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A retrospective analysis of pain and opioid usage in head and neck free flap reconstruction

World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 153-159页

作者： Parhom Towfighi Alison Hill Jason R.Crossley Amanda Walsh james a.leonard Jonathan P.Giurintano Matthew L.Pierce Michael J.Reilly Georgetown University School of Medicine WashingtonDistrict of ColumbiaUSA Department of Otolaryngology-Head and Neck Surgery Medstar GeorgetownWashingtonDistrict of ColumbiaUSA

Objectives:Investigate opioid usage and postoperative pain in patients undergoing head and neck free flap ***:A retrospective review of 100 consecutive patients undergoing head and neck free flap reconstruction at two academic centers was *** captured included demographics,postoperative inpatient pain,pain at postoperative visits,morphine equivalent doses(MEDs)administration,medication history,and *** were analyzed using regression models,χ2 tests,and student’’***:Seventy-three percent of patients were discharged with opioid medication,with over half(53.4%)continuing to take opioids at their second postoperative visit,and over one-third(34.2%)continuing to take them around 4-month *** out of every five(20.3%)opioid-na?ve patients chronically took opioids *** was a poor association between inpatient postoperative pain scores and daily MEDs administered(R2=0.13,0.17,and 0.22 in postoperative Days 3,5,and 7,respectively).Neither preoperative radiotherapy nor postoperative complications were associated with an increase in opioid ***:For patients undergoing head and neck free flap operations,opioid medications are commonly used for postoperative *** practice may increase the chance an opioid-na?ve patient uses opioids *** found a poor association between MEDs administered and patient-reported pain scores,which suggests that standardized protocols aimed at optimizing analgesia while reducing opioid administration may be *** of Evidence:3(Retrospective cohort study).

关键词： free flap reconstruction head and neck multimodal analgesia opioids postoperative pain

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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A Case Study of Ocean-Atmosphere Interactions during the Passage of an Extra-Tropical Cyclone in the Vicinity of Cape Hatteras, North Carolina

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International Journal of Geosciences 2023年第9期14卷 855-876页

作者： Neil Jacobs james Churchill leonard Pietrafesa Shaowu Bao Paul Gayes University Corporation for Atmospheric Research Boulder USA Department of Physical Oceanographym Woods Hole Oceanographic Institution Woods Hole USA School of Coastal & Marine Systems Science Burroughs & Chapin Center for Marine & Wetland Studies Coastal Carolina University Conway USA Department of Marine Earth Atmospheric Sciences North Carolina State University Raleigh USA

The authors document the interaction of the atmosphere and ocean during the formation and passage of an Extra-Tropical Cyclone, which is a Nor-Easter, winter storm that formed in the southern apex of the Middle Atlantic Bight near Cape Hatteras North Carolina, between February 15 and 18, 1996. While Nor-Easters per se, which have formed along the Atlantic Eastern Seaboard of the United States have been studied for decades, the actual atmospheric-oceanic mechanics and thermodynamics in the formation of a Nor-Easter has never been documented. We report on having done so with in-situ observations and data-based calculations and a numerical model. The in-situ observations were made via a Control Volume consisting of an array of Eulerian Oceanic-Atmospheric Moorings with current meters, temperature and salinity sensors and meteorological towers. We find that Gulf Stream waters were located surrounding the mooring array, and that with the invasion of cold dry atmospheric air, there was a rapid loss of heat from the ocean to the atmosphere via latent and sensible surface heat flux during the cyclogenesis onset of the storm. A unique feature of this storm was that neither satellite nor buoy data showed significant sea surface cooling in the control volume. The findings indicate that storm winds drove warm saline waters from the Gulf Stream across the continental shelf into the control volume, accounting for a 51 cm rise in water level along the coast. This lateral heat advection provided heat to the control volume of 3.4e+18 Joules. On average, the heat loss at the surface of the control volume, via sensible and latent heat fluxes and radiation, was 0.7e+18 Joules, corresponding to a surface heat flux of -600 Watts per Meter2 (W/m2). However, the heat lost by the control volume as latent and sensible heat fluxes was less than the heat it received via lateral heat advection, resulting in the lack of an often-observed sea surface cooling during other winter storms.

关键词： Mid-Latitude Cyclone Extra-Tropical Cyclone Cyclogenesis Nor’easter Winter Storms Latent and Sensible Heat Fluxes Salt Flux

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Sulphuric Acid Bake-Leach Process for the Treatment of Mixed Copper-Cobalt Oxide Ores

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Journal of Minerals and Materials Characterization and Engineering 2022年第2期10卷 174-184页

作者： Precious Mwamba Jewette H. Masinja james Manchisi leonard Kabondo Department of Metallurgy and Mineral Processing University of Zambia Lusaka Zambia Metallurgy Department Copperbelt University Kitwe Zambia

A sulphuric acid bake–leach method for the treatment of mixed copper-cobalt oxide minerals was investigated as an alternative to the reductive leaching method. Sulphuric acid bake-leach process of the mixed copper-cobalt oxide ore was carried out by mixing the sample with sulphuric acid followed by baking of the mixture in a muffle furnace. Baking tests were conducted at different conditions such as temperature, time, and varying amounts of acid. The reacted samples were then subjected to water leaching at room temperature to determine the leachability of copper and cobalt from the baked material. The dissolutions of copper and cobalt were dependent on acid concentration with cobalt showing more sensitivity to the amount of acid. Both copper and cobalt were extracted from the baked material within short leaching times and without the addition of reducing agents. The outcome of this work has shown that the sulphuric acid bake-leach process is a possible alternative to the reductive leaching method for copper-cobalt oxide ores.

关键词： Democratic Republic of Congo (DRC) Mixed Copper-Cobalt Oxide Sulphuric Acid Baking Sulphate Reducing Agent Metal Dissolution

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The Health Benefits of a Pedometer-Based 100,000 Steps/Week Physical Activity Program

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Journal of Science in Sport and Exercise 2019年第2期1卷 176-183页

作者： Earlene Masi james E.Peterman leonard A.Kaminsky Department of Kinesiology Kardatzke Wellness CenterAnderson UniversityAndersonIN 46012USA Fisher Institute of Health and Well-Being Health and Physical Activity BuildingRoom 302Ball State UniversityMuncieIN 47306USA

Purpose Pedometers can be an effective tool to increase step counts in a physically inactive *** a more active population,pedometers may also be useful for further increasing physical activity and improving cardiovascular disease risk *** purpose was to assess the adherence and determine the health impact of a 100,000 steps/week(14,286 steps/day)goal in a somewhat-active(7500-9999 steps/day)to active(10,000-12,500 steps/day)*** Thirty-two apparently healthy subjects,13 males(age 44±14 years)and 19 females(age 39±13 years)who had a baseline activity level between 7500 and 12,500 steps/day,were *** were assessed prior to and 16 weeks after completing a 100,000 steps/week ***-and post-assessments of health included body composition,rest-ing blood pressure,blood lipid profile,fasting blood glucose,and a 3-min walk test to estimate cardiorespiratory *** Fifty-three percent of participants adhered(≥90,000 steps/week)to the 100,000 steps/week physical activity program yet all participants increased their stepping by 23,303±11,480 steps/*** increased stepping,significant improvements in body composition were *** included reduced body mass index(pre:27.2±3.6 kg/m^(2);post:26.9±3.6 kg/m^(2);P=0.026),reduced total percent body fat(pre:35.7±9.9%;post:34.3±10.4%;P<0.001),and reduced waist circumference(pre:83.8±10.2 cm;post:81.5±10.0 cm;P=0.001).An unexpected increase was observed for low density lipoprotein cholesterol(pre:109.7±22.7 mg/dL;post:117.6±20.4 mg/dL;P<0.05).Conclusions Individuals who were previously somewhat-active or active can gain additional health benefits,particularly improvements in body composition,by increasing to 100,000 steps/week with the use of a pedometer.

关键词： Physical activity Pedometer Body composition Adherence Dose-response

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Nanotrains and Self-Assembled Two-Dimensional Arrays Built from Carboranes Linked by Hydrogen Bonding of Dipyridones

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Nano Research 2008年第5期1卷 412-419页

作者： Takashi Sasaki Jason M.Guerrero Ashley D.leonard james M.Tour Department of Chemistry Department of Mechanical Engineering and Materials ScienceRice UniversityMS 2226100 Main St.HoustonTexas 77005USA

The strong hydrogen bonding ability of 2-pyridones were exploited to build nanotrains on *** wheels on axles difunctionalized with 2-pyridone hydrogen bonding units were synthesized and displayed spontaneous formation of linear nanotrains by self-assembly on SiO_(2)or mica *** using atomic force microscopy confi rmed linear formations with lengths up to 5μm and heights within the range of the molecular height of the carborance-tipped axles.

关键词： Nanovehicles nanotrains 2-pyridone hydrogen bonding self-assembly

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Characterization and transcriptional analyses of cDNAs encoding three trypsin- and chymotrypsin-like proteinases in CrylAb-susceptible and CrylAb-resistant strains of sugarcane borer, Diatraea saccharalis

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Insect Science 2013年第4期20卷 485-496页

作者： Yunlong Yang Yu Cheng Zhu james Ottea Claudia Husseneder B. Rogers leonard Craig Abel Randall Luttrell Fangneng Huang Department of Entomology Louisiana State University Agricultural Center Baton Rouge Louisiana Southern Insect Management Research Unit Agricultural Research Service United States Department of Agriculture Stoneville Mississippi Corn Insects and Crop Genetics Research Unit Agricultural Research Service United States Department of Agriculture Ames Iowa USA

Diatraea saccharalis is a major corn borer pest. Midgut serine proteinases are essential for insect growth and development. Alteration of midgut proteinases is re- sponsible for Bt resistance development in some species. To clone midgut trypsin and chymotrypsin cDNAs and to test if the CrylAb resistance in D. saccharalis is associ- ated with changes in midgut proteinases, total midgut tryptic and chymotryptic activities, cDNA sequences, and gene expressions of three trypsin and three chymotrypsin genes were comparatively examined between Cry 1 Ab-susceptible （Cry 1 Ab- S S） and Cry 1 Ab-resistant （Cry 1 Ab-RR） strains. Full-length cDNAs encoding three trypsin- and three chymotrypsin- like proteinases were sequenced from CrylAb-SS and CrylAb-RR larvae. These cDNAs code for active forms of midgut serine proteinases with all fimctional motifs, includ- ing signal peptide, conserved His-Asp-Ser for the catalytic triad, three pairs of cysteines for disulfide bridge configurations, and conserved substrate specificity determination residues. In general, cDNA and putative protein sequences are highly similar between CrylAb-SS and CrylAb-RR strains, except for a few nucleotide and predicted amino acid substitutions, whose function need to be further clarified. Total trypsin and chymotrypsin activities were also similar between CrylAb-SS and CrylAb-RR strains. Transcriptional levels of the trypsin and chymotrypsin genes had numerical difference between Cry 1 Ab-SS and CrylAb-RR strains, but the difference was not statistically significant. Data suggest that the development of CrylAb resistance in D. saccharalis was not significantly as- sociated with these trypsins and chymotrypsins. Results clarified the role of six midgut proteinases and provided a foundation for continuing examination of potential involvement of other midgut proteinases in Bt resistance development and other important biochemical processes.

关键词： Bt cDNA chymotrypsin enzymatic activity resistance trypsin

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The Effects of Externally Paced Exercise on Executive Function and Stress in College-Aged Students

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Journal of Science in Sport and Exercise 2023年第2期5卷 149-155页

作者： Peter C.Douris Joseph Cottone Patricia Cruz Nicholas Frosos Christie Marino leonard Singamenggala Joshua Shapiro Amber Sousa John P.Handrakis Joanne DiFrancisco‑Donoghue Department of Physical Therapy School of Health ProfessionsNew York Institute of TechnologyOld WestburyNY 11758USA College of Osteopathic Medicine New York Institute of Technology(NYIT)Old WestburyNYUSA VA RR&D National Center for the Medical Consequences of Spinal Cord Injury James J.Peters VA Medical CenterBronxNYUSA

Purpose The purpose of the study was to investigate the acute effect of a beginner martial art class and aerobic exercise on executive function(EF)in college-aged young *** is overwhelming evidence that demonstrates acute as well as long-term aerobic exercise improves ***,there is limited research comparing externally paced exercise(EPE)to self-paced exercise(SPE)such as walking on improving *** requires greater cortical demand than SPE to execute a motor *** Eight men and eight women,aged 24.2±2.8 years,participated in a Repeated Measures Crossover ***-and post-testing of EF with the Stroop and Tower of London(ToL)and stress level were measured after each of the two 1-h conditions:the SPE consisted of a walk(aerobic exercise)and the EPE was a beginner martial art *** There were significant main effects for the martial art class for the Stroop’s mean reaction time for congruent trials(P=0.01)with a large-effect *** mean reaction time for incongruent trials was significant(P=0.05)with a medium-effect *** ToL’s mean solution time(P=0.003)and mean execution time(P=0.002)were also significant with large-effect *** levels were not significantly improved following either *** The martial art class significantly improved all the major domains of EF,while aerobic exercise of a similar intensity did not demonstrate any measured significant *** physiological benefits of physical exercise are well documented;however,the cognitive enhancing capability of EPE should also be appreciated given the results of this study.

关键词： Externally paced exercise Self-paced exercise Cognitive performance Executive function

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The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize

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Molecular Plant 2022年第5期15卷 904-912页

作者： Ce Deng April leonard james Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding College of Agronomy Henan Agricultural UniversityZhengzhou 450046China The State Key Laboratory of Wheat and Maize Crop Science and Center for Crop Genome Engineering Henan Agricultural UniversityZhengzhou 450046China Corteva Agriscience JohnstonIA 50131USA Institute of Plant Protection Henan Academy of Agricultural SciencesZhengzhou 450002China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Plant Physiology and Biochemistry National Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100193China International Maize and Wheat Improvement Center(CIMMYT) El Batan56237 TexcocoMexico Center of Biotechnology Beijing Lantron SeedZhengzhou 450001China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Henan Dingyou Agricultural Science and Technology Co. LtdZhengzhou 450001China

Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction *** breeding and deployment of resistant hybrids are key to achieving durable control of ***,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait ***-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by *** and triggers RppC-mediated *** variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize ***,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability.

关键词： maize Zea mays RppC AvrRpp Csouthern corn rust SCR

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Body Composition and Performance Capabilities Based on Protein Intake in Collegiate Dancers： A Pilot Study

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Journal of Sports Science 2017年第4期5卷 189-197页

作者： Ann Frost Brown Christopher William Bach Giuliana De Almeida Shawn leonard Tom Welsh Michael james Ormsbee Institute of Sports Sciences and Medicine Department of Nutrition Food and Exercise Sciences Florida State UniversityTallahassee FL 32306 USA Department of Movement Sciences University of Idaho Moscow ID 83843 USA University of Nebraska-Lincoln Nebraska Athletic Performance Laboratory Lincoln NE 68588 USA School of Dance Florida State University Tallahassee FL 32306 USA Department of Biokinetics Exercise and Leisure Sciences University of KwaZulu-Natal Durban 4000 South Africa

The aesthetic nature of dance places pressure on the athlete to have low body weight and fat and despite data showing higher protein intake improving body composition in numerous populations, a paucity of data exists on dancers. Therefore, the purpose of this study was to examine associations between protein intake, body composition and performance among dancers. Female dancers (n = 25; age 20.7 ± 1.8 years; mean ± SD) completed three-day diet logs, body composition (DXA), and performance testing. Protein intake was expressed as g/kg/day and three equal tertiles were created (Low protein: LP, 1.6 g/kg/day). Data were analyzed using one-way ANOVA to compare group means with significance at P < 0.05. Protein and energy intake were greater in HP compared to LP (P = 0.001, 0.033, respectively). The only performance difference observed was peak horizontal force (AMTI force platform) which was significantly greater in HP compared to LP (LP: 295.7 ± 111.1N, HP: 419.9 ± 76.7N; P = 0.029). In conclusion, no significant differences were found between protein tertiles and body composition. Nevertheless, protein intake may be physiologically important to dancers when combined with evidence from other athletic populations indicating high protein and energy intake may be beneficial to body composition.

关键词： Body composition nutrition protein performance dance

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