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Multicriteria to estimate the environmental risk of sediment from the Obedska Bog(Northern Serbia),a reservation area on UNESCO's list

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International Journal of Sediment Research 2020年第5期35卷 527-539页

作者： Dejan kr?mar Nenad Grba Marijana kragulj Isakovski Nata?a Varga Jelena Spasojevi? Jasmina Agbaba Bozo Du?an Dalmacija University of Novi Sad Faculty of Sciences Department of ChemistryBiochemistry and Environmental Protection

The objective of this current study is to compare related sediment legislation standards and norms to the diversity and influence of anthropogenic and natural(geogenic) sources of pollution in the investigated fluvial relief test site region of the Obedska *** metals(nickel(Ni).zinc(Zn),cadmium(Cd),copper(Cu) and lead(Pb) except chromium(Cr)) and arsenic(As) have higher values than the Upper Continental Crust(UCC) for loess *** sharp leaps in the enrichment factor(r) suggested "indicators of anthropogenic metal pollution" for Cd,Cu(r> 5.0) and Zn,Ni(r> 1.0) for this *** addition,the Chemical Proxy of Alteration(CPA,60-95) from the unique Jadar block terrane and neighbouring representative catchment areas,confirmed moderate to higher intensity of *** Component Analysis/Factor Analysis(PCA/FA) and cluster analysis suggest that Ni,Zn,Cu and Cd are derived from several anthropogenic sources,whereas As is convincingly of geogenic origin,and Pb and Cr exhibit dual *** sum of 16 *** Protection Agency Polycyclic Aromatic Hydrocarbons(EPA PAHs) indicated heterogenic sources,but minor effects to *** results of the current investigation indicated intensive and highly diffuse sources of pollution in this United Nations Educational,Scientific and Cultural Organization [UNESCO's] *** outcomes indicate that Cu should be added to the European Union [EU] watch list of emerging contaminants.

关键词： Priority substances in sediment Contamination criteria Multivariate statistical techniques Heterogeneous sources

Multiple Sclerosis:A Mast Cell Mediated Psycho-Somatic Disease?

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World Journal of Neuroscience 2018年第4期8卷 444-453页

作者： Per Goran krüger University of Bergen BergenNorway

This paper reviews evidence that the presence of mast cells in specific sites of central nervous system, suggesting inflammatory processes, may explain all the symptoms observed in multiple sclerosis. This hypothesis ... 详细信息

关键词： Multiple Sclerosis Mast Cells Blood-Brain Barrier Oedemas Plaque Formation Relapsing-Remitting MS Primary and Secondary Progressive MS Nutrition Stress Enteroendocrine System

Aging in the Shadow of COVID-19

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Journal of Geriatric Medicine 2020年第3期2卷 12-17页

作者： Satish kr.Gupta Rajiv Gandhi Institute of Petroleum Technology(RGIPT) JaisUttar Pradesh229304India

The coronavirus disease 2019(COVID-19)pandemic presents a major challenge to societies all over the *** new virus threat both socially as well as economically regarding health and safety of human being irrespective of age,race or social status across the *** expository paper focuses on impact of COVID-19 upon elderly and importance of social distancing and isolation for elderly *** paper also explores the scenario of COVID-19 in India and the measures that government bodies are taking to contain and mitigate *** and responsibilities of families and caregivers to keep away the elderly disease-free,spirited and mentally *** in isolation or quarantine need special care:telephonic counselling,digital contact with family and ensuring adequate nutrition is *** study is primarily based on secondary data including books,journals,newspapers,and other governmental reports.

关键词： COVID-19 Elderly Isolation

Assessing the microstructure and in vitro degradation behavior of Mg-xGd screw implants using μCT

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Journal of Magnesium and Alloys 2021年第6期9卷 2208-2223页

作者： Diana krüger Berit Zeller-Plumhoff Björn Wiese Sangbong Yi Marcus Zuber D.C.Florian Wieland Julian Moosmann Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Institute of Material and Process Design Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Institute for Photon Science and Synchrotron Radiation Karlsruhe Institute of TechnologyHerrmann-von-Helmholtz-Platz 1Eggenstein-Leopoldshafen 76344Germany Laboratory for Applications of Synchrotron Radiation Karlsruhe Institute of TechnologyKaiserstr.12KarlsruheGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Biodegradable implants are taking an increasingly important role in the area of orthopedic implants with the aim to replace permanent implants for temporary bone healing *** the implant preparation process,the material’s surface and microstructure are being changed by stresses induced by *** degradable metal implants need to be fully characterized in terms of the influence of machining on the resulting microstructure and corrosion *** this study,micro-computed tomography(μCT)is used for the quantification of the degradation rate of biodegradable *** our best knowledge,for the first time quantitative measures are introduced to describe the degradation homogeneity in *** information enables a prediction in terms of implant stability during the degradation in the *** magnesium gadolinium alloys,Mg-5Gd and Mg-10 Gd(all alloy compositions are given in weight%unless otherwise stated),in the shape of M2 headless screws have been investigated for their microstructure and their degradation performance up to 56 *** the microstructure investigations particular attention was paid to the localized deformation of the alloys,due to the machining *** vitro immersion testing was performed to assess the degradation performance quantified by subsequent weight loss and volume loss(usingμCT)*** differences were observed in the degree of screw’s near surface microstructure being influenced from machining,the degradation rates of both materials appeared to be suitable for application in orthopedic *** the degradation homogeneity point of view no obvious contrast was detected between both ***,the higher degradation depth ratios between the crests and roots of Mg-5Gd ratios may indicated a less homogeneous degradation of the screws of these alloys on contract to the ones made of Mg-10Gd *** to its lower degradation rates,its more homogeneous microstructure,its weaker texture

关键词： Magnesium alloys Biodegradable implant Degradation rate Degradation homogeneity Micro-comptued tomography

Structural Performance Evaluation Procedure for Large Flexible Airship of HALE Stratospheric Platform Conception

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Journal of Shanghai Jiaotong university(Science) 2007年第2期12卷 293-300页

作者：陈务军肖微微 Bernd krplin Andreas KunzeInst.of Static and Dynamic for Aerospace Structures Univ.of Stuttgart Germany Space Structures Research Centre-SSRC Shanghai Jiaotong Univ. Inst.of Static and Dynamic for Aerospace Structures Univ.of StuttgartGermany

Basic loads applied on the airship envelope were *** resultant forces,the static bending moment and the dynamic bending moment were *** on classic linear elastic membrane theory,the procedures to calculate the minimum pressure were proposed for sufficient rigidity *** limit load capacity was further investigated,and the related formula were ***,the stress and internal forces analysis was carried out for cylindrical and non-cylindrical approximations of envelope hull of *** present research is very valuable to the overall preliminary design of airship and further research.

关键词： airship stratospheric platform minimum pressure structural performance

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蒙特卡罗哈密顿新方案及其检验

高能物理与核物理 2005年第9期29卷 928-932页

作者：黄纯青罗向前 H.krger 中山大学理工学院物理学系 Département de Physique Université LavalQuébecPQ G1K 7P4Canada

蒙特卡罗哈密顿方法(MCH)是研究量子理论的数值模拟新方法,其优点是可求出超出基态的能谱和波函数.旧MCH方案需要自由粒子的信息,较难推广应用于格点规范理论.本文提出克服这个困难的新方案.首先介绍这一方案的思想,并以1维量子力学模型... 详细信息

蒙特卡罗哈密顿方法(MCH)是研究量子理论的数值模拟新方法,其优点是可求出超出基态的能谱和波函数.旧MCH方案需要自由粒子的信息,较难推广应用于格点规范理论.本文提出克服这个困难的新方案.首先介绍这一方案的思想,并以1维量子力学模型V(x)=μ2x2+λx4(其中μ20)为例说明实现这一新方案的具体计算步骤和方法.

关键词：蒙特卡罗等效哈密顿量新方案波函数能谱哈密顿检验格点规范理论量子力学模型数值模拟

Chemistry-led investigations into the mode of action of NAMPT activators,resulting in the discovery of non-pyridyl class NAMPT activators

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Acta Pharmaceutica Sinica B 2023年第2期13卷 709-721页

作者： Siyuan Tang Miguel Garzon Sanz Oliver Smith Andreas krämer Daniel Egbase Paul W.Caton Stefan Knapp Sam Butterworth Division of Pharmacy and Optometry School of Health SciencesManchester Academic Health Sciences CentreUniversity of ManchesterManchester M139PLUK Structural Genomics Consortium(SGC) 60438 Frankfurt Am MainGermany Buchmann Institute for Life Sciences(BMLS) 60438 Frankfurt Am MainGermany Institut für Pharmazeutische Chemie Goethe University60438 Frankfurt Am MainGermany Frankfurt Cancer Institute(FCI) 60596 Frankfurt Am MainGermany Department of Diabetes School of Cardiovascular and Metabolic Medicine&SciencesFaculty of Life Sciences&MedicineKing's College LondonLondon SE11ULUK

The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy ***,several classes of nicotinamide phosphoribosyl transferase(NAMPT)activators have been shown to increase NAD+levels in vitro and in vivo and to demonstrate beneficial effects in animal *** best validated of these compounds are structurally related to known urea-type NAMPT inhibitors,however the basis for the switch from inhibitory activity to activation is not well *** we report an evaluation of the structure activity relationships of NAMPT activators by designing,synthesising and testing compounds from other NAMPT ligand chemotypes and mimetics of putative phosphoribosylated adducts of known *** results of these studies led us to hypothesise that these activators act via a through-water interaction in the NAMPT active site,resulting in the design of the first known urea-class NAMPT activator that does not utilise a pyridine-like warhead,which shows similar or greater activity as a NAMPT activator in biochemical and cellular assays relative to known analogues.

关键词： Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery Bioisosteres Medicinal chemistry

Optimization of Tribological Performance of Al-6061T6-15% SiCp-15% Al2O3Hybrid Metal Matrix Composites Using Taguchi Method &Grey Relational Analysis

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Journal of Minerals and Materials Characterization and Engineering 2014年第4期2卷 351-361页

作者： Ashok kr. Mishra Vinod Kumar Rajesh kr. Srivastava BIT Sindri Dhanbad India BRCM College of Engineering & Technology Bahal India SKIET Kurukshetra India

In this investigation, optimization of tribological performance parameters of Al-6061T6 alloy reinforced with SiC (15% by weight) and Al2O3 (15% by weight) particulates having particle size of 37 μm each has been presented. The wear and frictional properties of the hybrid metal matrix composites have been studied by performing dry sliding wear test using pin-on-disc wear tester. A L27 orthogonal array is selected for the analysis of the data. From the test results it is observed that sliding distance has the significant contribution in controlling the friction and wear behaviour of hybrid composites. A confirmation test is also carried out to verify the accuracy of the results obtained through the optimization. In addition an optical micrograph test is also performed on the wear tracks to study the wear mechanism.

关键词： Metal Matrix Composites (MMCs) Friction Wear Taguchi Method Grey Relational Analysis Analysis of Variance (ANOVA)

Accordion Manoeuvre with Ilizarov Frame over Nail in Situin a Case of Infected Non-Union of Femur: Discussion on Strategies: A Case Report

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Open Journal of Orthopedics 2014年第7期4卷 183-188页

作者： Ranjit kr. Baruah Department of Orthopaedics Assam Medical College Dibrugarh India

Quiescent Type of H. Rosen & Stage 2 of C.L. Romano et al. for Infected Non Union of Femur after K-nailing (Küntscher nailing) require no debridement & removal of nail and therefore can be treated by a single stage procedure. There are a few reports of treating aseptic non-union of femur by compression alone or compression distraction over nail by Ilizarov Technique. However, no case of Infected Non-Union femur being treated by Accordion Manoeuvre with Ilizarov over nail in situ (i.e. without exchange nailing) has been reported so far. Here, we are reporting a case of Infected Non-Union following K-nailing for a fracture shaft of femur in a 15-year-old female, who was treated by this technique as a single stage procedure. An Ilizarov frame was mounted on the femur with nail in situ followed by Accordion Manoeuvre. The fracture was healed in 5.6 months with two cycles of Accordion Manoeuvre followed by rhythmic compression. There was no recurrence of infection.

关键词： Infected Non-Union Femur Accordion Manoeuvre by Ilizarov over Nail in Situ