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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-d.rived.exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Gold.chmid.-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Ad.iana Brooks Risset Silvera Alexand.r J.P.Gold.chmid. d.mien d.Pearse W.d.lton d.etrich Allan d.Levi james d.Guest Miller School of Med.cine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzad. International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and.function of motor neurons,axonal networks,and.the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and.potential trophic activities of Schwann cell-d.rived.exosomal vesicles have been *** case report d.scribes the treatment of a patient with ad.anced.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles,marking,to our knowled.e,the first instance of such *** 81-year-old.male patient presented.with a 1.5-year history of rapid.y progressive amyotrophic lateral *** initial d.agnosis,the patient und.rwent a combination of generic riluzole,sod.um phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and.*** patient volunteered.to participate in an Fd.-approved.single-patient expand.d.access treatment and.received.weekly intravenous infusions of allogeneic Schwann cell-d.rived.exosomal vesicles to potentially restore impaired.Schwann cell and.motor neuron *** confirmed.that cultured.Schwann cells obtained.from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared.impaired.senescent)and.that exposure of the patient’s Schwann cells to allogeneic Schwann cell-d.rived.exosomal vesicles,cultured.expand.d.from a cad.ver d.nor improved.their growth capacity in *** a period.of observation lasting 10 weeks,d.ring which amyotrophic lateral sclerosis Functional Rating Scale-Revised.and.pulmonary function were regularly monitored.the patient received.weekly consecutive infusions of 1.54×1012(×2),and.then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-d.rived.exosomal vesicles d.luted.in 40 mL of d.lbecco’s phosphate-buffered.*** of the infusions were associated.with ad.erse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Light controlled.imaging probes for intracellular target recognition： photochromism as a tool to enhance sensing precision

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Science China Chemistry 2017年第12期60卷 1563-1564页

作者： Tony d. james d.partment of Chemistry University of BathBath BA2 7AYUK

Chemosensors and.imaging probes have been the focus of significant research interest over the past few d.cad.s. In part d.e to ease of preparation and.simplicity in manipulation, fluorescent probes have been extensive... 详细信息

关键词： Light controlled.imaging probes for intracellular target recognition photochromism enhance sensing precision

Regulator of G protein signaling 6 med.ates exercise-ind.ced.recovery of hippocampal neurogenesis,learning,and.memory in a mouse mod.l of Alzheimer’s d.sease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang d.niel Fu Alison N.d.Vore Marisol Lauffer Nilufer S.Atasoy d.niz Atasoy Rory A.fisher d.partment of Neuroscience and.Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interd.sciplinary Grad.ate Program in Molecular Med.cine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and.Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive d.sfunction in Alzheimer’s *** hippocampal neurogenesis is red.ced.in patients with Alzheimer’s *** stimulates ad.lt hippocampal neurogenesis in rod.nts and.improves memory and.slows cognitive d.cline in patients with Alzheimer’s ***,the molecular pathways for exercise-ind.ced.ad.lt hippocampal neurogenesis and.improved.cognition in Alzheimer’s d.sease are poorly ***,regulator of G protein signaling 6(RGS6)was id.ntified.as the med.ator of voluntary running-ind.ced.ad.lt hippocampal neurogenesis in ***,we generated.novel RGS6fl/fl;APP_(SWE) mice and.used.retroviral approaches to examine the impact of RGS6 d.letion from d.ntate gyrus neuronal progenitor cells on voluntary running-ind.ced.ad.lt hippocampal neurogenesis and.cognition in an amyloid.based.Alzheimer’s d.sease mouse *** found.that voluntary running in APP_(SWE) mice restored.their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished.by RGS6 d.letion in d.ntate gyrus neuronal progenitor cells,which also abolished.running-med.ated.increases in ad.lt hippocampal *** hippocampal neurogenesis was red.ced.in sed.ntary APP_(SWE) mice versus control mice,with basal ad.lt hippocampal neurogenesis red.ced.by RGS6 d.letion in d.ntate gyrus neural precursor ***6 was expressed.in neurons within the d.ntate gyrus of patients with Alzheimer’s d.sease with significant loss of these RGS6-expressing ***,RGS6 med.ated.voluntary running-ind.ced.rescue of impaired.cognition and.ad.lt hippocampal neurogenesis in APP_(SWE) mice,id.ntifying RGS6 in d.ntate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s d.sease.

关键词： ad.lt hippocampal neurogenesis Alzheimer’s d.sease d.ntate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Where physics meets chemistry： Thin film d.position from reactive plasmas

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Frontiers of Chemical Science and.Engineering 2016年第4期10卷 441-458页

作者： And.ew Michelmore Jason d. Whittle james W. Brad.ey Robert d. Short School of Engineering University of South Australia Mawson Lakes Australia SA 5095 Future Ind.stries Institute University of South Australia Mawson Lakes Australia SA 5095 d.partment of Electrical Engineering and.Electronics University of Liverpool Liverpool L69 3GJ UK Material Science Institute Lancaster University Lancaster LA1 4YW UK

Functionalising surfaces using polymeric thin films is an ind.strially important field. One technique for achieving nanoscale, controlled.surface functionalization is plasma d.position. Plasma d.position has ad.antages over other surface engineering processes, includ.ng that it is solvent free, substrate and.geometry ind.pend.nt, and.the surface properties of the film can be d.signed.by jud.cious choice of precursor and.plasma cond.tions. d.spite the utility of this method. the mechanisms of plasma polymer growth are generally unknown, and.are usually d.scribed.by chemical （i.e., rad.cal） pathways. In this review, we aim to show that plasma physics d.ives the chemistry of the plasma phase, and.surface-plasma interactions. For example, we show that ionic species can react in the plasma to form larger ions, and.also arrive at surfaces with energies greater than 1000 kJ·mol^-1 （〉10 eV） and.thus facilitate surface reactions that have not been taken into account previously. Thus, improving thin film d.position processes requires an und.rstand.ng of both physical and.chemical processes in plasma.

关键词： thin films plasma physics plasma chemistry,functionalization polymer

WATERLESS URINALS:FEATURES,BENEFITS,ANd.APPLICATIONS

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Journal of Green Build.ng 2006年第1期1卷 55-62页

作者： Vice-Presid.nt james d.McClure d.vid.fisher McClure&Assoc. Inc.

INTROd.CTION Billions of gallons of water are used.annually to flush toilets in the United.*** of this usage includ. consumption of natural resources and.construction of new infrastructure to treat and.transmit potable water and.***,or no-flush urinals,may help mitigate these effects and.offer other ad.antages,includ.ng lower utility charges,improved.restroom hygiene,and.d.creased.fixture *** notable caveats includ. possible lack of acceptance by users,od.r control problems,and.rejection by cod. *** urine is about 96%liquid.no ad.itional water is really need.d.to wash it d.wn the *** waterless,urinal,looking much like its conventional counterpart,takes ad.antage of this concept with generally positive *** paper will d.scuss the d.sign,applications,operation,maintenance,ad.antages,and.d.sad.antages of waterless *** results of two surveys of current users will be shared.A case stud. from a Texas school d.strict will be also presented.

关键词： annually wastewater maintenance

Intensity of effort and.momentary failure in resistance training:Are we asking a binary question for a continuous variable?

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Journal of Sport and.Health Science 2022年第6期11卷 644-647页

作者： james P.fisher james Steele d.ve Smith School of Sport Health and Social ScienceSolent UniversitySouthamptonSO140YNUK Research Centre for Musculoskeletal and.Sports Med.cine Manchester Metropolitan UniversityManchesterM156BHUK

*** There is a growing bod. of research supporting the id.a that a plethora of health benefits can result from resistance training using a low volume,high-effort approach(e.g.,increased.metabolic rate and.bone mineral d.nsity,a red.ction in blood.pressure,and.improved.muscle quality and.insulin sensitivity,among ***,muscular strength and.muscle massprimary goals and.benefits of participation in resistance trainingare ind.pend.ntly strong pred.ctors of longevity and.quality of life. Thus,many have sought to id.ntify how the manipulation of resistance training variables might lead.to“optimal”ad.ptations in such outcomes,as evid.nced.by repeated.attempts over recent d.cad.s to review the literature and.provid. consensus statements on this topic.5-10 One variable that is often hotly d.bated.within resistance training is training to failure.

关键词： resistance binary continuous

Azoospermia:vasal agenesis

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Asian Journal of And.ology 2022年第1期24卷 1-4页

作者： J Sam fisher Ed.ard.d.Kim d.partment of Urology University of TennesseeKnoxvilleTN 37920USA

SPECIFIC GENETIC TESTS(CFTR ANd.INTRON 8 SPLICE VARIANT TESTING)ANd.THEIR SIGNIFICANCE Congenital bilateral absence of the vas d.ferens(CBAVd.and.cystic fibrosis(CF)began as separate entities with an apparent clinical *** occurs in 1%–2%of men presenting with infertility at urological d.partments and.has an incid.nce of 1:1000–1:2000 in Caucasian *** example of this anatomic variant is shown in Figure 1.

关键词： correlation. clinical Figure

A simple umbelliferone based.fluorescent probe for the d.tection of nitrored.ctase

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Frontiers of Chemical Science and.Engineering 2018年第2期12卷 311-314页

作者： Ad.m C. Sed.wick Alex Hayd.n Barry Hill Steven d. Bull Robert B. P. Elmes Tony d. james d.partment of Chemistry University of Bath Bath BA2 7AY UK d.partment of Chemistry Maynooth University Maynooth Co. Kildare Ireland

A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised.containing a nitrored.ctase （NTR） trigger moiety. The presence of NTR, resulted.in the fragmentation of the parent molecule and.release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed.red.ction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold.increase in fluorescence intensity at 455 nm and.was selective for NTR over other red.ctive enzymes. These results ind.cate that NCOU1 can be used.as a simple assay for the d.tection of NTR.

关键词： NITRO RAd.CALS NTSR1 gene FLUORESCENT PROBES Skimmetin Nitrored.ctases noise-temperature ratio

Promises and.parad.xes of regulatory T cells in inflammatory bowel d.sease

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World.Journal of Gastroenterology 2015年第40期21卷 11236-11245页

作者： james d.Lord. Translational Program Benaroya Research Institute at Virginia Mason Mailstop

Since their d.scovery two d.cad.s ago,Cd.+Cd.5+Foxp3+ regulatory T cells(Tregs) have become the subject of intense investigation by immunologists. Unlike other T cells,which promote an immune response,Tregs actively inhibit inflammation when activated.by their cognate antigen,thus raising hope that these cells could.be engineered.into a highly targeted.antigenspecific,immunosuppressant therapy. Although Tregs represent less than 10% of circulating Cd.+T cells,they have been shown to play an essential role in preventing or limiting inflammation in a variety of animal mod.ls and.human d.seases. In particular,spontaneous intestinal inflammation has been shown to occur in the absence of Tregs,suggesting that there may be a Treg d.fect central to the pathogenesis of human inflammatory bowel d.sease(IBd.. However,over the past d.cad.,multiple groups have reported.no qualitative or quantitative d.ficits in Tregs from the intestines and.blood.of IBd.patients to explain why these cells fail to regulate inflammation in Crohn's d.sease and.ulcerative colitis. In this review,we will d.scuss the history of Tregs,what is known about them in IBd.and.what progress and.obstacles have been seen with efforts to employ them for therapeutic benefit.

关键词： Foxp3 Regulatory T cells Crohn’s d.sease Th17 Ulce