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Appropriateness of the study of iron deficiency anemia prior to referral for small bowel evaluation at a tertiary center

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World Journal of Gastroenterology 2017年第24期23卷 4444-4453页

作者： jaime pereira rodrigues Rolando Pinho Joana Silva Ana Ponte Mafalda Sousa Joao Carlos Silva Joao Carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoRua Conceicao FernandesVila Nova de Gaia

To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODSAll consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected. Relevant clinical information regarding prior anemia workup was retrospectively collected from medical records. An appropriate pre-referral study was considered the execution of esophagogastroduodenoscopy (EGD) with Helicobacter pylori (H. pylori) investigation, colonoscopy with quality standards (recent, total and with adequate preparation) and celiac disease (CD) screening (through serologic testing and/or histopathological investigation). RESULTSA total of 77 patients (58.4% female, mean age 67.1 ± 16.7 years) were included. Most (53.2%) patients were referred from general practitioners, 41.6% from other hospital specialties and 5.2% directly from the emergency department. The mean pre-referral hemoglobin concentration was 8.8 ± 2.0 g/dL and the majority of anemias had microcytic (71.4%) and hypochromic (72.7%) characteristics. 77.9% of patients presented with an incomplete pre-referral study: EGD in 97.4%, with H. pylori investigation in 58.3%, colonoscopy with quality criteria in 63.6%, and CD screening in 24.7%. Patients with an appropriate study at the time of referral were younger (48.7 ± 17.7 vs 72.3 ± 12.3 years, P < 0.001). Small bowel evaluation was ultimately undertaken in 72.7% of patients, with a more frequent evaluation in patients with a quality colonoscopy at referral (78.6% vs 23.8%); P < 0.001 (OR = 11.7, 95%CI: 3.6-38.6). The most common diagnosis regarded as the likely cause of IDA was small bowel angioectasia (18.2%) but additional causes were also found in the upper and lower ga

关键词： Iron deficiency anemia Colonoscopy Celiac disease Esophagogastroduodenoscopy Helicobacter pylori Small bowel

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Yield of capsule endoscopy in obscure gastrointestinal bleeding:A comparative study between premenopausal and menopausal women

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World Journal of Gastrointestinal Endoscopy 2018年第10期10卷 301-307页

作者： Joao Carlos Silva Rolando Pinho Adélia rodrigues Ana Ponte jaime pereira rodrigues Mafalda Sousa Catarina Gomes Joao Carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoPorto 4434-502Portugal

AIM To evaluate differences in capsule endoscopy(CE) performed in the setting of obscure gastrointestinal bleeding(OGIB) among premenopausal women(PMW) and menopausal women(MW).METHODS Retrospective, single-center study, including female patients submitted to CE in the setting of OGIB between May 2011 and December 2016. Patients were divided into 2 groups according to age, considering fertile age as ≤ 55 years and postmenopausal age as > 55 years. The diagnostic yield(DY), the rebleeding rate and the time to rebleed were evaluated and compared between groups. Rebleeding was defined as a drop of Hb > 2 g/dL or need for transfusional support or presence of melena/*** A hundred and eighty three female patients underwent CE for OGIB, of whom 30.6%(n = 56) were PMW and 69.4%(n = 127) were MW. The DY was 30.4% in PMW and 63.8% in MW. The most common findings were angiodysplasias in both groups(PMW: 21.4%, MW: 44.9%)(P = 0.003). In PMW, only 1.8% required therapeutic endoscopy. In 17.3% of MW, CE findingsled to additional endoscopic treatment. Rebleeding at 1, 3 and 5 years in PMW was 3.6%, 10.2%, 10.2% and 22.0%, 32.3% and 34.2% in MW. Postmenopausal status was significantly associated with higher DY(P < 0.001), TY(P = 0.003), rebleeding(P = 0.031) and lower time to rebleed(P = 0.001).CONCLUSION PMW with suspected OGIB are less likely to have significant findings in CE. In MW DY, need for endoscopic treatment and rebleeding were significantly higher while time to rebleed was lower.

关键词： Diagnostic yield Obscure gastrointestinal bleeding Premenopausal women Menopausal women Capsule endoscopy

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Impact of the timing of capsule endoscopy in overt obscure gastrointestinal bleeding on yield and rebleeding rate-is sooner than 14 d advisable?

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World Journal of Gastrointestinal Endoscopy 2018年第4期10卷 74-82页

作者： Catarina Gomes Rolando Pinho Adélia rodrigues Ana Ponte Joana Silva jaime pereira rodrigues Mafalda Sousa Joao Carlos Silva Joao Carvalho Department of Gastroenterology Centro Hospitalar Vila Nova de Gaia/EspinhoPorto 4434502Portugal

AIM To evaluate the impact of the timing of capsule endoscopy(CE) in overt-obscure gastrointestinal bleeding(OGIB). METHODS Retrospective, single-center study, including patients submitted to CE in the setting of overt-OGIB between January 2005 and August 2017. Patients were divided into 3 groups according to the timing of CE(≤ 48 h; 48 h-14 d; ≥ 14 d). The diagnostic and therapeutic yield(DY and TY), the rebleeding rate and the time to rebleed were calculated and compared between groups. The outcomes of patients in whom CE was performed before(≤ 48 h) and after 48 h(> 48 h), and before( 48 h groups(P = 0.03).CONCLUSION Performing CE within 48 h from overt-OGIB is associated to a higher TY and a lower rebleeding rate and longer time to rebleed.

关键词： Overt-obscure gastrointestinal bleeding Capsule endoscopy Timing Diagnosis Therapeutic Rebleeding

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Genetic diversity,population structure,and relationships in a collection of pepper(Capsicum spp.)landraces from the Spanish centre of diversity revealed by genotypingby-sequencing(GBS)

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Horticulture Research 2019年第1期6卷 1030-1042页

作者： Leandro pereira-Dias Santiago Vilanova Ana Fita jaime Prohens Adrián Rodríguez-Burruezo Instituto de Conservación y Mejora de la Agrodiversidad Valenciana Universitat Politècnica de València46022 ValenciaSpain

Pepper(Capsicum spp.)is one of the most important vegetable crops;however,pepper genomic studies lag behind those of other important *** we present the results of a high-throughput genotyping-by-sequencing(GBS)study of a collection of 190 Capsicum ***,including 183 of five cultivated species(***,***,***,***,and ***)and seven of the wild form *** *** generated 6,766,231 high-quality read tags,of which 40.7%were successfully aligned to the reference *** calling yielded 4083 highly informative segregating *** diversity and relationships of a subset of 148 accessions,of which a complete passport information was available,was studied using principal components analysis(PCA),discriminant analysis of principal components(DAPC),and phylogeny ***,***,and *** were successfully separated by all *** population was divided into seven clusters by DAPC,where *** accessions were clustered together with *** *** accessions were spread into two distinct genetic pools,while European accessions were admixed and closely *** of accessions was mainly associated to differences in fruit characteristics and *** studies showed a close relation between Spanish and Mexican accessions,supporting the hypothesis that the first arose from a main genetic flow from the ***’s D statistic values were consistent with positive selection in the *** clusters,possibly related to domestication or selection towards traits of *** work provides comprehensive and relevant information on the origin and relationships of Spanish landraces and for future association mapping studies in pepper.

关键词： crops pepper GBS

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Morphoagronomic characterization and wholegenome resequencing of eight highly diverse wild and weedy *** and *** *** accessions used for the first interspecific tomato MAGIC population

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Horticulture Research 2020年第1期7卷 477-492页

作者： Pietro Gramazio Leandro pereira-Dias Santiago Vilanova jaime Prohens Salvador Soler Javier Esteras Alfonso Garmendia María JoséDíez Faculty of Life and Environmental Sciences University of Tsukuba1-1-1 Tennodai305-8572 TsukubaJapan Instituto de Conservación y Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain Departamento de Ecosistemas Agroforestales Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain Instituto Agroforestal Mediterráneo Universitat Politècnica de ValènciaCamino de Vera 1446022 ValenciaSpain

The wild Solanum pimpinellifolium(SP)and the weedy *** ***(SLC)are largely unexploited genetic reservoirs easily accessible to breeders,as they are fully cross-compatible with cultivated tomato(*** ***).We performed a comprehensive morphological and genomic characterization of four wild SP and four weedy SLC accessions,selected to maximize the range of variation of both *** eight accessions are the founders of the first tomato interspecific multi-parent advanced generation inter-cross(MAGIC)*** morphoagronomic characterization was carried out with 39 descriptors to assess plant,inflorescence,fruit and agronomic traits,revealing the broad range of diversity *** of the morphological variation observed in SP was likely associated to the adaptation of the accessions to different environments,while in the case of SLC to both human activity and adaptation to the ***-genome resequencing of the eight accessions revealed over 12 million variants,ranging from 1.2 to 1.9 million variants in SLC and from 3.1 to 4.8 million in SP,being 46.3%of them(4,897,803)private *** genetic principal component analysis also confirmed the high diversity of SP and the complex evolutionary history of *** was also reflected in the analysis of the potential footprint of common ancestors or old introgressions identified within and between the two *** functional characterization of the variants revealed a significative enrichment of GO terms related to changes in cell walls that would have been negatively selected during domestication and *** comprehensive morphoagronomic and genetic characterization of these accessions will be of great relevance for the genetic analysis of the first interspecific MAGIC population of tomato and provides valuable knowledge and tools to the tomato community for genetic and genomic studies and for breeding purposes.

关键词： agronomic breeding MAGIC

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Terpinolene inhibits acute responses triggered by different inflammatory agents in vivo models of mouse

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Food Bioscience 2023年第3期53卷 3038-3046页

作者： Isis Oliveira Menezes Lucas Yure Santos da Silva Renata Torres Pessoa Andreza Guedes Barbosa Ramos Francisco Assis Bezerra da Cunha jaime Ribeiro-Filho Anita Oliveira Brito pereira Bezerra Martins Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Laboratory of Pharmacology and Molecular Chemistry(LFQM) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Semi-arid Bioprospecting Laboratory(LABSEMA) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Research Laboratory in Genetics and Translational Hematology(LIGHT) Gonçalo Moniz Institute(IGM)Oswaldo Cruz Foundation(FIOCRUZ)Rua Waldemar Falcão121Candeal40296-710SalvadorBABrazil Gonçalo Moniz Institute–IGM Fiocruz-BASalvador40296-710BABrazil Department of Biological Chemistry Regional University of CaririAv.Cel.Antonio Luiz1161.PimentaCratoCE63105-000Brazil

The aim of this work was evaluate the effects of terpinolene on acute inflammatory responses in *** vivo preclinical research using different inflammatory agents to induce acute responses and evaluate the effects of terpinolene in orally treated *** acute inflammatory responses were induced by injecting phlogistic agents in the mice paw to observe the development of pain responses(formalin test)or edema(carrageenan,dextran,histamine,arachidonic acid,and prostaglandin).The antiedematogenic activity was also evaluated using a croton oil-induced ear edema ***,cotton pellet-induced granuloma was used to carry out a pre-liminary evaluation of terpinolene in a chronic inflammatory *** administered terpinolene(5,10,and 20 mg/mL)significantly inhibited ear edema development(by 33.82%,29.63%,and 33,30%,respectively).Following an oral administration,only the highest dose of the monoterpene(200 mg/kg)reduced the licking time of the formalin test in both phases 1(73.55%)and 2(96.61%).The carrageenan-induced edema signifi-cantly inhibited over time following the oral administration of terpinolene at 50 mg/kg(T1:47.74%,T2:54.67%,T3:48.63%,and T4:62.99%),100 mg/kg(T1:72.86%,T2:71.03%,T3:48.63%,and T4:57.83%),and 200 mg/kg(T1:43.22%,T2:34.11%,T3:36.47%,and T4:45.20%).On the other hand,only the dose of 200 (mg/kg)caused a significant reduction of the dextran-induced paw edema(T1:51.18%,T2:60%,T3:50.92%,and T4:65.15%).Regarding the participation of inflammatory pathways,the monoterpene(200 mg/kg,p.o.)had little impact on histamine-induced edema,while the edema induced by arachidonic acid was significantly reduced at all time-points(T1:37.04%,T2:24.32%,and T3:35.13%,and T4:35.53%),which was corroborated by the observation that the compound inhibited the response triggered by prostaglandin E2(PGE2),suggesting inter-ference with downstream signaling ***,terpinolene(200 mg/kg,p.o.)reduced both the weight(21.43%)and total protein content(36.21%)

关键词： Terpinolene Antiedematogenic Inflammation In vivo study Inflammatory pathways

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Vadose Zone Heterogeneity Effect on Unsaturated Water Flow Modeling at Meso-Scale

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Journal of Water Resource and Protection 2015年第4期7卷 353-368页

作者： Artur Paiva Coutinho Laurent Lassabatere Thierry Winiarski jaime Joaquim da Silva pereira Cabral Antonio Celso Dantas Antonino Rafael Angulo-Jaramillo LEHNA UMR 5023 CNRS ENTPE UCB-Lyon-1 Vaulx-en-Velin France Universidade Federal de Pernambuco Centro de Tecnologia e Geociências Programa de Pós Graduacao em Engenharia Civil/Tecnologia Ambiental e Recursos Hídricos Recife Brasil

The understanding of unsaturated flow in heterogeneous formations is a prerequisite to the understanding of pollutant transfer in the vadose zone and the proper management of infiltration basins settled over such heterogeneous formations. This study addresses the effect of lithological heterogeneity of a glaciofluvial deposit on flow in the vadose zone underneath an infiltration basin settled in the Lyon suburbs. The basin had already been the subject of several previous studies, some of which demonstrated the impact of soil heterogeneity. But all of them were only based on the sedimentological study of a trench and no study addressed the potential spatial variability of results due to the spatial variability of soil heterogeneity. In this study, we model flow in the vadose zone for several case studies, including drainage, water infiltration during a rainfall event, and a complete meteorological chronic. These calculations were conducted for several sections, previously characterized in the basin using GPR and sedimentological study and compared with a blank (homogeneous section). The results clearly show that heterogeneity impacts unsaturated flow and that these impacts depend upon the section considered. Some geometrical architectural and textural parameters were proposed to explain the spatial variability and effect of the soil heterogeneity on unsaturated flow, thus establishing the first step towards modeling unsaturated flow in the basin at the meso-scale.

关键词： Architectural and Structural Indicators Ground Penetration Radar Numerical Modeling Preferential Flow Structural Heterogeneity Unsaturated Flow

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