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Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 162-167页

作者： Paulo Figueiredo Costa Fabricio Ferreira Coelho Vagner Birk Jeismann jaime Arthur Pirola Kruger Gilton Marques Fonseca Ivan Cecconello Paulo Herman Digestive Surgery Brazilian College of Digestive Surgery(Colégio Brasileiro de Cirurgia Digestiva-CBCD) São PauloBrazil Digestive Surgery Division Department of GastroenterologyUniversity of São Paulo School of MedicineSão PauloBrazil Instituto do Câncer do Estado de São Paulo(ICESP) São PauloBrazil

Background: Liver recurrence after resection of colorectal liver metastases(CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: Consecutive adult patients undergoing hepatectomy for CRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). Conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence.

关键词： Colorectal cancer Metastasis Hepatectomy Postoperative complications Survival analysis

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Properties of a Scale of Self-Care Behaviors Facing COVID-19:An Exploratory Analysis in a Sample of University Students in Huanuco,Peru

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International Journal of Mental Health Promotion 2022年第6期24卷 959-974页

作者： Mely Ruiz-Aquino Viter Gerson Carlos Trinidad Aldo Alvarez-Risco jaime A.Yáñez Universidad de Huánuco Facultad de Ciencias de la SaludHuánucoPeru EsSalud Hospital Bicentenario de JaujaHuancayoPeru Universidad de Lima Facultad de Ciencias Empresariales y EconomicasCarrera de Negocios InternacionalesLimaPeru Universidad Norbert Wiener Vicerrectorado de InvestigaciónLimaPeru Teoma Global Gerencia Corporativa de Asuntos Científicos y RegulatoriosLimaPeru

The general objective of this article was to construct and describe the psychometric properties of a scale of selfcare behaviors against *** was a descriptive,cross-sectional,psychometric validation study of a scale created to measure self-care behaviors in relation to COVID-19 in a total sample of 333 probabilistically *** validity was evaluated by a review of 10 experts and quantitative validity by means of exploratory factor analysis using the principal components *** consistency was measured with Cronbach’s alpha twice and the test-retest was evaluated by calculating the intraclass *** final scale consisted of 29 *** Kaiser-Meyer-Olkin test of adequacy yielded a value of 0.926,and the Bartlett’s test of sphericity X^(2)=4611 with a p-value<*** variance explained by the three retained factors with a total of 29 items was 50.03%.The Cronbach’s alpha internal consistency evaluation yielded an initial value of 0.923 and,in a second evaluation,showed a value of *** addition,the intraclass coefficient in the test-retest yielded a value of *** instrument created and validated possessed the necessary conditions as a useful and reliable tool for measuring self-care behaviors in relation to COVID-19 in a population of university students and it is important that it can be applied in other regions of the world.

关键词： COVID-19 Peru self-care physical health social health mental health validation instrument

The relevance of James Lovelock’s research and philosophy to environmental science and academia

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Frontiers of Environmental Science & Engineering 2023年第3期17卷 143-144页

作者： jaime A.Teixeira da Silva Panagiotis Tsigaris Independent Researcher Ikenobe 3011-2Kagawa-ken761-0799Japan Department of Economics Thompson Rivers University805 TRU WayKamloopsBritish ColumbiaV2C 0C8Canada

James ***,famed for his Gaia hypothesis,which views the Earth as a living integrated and interconnected self-regulating system whose equilibrium comes about from complex energy-based interactions and feedback loops,ultimately sustaining life,passed away at the end of July,2022 at the age of *** only are the adaptive mechanisms of Gaia central to the conversation of environmental homeostasis,they lie at the heart of climate change and global *** is also remembered as the co-inventor of the electron capture detector that eventually allowed for the sensitive detection of chlorofluorocarbons and ***,Lovelock’s free-spirited nature and research independence allow academia to rethink current research’s modus operandi.

关键词： Academic independence Climate change Electron capture detector Environmental equilibrium Global warming Homeostasis

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General and Exact Inbreeding Coefficient of Maize Synthetics Derived from Three-Way Line Hybrids

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 33-43页

作者： Alejandro Ibarra-Sánchez Juan Enrique Rodríguez-Pérez Aureliano Peña-Lomelí Clemente Villanueva-Verduzco jaime Sahagún-Castellanos Crop Science Department Chapingo Autonomus UniversityChapingo56230México

Synthetic varieties(SVs)are populations generated by randomly mating their *** are a good alternative for low-input farmers who grow onions,maize,and other allogamous crops since the seed produced by a SV does not change from one generation to the *** SV progenitors are commonly pure lines,in this case a synthetic(Syn_(TC))whose parents are t three-way line crosses,a very common type of maize hybrid grown in Mexico,is *** aim was to develop a general and exact equation for the inbreeding coefficient of a Syn_(TC)eF_(m)^(f)Syn_(TC)T because of its relationship with the mean of economically important *** objective arose due to the need for a more advanced study in terms of determining whether F_(m)^(f)Syn_(TC)can be applied specifically and accurately for any number of parents(t),plants per parent(m)and inbreeding coefficient(IC)of the initial lines(F_(L)).A formula for the IC of the Syn_(TC)was derived that,given any values of F_(L)(0≤F_(L)≤1)and t,is specific for any value of m,not just for“large”numbers associated with the context in which the Hardy-Weinberg law is *** was found that F_(m)^(f)Syn_(TC)is very sensitive to changes in m when m is not greater than eight,after which it tends to stabilize very *** summary,unlike previously derived formulas,F_(m)^(f)Syn_(TC)is exact for any values of t,m and F_(L).

关键词： Genotypic array genotypic mean hybrid random mating Zea mays L

A bibliometric review of cryptocurrencies:how have they grown?

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Financial Innovation 2022年第1期8卷 25-55页

作者： Francisco Javier García-Corral JoséAntonio Cordero-García jaime de Pablo-Valenciano Juan Uribe-Toril Research Group:Almeria Group of Applied Economy(SEJ 147) University of AlmeriaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain Department of Law Financial and Tax LawUniversity of AlmeriaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain Department of Business and Economics Applied Economic AreaUniversity of AlmeríaCarretera Sacramento s/n04120La Cañada de San UrbanoAlmeríaSpain

With the development of new technologies,some concepts become relevant in the economic area,as is the case with cryptocurrencies,in general,or Bitcoin and Ethereum,in *** to the impact of these tools,a detailed bibliometric study that allows us to obtain all information about cryptocurrencies must be *** study will help scientific production by specifying the development and lines of related research that have been followed and are currently being *** have used Tableau,R(Bibliometrix R Package),and VOSviewer software to analyze the *** have been combined to create and review unified metadata from the Web of Science(WoS)and Scopus *** bibliometric analysis shows 771 articles on the WoS database and 648 articles on Scopus published between 2010 and early *** present the most relevant articles,research areas,countries,institu-tions,authors,journals,and trends during the last few *** conclusion,the number of publications has grown in the last 3 *** analysis shows the evolution of block-chain technology used in this type of *** review of this period marks a possible end to the historical part of cryptocurrencies,thereby opening the current topic to its multiple applications.

关键词： Cryptocurrency Bitcoin Ethereum Bibliometric analysis Business and economics

Characterization and QTL identification in eggplant introgression lines under two N fertilization levels

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Horticultural Plant Journal(园艺学报:英文版) 2023年第5期9卷 971-985页

作者： Elena Rosa-Martínez Gloria Villanueva Ahmet Sahin Pietro Gramazio María Dolores García-Martínez María Dolores Raig on Santiago Vilanova jaime Prohens Mariola Plazas Instituto de Conservacion y Mejora de la Agrodiversidad Valenciana Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas-Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain

Lowering nitrogen inputs is a major goal for sustainable *** the present study,a set of 10 Solanum melongena introgression lines(ILs)developed using Solanum incanum as the exotic donor parent were grown under two nitrogen fertilization doses supplied with the irrigation system:1)8.25 mmol·L-1NH4NO3,corresponding to the high nitrogen treatment(HN),and 2)no external nitrogen supply,corresponding to the low nitrogen treatment(LN).Twenty traits,including plant growth and yield parameters,fruit size and morphology,nitrogen and carbon content in leaf and fruit,and phenolics content in fruit,were *** aim was to select of potential materials for eggplant breeding under low N inputs,as well as to identify and locate putative QTLs associated with the traits *** significant differences were observed between the soil characteristics of the HN and LN treatments,except for nitrogen and iron content,which was slightly lower in the HN,probably as a consequence of higher nutrient removal from soil by plants in the latter *** of variance showed that lowering nitrogen inputs did not significantly affect the final yield,fruit morphology,size and phenolics *** agronomic traits were highly and positively correlated with each other under both treatments,as well as total phenolics with chlorogenic acid *** assessment of the differences between each IL and the recipient parent resulted in the identification of 36 QTLs associated with most of the traits—12 were specific to the HN,17 specific to the LN,and 7 were stable across *** introgressed fragment of *** generally had a negative effect on the trait,except for QTLs for fruit dry matter,for fruit length on chromosome 10 under the HN,and for fruit pedicel length on chromosome 9 under the *** increase over AN-S-26 of the allele of *** for the QTLs detected ranged between-73.98% and 26.03% in HN and-73.67%and 34.43% in *** findings provide useful tools fo

关键词： Solanum melongena Solanum incanum Wild relatives N fertilization Abiotic stress QTL

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Use of nasal tampons for on-field management of nasal bleeds (epistaxis) in sports

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运动医学与健康科学(英文) 2023年第1期5卷 81-82页

作者： jaime A.Teixeira da Silva Independent researcher Ikenobe 3011-2Kagawa-ken761-0799Japan

In a medical setting,such as the treatment of post-operative nosebleeds,nasal packing,including the use of nasal packs,nasal plugs or nasal tampons(NTs),is widely used to temporarily control anterior *** some literature has documented the use of NTs as a quick,easy and temporary solution to deal with anterior epistaxis in sports-induced nasal injuries,additional research is needed to appreciate on-field versus off-field efficacy,as well as the efficiency of different brands of NTs and packing materials.

关键词： Feminine hygiene Nasal packing Nasal plugs Otolaryngology Rhinology

Abandoned corrals: colonization and vegetation recovery of ephemeral habitats in silvo-pastoral systems

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Journal of Plant Ecology 2020年第6期13卷 722-731页

作者： Arie Vinograd Eli Zaady jaime Kigel Institute of Plant Science and Genetics in Agriculture Robert H.Smith Faculty of AgricultureFood and EnvironmentHebrew University of JerusalemRehovot 76100Israel Department of Natural Resources Gilat Research CenterAROMobile Post Negev 85280Israel

半干旱地中海地区人工林和天然林的林牧业系统管理经常使用季节性的夜间畜栏来保护动物。这种管理制度改变了动物排泄物的空间分布,导致土壤矿产资源的净转移和在畜栏内的积累。畜栏被遗弃后,荒地植物代替了畜栏,成为它们在森林中传播... 详细信息

半干旱地中海地区人工林和天然林的林牧业系统管理经常使用季节性的夜间畜栏来保护动物。这种管理制度改变了动物排泄物的空间分布,导致土壤矿产资源的净转移和在畜栏内的积累。畜栏被遗弃后,荒地植物代替了畜栏,成为它们在森林中传播的集中来源。我们的目的是在更好地了解废弃畜栏后植被生长过程的基础上,对季节性畜栏进行合理管理,以减轻其对森林的负面影响。本论文研究了以色列内盖夫(Negev)西北半干旱地区的人工桉树林(Eucalyptus)在废弃畜栏后的时间序列上,植被、土壤种子库和土壤养分水平的时间变化关系,并与附近的对照样地进行比较。该地区为双季节地中海型气候,放牧区内一年生物种占据优势。研究结果表明,废弃的羊畜栏被原产于旧的废弃畜栏的荒草种子定殖。在废弃畜栏土壤资源耗竭的驱动下,随后的演变速度缓慢,在畜栏废弃后20年仍在继续。荒草首先是被较高的草,然后是矮草所取代,但大多数为非禾草的杂类草植物,特别是在这一时期没有恢复的地下芽植物。畜栏内原有草本植被的恢复是通过种子从周围植被中扩散,而不是从废弃后留在畜栏内的原始土壤种子库中恢复。在人工林放牧区中的荒草物种可视为具有斑块性的集合种群。它们的持久性依赖于不断创造新的畜栏来补偿旧的废弃畜栏中逐渐减少的种群,以及依赖于传播路径的有效性。

关键词：集合种群荒草季节性放牧种子库羊群演替