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Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 813-819页

作者： Izatus Shima TAIB Siti Balkis BUDIN Seri Maseran SITI NOR AIN jamaludin mohamed Santhana Raj LOUIS Srijit DAS Sulaiman SALLEHUDIN Nor Fadilah RAJAB Othman HIDAYATULFATHI Department of Biomedical Sciences Faculty of Allied Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia Unit of Electron Microscope Institute for Medical ResearchJalan Pahang50588 Kuala LumpurMalaysia Department of Anatomy Universiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia

Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity,chemopreventative and insecticidal properties. In this study,the toxic effects of L. elliptica essential oil against Sprague-Dawley rat’s red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125,250,and 500 mg/(kg body weight),respectively,and the control group received distilled water. Full blood count,RBC osmotic fragility,RBC morphological changes,and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb),mean cell hemoglobin concentration (MCHC),mean cell volume (MCV),and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

关键词： Litsea elliptica Toxicity Red blood cells Morphology Cell membrane Echinocyte

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Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 176-185页

作者： Zariyantey ABDUL HAMID Siti Balkis BUDIN Ng WEN JIE Asmah HAMID Khairana HUSAIN jamaludin mohamed Department of Biomedical Science Faculty of Health Sciences Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia Drug and Herbal Research Center Faculty of Pharmacy Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia

Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+ 200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.

关键词： Zingiber zerumbet Antioxidant Oxidative stress Nephrotoxicity Paracetamol

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Survey of Robotics in Education, Taxonomy, Applications, and Platforms during COVID-19

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Computers, Materials & Continua 2021年第4期67卷 687-707页

作者： Hussain A.Younis A.S.A.mohamed R.jamaludin M.N.Ab Wahab College of Education for Women University of Basrah BasrahIraq School of Computer Sciences Universiti Sains MalaysiaMinden11800PenangMalaysia Centre For Instructional Technology&Multimedia Universiti Sains MalaysiaMinden11800PenangMalaysia

The coronavirus disease 2019(COVID-19)is characterized as a disease caused by a novel coronavirus known as severe acute respiratory coronavirus syndrome 2(SARS-CoV-2;formerly known as 2019-nCoV).In December 2019,COVID-19 began to appear in a few *** the beginning of 2020,it had spread to most countries across the *** is when education challenges began to *** COVID-19 crisis led to the closure of thousands of schools and universities all over the *** a situation requires reliance on e-learning and robotics education for students to continue their studies to avoid the mingling between people and *** relation to this alternative learning solution,the present study was conducted.A systematic literature review on educational robotics(ER)keywords between 2015–2020 was carried out for the purpose to review a total of 2253 articles from the selected sources;Scopus(452),Taylor&Francis(311),Science Direct(427),IEEE Xplore(221),and Web of Science(842).This review procedure was labelled as Taxonomy *** ltering Taxonomy 1,it was found that 98 scientic articles formed the so-called Taxonomy II that was categorized into six categories:(i)Robotics concepts,(ii)Device,(iii)Robotic applications,(iv)Manufacturing robots,(v)Robotics analysis,and(vi)Education/*** this study,only 35 articles in this specic eld were selected,of which were then assigned into three categories:(i)Application,(ii)Platform,and(iii)*** results show that the application category carries 17.4%,platform 20%,and education 22.85%.This study serves as the application platform to help students,academics,and researchers.

关键词： COVID-19 educational educational robotics taxonomy application platform

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Assessment of Physical and Mechanical Properties of Cement Panel Influenced by Treated and Untreated Coconut Fiber Addition

Assessment of Physical and Mechanical Properties of Cement P...

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2011 International Conference on Physics Science and Technology (ICPST 2011)

作者： Alida Abdullah Shamsul Baharin jamaludin mohamed Iylia Anwar Mazlee Mohd Noor Kamarudin Hussin School of Materials Engineering Universiti Malaysia Perlis

This project was conducted to produce a cement panel with the addition of treated and untreated coconut fiber in cement panel. Coconut fiber was added to replace coarse aggregate（sand） in this cement panel. In this project, the ratios used to design the mixture were 1:1:0, 1:0.97:0.03, 1:0.94:0.06, 1:0.91:0.09（cement: sand: coconut fiber）. The water cement ratio was constant at 0.55. The sizes of sample tested were, 160 mm x 40 mm x 40 mm for compression test, and 100 mm x 100 mm x 40 mm for density, moisture content and water absorption tests. After curing samples for 28 days, it was found that the addition of coconut fiber, further increase in compressive strength of cement panel with untreated coconut fiber. Moisture content of cement panel with treated coconut fiber increased with increasing content of coconut fiber whereas water absorption of cement panel with untreated coconut fiber increased with increasing content of coconut fiber. The density of cement panel decreased with the addition of untreated and treated coconut fiber.

关键词： Treated coconut fiber cement panel compressive strength density moisture content water absorption

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