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Knowledge,management,and complications of sepsis and septic shock:A significant therapeutic challenge in the intensive care unit

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Journal of Acute Disease 2024年第2期13卷 53-59页

作者： jakub Mizera Adrian Bystroń Karolina Matuszewska Justyna Pilch Ugo Giordano Wroclaw Medical University wyb.Ludwika Pasteura 150-367 WrocławPoland

Sepsis and septic shock are life-threatening conditions that are globally responsible for almost 20%of mortality,especially in low and middle-income *** review was conducted on PubMed and Google Scholar databases with keywords sepsis,septic shock,sepsis management,and sepsis *** published up to July 2023 in English were *** and management should be carried out without unnecessary *** between various medical specialties including intensive care doctors,neurologists,hepatologists,cardiologists,and pediatric doctors is needed if a child is *** strategies have to be implemented in low and middle-income countries to decrease the sepsis incidence and reduce mortality in the population.

关键词： Sepsis Septic shock Management Complications Diagnosis Review

In vitro and in vivo degradation behavior of Mg-0.45Zn-0.45Ca(ZX00)screws for orthopedic applications

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Bioactive Materials 2023年第10期28卷 132-154页

作者： Diana C.Martinez Anna Dobkowska Romy Marek Hanna Cwieka jakub Jaroszewicz Tomasz Płocinski Crtomir Donik Heike Helmholz Berengere Luthringer-Feyerabend Berit Zeller-Plumhoff Regine Willumeit-Romer Wojciech Swięszkowski Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWołoska 14102-507WarsawPoland Department of Orthopedics and Traumatology Medical University of GrazAuenbruggerplatz 58036GrazAustria Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon GmbH21502GeesthachtGermany Department of Physics and Chemistry of Materials Institute of Metals and TechnologyUniversity of Ljubljan1Lepi Pot 11SI-1000Ljubljan1Slovenia

Magnesium (Mg) alloys have become a potential material for orthopedic implants due to their unnecessary implant removal, biocompatibility, and mechanical integrity until fracture healing. This study examined the in vitro and in vivo degradation of an Mg fixation screw composed of Mg-0.45Zn-0.45Ca (ZX00, in wt.%). With ZX00 human-sized implants, in vitro immersion tests up to 28 days under physiological conditions, along with electrochemical measurements were performed for the first time. In addition, ZX00 screws were implanted in the diaphysis of sheep for 6, 12, and 24 weeks to assess the degradation and biocompatibility of the screws in vivo. Using scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy (EDX), micro-computed tomography (μCT), X-ray photoelectron spectroscopy (XPS), and histology, the surface and cross-sectional morphologies of the corrosion layers formed, as well as the bone-corrosion-layer-implant interfaces, were analyzed. Our findings from in vivo testing demonstrated that ZX00 alloy promotes bone healing and the formation of new bone in direct contact with the corrosion products. In addition, the same elemental composition of corrosion products was observed for in vitro and in vivo experiments;however, their elemental distribution and thicknesses differ depending on the implant location. Our findings suggest that the corrosion resistance was microstructure-dependent. The head zone was the least corrosion-resistant, indicating that the production procedure could impact the corrosion performance of the implant. In spite of this, the formation of new bone and no adverse effects on the surrounding tissues demonstrated that the ZX00 is a suitable Mg-based alloy for temporary bone implants.

关键词： Magnesium alloys Biodegradable implants Microstructure Electron microscopy Corrosion layers

Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate

Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

Sufficient Conditions for Absolute Stability and Optimization Using Genetic Algorithms of Specific Class Mamdani Fuzzy Logic State Variable Controllers

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Sufficient Conditions for Absolute Stability and Optimizatio...

Residence Time Distribution at Laminar Pulsatile Flow in a Straight Pipe

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作者： Osmic jakub Prljaca Naser Sehic Zenan Faculty of electrical engineering Tuzla Tuzla 75000Bosnia and Herzegovina

This paper has proposed a specific class of Multiple Input Single Output（MISO） Mamdani Fuzzy Logic State Variable Controllers（FLSVC） with triangle input membership functions,output membership functions with the same area,product fuzzy AND operator,sum fuzzy OR operator and centroid of area defuzzifier for control of stable Single Input Multiple Output（SIMO） linear time invariant *** proposed FLSVC in fact represents memoryless,nonlinear,locally Lipschitz mapping between its inputs and its *** to the multivariable circle criterion for absolute stability,nonlinear part of the system must satisfy the sector *** this paper necessary and sufficient conditions have been determined,which must satisfy FLSVC parameters in order for the memoryless function represented by FLSVC to satisfy the sector ***-quently,using the multivariable circle criterion,the sufficient conditions for absolute stability of feedback connected linear system and FLSVC have been *** on the results achieved,an optimization method for both parameters and FLSVC decision rules has been proposed using Genetic Algorithms（GA） .

关键词： Absolute stability Fuzzy control Givens rotation Multivariable circle criterion Optimization

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Journal of Chemistry and Chemical Engineering 2011年第4期5卷 358-368页

作者： Pavel Novotny Rudolf Zitny Hynek Chlup jakub Kronek David Hromadka Faculty of Mechanical Engineering Czech Technical University in Prague Prague 4 166 07 Czech Republic

This paper deals with the problem of theoretical identification of the residence time distribution （RTD） characteristics of a straight pipe at laminar pulsatile flow, if tracer diffusion can be neglected. This situation is typical for micro-apparatuses （e.g. fluidic element） and also for flow in large arteries. Residence time distribution based on velocity profiles at pulsatile flow of a Newtonian liquid in a rigid pipe will be derived theoretically and compared with the well known results for a constant flow rate E（τ） = τ-^2/2τ^3 at τ 〉 τ^-/2, where E （τ） is differential distribution, x is residence time and τ^- is the mean residence time. The following part of the paper deals stimulus response experimental techniques using tracers. The principal problem related to laminar and convection dominated pulsatile flows is discussed： Can the impulse response also be identified with the actual residence time distribution in the case of variable flow？ The general answer is no, and differences between RTD and impulse responses are evaluated as a function of the frequency and amplitude of pulsatile flows.

关键词： Convective flow regime impulse response pulsatile flow residence time distribution

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage

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Acta Pharmaceutica Sinica B 2021年第2期11卷 456-475,604页

作者： Dominik Bakalarz Marcin Surmiak Xiaoxiao Yang Dagmara Wójcik Edyta Korbut ZbigniewSliwowski Grzegorz Ginter Grzegorz Buszewicz Tomasz Brzozowski jakub Cieszkowski Urszula Głowacka Katarzyna Magierowska Zhixiang Pan Binghe Wang Marcin Magierowski Department of Physiology Jagiellonian University Medical CollegeCracow 31-531Poland Department of Forensic Toxicology Institute of Forensic ResearchCracow 31-033Poland Department of Internal Medicine Jagiellonian University Medical CollegeCracow 31-531Poland Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlantaGA30303USA Department of Forensic Medicine Medical University of LublinLublin 20-093Poland

Metal-based carbon monoxide(CO)-releasing molecules have been shown to exert antiinflammatory and anti-oxidative properties maintaining gastric mucosal *** are interested in further development of metal-free CO-based therapeutics for oral ***,we examine the protective effect of representative CO prodrug,*** rat models of gastric damage induced by necrotic ethanol or aspirin,a representative non-steroidal anti-inflammatory *** effectiveness was assessed by measuring the microscopic/macroscopic gastric damage area and gastric blood flow by laser *** mucosal mRNA and/or protein expressions of HMOX1,HMOX2,nuclear factor erythroid 2-related factor 2,COX1,COX2,iNos,Anxa1 and serum contents of TGFB1,TGFB2,IL1 B,IL2,IL4,IL5,IL6,IL10,IL12,tumor necrosis factorα,interferonγ,and GM-CSF were *** content in gastric mucosa was assessed by gas *** with BW-CO-111(0.1 mg/kg,i.g.)increased gastric mucosal content of CO and reduced gastric lesions area in both models followed by increased *** protective effects of the CO prodrug were supported by changes in expressions of molecular ***,because the pathomechanisms of gastric damage differ between topical administration of ethanol and aspirin,the possible protective and anti-inflammatory mechanisms of BW-CO-111 may be somewhat different in these models.

关键词： Gastroprotection Carbon monoxide Prodrug Anti-inflammation NSAID Ethanol Gastric mucosal damage

COMPARISON OF CHARACTERIZATION TECHNIQUES IN P-ON-N HgCdTe LWIR PHOTODIODES TECHNOLOGY 

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红外与毫米波学报 2000年第2期19卷 81-87页

作者： WENUS jakub MADEJCZYK Pawel RUTKOWSKI Jaroslaw (Institute of Applied Physics, Military University of Technology, 2 Kaliskiego Str., 00 908 Warsaw, Poland) 波兰Military University of Technology 波兰 Warsaw 0 0 - 90 8

In this paper standard techniques for characterization of HgCdTe liquid phase epitaxial layers (LPE) were presented. The performance of long wavelength p on n HgCdTe photodiodes fabricated by arsenic diffusion was described. The correlation between LPE HgCdTe material parameters and properties of the infrared photodiodes was demonstrated.

关键词： HgCdTe LPE growth methods of material characterization p-on-n HgCdTe LWIR photodiodes.

Sustainable Development of the City’s Transport Infrastructure--A Project of a New Tram Line with a Linear Park along the Exhibition Channel in Warsaw

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Journal of Environmental Science and Engineering(A) 2018年第7期7卷 285-300页

作者： Jan Lukaszkiewicz Beata Fortuna-Antoszkiewicz jakub Botwina Lukasz Oleszczuk Piotr Wisniewski Department of Landscape Architecture Warsaw University of Life Sciences-SGGW159 Nowoursynowska StreetWarsaw 02-776Poland Warsaw Trams Llc.(Tramwaje Warszawskie sp.z o.o.)Siedmiogrodzka 20 St.Warsaw 01-232Poland Department of Environmental Protection of Mokotów District City of Warsaw 01-232Poland

A new double-circuit tram route planned in Warsaw(Vmax=70.0 km/h),running through the Praga Po?udnie district from Waszyngton Avenue(Washington Avenue)to Goc?aw loop(total length of about 3.5 km),is designed to reduce the existing road load in this area of the access routes from outside Warsaw to the center of the capital,as well as to improve the conditions of transport service in the areas of Saska K?pa,Mi?dzynarodowa housing estate,Kepa Goclawska and Goclaw,thereby increasing the use of public transport in *** paper concerns the first part of the planned investment—a new tram route on the section between Waszyngton Av.(Washington Avenue)and Stanów Zjednoczonych Av.(United States of America Avenue)in Warsaw,along the historical Exhibition Channel in its immediate vicinity(Saska Kepa).Specialists-constructors(Tramwaje Warszawskie Llc.)cooperated with landscape architects(Landscape Architecture Department,Warsaw University of Life Sciences—SGGW),in accordance with contemporary canons of sustainable urban *** aimed at restoring proper proportions in the use of the area,taking into account functional aspects(optimal communication and various forms of recreation),natural aspects(preserving valuable vegetation and enriching resources),landscape aspects(“recovering”water as the main element of space)and reconstructing connections with adjacent areas(residential areas and allotments).

关键词： Linear park biologically active area tram route Goclaw-Saska Kepa green tracks green infrastructure sustainable transport social participation

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口语难点——H篇

疯狂英语（新悦读） 2017年第7期 40-41页

作者： jakub Marian 不详

First,let me note that some people use"an"as the indefinite article[不定冠词]form before"historic,""horrific,""hotel"and a couple more words beginning with an"h,"so they say"an istoric"rather than"a historic."However,virtually[事实上]all speakers do pronounce the"h"at the beginning,when the word is not preceded[在……前]by the indefinite article(people do not say,for example,"Istory is an interesting subject.")

关键词：口语 First the that some 不定冠词 more with