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Pancreatic biomarkers:Could they be the answer?

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World Journal of Gastroenterology 2014年第24期20卷 7819-7829页

作者： Angela Lamarca jaime Feliu Department of Medical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Medical Oncology La Paz University Hospital28046 MadridSpain

Pancreatic ductal adenocarcinoma(PDA)is known for its poor *** of the patients are diagnosed with advanced stages,when no curative treatment is ***,despite extensive clinical research on PDA,the median overall survival remains *** delay and primary chemo-resistance due to its intrinsic biological nature may explain the challenges to improve our *** knowledge about the molecular biology of PDA has exponentially increased during the last decades and its use for the development of biomarkers could help to reach better results in the clinical *** biomarkers could be the clue for the improvement in PDA clinical research by earlier detection strategies with diagnostic biomarkers,and by an individualization of treatment approach with prognostic and predictive *** review summarizes the current knowledge about the molecular biology of PDA and the status of the most important prognostic and predictive biomarkers.

关键词： Pancreatic adenocarcinoma Biomarkers Diagnosis Prognostic Predictive Treatment

LL-37 and CsgC exemplify the crosstalk between anti-amyloid, antimicrobial, and anti-biofilm protein activities

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Neural Regeneration Research 2023年第5期18卷 1027-1028页

作者： jaime Santos Salvador Ventura Irantzu Pallares Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia Molecular Universitat Autònoma de Barcelona

Protein misfolding and aggregation into amyloid fibrils is the main pathological hallmark of neurodegenerative diseases,including Alzheimer’s,Parkinson’s,Huntington’s,and prion diseases(Chiti and Dobson,2017).These insoluble fibrillar deposits possess a common structure characterized by a cross-β-sheet conformation in which β-strands run transversely to the fiber axis and form an intermolecular network of hydrogen bonds.

关键词： amyloid Huntington diseases

Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

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Journal of Pharmaceutical Analysis 2023年第11期13卷 1346-1352页

作者： jaime Millan-Santiago Rafael Lucena Soledad Cardenas Affordable and Sustainable Sample Preparation(AS2P)Research Group Analytical Chemistry DepartmentChemical Institute for Energy and Environment(IQUEMA)University of CordobaE-14071CordobaSpain

This study proposes a hypodermic needle(HN)as a sorbent holder and an electrospray(ESI)emitter,thus combining extraction and analysis in a single device.A novel nylon 6-cellulose(N6-Cel)composite sorbent is proposed to extract methadone from oral fluid *** cellulosic substrate provides the composite with high porosity,permitting the flow-through of the sample,while the polyamide contributes to the extraction of the *** low price of the devices(considering the holder and the sorbent)contributes to the affordability of the method,and their small size allows easy transportation,opening the door to on-site *** the optimum conditions,the analyte can be determined by high-resolution ambient ionization mass spectrometry at a limit of detection(LOD)as low as 0.3 mg/L and precision(expressed as relative standard deviation,RSD)better than 9.3%.The trueness,expressed as relative recovery(RR),ranged from 90%to 109%.As high-resolution mass spectrometers are not available in many laboratories,the method was also adapted to low-resolution *** this sense,the direct infusion of the eluates in a triple quadrupole-mass spectrometry provided an LOD of 2.2 mg/*** RSD was better than 5.3%,and the RR ranged from 96%to 121%.

关键词： ESI emitter Mass spectrometry Hypodermic needle Composite Methadone

Abandoned corrals: colonization and vegetation recovery of ephemeral habitats in silvo-pastoral systems

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Journal of Plant Ecology 2020年第6期13卷 722-731页

作者： Arie Vinograd Eli Zaady jaime Kigel Institute of Plant Science and Genetics in Agriculture Robert H.Smith Faculty of AgricultureFood and EnvironmentHebrew University of JerusalemRehovot 76100Israel Department of Natural Resources Gilat Research CenterAROMobile Post Negev 85280Israel

Aims Management of silvo-pastoral systems in planted and natural forests in semi-arid Mediterranean regions often employs seasonal night corrals for animal *** management system changes the spatial distribution of animal excreta,resulting in a net transfer of soil mineral resources and their accumulation in the *** abandonment,corrals are colonized by ruderal species,becoming focal sources for their spread in the *** aimed to implement a rational management of seasonal sheep corrals based on a better understanding of the vegetation processes occurring in abandoned corrals,in order to alleviate their negative impact in the *** Relationships between temporal changes in the vegetation,the soil seed-bank and levels of soil nutrients were studied in a chronosequence of abandoned sheep corrals and compared with nearby reference plots in planted Eucalyptus forests grazed by sheep in the semi-arid North-Western Negev,*** region has a bi-seasonal Mediterranean climate,with high dominance of annual species in the grazing *** Findings Abandoned sheep corrals were colonized by seeds of ruderals originating in older abandoned *** successional changes occur at a slow rate,driven by the depletion of soil resources in the abandoned corrals,and were still in progress 20 years after *** were gradually replaced,first by taller grasses and followed by short grasses,but most forbs and particularly geophytes did not recover during this *** of the original herbaceous vegetation in the corrals was through seed dispersal from the surrounding vegetation,not from the original soil seed-bank remaining in the corrals after *** species in the grazed,planted forests behave as patch-tracking *** persistency depends on constant creation of new corrals compensating for the gradually dwindling populations in older abandoned corrals,and on the availability of dispersa

关键词： metapopulation ruderals seasonal grazing seed-bank sheep succession

The relevance of James Lovelock’s research and philosophy to environmental science and academia

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Frontiers of Environmental Science & Engineering 2023年第3期17卷 143-144页

作者： jaime A.Teixeira da Silva Panagiotis Tsigaris Independent Researcher Ikenobe 3011-2Kagawa-ken761-0799Japan Department of Economics Thompson Rivers University805 TRU WayKamloopsBritish ColumbiaV2C 0C8Canada

James ***,famed for his Gaia hypothesis,which views the Earth as a living integrated and interconnected self-regulating system whose equilibrium comes about from complex energy-based interactions and feedback loops,ultimately sustaining life,passed away at the end of July,2022 at the age of *** only are the adaptive mechanisms of Gaia central to the conversation of environmental homeostasis,they lie at the heart of climate change and global *** is also remembered as the co-inventor of the electron capture detector that eventually allowed for the sensitive detection of chlorofluorocarbons and ***,Lovelock’s free-spirited nature and research independence allow academia to rethink current research’s modus operandi.

关键词： Academic independence Climate change Electron capture detector Environmental equilibrium Global warming Homeostasis

Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients:A systematic review of clinical trials

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World Journal of Transplantation 2025年第1期15卷 156-164页

作者： Carlos M Ardila Pradeep K Yadalam jaime Ramírez-Arbelaez Department of Basic Sciences Faculty of Dentistry Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia Department of Postdoctoral Program CIFE University CenterCuernavaca 62330MorelosMexico Department of Periodontics Saveetha Dental CollegeSaveetha Institute of Medical and HealthSIMATSSaveetha UniversityChennai 600077Tamil NaduIndia Department of Transplantation Hospital San Vicente FundaciónRionegro 054047Colombia

BACKGROUND In the absence of effective antimicrobials,transplant surgery is not viable,and antirejection immunosuppressants cannot be administered,as resistant infections compromise the life-saving goal of organ *** To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant *** A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and *** review included randomized clinical trials that evaluated the efficacy of antimicrobial agents(prophylactic or therapeutic)aimed at preventing antimicrobial *** search strategy involved analyzing multiple databases,including PubMed/MEDLINE,Web of Science,Embase,Scopus,and SciELO,as well as examining gray literature sources on Google Scholar.A comprehensive electronic database search was conducted from the databases’inception until May 2024,with no language *** After the final phase of the eligibility assessment,this systematic review ultimate-ly included 7 articles.A total of 2318 patients were *** most studied microorganisms were cytomegalovirus,although vancomycinresistant enterococci,Clostridioides difficile,and multidrug-resistant Enterobacterales were also *** antimicrobials used in the interventions were mainly maribavir,valganciclovir,gancic-lovir,and *** concern,all clinical trials showed significant proportions of resistant microorga-nisms after the interventions,with no statistically significant differences between the groups(mean resistance 13.47%vs 14.39%),except for two studies that demonstrated greater efficacy of maribavir and valganciclovir(mean resistance 22.2%vs 41.1%in the control group;P<0.05).The total reported deaths in three clinical trials were 75,and there were 24 graft rejections in two *** All clinical trials reported significant proportions of antimicrobial-resistant microor

关键词： Antimicrobial resistance Antimicrobials Antivirals Solid organ transplant recipients Infections Microorganisms Cytomegalovirus

Slow light bimodal interferometry in onedimensional photonic crystal waveguides

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Light(Science & Applications) 2021年第2期10卷 154-165页

作者： Luis Torrijos-Morán Amadeu Griol jaime García-Rupérez Nanophotonics Technology Center Universitat Politècnica de Valencia46022 ValenciaSpain

Strongly influenced by the advances in the semiconductor industry,the miniaturization and integration of optical circuits into smaller devices has stimulated considerable research efforts in recent *** other structures,integrated interferometers play a prominent role in the development of photonic devices for on-chip applications ranging from optical communication networks to point-of-care analysis ***,it has been a longstanding challenge to design extremely short interferometer schemes,as long interaction lengths are typically required for a complete modulation *** approaches,including novel materials or sophisticated configurations,have been proposed to overcome some of these size limitations but at the expense of increasing fabrication complexity and ***,we demonstrate for the first time slow light bimodal interferometric behaviour in an integrated single-channel one-dimensional photonic *** proposed structure supports two electromagnetic modes of the same polarization that exhibit a large group velocity ***,an over 20-fold reduction in the higher-order-mode group velocity is experimentally shown on a straightforward all-dielectric bimodal structure,leading to a remarkable optical path reduction compared to other conventional ***,we experimentally demonstrate the significant performance improvement provided by the proposed bimodal photonic crystal interferometer in the creation of an ultra-compact optical modulator and a highly sensitive photonic sensor.

关键词： interferometer polarization modulator

GBP-WAHSN:A Group-Based Protocol for Large Wireless Ad Hoc and Sensor Networks

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Journal of Computer Science & Technology 2008年第3期23卷 461-480页

作者： jaime Lloret Miguel Garcia Jesus Tomás Fernando Boronat Department of Communications Polytechnic University of ValenciaCamino Vera s/n46022ValenciaSpain

Grouping nodes gives better performance to the whole network by diminishing the average network delay and avoiding unnecessary message forwarding and additional overhead. Many routing protocols for ad-hoc and sensor networks have been designed but none of them are based on groups. In this paper, we will start defining group-based topologies, and then we will show how some wireless ad hoc sensor networks （WAHSN） routing protocols perform when the nodes are arranged in groups. In our proposal connections between groups are established as a function of the proximity of the nodes and the neighbor＇s available capacity （based on the node＇s energy）. We describe the architecture proposal, the messages that are needed for the proper operation and its mathematical description. We have also simulated how much time is needed to propagate information between groups. Finally, we will show a comparison with other architectures.

关键词： group-based protocol group-based architecture group-based routing algorithm large networks

Incipient sexual isolation in Laupala cerasina： Females discriminate population-level divergence in acoustic characters

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Current Zoology 2012年第3期58卷 416-425页

作者： jaime L. GRACE Kerry L. SHAW Department of Biology University of Maryland College Park MD 20742 USA Department of Neurobiology and Behavior Cornel1 University Ithaca NY 14853 USA kls4@cornell.edu

Sexual selection by female choice can shape the evolution of male traits within populations, since the most attractive males experience an increase in fitness through elevated mating success. Speciation by sexual selection occurs when evolution in traits and preferences within populations causes differentiation among populations, such that females in alternative populations prefer sexual signals of their own population relative to others. Differentiated traits and preferences thereby play an active role in limiting gene flow between divergent populations. The effectiveness of differentiated preferences in maintaining differentiated male signals against the homogenizing effects of gene flow across populations will be limited by both the degree to which fe- males can discriminate against non-local males, and the breeding values of traits and preferences. Populations of the Hawaiian cricket Laupala cerasina have diverged in pulse rate, a sexually selected male signal, and female acoustic preference for pulse rate. Gene flow between neighboring populations may be reduced if migrants from sexually diverged populations experience re- duced mating success. We show that females discriminate among divergent songs characteristic of neighboring populations, that differences among populations in song and preference breed true in a common environment, and that mean preferences for each population closely match the mean pulse rates. Divergence in preference was observed only between populations that also dif- fered in song. Along with a striking ability to discriminate slight differences in song, correlated evolution of song and preference within populations could be a mechanism that promotes assortative mating among populations, thereby reducing gene flow, and leading to speciation in Laupala [Current Zoology 58 （3）： 416-425, 2012].

关键词： Sexual selection Phenotypic divergence Behavioral isolation Preference functions Speciation