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Future challenges in the in vitro and in vivo evaluation of biomaterial biocompatibility

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Regenerative Biomaterials 2016年第2期3卷 73-77页

作者： james M.anderson Case Western Reserve University 2103 Cornell RoadWRB 5105ClevelandOH 44106-7288USA

As the science and engineering of biomaterials continues to expand with increased emphasis on the development of nanomaterials and tissue engineering scaffolds,emphasis also must be placed on appropriate and adequate approaches to the in vivo and in vitro evaluation of biomaterial biocompatibility/biological response *** article presents six topic areas that should be addressed by investigators as they move forward in the development of new systems for regenerative *** certainly,there are other areas that require attention to detail and a more complete understanding of the strengths and weaknesses of various experimental approaches to biomaterial/biological response *** small number of issues addressed in this article is only meant to bring to the attention of prospective investigators and authors,the importance of the development of adequate and appropriate evaluation techniques that address the unique features of biomaterials utilized in the development of new medical devices.

关键词： biomaterials nanomaterials tissue engineering

ecent advances in selective acetylene hydrogenation using palladium containing catalysts

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Frontiers of Chemical Science and Engineering 2015年第2期9卷 142-153页

作者： Alan J. McCue james A. anderson Surface Chemistry and Catalysis Group Department of Chemistry University of Aberdeen Aberdeen AB24 3UE UK Materials and Chemical Engineering Group School of Engineering University of Aberdeen Aberdeen AB24 3UE UK

Recent advances with Pd containing catalysts for the selective hydrogenation of acetylene are described. The overview classifies enhancement of catalytic proper- ties for monometallic and bimetallic Pd catalysts. Activity/ selectivity of Pd catalysts can be modified by controllingparticle shape/morphology or immobilisation on a support which interacts strongly with Pd particles. In both cases enhanced ethylene selectivity is generally associated with modifying ethylene adsorption strength and/or changes to hydride formation. Inorganic and organic selectivity modifiers （i.e., species adsorbed onto Pd particle surface） have also been shown to enhance ethylene selectivity. Inorganic modifiers such as TiO2 change Pd ensemble size and modify ethylene adsorption strength whereas organic modifiers such as diphenylsulfide are thought to create a surface template effect which favours acetylene adsorption with respect to ethylene. A number of metals and synthetic approaches have been explored to prepare Pd bimetallic catalysts. Examples where enhanced selectivity is observed are generally associated with decreased Pd ensemble size and/or hindering of the ease with which an unselective hydride phase is formed for Pd. A final class of bimetallic catalysts are discussed where Pd is not thought to be the primary reaction site but merely acts as a site where hydrogen dissociation and spillover occurs onto a second metal （Cu or Au） where the reaction takes place more selectively.

关键词： acetylene ethylene selective hydrogenation,palladium bimetallic

Gold modified cobalt-based Fischer-Tropsch catalysts for conversion of synthesis gas to liquid fuels

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Frontiers of Chemical Science and Engineering 2013年第3期7卷 262-269页

作者： Alan J. Mccue Jura Aponaviciute Richard P.K. Wells james A. anderson Surface Chemistry and Catalysis Group Department of Chemistry University of Aberdeen AB24 3UE Abcrdccn UK Surface Chemistry and Catalysis Group School of Engineering University of Aberdeen AB24 3UE Aberdeen UK

The addition of Au as a promoter/modifier for alumina supported Co catalyst has been studied by combined in-situ high temperature, high pressure Fourier transform infrared （FTIR） and on-line gas chromatography. The combination of these tools permitted the state of the active catalyst surface to be monitored while following the elution of reaction products during the first 5-7 h on stream of the catalyst. The catalysts under study were a 10%Co/ A1203 and a 2.5%Au/10%Co/A1203. Samples were characterised before use using Raman and temperature programmed reduction （TPR）. During the initial stages of reaction, hydrocarbons were built up on the surface of the catalyst as monitored by FTIR and the nature and amount of these species were assessed in terms of CH2/CH3 ratio and the density of these alkyl fragments by employing absorption coefficients for the individual components. The nature and reducibility of the Co particles were modified by the presence of Au while the later also shifted the CO/ H2 balance by acting as an effective water-gas shift catalyst during the early stages of reaction. This characteristic was lost during reaction as a consequence of redistribution of the two metallic phases.

关键词： gold modified catalyst conversion of synthesis gas

Microhabitat use by white-footed mice Peromyscus leucopus in forested and old-field habitats occupied by Morrow's honeysuckle Lonicera morrowii

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Current Zoology 2009年第2期55卷 111-122页

作者： Jennifer A. EDALGO Holly M. McCHESNEY Jason P. LOVE james T. anderson West Virginia University Division of Forestry and Natural Resources

We quantified microhabitat use by white-footed mice Peromyscus leucopus in forest and old-field habitats occupied by Morrow＇ s honeysuckle Lonicera morrowii, an invasive exotic shrub imported from Japan. Microhabitat characteristics were compared between trails used by mice （ n = 124） and randomly selected trails （ n = 127） in 4 study plots located at Fort Necessity National Battlefield, Farmington, Pennsylvania, USA. We compared 10 mierohabitat variables between used and random trails using non-metric multidimensional scaling （NMDS） and classification and regression tree （CART） analysis. Trails used by mice were statistically different from randomly selected trails in both forested plots （ P 〈 0. 008） and old-field plots （ P 〈 0. 001 ）. In the forested plots, trails of white-footed mice were more often associated with a greater percent cover （% cover） of coarse woody debris （CWD） than were randomly selected trails. In the old-field plots, mouse trails were commonly characterized by having a lower % cover of exotic herbaceous vegetation, a greater % cover of shrubs, and a greater % cover of Morrow＇ s honeysuckle than randomly selected trails. Our study indicates that white-footed mice do not move randomly and prefer areas of high structural complexity, thereby showing significant microhabitat preference. The preference of white-footed mice for areas with a relatively high percent cover of Morrow＇s honeysuckle could 1 ） be a factor in the aggressive nature of the exotic honeysuckle shrub＇s spread throughout the Battlefield or 2） cause the shrub to spread even faster into adjacent areas not yet occupied by Morrow＇ s honeysuckle

关键词： Microhabitat selection Morrow' s honeysuckle Peromyscus White-footed mice Exotic species Seed distribution

Lactosylated N-Alkyl polyethylenimine coated iron oxide nanoparticles induced autophagy in mouse dendritic cells

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Regenerative Biomaterials 2018年第3期5卷 141-149页

作者： Taipeng Shen Wencheng Zhu Li Yang Li Liu Rongrong Jin Jimei Duan james M.anderson Hua Ai National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065People’s Republic of China Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of SciencesShanghai 200031People’s Republic of China Departments of Pathology Macromolecular Science and Biomedical EngineeringCase Western Reserve UniversityClevelandOH 44106USA Department of Radiology West China HospitalSichuan UniversityChengdu 610065People’s Republic of China

Dendritic cell(DC)-based vaccines have shown promising therapeutic results in cancer and some immune *** is critical to track in vivo migration behaviours of DCs and monitor the whole process dynamically and *** iron oxide(SPIO)nanoparticles are chosen for DC labelling under magnetic resonance imaging(MRI)because of their proven biosafety as contrast ***,when used for cell labelling,sensitive biological indicators such as cell autophagy may be helpful to better understand the process and improve the probe ***,lactosylated N-Alkyl polyethylenimine coated SPIO nanoparticles are used for DC *** probe shows satisfactory cell labelling efficiency and low *** this study,autophagy was used as a key factor to understand how DCs react to nanoparticles after *** results demonstrate that the nanoparticles can induce protective autophagy in DCs,as inhibition of the autophagy flux could lead to cell ***,the nanoparticles induced autophagy could promote DC maturation which is an essential process for its migration and antigen *** induced DC maturation is known to enhance the vaccine functions of DCs,therefore,our results suggest that beyond the MRI tracking ability,this probe might enhance therapeutic immune activation as well.

关键词： dendritic cell nanoparticle autophagy cell maturation

Crisis-Free Millennium Spreads Around the Globe

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当代外语研究 2000年第2期 10-13页

作者： james anderson 吕雁湖

人类已经跨入了新的千年。我在网上读到这篇文章,仍然心潮起伏。本文全景式地扫描世界各地在迎接新千年的到来时所呈现的狂欢一刹那。一句写一地,文采斐然,字里行间,透出磅礴气势。莫斯科人最浪漫:…stranger kissed stranger in Red S... 详细信息

人类已经跨入了新的千年。我在网上读到这篇文章,仍然心潮起伏。本文全景式地扫描世界各地在迎接新千年的到来时所呈现的狂欢一刹那。一句写一地,文采斐然,字里行间,透出磅礴气势。莫斯科人最浪漫:…stranger kissed stranger in Red Square. 菲律宾人最不幸:…where three people were killed and about 200 injuredby firecrackers and gunfire. 纽约时代广场最具吸引力:Zlatka Petrova,22,who saved for months totravel from the Bulgarian(保加利亚的)town of Gocedelchev to New York’sTimes Square. 中国的长城最壮观:At the Great Wall of China,revelers(饮酒狂欢者)litup the clear night skies with fireworks and dragon dancers… 当人们以前所未有的快乐心情走进2000年之后,此前许多对我们这个世界是否会安然度过世纪之交的担忧也随之烟消云散。然而,一些争论仍在继续,电脑“千年虫”问题就是其中之一。一年多之前,曾有专家预言——1999年岁末之际,世界各地的消费者将把食品店的提款机掠扫一空,管理人类生活的计算机将由于“千年虫”猖獗而陷于瘫痪,人们将在黑暗和寒冷中度过新千年之夜。然而,除了几段有惊无险的“小插曲”之外,噩梦最终并未成真。据匡算,全世界为对付“千年虫”

关键词：狂欢者千年虫保加利亚

Invertebrate Abundance, Biomass, and Richness Associated with an Exotic Invasive Shrub (Lonicera morrowii A. Gray)

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Natural Resources 2020年第7期11卷 257-282页

作者： Jason P. Love james T. anderson Division of Forestry and Natural Resources West Virginia University Morgantown WV USA Highlands Biological Station Western Carolina University Highlands NC USA

Exotic bush honeysuckles (Lonicera spp.) are becoming increasingly common in the eastern and mid-western United States, but little is known about their impacts on invertebrates. We used a modified leaf vacuum to sample invertebrates in the shrub strata and understory of three shrub types (and open plots in the understory): single Morrow’s honeysuckle (L. morrowii A. Gray) shrubs, single native southern arrowwood (Viburnum recognitum Fernald) shrubs, and dense thickets of Morrow’s honeysuckle, in southwestern PA, USA during 2004 and 2005. We also assessed the degree of herbivory on the two species of shrubs. Within the shrub strata, invertebrate biomass was lower in southern arrowwood shrubs, but there was no difference in invertebrate abundance or family richness. Invertebrate abundance and richness were lowest in August, but there was no difference in biomass among the months. Invertebrate abundance, biomass, and family richness were lowest in the understory below dense thickets of Morrow’s honeysuckle. Overall, the percent cover of herbs was the pr

关键词： Invertebrate Biomass Lonicera morrowii Morrow’s Honeysuckle Southern Arrowwood Terrestrial Invertebrates Viburnum recognitum

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Foreword

Regenerative Biomaterials 2016年第2期3卷 65-65页

作者： james M.anderson Case Western Reserve University USA

This special issue of Regenerative Biomaterials presents 13 manuscriptsprovided by participants of the China–US Forum on GrandChallenges for Biomaterials in the 21st Century. This forum washeld on November 17, 2015, in Chengdu, China and was chaired bythe Editor of Regenerative Biomaterials, Professor Xingdong Zhangand Professor Nicholas Peppas. The participants of this forum wereinternationally recognized experts from the United States ofAmerica and the Peoples Republic of China. It is noteworthy thatthe United States speakers were members of the National Academyof Engineering, Section 2. Bioengineering, and most of the Chinesespeakers were members of the Chinese Academy of Engineering orthe Chinese Academy of Sciences. The overlying theme of this forumand this resultant special issue is the impact that the biological environmentin which biomaterials will be utilized is now recognized asproviding a wide variety of significant and impactful challenges thatmust be overcome if biomaterials are to achieve clinical application.

关键词： speakers biomaterials overcome

Functional Equivalence of Created Wetland Water Quality: A Comparison of Amphibian Metamorphic Success

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Open Journal of Ecology 2020年第7期10卷 418-439页

作者： Lauren A. McPherson Ida Holásková james T. anderson School of Natural Resources West Virginia University Morgantown WV USA Office of Statistics Davis College of Agriculture Natural Resources and Design West Virginia University Morgantown WV USA

Wetlands are often created through wetland mitigation to replace lost natural wetlands, but further evaluation is needed to determine the ability of a created wetland to replace lost wetland functions, especially providing wildlife habitat. We used a mesocosm design to compare the water quality between three created wetlands and three natural wetlands in West Virginia, USA and to evaluate how the water quality from the two wetland types were able to support metamorphosis in larval spring peepers (Pseudacris crucifer) and wood frogs (Lithobates sylvaticus) across two years (2014-2015). Responses in metamorphosis rates differed between species and between years. Spring peepers displayed similar metamorphosis rates in the created and natural wetlands in both years of the study. Wood frogs displayed similar metamorphosis rates in created and natural wetlands in 2015, but in 2014 wood frogs reached metamorphosis in less time and at a larger body size in the natural wetlands, suggesting that the wood frogs that developed in the natural wetlands may have higher fitness than those that developed in the created wetlands. Water quality was largely similar between created and natural wetlands, although dissolved oxygen, conductivity, and pH varied between mesocosms and wetlands. Our study suggests that created wetlands may be providing partial mitigation in terms of water quality for amphibian development. We recommend that future monitoring of created wetlands include measures of juvenile amphibian recruitment as well as additional habitat variables to better determine the ability of created wetlands to function as amphibian habitat.

关键词： Appalachians Pseudacris crucifer Spring Peeper Lithobates sylvaticus West Virginia Wood Frog