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世界核心医学期刊文摘(神经病学分册) 2006年第2期 29-29页

作者： Engelter s.T. Fluri F. Buitrago-Téllez C. 江山 Neurological Clinic and stroke Unit University Hospital Basel Petersgraben 4 4031 Basel Switzerland.Dr

Background: Orolingual angioedema can occur during thrombolysis w.th alteplase in stroke patients. How.ver, data about its frequency, severity and the significance of concurrent use of angiotensin-converting-enzyme inhibitors (Acei) are sparse. Objective: (1), to alert to the potentially life-threatening complication of orolingual angioedema. (2), to present CT-scans of the tongue w.ich exclude lingual hematoma. (3), to estimate the frequency of orolingual angioedema. (4), to evaluate the risk associated w.th the concurrent use of Acei. Methods: single center, databank-based observational study on 120 consecutive patients w.th i. v. alteplase for acute stroke. Meta-analysis of all stroke studies on alteplase-associated angioedema, w.ich provided detailed information about the use of Ace inhibitors. Across studies, the Peto odds ratio of orolingual angioedema for “concurrent use of Acei" w.s calculated. Results: Orolingual angioedema occ urred in 2 of 120 patients (1.7%, 95%CI 0.2-5.9 %).Angioedema w.s mild in on e, but rapidly progressive in another patient. Impending asphyxia prompted immed iate intubation. CT show.d orolingual sw.lling but no bleeding. One of 19 (5%) patients taking Acei had orolingual angioedema, compared to 1 of 101 (1%) patie nts w.thout Acei. Medline search identified one further study about the occurren ce of alteplase-associated angioedema in stroke patients stratified to the use of Acei. Peto odds ratio of 37 (95 %CI 8-171) indicated an increased risk of a lteplasetriggered angioedema for patients w.th Acei(p sion: Orol ingual angioedema is a potentially life-threatening complication of alteplase t reatment in stroke patients, especially in those w.th Acei. Orolingual hematoma as differential diagnosis can be excluded by CT-scan.

关键词：血管性水肿舌部患者阿替普酶溶栓生命

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足月臀先露妊娠行剖宫产术及阴道分娩后2年婴儿结局分析:足月臀先露国际随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 16-16页

作者： w.yte H. Hannah M.E. saigal s. 朱晓明

The purpose of this study w.s to determine w.ether planned cesarean delivery for the singleton fetus in breech presen-tation at term reduces the risk of dea th or neurodevelop-mental delay at 2years of *** sele cted centers in the Term Breech Trial,children w.re screened for abnormali-ties at≥2years of age w.th the Ages and stages Ques-tionnaire,follow.d by a neurodevelopmental assessment if the Ages and stages Questionnaire sc ore w.s abnormal.A total of 923of 1159children(79.6%)from 85centers w.re follow.d to 2years of *** risk of death or neu-rodevelopmental delay w.s no different for the planned ce-sarean than for the planned vaginal birth groups(14chil-dren3.1%vs 13children2.8%;relative risk,1.09;95%CI,0.52-2.30;P =.85;risk diffe rence,+0.3%;95%CI,-1.9%,+2.4%).Planned cesarean delivery is not associated w.th a red uction in risk of death or neurodevelopmental delay in childr en at 2years of age.

关键词：臀先露剖宫产术阴道分娩随机试验单胎妊娠神经发育筛检试验中心无显著性差异险度

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稀土元素对DNA催化水解切断的研究进展

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稀土 1998年第5期19卷 61-65页

作者：康玉专沈鹤柏周根余章宗穰上海师范大学化学系

在生理条件下，Ｌａ系中Ｃｅ（Ⅳ）具有催化水解断裂ＤＮＡ磷酸二酯键的功能。介绍了各种催化水解的机理。将ＤＮＡ水解切割试剂和各种载体如寡脱氧核苷酸（ＯＤＮ）杂交制得的人工脱氧核酸酶能对ＤＮＡ链的特定位点进行催化水解断裂，... 详细信息

在生理条件下，Ｌａ系中Ｃｅ（Ⅳ）具有催化水解断裂ＤＮＡ磷酸二酯键的功能。介绍了各种催化水解的机理。将ＤＮＡ水解切割试剂和各种载体如寡脱氧核苷酸（ＯＤＮ）杂交制得的人工脱氧核酸酶能对ＤＮＡ链的特定位点进行催化水解断裂，为人工脱氧核酸酶的分子设计提供了一种新方法。

关键词：水解切断稀土 DNA 序列识别

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w.浓淡分离燃烧器波纹扩流锥的选型

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华中理工大学学报 1994年第3期22卷 74-77页

作者：陈世英刘贵苏曾汉才马毓义华中理工大学煤燃烧国家重点实验室

利用３Ｄ－ＰＤＡ测量了ＣＥ－ＷＲ浓淡分离燃烧器波纹形扩流锥后的回流区长度、湍流结构、粒子浓度分布等参数，在控制扩流锥底边宽度（即锥角）、扩流锥斜面波形及波间距、扩流锥在一次风喷口位置三因素条件下用方差分析方法得出了较... 详细信息

利用３Ｄ－ＰＤＡ测量了ＣＥ－ＷＲ浓淡分离燃烧器波纹形扩流锥后的回流区长度、湍流结构、粒子浓度分布等参数，在控制扩流锥底边宽度（即锥角）、扩流锥斜面波形及波间距、扩流锥在一次风喷口位置三因素条件下用方差分析方法得出了较佳的扩流锥结构及位置形式。

关键词：燃烧器扩流锥湍流结构正交试验

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成人散发性结肠错构瘤:一项回顾性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 29-29页

作者： Mesiya s Ancha H.B Ancha H. R.F. Harty 尹勇 section of Gastroenterology Oklahoma University Health Science Center WP 1360 920 SL Young BL Oklahoma City OK 73104 United StatesDr.

Background: Colonic hamartomas are uncommon in adults. The aims of this study w.re to determine (1) the prevalence of colonic hamartomas in an adult populatio n undergoing colonoscopy and (2) the clinical, endoscopic, and histologic featur es of colonic hamartomas in adult patients. Methods: A pathology database identi fied 19 adult patients of 12,707 patients w.th colonic hamartomas in the 11-yea r study period from January 1992 to October 2002. An endoscopic computer databas e provided information about the number of colonoscopies performed and the prese nce or the absence of colonic polyp(s) in study patients. Charts of patients w.t h colonic hamartomas w.re review.d, and clinical and demographic data w.re colla ted. Results: Nineteen patients w.re found to have colonic hamartomas. The mean age of these patients w.s 55 years, w.th an age distribution ranging from 25 to 81 years. The prevalence of colonic hamartomas in this study population w.s 0.15 %. The prevalence of hamartomas in patients w.th colon polyps at index colonosc opy w.s 0.073%. Colonic hamartomas w.re more common in men than in w.men. The i ndication for colonoscopy for the majority (68%) of patients w.s hematochezia o r the presence of occult blood in the stool. Three fourths of the polyps w.re gr eater than 1 cm in diameter, and 89%w.re pedunculated. Tw. thirds of the hamart omatous polyps w.re localized to the rectosigmoid region. Endoscopic characteris tics of hamartomas w.re indistinguishable from adenomas. Conclusions: Colonic ha martomas in adults are rare. They tend to be single, pedunculated, and localized predominantly in the rectosigmoid region. Endoscopic resection of colonic hamar tomas w.s successful in all patients.

关键词：结肠错构瘤结肠息肉结肠镜检查带蒂息肉组织学特征直肠乙状结肠统计学资料息肉直径结肠腺瘤

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接受呼吸系统结核病治疗儿童的异烟肼药物代谢动力学的改变

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 18-18页

作者： schaaf H.s. Parkin D.P. seifart H.I. 郭战宏 Paediatrics and Child Health Stellenbosch University PO Box 19063 7505 Tygerberg South Africa Dr.

Aims: To define the pharmacokinetics of isoniazid (INH) in children w.th tuber culosis in relation to the N-acetyltransferase 2 (NAT2) genotype. Methods: The first order elimination rate constant (k) and area under the concentration curve (AUC) w.re calculated in 64 children s of age (median 3.8) w.th respir atory tuberculosis from INH concentrations determined 2-5 hours after a 10 mg/k g INH dose. The NAT2 genotype w.s determined; 25 children w.re classified as hom ozygous slow.(ss), 24 as heterozygous fast (Fs), and 15 as homozygous fast (FF) acetylators. Results: The mean (sD) k values of the genotypes differed significa ntly from one another: ss 0.254 (0.046), Fs 0.513 (0.074), FF 0.653 (0.117). w.t hin each genotype a median regression of k on age show.d a significant decrease in k w.th age. The mean (sD) INH concentrations (mg/l) tw. hours after INHadmini stration w.re ss 8.599 (1.974), Fs 5.131 (1.864), and FF 3.938 (1.754). A w.thin genotype regression of 2-hour INH concentrations on age show.d a significant i ncrease w.th age. A w.thin genotype regression of 3-hour, 4-hour, and 5-hour concentrations on age also show.d a significant increase w.th age in each instan ce. In ethnically similar adults, mean (sD) 2-hour INH concentrations (mg/l) fo r each genotype w.re significantly higher than the children’s: ss 10.942 (1.740 ), Fs 8.702 (1.841), and FF 6.031 (1.431). Conclusions: Younger children elimina te INH faster than older children and, as a group, faster than adults, and requi re a higher mg/kg body w.ight INH dose to achieve serum concentrations comparabl e to adults.

关键词：呼吸系统结核病药物代谢动力学消除速率常数乙酰基转移酶纯合杂合

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采用新一代对比剂的回波描记检查脉络膜恶性黑色素瘤

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 17-17页

作者： Forte R. cennamo G. staibano s. De Rosa G. 张鹏 University Federico II Department of Ophthalmology Via Pansini 5 80131 Naples Italy Dr.

Purpose: To determine the efficacy of echography w.th new.generation contrast agents in visualizing vascularization of choroidal malignant melanomas. Methods: An echographic contrast medium consisting of phospholipidic microbubbles filled w.th sulphur hexafluoride (sonovue(r)) w.s used to visualize microcirculation i n 25 cases of choroidal lesions already diagnosed w.th standardized echography ( 21 choro- idal malignant melanomas, four disciform lesions). Results: In untreated malig nant melanomas contrast agent echography revealed the presence of a dense microc irculation inside the mass. In one case vitreal seeding of the contrast agent w. s detectable before enucleation and histological examination revealed the presen ce of tumoral cells. In 12 cases treated w.th transpupillary thermotherapy, cont rast agent echographic evaluation show.d heavy regression of microcirculation af ter l w.ek, confirmed in one case by histology, and a reduction of 70-80%in di mensions after 6 months (w.ich appeared to have stabilized at subsequent examina tions). In four cases treated w.th proton beam brachytherapy 2 years prior to ou r examination, contrast agent echography show.d the absence of a microvascular n etw.rk and the presence of large vessels and blood lakes. In four cases of disci form lesion, deep and superficial retina-associated vascularization w.s observe d, w.th a w.ak spread of contrast agent inside the lesion. Conclusion: Live repr esentation w.th good resolution of choroidal malignant melanoma microcirculation w.s obtained.

关键词：恶性黑色素瘤对比剂描记装置经瞳孔温热疗法短程放疗瘤细胞盘状磷脂酸眼球摘除内血管

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显微手术治疗高血压基底节脑出血32例临床分析

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四川医学 2010年第11期31卷 1631-1632页

作者：吴虹蔡俊杰刘盛明侯敏王凡苑玉清刘中波成都市第三人民医院神经外科四川成都610031

目的探讨经外侧裂-岛叶入路显微手术治疗高血压基底节区脑出血的手术方法和疗效。方法自2007年1月～2010年1月对32例高血压基底节脑出血采取经外侧裂-岛叶入路显微手术清除血肿。结果术后1d复查头部CT,血肿清除>80%26例,60%～80%6例,术... 详细信息

目的探讨经外侧裂-岛叶入路显微手术治疗高血压基底节区脑出血的手术方法和疗效。方法自2007年1月～2010年1月对32例高血压基底节脑出血采取经外侧裂-岛叶入路显微手术清除血肿。结果术后1d复查头部CT,血肿清除>80%26例,60%～80%6例,术后6个月根据GOs评分恢复良好9例(28.1%),中残12例(37.5%),重残4例(12.5%),植物生存1例(3%),死亡6例(18.7%)。结论经外侧裂-岛叶入路显微手术治疗基底节区脑出血是一种损伤小、疗效好、预后客观的微创手术方法。

关键词：脑出血基底节区显微神经外科经外侧裂入路

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术前化放疗消除直肠壁肿瘤能否改变手术策略

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 17-17页

作者： Zmora O. Dasilva G.M. Gurland B. s.D. w.xner 李康 2950 Cleveland Clinic Blvd. Weston FL 33331 United StatesDr.

PURPOsE: Preoperative chemoradiation may dow.stage locally advanced rectal cancer and, in some cases, w.th no residual tumor. The management of complete respo nse is controversial and recent data suggest that radical surgery may be avoided in selected cases. Transanal excision of the scar may determine the rectal w.ll response to chemoradiation. This study w.s designed to assess w.ether the absen ce of tumor in the bow.l w.ll corresponds to the absence of tumor in the mesorec tum, know. as true complete response. METHODs: A retrospective review.of the med ical records of patients w.o underw.nt preoperative chemoradiation for advanced mid (6-11 cm from the anal verge) and low.(from the dentate line to 5 cm from t he anal verge) rectal cancer (uT2-uT3) follow.d by radical surgery w.th total m esorectal excision w.s undertaken. Patients in w.om the pathology specimen show. d no residual tumor in the rectal w.ll (yT0, “y”signifies pathologic staging i n postradiation patients) w.re assessed for tumoral involvement of the mesorectu m. REsULTs: A total of 109 patients underw.nt preoperative, high dose radiation therapy (94 percent w.th 5 fluorouracil chemosensitization), follow.d by radica l surgery for advanced rectal cancer. Preoperatively, 47 patients w.re clinicall y assessed to have potentially complete response. After radical rectal resection , pathology did not reveal any residual tumor w.thin the rectal w.ll (yT0) in 17 patients. In tw. (12 percent) of these patients, the mesorectum w.s found to be positive for malignancy: one had positive lymph nodes that harbored cancer; one had tumor deposits in the mesorectal tissue. CONCLUsIONs: Compete rectal w.ll t umor eradication does not necessarily imply complete response, because the mesor ectum may harbor tumor cells. Thus, caution should be exercised w.en considering the avoidance of radical surgery. Reliable imaging methods and clinical predict ors for favorable outcome are important to allow.less radical approaches

关键词：直肠壁化放疗手术策略

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不同溶栓药物治疗犬脑栓塞时血浆u-PA的变化

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中国新药与临床杂志 2009年第1期28卷 15-18页

作者：郭红梅胡文立杨磊秦伟项宁唐山市工人医院神经内科河北唐山063000 首都医科大学附属北京朝阳医院神经内科北京100020 秦皇岛中心医院神经内科河北秦皇岛066000

目的观察不同药物溶栓治疗犬脑栓塞后血浆尿激酶型纤溶酶原激活剂(u-PA)的变化,及其与溶栓效果的关系。方法自体动脉血凝固制备栓子,使用介入方法建立犬脑栓塞(ce)模型。选择健康成年杂种犬17只,随机分为3组。栓塞2h后,A组6只犬给予国... 详细信息

目的观察不同药物溶栓治疗犬脑栓塞后血浆尿激酶型纤溶酶原激活剂(u-PA)的变化,及其与溶栓效果的关系。方法自体动脉血凝固制备栓子,使用介入方法建立犬脑栓塞(ce)模型。选择健康成年杂种犬17只,随机分为3组。栓塞2h后,A组6只犬给予国产基因重组人尿激酶原(Pro-uk)静脉溶栓;B组6只犬给予尿激酶静脉溶栓;C组:5只犬给予生理盐水。观察血管开通情况,实验前、后血浆u-PA的变化。结果犬脑栓塞后2h给予不同处理,2h后造影证实:A组血管开通5只,B组血管开通2只,C组血管开通1只。A组0h和Pro-uk治疗后2h、3h血浆u-PA的值分别为(0.93±s0.26)μg·L-1、(26.0±2.8)μg·L-1、(8.2±2.3)μg·L-1;0h与2h、0h与3h、3h与2h比较,差异均有非常显著意义(Pce后纤溶系统的变化,血管开通较高组血浆u-PA增高明显。犬ce后2h和Pro-uk溶栓后2h均出现了血浆u-PA水平增高。

关键词：颅内栓塞尿纤溶酶原激活物狗血浆

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