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Polyplex i.teracti.n strength as a dri.er of potency duri.g cancer i.munotherapy

Nano Research 2018年第10期11卷 5642-5656页

作者： shannon d. Tsai.jam.s i. andorko Xi.ngbi. Zeng Joshua M. Gammon Chri.topher M. dewell Fi.chell Department of Bi.engi.eeri.g University of Marylond 8278 Paint Branch Drive College Park MD 20742 USA Robert E. Fi.chell i.sti.ute for Bi.medi.ol Devi.es University of Maryland 8278 Paint Branch Drive College Park MD 20742 USA Uni.ed states Department of Veterans Affai.s Maryland VA Health Care System 10 North Greene Street Baltimore MD 21201 USA Deportment of Mi.robi.logy and i.munology University of Maryland Medical School 685 West Baltimore Street Baltimore MD 21201 USA Marlene and stewart Greenebaum Cancer Center 22 South Greene Street Baltimore MD 21201 USA

Many experi.ental cancer vacci.es are explori.g toll-li.e receptor agoni.ts （TLRas） such as CpG, a DNA moti. that agoni.es toll-li.e receptor 9 （TLR9）, to tri.ger i.mune responses that are potent and molecularly-speci.i.. The abi.i.y to tune the i.mune response i. especi.lly i.portant i. the i.munosuppressi.e mi.roenvi.onments of tumors. Because TLR9 i. located i.tracellularly, CpG must be i.ternali.ed by i.mune cells for functi.nali.y. Polyplexes can be self- assembled through electrostati.s usi.g DNA （ani.ni.） condensed by a posi.i.ely charged carri.r. These structures i.prove cell deli.ery and have been wi.ely explored for gene therapy. i. contrast, here we use cati.ni. poly （^-ami.o esters）（PBAEs） to assemble polyplexes from CpG as an adjuvant to target and i.prove i.mune sti.ulati.n i. cells and mouse models. Polyplexes were formed over a range of PBAE：CpG rati.s, resulti.g i. a li.rary of complexes wi.h i.creasi.gly posi.i.e charge and stronger bi.di.g as PBAE：CpG rati. i.creased. Although hi.her PBAE：CpG rati.s exhi.i.ed i.proved CpG uptake, lower rati.s of PBAE：CpG--whi.h condensed CpG more weakly, acti.ated DCs and tumorspeci.i. T cells more effecti.ely. i. a mouse melanoma model, polyplexes wi.h lower bi.di.g affi.i.i.s i.proved survi.al more effecti.ely compared wi.h hi.her bi.di.g affi.i.i.s. These data demonstrate that alteri.g the polyplex i.teracti.n strength i.pacts accessi.i.i.y of CpG to TLRs i. i.mune cells. Thus, physi.chemi.al properti.s, parti.ularly the i.terplay between charge, uptake, and affi.i.y, play a key role i. determi.i.g the nature and effi.acy of the i.mune response generated. Thi. i.si.ht i.enti.i.s new desi.n consi.erati.ns that must be balanced for engi.eeri.g effecti.e i.munotherapi.s and vacci.es.

关键词： cancer i.munotherapy nanoparti.le vacci.e polyplex

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Are faecal markers good i.di.ators of mucosal heali.g i. i.flammatory bowel di.ease?

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World Journal of Gastroenterology 2015年第40期21卷 11469-11480页

作者： Gudula jam Boon Andrew s Day Chri. J Mulder Ri.hard B Gearry Departments of Paedi.tri.s University of Otago Department of Gastroente-rology and Hepatology VU University Medical CenterUniversity of Amsterdam Departments of Medi.i.e University of Otago

Ai.: To revi.w the publi.hed li.erature concerni.g the accuracy of faecal i.flammatory markers for i.enti.yi.g mucosal heali.g. METHODs: Bi.li.graphi.al searches were performed i. MEDLi.E electroni. database up to February 2015,usi.g the followi.g terms: "i.flammatory bowel di.ease","Crohn′s di.ease","ulcerati.e coli.i.","faecal markers","calprotecti.","lactoferri.","s100A12","endoscop*","mucosal heali.g","remi.si.n". i. addi.i.n,relevant references from these studi.s were also i.cluded. Data were extracted from the publi.hed papers i.cludi.g odds rati.s wi.h 95%Ci.P values and correlati.n coeffi.i.nts. Data were grouped together accordi.g to each faecal marker,Crohn's di.ease or ulcerati.e coli.i.,and paedi.tri. compared wi.h adult study populati.ns. studi.s i.cluded i. thi. revi.w assessed mucosal i.flammati.n by endoscopi. and/or hi.tologi.al means and compared these fi.di.gs to faecal marker concentrati.ns i. i.flammatory bowel di.eases(i.D) pati.nt cohorts. Arti.les had to be publi.hed between 1990 and February 2015 and wri.ten i. Engli.h. Papers excluded from the revi.w were those where the faecal bi.marker concentrati.n was compared between pati.nts wi.h i.D and controls or other di.ease groups,those where serum bi.markers were used,those wi.h a heterogeneous study populati.n and those only assessi.g post-operati.e di.ease. REsULTs: The avai.able studi.s show that faecal markers,such as calprotecti. and lactoferri.,are promi.i.g non-i.vasi.e i.di.ators of mucosal heali.g. However,due to wi.e vari.bi.i.y i. study desi.n,especi.lly wi.h regard to the defi.i.i.n of mucosal heali.g and evaluati.n of marker cut offs,the avai.able data do not yet i.di.ate the opti.al roles of these markers. Thi.ty-si. studi.s publi.hed between 1990 and 2014 were i.cluded. studi.s compri.ed vari.ble numbers of study parti.i.ants,consi.ered CD(15-164 parti.i.ants) or UC(12-152 parti.i.ants) separately or as a combi.ed group(11-252 parti.i.ants). Ei.ht reports i.cluded paedi.tri. pati

关键词： Crohn’s di.ease Ulcerati.e coli.i. Mucosal heali.g

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Removal of Hes duri.g Anaerobi. Bi.conversi.n of Dai.y Manure

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Chi.ese Journal of Chemi.al Engi.eeri.g 2009年第2期17卷 273-277页

作者： jam.sai.ullah Lar 李秀金 Department of Envi.onmental sci.nce and Engi.eeri.g Beijing University of Chemical Technology Beijing 100029 China Department of Chemi.try Government Degree College Uch Sharif Bahawalpur Pakistan

The mai. ai. of thi. research was the experi.ental study at lab scale to check the absorpti.n technology for the i. si.u removal of H2s from bi.gas duri.g anaerobi. di.esti.n process. The reagent FeCl3 was used to check the removal effi.i.ncy of H2s produced from dai.y manure duri.g anaerobi. bi.conversi.n process. The experi.ents were conducted under mesophi.i. condi.i.ns. The composi.i.n of bi.gas was analyzed by gas chromatography analyzer equi.ped wi.h flame photometer and thermal conducti.i.y detectors. Experi.ental results under the same condi.i.ns demonstrate that hi.h concentrati.n of H2s i. the form of Fes can be removed totally from the bi.gas usi.g FeCl3 dosi.g wi.h i. anaerobi. batch di.ester.

关键词： anaerobi. di.esti.n bi.gas dai.y manure FeCl3 hydrogen sulfi.e

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Gorgan Bay： a mi.rocosm for study on macrobenthos speci.senvi.onment relati.nshi.s i. the southeastern Caspi.n sea

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Acta Oceanologi.a si.i.a 2016年第4期35卷 82-88页

作者： GHAsEMi.Ami. Faraz TAHERi.Mehrshad FOsHTOMi.Maryam Yazdani.NORANi.N Maji. Mi.A seyed sahab jam Armi. i.ani.n Nati.nal i.sti.ute for Oceanography and Atmospheri. sci.nce (i.i.As) Tehran *** Iran Department of the Envi.onment Golestan Provi.ce Gorgan *** Iran

The relati.nshi. between spati.l patterns of macrobenthos communi.y characteri.ti.s and envi.onmental condi.i.ns（sali.i.y, temperature, di.solved oxygen, organi. matter content, sand, si.t and clay） was i.vesti.ated throughout the Gorgan Bay i. June 2010. Pri.ci.al components analysi.（PCA） based on envi.onmental data separated eastern and western stati.ns. The maxi.um（4 500 i.d./m2） and mi.i.um（411 i.d./m2） densi.i.s were observed at stas 1 and 6, respecti.ely. Polychaeta was the major group and streblospi. gynobranchi.ta was domi.ant speci.s i. the bay. Accordi.g to Di.tance Based Li.ear Models results, macrofaunal total densi.y was correlated wi.h si.t percentage and sali.i.y and these two factors explai.i.g 64% of the vari.bi.i.y whi.e macrofaunal communi.y structure just correlated wi.h sali.i.y（22% total vari.ti.n）. i. general, western part of the bay showed the hi.hest number of speci.s and bi.di.ersi.y whi.e, the hi.hest densi.y was found at sta. 1 and i. the mi.dle part of the bay. Furthermore, relati.nshi. between di.ersi.y i.di.es and macrobenthi. speci.s wi.h measured factors i. also di.cussed. Our results confi.m the effect of sali.i.y as an i.portant factor on di.tri.uti.n of macrobenthi. fauna i. south Caspi.n bracki.h waters.

关键词： sali.i.y macrobenthos speci.s-envi.onment relati.nshi. Gorgan Bay Caspi.n sea

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Di.ersi.y of Botryosphaeri.ceae speci.s associ.ted wi.h grapevi.e and other woody hosts i. i.aly,Algeri. and Tuni.i.,wi.h descri.ti.ns of Lasi.di.lodi. exi.ua and Lasi.di.lodi. medi.erranea ***

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Fungal Di.ersi.y 2015年第2期71卷 201-214页

作者： B.T.Li.aldeddu A.Dei.da B.scanu A.Franceschi.i.s.serra A.Berraf-Tebbal M.Zouaoui.Bouti.i.M.L.Ben jamâa A.J.L.Phi.li.s Di.arti.ento di.Agrari. Sezione di Patologia vegetale ed EntomologiaUniversitàdegli Studi di Sassarivia E.De Nicola 107100 SassariItaly Département des Bi.technologi.s Facultédes Sciences de la Vie et de la TerreUniversitéSaad Dahleb09000 BlidaAlgeria i.RGREF Laboratoire de Gestion et de Valorisation des Ressources ForestièresB.P.N 22080 ArianaTunisia Centro de Recursos Mi.robi.lógi.os Departamento de Ciências da VidaFaculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

The di.ersi.y of Botryosphaeri.ceae speci.s associ.ted wi.h“Botryosphaeri. di.back”of grapevi.e was i.vesti.ated i. 18 vi.eyards i. sardi.i.,*** i.olates obtai.ed from di.ferent woody hosts i.cludi.g holm oak,sweet orange and broom bush i. i.aly,Algeri. and Tuni.i. were also *** and cultural characteri.ti.s as well as i.s and EF1-αsequence data were used to i.enti.y the fungal ***-ei.ht botryosphaeri.ceous i.olates were obtai.ed from 113 symptomati. grapevi.e samples,from whi.h ten speci.s were *** seri.ta was the domi.ant speci.s(25%of i.olates),followed by Neofusi.occum parvum(21.7%).Two speci.s,Di.lodi. oli.arum and *** are reported for the fi.st ti.e on *** addi.i.n,two new speci.s namely Lasi.di.lodi. medi.erranea *** grapevi.e,holm oak and sweet orange and Lasi.di.lodi. exi.ua *** broom bush are *** arti.i.i.l i.oculati.n experi.ents conducted on exci.ed green grapevi.e shoots and li.ni.i.d canes as well as holm oak seedli.gs,*** was shown to be an aggressi.e pathogen.

关键词： Ci.rus×si.ensi. Di.lodi. Lasi.di.lodi. Neofusi.occum Quercus i.ex Retama raetam

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快门速度实战手册

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摄影之友 2014年第11期 80-93页

作者：刘岩 Ki.era jam 摄影之友

在摄影实践中,与"速度"结合最紧密的词就是"快门速度",今天我们利用不同快门速度来让你了解,在什么样的题材下适合用什么样的快门速度去表现,用什么样的快门速度可以创意出怎样的作品。1/4000 s凝固下肉眼看不见的瞬间快门速度进入到1/4... 详细信息

在摄影实践中,与"速度"结合最紧密的词就是"快门速度",今天我们利用不同快门速度来让你了解,在什么样的题材下适合用什么样的快门速度去表现,用什么样的快门速度可以创意出怎样的作品。1/4000 s凝固下肉眼看不见的瞬间快门速度进入到1/4000秒,可以说是进入到高速摄影的领域了。既然是高速摄影,我们拍摄一些更有创意的作品吧。1泥浆泼洒的状态很惊人一般在泼水节或者是其他往身上泼洒液体的跑步节日都适合用高速快门将水花凝固住。

关键词：快门速度高速快门曝光时间安全快门减光镜摄影实践跑来跑去刘老师快门线自动触发

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从《士师记》的文学特征和神学蕴涵看女性角色

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圣经文学研究 2007年第1期 228-250页

作者：吴献章美国伊利诺大学

本文首先针对《士师记》第17至21章所载女性在无政府状态中被迫害、被虐待、被奸、被杀、被抢的种种残酷社会议题进行探讨;接着由《士师记》的文学手法,包括观点、时空、角色、布局、排场、情节、情景次序等,和修辞风格如重复、对比、... 详细信息

本文首先针对《士师记》第17至21章所载女性在无政府状态中被迫害、被虐待、被奸、被杀、被抢的种种残酷社会议题进行探讨;接着由《士师记》的文学手法,包括观点、时空、角色、布局、排场、情节、情景次序等,和修辞风格如重复、对比、平行、意象、双关语、省略、模糊、讽刺、交叉型架构、衬托、首尾呼应、伏笔、预示、预告、绰号等,来分析该书叙述者所描绘的主要角色如以笏、俄陀聂、基甸、耶弗他、参孙等"圆形"人物的性格和事迹。叙述者在本书精辟的"文以载道"意图中,巧妙地突显了乱世中巾帼英雄的女性角色,并详实地刻画全书社会悲剧的真实面貌和缘由——以色列的社会和政治问题不能单单从性别角度来剖析,整个《士师记》中的混乱乃来自信仰的堕落。当以色列背约,走上迦南人世俗化的路线而直接威胁到女性的自尊和安全时,势必导致尸骨不全、"肢"离破碎的结局。但是叙述者也呈现,进入士师"隧道"中堕落的以色列百姓的唯一盼望,乃是归向那位仍然信实守约、已经预备了完备救恩的上帝。

关键词：社会败坏女性主义首尾呼应交叉型架构圣经神学

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Travel ti.e predi.ti.n wi.h vi.coelasti. traffi. model

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Appli.d Mathemati.s and Mechani.s(Engli.h Edi.i.n) 2018年第12期39卷 1769-1788页

作者： Yongli.ng ZHANG M.N.sMi.NOVA A.i.BOGDANOVA Zuoji. ZHU N.N.sMi.NOV Faculty of Engi.eeri.g sci.nce University of Science and Technology of China Faculty of Mechani.s and Mathemati.s Moscow M.V.Lomonosov State University sci.nti.i. Research i.sti.ute for system Analysi. Russian Academy of Sciences

Travel ti.e through a ri.g road wi.h a total length of 80 km has been predi.ted by a vi.coelasti. traffi. model(VEM), whi.h i. developed i. analogous to the non-Newtoni.n flui. flow. The VEM expresses a traffi. pressure for the unfree flow case by space headway, ensuri.g that the pressure can be determi.ed by the assumpti.n that the relevant second cri.i.al sound speed i. exactly equal to the di.turbance propagati.n speed determi.ed by the free flow speed and the braki.g di.tance measured by the average vehi.ular length. The VEM assumes that the sound speed for the free flow case depends on the traffi. densi.y i. some speci.i. aspects, whi.h ensures that i. i. exactly i.enti.al to the free flow speed on an empty road. To make a compari.on, the open Navi.r-stokes type model developed by Zhang(ZHANG, H. M. Dri.er memory, traffi. vi.cosi.y and a vi.cous vehi.ular traffi. flow model. Transp. Res. Part B, 37, 27–41(2003)) i. adopted to predi.t the travel ti.e through the ri.g road for provi.i.g the counterpart *** the traffi. free flow speed i. 80 km/h, the braki.g di.tance i. supposed to be 45 m,wi.h the jam densi.y uni.uely determi.ed by the average length of vehi.les l ≈ 5.8 m. To avoi. possi.le si.gular poi.ts i. travel ti.e predi.ti.n, a di.ti.gui.hi.g peri.d for ti.e averagi.g i. pre-assi.ned to be 7.5 mi.utes. i. i. found that the travel ti.e i.creases monotoni.ally wi.h the i.i.i.l traffi. densi.y on the ri.g road. Wi.hout ramp effects, for the ri.g road wi.h the i.i.i.l densi.y less than the second cri.i.al densi.y, the travel ti.e can be si.ply predi.ted by usi.g the equi.i.ri.m speed. However, thi. si.pler approach i. unavai.able for scenari.s over the second cri.i.al.

关键词： travel ti.e vi.coelasti. modeli.g di.ti.gui.hi.g peri.d for ti.e averagi.g spati.l-temporal pattern traffi. jam

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都兰吐蕃古墓考古研究综述

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西藏研究 2016年第4期 107-113页

作者：周毛先宗喀.漾正冈布西北民族大学<格萨尔>研究院甘肃兰州730130 兰州大学西北少数民族研究中心暨民族学研究院甘肃兰州730000

分布于青藏高原柴达木盆地东南隅的都兰古墓群是继敦煌、吐鲁番发现以后,中国西部最大的考古发现,备受各个学科领域的关注。研究者们分别从自然科学、考古学、历史学、语言学、藏学等多学科、多视角探讨了都兰吐蕃古墓的形制、族属、年... 详细信息

分布于青藏高原柴达木盆地东南隅的都兰古墓群是继敦煌、吐鲁番发现以后,中国西部最大的考古发现,备受各个学科领域的关注。研究者们分别从自然科学、考古学、历史学、语言学、藏学等多学科、多视角探讨了都兰吐蕃古墓的形制、族属、年代、出土文物及其文化内涵等,涌现了不少新的观点。对这些研究成果做一简单梳理,有助于研究都兰吐蕃的学者和爱好者系统了解和掌握相关动态。

关键词：都兰古墓吐蕃文化古墓形制古墓族属

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sDN-based i.trusi.n detecti.n system for i.T usi.g deep learni.g classi.i.r (i.si.T-sDL)

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CAAi.Transacti.ns on i.telli.ence Technology 2021年第3期6卷 281-290页

作者： Azka Wani.Revathi.s Rubeena Khali. Department of Computer Appli.ati.ns Crescent B S Abdur Rahman Institute of Science and TechnologyChennaiIndia Department of Computer sci.nce and Engi.eeri.g Crescent B S Abdur Rahman Institute of Science and TechnologyChennaiIndia Department of Mathemati.s Crescent B S Abdur Rahman Institute of Science and TechnologyChennaiIndia

The parti.i.ati.n of ordi.ary devi.es i. networki.g has created a world of connected devi.es *** i.ternet of Thi.gs(i.T)i.cludes heterogeneous devi.es from every *** are no defi.i.e protocols or standards for i.T communi.ati.n,and most of the i.T devi.es have li.i.ed *** a complete securi.y measure for such devi.es i. a challengi.g task,yet *** li.htwei.ht securi.y soluti.ns have surfaced lately for *** li.htwei.ht securi.y protocols are unable to provi.e an opti.um protecti.n agai.st prevai.i.g powerful threats i. cyber *** i. also hard to deploy any tradi.i.nal securi.y protocol on resource-constrai.ed i.T ***-defi.ed networki.g i.troduces a centrali.ed control i. computer *** has a programmable approach towards networki.g that decouples control and data *** sDN-based i.trusi.n detecti.n system i. proposed whi.h uses deep learni.g classi.i.r for detecti.n of anomali.s i. *** proposed i.trusi.n detecti.n system does not burden the i.T devi.es wi.h securi.y *** proposed work i. executed on the si.ulated *** results of the si.ulati.n test are evaluated usi.g vari.us matri.es and compared wi.h other relevant methods.

关键词： i.T classi.i.r system

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