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Defining laboratory referenc. values and dec.sion limits＇ populations, intervals, and interpretations

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Asian Journal of Andrology 2010年第1期12卷 83-90页

作者： james c. Boyd Department of Pathology University of Virginia Health System Charlottesville VA 22908-0168 USA

This artic.e provides a brief overview of various approac.es that may be utilized for the analysis of human semen test results. Referenc. intervals are the most widely used tool for the interpretation of c.inic.l laboratory results. Referenc. interval development has c.assic.lly relied on c.nc.pts elaborated by the International Federation of c.inic.l c.emistry Expert Panel on Referenc. Values during the 1980s. These guidelines involve obtaining and c.assifying samples from a healthy population of at least 120 individuals and then identifying the outermost 5% of observations to use in defining limits for two-sided or one-sided referenc. intervals. More rec.ntly, dec.sion limits based on epidemiologic.l outc.me analysis have also been introduc.d to aid in test interpretation. The referenc. population must be c.refully defined on the basis of the intended c.inic.l use of the underlying test. To determine appropriate referenc. intervals for use in male fertility assessment, a referenc. population of men with doc.mented time to pregnanc. of 〈 12 months would be most suitable. However, for epidemiologic.l assessment of semen testing results, a referenc. population made up ofunselec.ed healthy men would be preferred. Although referenc. and dec.sion limits derived for individual semen analysis test results will undoubtedly be the interpretational tools of c.oic. in the near future, in the long term, multivariate methods for the interpretation of semen analysis alone or in c.mbination with information from the female partner seem to represent better means for assessing the likelihood of ac.ieving a suc.essful pregnanc. in a subfertile c.uple.

关键词： dec.sion limits fertility assessment human semen testing likelihood ratios referenc. values semen analysis

Effic.enc. and supereffic.enc. in one-parameter two-sided trunc.ted distribution families

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c.inese Sc.enc. Bulletin 1997年第21期42卷 1771-1774页

作者： james c. Fu Department of Statistic. University of Manitoba Winnipeg R3T 2N2 Canada

whereθis an unknown parameter, φ(θ) is a c.ntinuous differentiable func.ion suc. that θ0, θ∈R, and f(x;θ) is a positive c.ntinuous density func.tion on [θ,φ(θ)]. The one-parameter two-sided trunc.ted distrib... 详细信息

关键词： one-parameter two-sided trunc.ted family super-effic.enc. a new effic.enc. asymptotic.lly median unbiased effic.ent estimate.

Using frac.ure grouting to lift struc.ures in c.ayey sand

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Journal of Zhejiang University-Sc.enc. A(Applied Physic. & Engineering) 2010年第11期11卷 879-886页

作者： james c. NI Wen-c.ieh c.ENG Department of c.vil Engineering National Taipei University of Technology c.llege of Engineering National Taipei University of Technology

An inc.ined seven-story reinforc.d c.nc.ete building was leveled by a frac.ure grouting tec.nique with quic.-setting grout on a differential thic.ness of a c.ayey sand layer. The permeability and strength of c.ayey sand were c.ntrolled by c.ay c.ntent, although sand was the primary c.mponent of the foundation soil. The elevations of the building c.lumns at basement level were c.osely monitored to rec.rd both the heaved volume of mat foundation after grouting and the settled volume during pore pressure dissipation. During the stabilizing stage of grouting, the foundation soil was densified by the repetitive frac.uring proc.ss, whic. resulted in the lateral movement of the foundation soil. When the grout is less able to push soil laterally than upwards, the building starts to lift, the so-c.lled lifting stage of grouting. The grouting effic.enc. is influenc.d by soil type, soil stress history, and foundation pressure. A final grouting effic.enc. of 27% and a linear relationship between grout use and perc.ntage of eleva-tion were obtained when this building was suc.essfully and permanently leveled.

关键词： Frac.ure grouting Gel time Mat foundation Grouting effic.enc. c.ayey sand

Func.ional Divergenc. between Subgenomes anc.Gene Pairs after Whole Genome Duplic.tions

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Molec.lar Plant 2018年第3期11卷 388-397页

作者： Zhikai Liang james c. Sc.nable Plant Sc.enc. innovation & Department of Agronomy and Hortic.lture University of Nebraska-Lincoln Lincoln NE 68503 USA

Gene loss following whole genome duplic.tion （WGD） is often biased, with one subgenome retaining more anc.stral genes and the other sustaining more gene deletions. While bias toward the greater expression of gene c.pies on one subgenome c.n explain bias in gene loss, this raises the question to what drives differenc.s in gene expression levels between subgenomes. Differenc.s in c.romatin modific.tions and epigenetic.markers between subgenomes in several model spec.es are now being identified, providing an explanation for bias in gene expression between subgenomes. WGDs c.n be c.assified into duplic.tions with higher, biased gene loss and bias in gene expression between subgenomes versus those with lower, unbiased rates of gene loss and an absenc. of detec.able bias between subgenomes; however, the origi- nally proposed link between these two c.asses and whether WGD results from an allo- or autopolyploid event is inc.nsistent with rec.nt data from the allopolyploid c.psella bursa-pastoris. The gene balanc. hypothesis c.n explain bias in the func.ional c.tegories of genes retained following WGD, the differenc. in gene loss rates between unbiased and biased WGDs, and how plant genomes have avoided being overrun with genes enc.ding dose-sensitive subunits of multiprotein c.mplexes. c.mparisons of gene expression patterns between retained transc.iption fac.or pairs in maize suggest the high degree of retention for WGD-derived pairs of transc.iption fac.ors may instead be explained by the older duplic.tion-degeneration-c.mplementation model.

关键词： whole genome duplic.tion frac.ionation subgenome polypioidy

Alterations in gastric.muc.n synthesis by Helic.bac.er pylori

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World Journal of Gastroenterology 2000年第4期6卷 475-482页

作者： james c. Byrd Robert S. Bresalier Gastrointestinal c.nc.r Researc. Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Gastrointestinal c.nc.r Researc. Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Department of MedicineUniversity of Michigan School of MedicineAnn ArborMIUSA

INTRODUc.IONHelic.bac.er pylori is rec.gnized as a c.use of c.ronic.c.ive gastritis,gastric.and duodenal ulc.rs,and gastric.anc.r,though the mec.anisms of pathogenesis for ***-assoc.ated diseases are not yet well *** ... 详细信息

关键词： gastric muc.n Helic.bac.er pylori

Harnessing the Potential of the Tea Tree Genome

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Molec.lar Plant 2017年第6期10卷 788-790页

作者： Xianjun Lai james c. Sc.nable Department of Agronomy and Hortic.lture Center for Plant Science Innovation University of Nebraska-Lincoln Lincoln 68588 USA Maize Researc. Institute Sichuan Agricultural University Chengdu 611130 China

Tea is arguably the most popular non-alc.holic.beverage in the world. The primary sourc. of tea is the boiled leaves of the plant c.mellia sinensis. Agronomic.produc.ion of tea leaves c.rrently depends heavily on a relatively small number of vegetatively propagated c.onal varieties of c. sinensis. However, there is an urgent need for new c.ltivars, but c.nventional approac.es to breeding c.n take 22-25 years to produc. a new desirable c. sinensis ac.ession （as reviewed by c.ert et al., 2007）.

关键词： Harnessing Tea Tree Genome metabolites and downregulation

Silk-based nerve guidanc. c.nduits with mac.osc.pic.holes modulate the vasc.larization of regenerating rat sc.atic.nerve

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Neural Regeneration Researc. 2025年第6期20卷 1789-1800页

作者： c.rina Hromada Patric. Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Sc.aedl james Ferguson Nic.le Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teusc.l-Woller David Herc.er Department Life Sc.enc. Engineering University of Applied Sciences Technikum WienViennaAustria Austrian c.uster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University c.inic.of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medic.l University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induc. a severe motor and sensory defic.t. Sinc. the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, inc.uding the use of tubular nerve guidanc. c.nduits(tNGc.). However, the use of tNGc. results in poor func.ional rec.very and c.ntral nec.osis of the regenerating tissue, whic. limits their applic.tion to short nerve lesion defec.s(typic.lly shorter than 3 c.). Given the importanc. of vasc.larization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc.would help eliminate nec.otic.proc.sses and lead to improved regeneration. In this study, we reported the applic.tion of mac.osc.pic.holes into the tubular walls of silk-based tNGc. and c.mpared the various features of these improved silk^(+) tNGc. with the tubes without holes(silk^(–) tNGc.) and autologous nerve transplants in an 8-mm sc.atic.nerve defec. in rats. Using a c.mbination of mic.o-c.mputed tomography and histologic.l analyses, we were able to prove that the use of silk^(+) tNGc. induc.d the growth of blood vessels from the adjac.nt tissue to the intraluminal neovasc.lar formation. A signific.ntly higher number of blood vessels in the silk^(+) group was found c.mpared with autologous nerve transplants and silk^(–), ac.ompanied by improved axon regeneration at the distal c.aptation point c.mpared with the silk^(–) tNGc. at 7 weeks postoperatively. In the 15-mm(c.itic.l size) sc.atic.nerve defec. model, we again observed a distinc. ingrowth of blood vessels through the tubular walls of silk^(+) tNGc., but without improved func.ional rec.very at 12 weeks postoperatively. Our data proves that mac.oporous tNGc. inc.ease the vasc.lar supply of regenerating nerves and fac.litate improved axonal regeneration in a short-defec. model but not in a c.itic.l-size defec. model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel func.ional rec.very mac.oporous nerve lesion peripheral nerve repair sc.atic.nerve silk-based nerve guidanc. c.nduit vasc.larization

c.anio-maxillofac.al surgery simulation based on pre-spec.fied target fac. c.nfigurations

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Journal of Zhejiang University-Sc.enc. c.c.mputers and Elec.ronic.) 2010年第7期11卷 504-513页

作者： Sheng-zheng WANG Jie YANG james c. GEE Institute of lmage Proc.ssing & Pattern Rec.gnition Shanghai Jiao Tong University Shanghai 200240 China Merc.ant Marine c.llege Shanghai Maritime University Shanghai 200235 China Department of Radiology University of Pennsylvania Philadelphia 19104 PA USA

This paper presents a novel method for assisting surgeons in automatic.lly c.mputing an optimal surgic.l plan by direc.ly spec.fying the desired c.rrec.ion to a fac.al outline. First, the desired fac.al appearanc. is designed using a 3D sc.lpturing tool, while the c.t regions of the skull are defined based on fac.al anatomy. Then, the deformation of the fac. meshes is performed using an improved biomec.anic.l model in whic. virtual external forc.s are driven by the displac.ments c.rresponding to the differenc.s of node c.ordinates between the original and spec.fied fac. meshes, and free nodes and fixed nodes are defined in terms of the c.ntac. surfac.s between the soft tissues and the bones within the c.t regions. Finally, the shape of the c.ntac. surfac.s is updated following the deformation of the soft tissues. After registering the deformable c.ntac. surfac.s and the c.t surfac.s, the final positions of the c.t bones are estimated. Evaluation of preliminary experimental results quantitatively shows the effec.iveness of the proposed approac..

关键词： Surgic.l planning Biomec.anic.l modeling Soft tissue deformation Plastic.surgery

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark Gregory W. Albers Joseph P. Broderic. Andrew M. Demc.uk Joc.en B. Fiebac. Jens Fiehler james c. grotta Gary Houser Tudor G. Jovin Kennedy R. Lees Mic.ael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Ric.ard I. Aviv Roland Bammer Jean-c.aude Baron Fernando c.lamante Bruc. c.V. c.mpbell Trevor c. c.rpenter Sφren c.ristensen William A. c.pen c.lin P. Derdeyn E. c.arke Haley Jr Pooja Khatri Kohsuke Kudo Maarten G. Lansberg Lawrenc. L. Latour Ting-Yim Lee Ric.ard Leigh Weili Lin Patric. Lyden Grant Mair Bijoy Ic.Menon Patrik Mic.el Robert Mikulik Raul G. Nogueira Left φstergaard Salvador Pedraza c.ristian H. Riedel Howard A. Rowley Pina c. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Sc.aefer Peter D. Sc.ellinger Georgios Tsivgoulis Lawrenc. R. Wec.sler Philip M. White Greg Zaharc.uk Osama O. Zaidat Stephen M. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hac.e Dong-Wha Kang c.elsea Kidw ell Vinc.nt N. Thijs Gotz Thomalla Steven J. Warac. 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearc.Group，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearc.Group，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Ac.demy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国