ric pre.sure.change. across we.site. on the.***:An Inte.ne. se.rch for re.e.ant te.ms was conducte.,and conte.t of the.re.ulting page. was asse.se. for associations be.we.n we.the.‐re.ate. pre.sure.change. and e.the. sinusitis or *** in re.orte. re.ults across diffe.e.t subtype. of Inte.ne. source. we.e.*** primary outcome. me.sure. we.e.1)whe.he. a give. me.ia source.associate. barome.ric we.the. change. with sinusitis,(2)whe.he. that source.associate. barome.ric we.the. change. with migraine.and(3)tre.tme.t options offe.e. by that ***:Of the.116 include. we.page.,36(31.03%)associate. sinusitis and routine.barome.ric pre.sure.*** the.e.10(27.77%)we.e.otolaryngology practice.***‐se.e. we.page.(57.76%)associate. migraine.and routine.barome.ric pre.sure.*** the.e.nonotolaryngology we.page. we.e.more.like.y to re.ort this ***:Otolaryngology practice.site. we.e.obse.ve. to be.the.most fre.ue.t profe.sional me.ical re.ource.re.orting the.unsubstantiate. claim that routine.barome.ric pre.sure.change. are.associate. with *** source. we.e.more.like.y to link we.the.‐re.ate. pre.sure.change. to *** re.ults sugge.t that opportunitie. e.ist for otolaryngology practice.site. to e.ucate.patie.ts about nonrhinoge.ic he.dache.e.iologie..

关键词： acute.rhinosinusitis balloon sinus dilation he.dache migraine sinusitis

Ranking e.vironme.tal and e.aphic attribute. driving soil microbial community structure.and activity with spe.ial atte.tion to spatial and te.poral scale.

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mLife 2024年第1期3卷 21-41页

作者： Vadakattu V.S.R.Gupta james M.Tie.je CSIRO Agriculture.Food UrrbraeSouth AustraliaAustralia Ce.tre.for Microbial e.ology Michigan State UniversityEast LansingMichiganUSA

The.incre.ibly comple. soil microbial communitie. at small scale. make.the.r analysis and ide.tification of re.sons for the.obse.ve. structure. *** community structure.is mainly a re.ult of the.inoculum(dispe.sal),the.se.e.tive.advantage. of those.organisms unde. the.habitat-base. e.vironme.tal attribute.,and the.ability of those.colonize.s to sustain the.se.ve. ove. *** soil is prote.tive.and its microbial inhabitants have.long adapte. to varie. soil conditions,significant portions of the.soil microbial community structure.are.like.y ***,a substantial portion of the.community will not corre.ate.to ofte. me.sure. soil *** sugge.t that the.drive.s be.ranke. on the.basis of the.r importance.to the.fundame.tal ne.ds of the.microbe.:(i)those.that supply e.e.gy,i.e.,organic carbon and e.e.tron acce.tors;(i)e.vironme.tal e.fe.tors or stre.sors,i.e.,pH,salt,drought,and toxic che.icals;(ii)macro-organism associations,i.e.,plants and the.r se.sonality,animals and the.r fe.al matte.,and soil fauna;and(iv)nutrie.ts,in orde.,N,P,and probably of le.se. importance.othe. micronutrie.ts,and *** re.e.ance.of drive.s also varie. with spatial and time.scale.,for e.ample.aggre.ate.to fie.d to re.ional,and pe.siste.t to dynamic populations to transcripts,and with the.e.te.t of phyloge.e.ic diffe.e.ce.he.ce.phe.otypic diffe.e.ce. in organismal *** pre.e.t a summary matrix to provide.guidance.on which drive.s are.important for particular studie.,with spe.ial e.phasis on a wide.range.of spatial and te.poral scale.,and illustrate.this with ge.omic and population(rRNA ge.e.data from se.e.te. studie..

关键词： abundance community structure dive.sity functional microbiome microorganisms