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Diffusion of lithium ions in Lithium-argyrodite solid-state electrolytes

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npj Computational Materials 2020年第1期6卷 326-335页

作者： Ardeshir baktash james C.reid Tanglaw Roman Debra J.Searles Centre for Theoretical and Computational Molecular Science Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandSt Lucia 4072 QLDAustralia School of Mathematics and Physics The University of QueenslandSt Lucia 4072 QLDAustralia School of Physics The University of SydneyCamperdown 2006 NSWAustralia School of Chemistry and Molecular biosciences The University of QueenslandSt Lucia 4072 QLDAustralia

The use of solid-state electrolytes to provide safer,next-generation rechargeable batteries is becoming more feasible as materials with greater stability and higher ionic diffusion coefficients are ***,accurate determination of diffusion coefficients in solids is problematic and reliable calculations are highly sought-after to understand how their structure can be modified to improve their *** this paper we compare diffusion coefficients calculated using nonequilibrium and equilibrium ab initio molecular dynamics simulations for highly diffusive solid-state electrolytes,to demonstrate the accuracy that can be ***,we show that ab initio nonequilibrium molecular dynamics can be used to determine diffusion coefficients when the diffusion is too slow for it to be feasible to obtain them using ab initio equilibrium simulations.

关键词： diffusion nonequilibrium feasible

Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

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Protein & Cell 2010年第2期1卷 188-197页

作者： Anne Jäkel Kenneth b.M.reid Howard Clark Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK University of Southampton MP 803 Level FSouth BlockSouthampton General HospitalSouthampton SO166YDUK

The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the *** we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human *** binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not *** cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for Jurkat cells and *** these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic ***,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.

关键词： surfactant proteins phosphatidylserine apoptotic cells

Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

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Protein & Cell 2010年第6期1卷 563-572页

作者： Anne Jäkel Howard Clark Kenneth b.M.reid Robert b.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(MPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised MPO binds SP-A and SP-D,and that MPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

Epidemiology of ovarian cancer:a review

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Cancer biology & Medicine 2017年第1期14卷 9-32页

作者： brett M.reid Jennifer b.Permuth Thomas A.Sellers Department of Cancer Epidemiology Division of Population SciencesMoffitt Cancer CenterTampa 33612FLUSA

Ovarian cancer(OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination,pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Genome-wide association studies have additionally identified 29 common susceptibility alleles for OC, including 14 subtype-specific alleles. Several reproductive and hormonal factors may lower risk, including parity, oral contraceptive use, and lactation, while others such as older age at menopause and hormone replacement therapy confer increased risks. These associations differ by histotype, especially for mucinous OC, likely reflecting differences in etiology. Endometrioid and clear cell OC share a similar, unique pattern of associations with increased risks among women with endometriosis and decreased risks associated with tubal ligation. OC risks associated with other gynecological conditions and procedures, such as hysterectomy,pelvic inflammatory disease, and polycystic ovarian syndrome, are less clear. Other possible risk factors include environmental and lifestyle factors such as asbestos and talc powder exposures, and cigarette smoking. The epidemiology provides clues on etiology,primary prevention, early detection, and possibly even therapeutic strategies.

关键词： Ovarian cancer epidemiology risk factors histology reproductive history

Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells

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Acta Pharmacologica Sinica 2007年第4期28卷 540-548页

作者： Paul reid Celtic biotech LtdDublinIreland

Aim:To investigate the role of crotoxin (CrTX)-induced autophagy in the death ofMCF-7 cells,a caspase-3-deficient,human breast cancer cell ***:Cul-tured MCF-7 cells were treated with various doses of CrTX,a phospholipase A2(PLA2) isolated from the venom of the South American rattlesnake,Crotalusdurissus *** cytotoxicity of CrTX in the presence and absence ofcaspase inhibitors was measured with methyl thiazolyl tetrazolium (MTT) andlactate dehydrogenase (LDH) leakage *** activation of autophagy wasdetermined with transmission electron microscope and monodansylcadaverin(MDC) *** upregulation of lysosomal enzymes,the release of cyto-chrome c (cyto-c),and the nuclear translocation of the apoptosis inducing factor(AIF) were examined by immunoblotting and ***:CrTXinhibited the viability of MCF-7 cells in a dose-and time-dependent ***-activated autophagy was revealed by punctuate MDC labeling,and an increase inthe formation of autophagosomes as well as apoptosis,as evidenced by nuclearcondensation and *** activation of cathepsin b,D,and L,inaddition to the release of cytochrome c and the relocation of AIF into nuclei,wereobserved after CrTX *** inhibitors 3-methyladenine (3-MA),NH4Cl,and the pan-caspase inhibitor,Z-Val-Ala-Asp-fluoromethylketone (Z-Vad-fmk),attenuated CrTX-induced cell ***:An autophagic mecha-nism contributes to the apoptosis of MCF-7 cells induced by CrTX.

关键词： crotoxin autophagy apoptosis cytochrome c apoptosis inducing factor

Hammer-Impact SH-Wave Seismic Reflection Methods in Neotectonic Investigations: General Observations and Case Histories from the Mississippi Embayment, U.S.A.

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Journal of China University of Geosciences 2009年第3期20卷 513-525页

作者： james b Harris Millsaps College Jackson MississippiUSA

Shallow shear-wave seismic reflection imaging, using a sledgehammer and mass energy source and standard processing, has become increasingly common in mapping near-surface geologic features, especially in water-saturated, unconsolidated sediments. Tests of the method in the Mississippi Embayment region of the central United States show interpretable reflection arrivals in the depth range of 〈10 m to 〉100 m with the potential for increased resolution when compared with compressional-wave data. Shear-wave reflection prof＇des were used to help interpret the significance of neotectonic surface deformation at five sites in the Mississippi Embayment. The interpreted profiles show a range of shallow structural styles that include reverse faulting, fault propagation folding, and reactivated normal faulting, and provide crucial subsurface evidence in support of paleoseismologic trenching and shallow drilling.

关键词： shear wave seismic reflection neotectonics.

Liver resection versus chemoembolization for patients with multifocal hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 543-545页

作者： Victor M.Zaydfudim reid b.Adams Department of Surgery Section of Hepatobiliary and Pancreatic SurgeryUniversity of VirginiaCharlottesvilleVAUSA

Curative intent treatment strategies for patients withhepatocellular carcinoma(HCC)include liver resection,livertransplantation,and arguably tumor ablation.

关键词： hepatocellular patients resection

Immunotherapy and therapeutic vaccines in prostate cancer： an update on current strategies and clinical implications

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Asian Journal of Andrology 2014年第3期16卷 364-371页

作者： b Harpreet Singh james L Gulley Medical Oncology branch Center for Cancer Research National Cancer Institute National Institutes of Health 10 Center Drive Bethesda Maryland USA

In recent years, immunotherapy has emerged as a viable and attractive strategy for the treatment of prostate cancer. While there are multiple ways to target the immune system, therapeutic cancer vaccines and immune checkpoint inhibitors have been most successful in late-stage clinical trials. The landmark Food and Drug Administration approval of sipuleuceI-T for asymptomatic or minimally symptomatic metastatic prostate cancer set the stage for ongoing phase III trials with the cancer vaccine PSA-TRICOM and the immune checkpoint inhibitor ipilimumab. A common feature of these immune-based therapies is the appearance of improved overall survival without short-term changes in disease progression. This class effect appears to be due to modulation of tumor growth rate kinetics, in which the activated immune system exerts constant immunologic pressure that slows net tumor growth. Emerging data suggest that the ideal population for clinical trials of cancer vaccines is patients with lower tumor volume and less aggressive disease. Combination strategies that combine immunotherapy with standard therapies have been shown to augment both immune response and clinical benefit.

关键词： androgen deprivation immunotherapy prostate cancer therapeutic cancer vaccines

内华达山花岗岩中的结晶分离作用真的至关重要吗?

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国外火山地质 1994年第1期 43-47页

作者： John b.reid Jr. 徐鹏山

尽管带状钙—碱性深成岩体的成分变化常归因于结晶分离作用,但是在这些缓慢冷却的岩体中,特征性的大规模晶体堆积的野外证据一般还是没有见到。然而,在许多深成岩体中,小规模的晶体堆积可以层状析离体的形式被保存下来,这种小型堆积体... 详细信息

尽管带状钙—碱性深成岩体的成分变化常归因于结晶分离作用,但是在这些缓慢冷却的岩体中,特征性的大规模晶体堆积的野外证据一般还是没有见到。然而,在许多深成岩体中,小规模的晶体堆积可以层状析离体的形式被保存下来,这种小型堆积体可以在微区范围内用来评价主岩体演化时结晶分离作用的重要性。在加利福尼亚的塞米蒂国家公园图奥勒米侵入岩系中,小而极分散的析离体形成了堆积体。其中最深色层高度富集了磁铁矿、榍石、黑云母、普通角闪石和锆石,并异常地分镏出常量元素和微量元素组分(FeO>33%;Al2O3<7%;La/La球粒陨石约750;Zr约2000×10-6)。在常量元素和微量元素Al-2O3的变异图上,深色层都显示出平滑的趋势,并大大偏离了图奥勒米侵入岩系的主要岩石系列和遍布于内华达山中的花岗岩类的趋势模式。从图奥勒米侵入岩系中任何主要岩石系列的岩浆中析出这种析离体后,会产生深成岩体的富铝演化岩石,而不是贫铝长英质岩石.这一发现表明,结晶分离作用不会产生像图奥勒米侵入岩系和类似于内华达山花岗岩中所见到的那种主要化学模式。

关键词：花岗岩结晶分离常量元素微量元素酸性岩痕量元素岩石侵入体深成岩体深色层火成岩侵入岩美国内华达