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Cyanobacteria,Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 458-463页

作者： Maheep kumar Manoj kumar Tripathi Akanksha Srivastava jalaj kumar gour Rakesh kumar Singh Ragini Tilak Ravi kumar Asthana Department of Botany Faculty of ScienceBanaras Hindu University Department of Biochemistry Faculty of ScienceBanaras Hindu University Department of Microbiology Institute of Medical SciencesBanaras Hindu University

Objective:To investigate two cyanobacteria isolated from different origins *** aestuarii(***)from brackish water and Aphanothece bullosa(***)from fresh water paddy fields for antifungal and antileishmanila activity taking Candida albicans and Leishmania donovain as ***:Biomass of *** and *** were harvested after 40 and60 d respectively and lyophilized twice in methanol(100%)and redissolved in methanol(5%)for *** bioassay was done by agar well diffusion method while antileishmanial,by counting cell numbers and flageller motility observation of promastigotes and amastigotes from *** and 5%methanol were used as ***:Both the cyanobacteria were found to be potent source of antifungal activity keeping fluconazole as positive control,however,methanolic crude extract(15 mg/mL)of *** was found more potent(larger inhibition zone)over that of methanolic crude extract of ***,Similarly antileishmanial activity of crude extract(24.0 mg/mL)of *** was superior over that of methanolic crude extract of ***(25.6 mg/mL).Conclusions:Antifungal and antileishmanial drugs are still limited in the *** of microbes possessing antifungal and antileishmanial activity drug is of prime *** are little explored in this context because most of the drugs in human therapy are derived from microorganisms,mainly bacterial,fungal and *** in the present study two cyanobacterial strains from different origins showed potent source of antifungal and antileishmanial biomolecules.

关键词： Antifungal Antileishmanial Secondary metabolite Cyanobacteria

PCSK9 inhibitors: A new era of lipid lowering therapy

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World Journal of Cardiology 2017年第2期9卷 76-91页

作者： Rahul Chaudhary jalaj Garg Neeraj Shah Andrew Sumner Department of Medicine Sinai Hospital of BaltimoreJohns Hopkins University Division of Cardiology Lehigh Valley Health Network

Hyperlipidemia is a well-established risk factor for developing cardiovascular disease(CVD). The recent American College of Cardiology and American Heart Association guidelines on lipid management emphasize treatment of individuals at increased risk for developing CVD events with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors(statins) at doses proven to reduce CVD events. However, there are limited options for patients who are either intolerant to statin therapy, develop CVD despite being on maximally tolerated statin therapy, or have severe hypercholesterolemia. Recently the Food and Drug Administration approved two novel medications for low-density lipoprotein(LDL)-cholesterol reduction: Evolocumab and Alirocumab. These agents target and inactivate proprotein convertase subtilsinkexin type 9(PCSK9), a hepatic protease that attaches and internalizes LDL receptors into lysosomes hence promoting their destruction. By preventing LDL receptor destruction, LDL-C levels can be lowered 50%-60% above that achieved by statin therapy alone. This review explores PCSK-9 biology and the mechanisms available to alter it; clinical trials targeting PCSK9 activity, and the current state of clinically available inhibitors of PCSK9.

关键词： Hyperlipidemia Statins Proprotein convertase subtilsin-kexin type 9

A model for defect formation in materials exposed to radiation

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Matter and Radiation at Extremes 2021年第1期6卷 64-72页

作者： Sergio Davis Felipe Gonzalez-Cataldo Gonzalo Gutierrez Gonzalo Avaria Biswajit Bora jalaj Jain Jose Moreno Cristian Pavez Leopoldo Soto Comision Chilena de Energıa Nuclear Casilla 188-DSantiagoChile Departamento de Fısica Facultad de Ciencias ExactasUniversidad Andres BelloSazie 2212piso 7Santiago 8370136Chile Department of Earth and Planetary Science University of CaliforniaBerkeleyCalifornia 94720USA Grupo de Nanomateriales Departamento de FısicaFacultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A simple model for the stochastic evolution of defects in a material under irradiation is *** the master-equation formalism,we derive an expression for the average number of defects in terms of the power flux and the exposure *** model reproduces the qualitative behavior of self-healing due to defect recombination,reaching a steady-state concentration of defects that depends on the power flux of the incident radiation and the material temperature,while also suggesting a particular time scale on which the incident energy is most efficient for producing defects,in good agreement with experimental *** this model,we discuss the integral damage factor,a descriptor that combines the power flux and the square of the irradiation *** recent years,the scientific community involved in plasma-facing materials for nuclear fusion reactors has used this parameter to measure the equivalent material damage produced in experiments of various types with different types of radiation and wide ranges of power flux and irradiation *** integral damage factor is useful in practice but lacks formal theoretical *** this simple model,we find that it is directly proportional to the maximum concentration of defects.

关键词： defect qualitative formal

Primary repair of ear laceration with wedge resection

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Plastic and Aesthetic Research 2015年第1期2卷 38-39页

作者： Bhupinder Singla Inderjit Chawla Prasant Gautam Anupam Goyal jalaj Rathi Department of General Surgery Rajindra HospitalPatiala 147001PunjabIndia

Although major contributions have been made in the field of reconstructive surgery,reconstructive surgery of the auricle is a daunting prospect even for the most experienced ***,we present a case who presented to us in the emergency surgical ward with a history of an accidental laceration of right *** repair of the ear laceration after wedge resection of the avulsed part was *** cosmesis achieved by this technique is discussed.

关键词： Ear laceration primary repair wedge resection

Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis

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World Journal of Cardiology 2017年第12期9卷 830-837页

作者： Rahul Chaudhary jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel Department of Medicine Sinai Hospital of BaltimoreBaltimoreMD 21215United States Division of Cardiology Lehigh Valley Health NetworkAllentownPA 18103United States Department of Medicine Division of CardiologyEinstein Healthcare NetworkPhiladelphiaPA 19141United States Inova Heart and Vascular Institute Inova Medical CenterFairfaxVA 22042United States Division of Cardiovascular Medicine University of FloridaGainesvilleFL 32611United States Queens Cardiac Care QueensNY 11428United States Division of Cardiovascular Medicine State University of New YorkBrooklynNY 12246United States Division of Cardiology University of Arizona College of MedicineTucsonAZ 85721United States

AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,*** criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end *** efficacyoutcome was "brain death or Cerebral Performance Category(CPC) score of 5".Secondary outcomes were "CPC score 1,and 2-4","overall thrombotic events" and "acute coronary stent thrombosis".RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical *** significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was *** Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy.

关键词： Erythropoietin Thrombosis Cardiac arrest Cardiopulmonary resuscitation