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Prevalence of celiac disease in Iranian children with idiopathic short stature

World Journal of Gastroenterology 2008年第48期14卷 7376-7380页

作者： jalal hashemi Eskandar Hajiani HBB Shahbazin Rahim Masjedizadeh Navab Ghasemi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Division of Endocrinology and Diabetes center Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Golestan Hospital

AIM： To determine the prevalence of celiac disease （CD） in children with idiopathic short stature （ISS） and the diagnostic value of immunoglobulin （Ig） A G antigliadin antibodies （AGA） and transglutaminase （TTG） antibodies for ***： A total of 104 children （49 male, 55 female） with ISS without a specific etiology were studied. Extensive endocrine investigations had shown no abnormalities in any subject. Anthropometric parameters and IgA AGA and IgA TTG antibodies were evaluated in this study group. These antibodies were measured by enzyme-linked immunosorbent assay. All patients were referred for an endoscopic intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria （UEGW 2001）.RESULTS： We detected positive IgA TTG antibodies in 36 and IgA AGA in 35 of these patients. Thirty one IgA TTG antibody positive and 28 IgA AGA positive subjects showed histological abnormalities compatible with celiac disease （33.6%）. Sensitivity, specificity, positive predictive value （PPV） and negative predictive value for IgA AGA were found to be 80%, 88.4%, 77.8% and 89.7%, respectively. Sensitivity, specificity and PPV for IgA TTG antibodies were 88.6%, 94.2% and 88.6%, ***： We conclude that the prevalence of celiac disease is high in patients with ISS and it is important to test all children with ISS for celiac disease by measuring serologic markers and performing an intestinal biopsy.

关键词： Celiac disease Growth disorders Transglu-taminases Antibodies Gliadin

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Hepatitis C virus transmission and its risk factors within families of patients infected with hepatitis C virus in southern Iran:Khuzestan

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World Journal of Gastroenterology 2006年第43期12卷 7025-7028页

作者： Eskandar Hajiani Rahim Masjedizadeh jalal hashemi Mehrdad Azmi Tahereh Rajabi Division of Gastroenterology and HepatologyDepartment of Internal Medicine Ahwaz Jundishapur Universityof Medical Sciences Ahwaz Iran Division of Gastroenterology and Hepatology Department of pathology Ahwaz Jundishapur University ofMedical Sciences Ahwaz Iran

AIM: To determine whether hepatitis C virus (HCV) infection of index cases increases intrafamilial transmission (sexual and nonsexual contacts) of HCV. METHODS: In a case-control descriptive study we enrolled 300-household contacts of 60 index cases (40 males and 20 females) of HCV infection and 360 pair- matched controls in Ahwaz JundiShapour University Hospitals from August 1, 1998 to September 1, 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion Organization. Serum samples and demographic data and a medical history including the existence of risk factors for HCV (after a questionnaire on the risk factors for parenteral exposure) were obtained from each subject. Antibodies to HCV were detected employing a commercially available second-generation enzyme immunoassay (EIA, Abbott Ⅱ). Positive serum specimens were retested using a second-generation recombinant immunoblot assay (RIBA-2) and a polymerase chain reaction for HCV RNA. Data analysis was carried out for intra-household clustering. RESULTS: Only 4 of 300 (1.33%) cases of household contacts without percutaneous risk factors were positive for HCV Ab while the remaining 296 family contacts were negative for anti-HCV. The mean age of the index cases was 28.4 (Std 15.22) years. The anti-HCV prevalences in parents, spouses, children of the index cases were 0.87% (1/115), 3.39% (2/59)) and 0.79% (1/126), respectively. Among couple partners negative for anti-HCV antibodies, the mean duration of the sexual relationship was 6 *** two-couple partners positive for anti-HCV antibodies married the index cases for longer than 15 years. The prevalence of positive HCV Ab among household contacts (1.33%) was not significantly higher than that in the controls (1%) (P > 0.06). CONCLUSION: Intrafamilial transmission of HCV is not the significant transmission route and sexual transmission does not seem to play a role in the intrafamilial spread of HCV infection. Intrafami

关键词： Intrafamilial transmission Hepatitis C virus Khuzestan South-west of Iran

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Seroepidemiology of hepatitis C and its risk factors in Khuzestan Province, South-West of Iran:A case-control study

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World Journal of Gastroenterology 2006年第30期12卷 4884-4887页

作者： Eskandar Hajiani jalal hashemi Rahim Masjedizadeh Ali Akbar Shayesteh Esmail Idani Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM：To evaluate possible risk factors for the spread of hepatitis C infection and to analyze the characteristics of the epidemiological and clinical patterns among the patients with hepatitis C infection. METHODS： During a five-year period a cross-sectional study was conducted among HCV positive individuals referred to the Ahwaz JundiShapour University Hospitals （AJSUH） and Hepatitis Clinic from 1 Sept 1999 to 1 Sept 2003. The control group consisted of first time blood donors referred to the Regional Blood Transfusion organization. Enzyme-linked immunosorbent assay and recombinant immunoblot assay anti-hepatitis C virus （HCV） tests were performed for two groups. Positive serum specimens were retested using polymerase chain reaction （PCR） for HCV RNA. Risk factors were evaluated using a questionnaire. Reported risk factors among infected subjects （＂HCV-positive＂） were compared to those of subjects never exposed （＂HCV-negative＂） to HCV. RESULTS： A total of 514 subjects were studied for HCV, of which 254 were HCV-positive and 260 HCV- negative donors comprised the control group. Mean age of the patients was 28.4 （Std 15.22） years. HCV-positive subjects were more likely to be of male gender （63% versus 37%）. Transfusion 132 （52%）, non-intravenous （n-iv） drug abuse and iv drug abuse 37 （14.5%）, haemodialysis 25 （10%）, receiving wounds at war and extramarital sexual activities （2.4%）, tattooing （3.6%） were found to be independent risk factors of being HCV-positive. No apparent risk factors could be demonstrated in 29 （11.2%） of the positive cases. CONCLUSION： Our data indicate that a history of transfusion and iv drug abuse and haemodialysis are important risk factors for HCV infection in our area and that more careful pretransfusion screening of blood for anti- HCV must be introduced in our blood banks. Improvements in certain lifestyle patterns, and customs in this area may be essential to prevent transmission of the infection.

关键词： Epidemiological patterns Hepatitis C virus Risk factors South-West of Iran

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Celiac disease in South-West of Iran

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World Journal of Gastroenterology 2006年第27期12卷 4416-4419页

作者： Rahim Masjedizadeh Eskandar Hajiani jalal hashemi Ali Akbar Shayesteh Karim Moula Tahereh Rajabi From the Division of Gastroenterology and Hepatology Department of Internal MedicineAhwaz Jundishapur University of Medical SciencesAhwazIran Department of pathology Ahwaz Jundishapur University of Medical SciencesAhwazIran

AIM： Celiac disease is characterized by life-long gluten intolerance. Clinical features of patients with celiac disease are variable. Studies about the prevalence of celiac disease in our country are scarce and there is no study on the prevalence of celiac disease in southern Iran. In the current study, clinical, laboratory and histological features of 52 patients with celiac disease were evaluated. METHODS： In a cross sectional study we retrospectively studied the characteristics of 52 celiac patients at Ahwaz JundiShapour University Hospitals （AJSUH） from November 1, 1999 to 1st Sep 2004. Intestinal biopsy and serum antigliadin and anti-endomysium antibodies were used for the diagnosis of patients. Mucosal lesions were classified according to the criteria of Marsh. Antigliadin antibodies were measured with a commercial enzyme-linked immunosorbent assay. Anti-endomysium antibodies were analyzed by indirect immunofluorescence with the use of a section of monkey esophagus. Routine hematological and biochemical analyses and measurement of immunoglobulin levels were undertaken.RESULTS： Male： female ratio was 1.08. The mean ＋ SD patient age was 21 ＋ 4.5 years （range 10-70 years） and the most common symptoms were diarrhea and weight loss （78.8%） followed by fatigue （73.1%）, pallor （65.4%）, anorexia （40.4%）, abdominal distention （32.7%）, and failure to thrive （23.1%）. Diarrhea and weight loss and fatigue were the most common findings. Iron deficiency anemia was found in 63.2% of patients and this became normal after adoption of a gluten-free diet in all patients. Immunoglobulin A, IgG antigliadin antibodies and IgA anti-endomysium antibodies were found in 33 and 48 cases, 78.8% and 85.4% of patients, respectively. Biopsy of the small intestine revealed that 90.4% of patients had typical lesions according to the Marsh classification. CONCLUSION： Although classical presentation was seen in most of the patients, atypical clinical manifestations of celiac disease should

关键词： Celiac disease IgG endomysial autoantibodies Southern Iran

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Clinical profile of gastric cancer in Khuzestan, southwest of Iran

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World Journal of Gastroenterology 2006年第30期12卷 4832-4835页

作者： Hajiani Eskandar Sarmast Shoshtari Mohammad Hossein Masjedizadeh Rahim hashemi jalal Azmi Mehrdad Tahereh Rajabi Division of Gastroenterology and Hepatology Department of Internal Medicine Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Surgery Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran Department of Pathology Ahwaz Jundishapur University of Medical Sciences Ahwaz Iran

AIM： To analyze the characteristics of epidemiological, clinical and survival patterns among patients with carcinoma of the stomach. METHODS： We retrospectively studied the characteristics of 186 gastric adenocarcinoma patients at Ahwaz Jundishapur University Hospitals （AJSUH） from September 1, 1996 to September 1, 2002. All the patients had histopathologically-confirmed malignancy. Demographic variables, family history of gastric cancer （GC）, clinicopathologic characteristics and treatment-related variables were analyzed. Univariate analysis was performed with the log-rank test and multivariate analysis with Cox regression. P 〈 0.05 was considered statistically significant. RESULTS： Male to female ratio was 2.6：1. The mean age was 60.6 years and 14% of the patients were younger than 40 years. Adenocarcinoma, gastric lymphoma, and gastric metastasis were found in 94.5%, 2.3%, and 3% patients, respectively. There was an average of 6-mo delay between the initial symptoms and the diagnosis. Among adenocarcinoma groups, intestinal type was the commonest （55.9%） and the distal third was the most common localization （88.4%）. One hundred and thirty-four patients （72.1%） were males. Thirty-one patients （17%） had a family history of GC. Surgery was performed in 90% of patients （non-curative）. CONCLUSION： The epidemiological features of GC in south Iran mimic those in high-risk areas. There is a higher frequency of GC in young patients at our institution. Patients are detected and treated after a relatively long delay. Most patients present in advanced stages, which favors a poor overall survival, Family history of GC has a significant problem in our area, Studying the etiology of this cancer in south Iran and earlier diagnosis and subsequent better cares are recommended.

关键词： Gastric cancer Epidemiological features Khuzestan Southwest of Iran

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