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Pyogenic liver abscess secondary to gastric perforation of an ingested toothpick:A case report

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世界临床病例杂志 2023年第23期11卷 5622-5627页

作者： Yeshong Park Ho-Seong Han Yoo-Seok Yoon jai young cho Boram Lee Mee young Kang Jinju Kim Hae Won Lee Department of Surgery Seoul National University Bundang HospitalSeongnam-si 13620South Korea

BACKGROUND Liver abscess due to foreign body-induced gastrointestinal tract perforation is a rare event that could be misdiagnosed due to low *** than 100 cases have been reported to *** SUMMARY We report a case of a 53-year old female patient with pyogenic liver abscess secondary to ingestion of a toothpick with penetration through the lesser curvature of the *** patient presented with persistent epigastric *** computed tomography demonstrated the presence of a linear radiopaque object associated with abscess formation in the left liver *** changes in the lesser curvature of the stomach indicated gastric wall penetration by the *** the abscess was refractory to antibiotic treatment,laparoscopic liver resection was performed to remove the foreign body and adjacent liver *** surgery,symptoms fully resolved without any *** This rare case demonstrates the importance of considering foreign body penetration as a cause of pyogenic liver abscess,particularly in abscesses of unknown origin that are resistant to antibiotic *** suspicion,early diagnosis,and prompt removal of the foreign body could lead to improved outcomes in these patients.

关键词： Foreign body ingestion Liver abscess Pyogenic liver abscess Liver resection Case report

Portal vein embolization failure:Current strategies and future perspectives to improve liver hypertrophy before major oncological liver resection

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2088-2096页

作者： Gianluca Cassese Ho-Seong Han Boram Lee jai young cho Hae Won Lee Boris Guiu Fabrizio Panaro Roberto Ivan Troisi Clinical Medicine and Surgery Federico II UniversityNaples 80131Italy Department of Surgery Seoul National University College of MedicineSeongnam 13620South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Medical Imaging and Interventional Radiology St-Eloi University HospitalMontpellier 34295France Digestive Surgery and Transplantation CHU de MontpellierMontpellier 34295France

Portal vein embolization(PVE)is currently considered the standard of care to improve the volume of an inadequate future remnant liver(FRL)and decrease the risk of post-hepatectomy liver failure(PHLF).PHLF remains a significant limitation in performing major liver surgery and is the main cause of mortality after *** degree of hypertrophy obtained after PVE is variable and depends on multiple *** to 20%of patients fail to undergo the planned surgery because of either an inadequate FRL growth or tumor progression after the PVE procedure(usually 6-8 wk are needed before surgery).The management of PVE failure is still debated,with a lack of consensus regarding the best clinical *** additional techniques have been proposed,such as sequential transarterial chemoembolization followed by PVE,segment 4 PVE,intra-portal administration of stem cells,dietary supplementation,and hepatic vein *** aim of this review is to summarize the up-to-date strategies to overcome such difficult situations and discuss future perspectives on improving FRL hypertrophy.

关键词： Portal vein embolization Portal vein embolization failure Rescue associating liver partition and portal vein ligation Hepatic vein embolization Liver venous deprivation Segment 4 portal vein embolization

The role of minimally invasive surgery in the treatment of HCC

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Hepatoma Research 2022年第1期8卷 301-312页

作者： Gianluca Cassese Ho-Seong Han Boram Lee Hae Won Lee jai young cho Roberto Ivan Troisi Department of HPB Surgery Seoul National University Bundang HospitalSeongnam-si 13620South Korea Department of Clinical Medicine and Surgery Minimally invasive and robotic HPB Surgery UnitFederico II UniversityNaples 80131Italy

Liver surgery is the first-line treatment for hepatocellular carcinoma(HCC).Minimally invasive liver resection(MILS)has become an attractive option thanks to reduced intraoperative blood losses,shortened length of hospital stay,and similar oncological outcomes when compared to open liver ***,the safety of MILS is still debated in challenging situations,such as in cirrhotic patients,difficult tumor locations,multiple or large tumors,and repeat *** aim of this review is to discuss current indications of laparoscopic liver resection for HCC treatment in the light of its outcomes,focusing on technical aspects of minimally invasive anatomic liver resection and state of the art of MILS in challenging situations.

关键词： Laparoscopic liver resection hepatocellular carcinoma minimally invasive liver surgery anatomic liver resection

Laparoscopic liver resection for hepatocellular carcinoma in patients with cirrhosis

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Hepatoma Research 2016年第1期2卷 259-263页

作者： jai young cho Ho-Seong Han Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 463-707South Korea

Hepatocellular carcinoma(HCC)is a common malignant tumor and many cases occur in patients with liver *** liver transplantation is the most effective treatment option,hepatectomy is still the first curative treatment option because liver transplantation is limited by the donors and high *** recent years,laparoscopic liver resection(LLR)has increasingly been performed in patients with liver cirrhosis,and has several advantages over open liver *** less pain and shorter hospital stay,LLR in patients with liver cirrhosis is also associated with lower incidences of postoperative liver failure and ascites because of greater preservation of collateral veins and less liver *** increasing experience,LLR for HCC located in segments 7 or 8 is now feasible,and anatomic LLR could be performed in patients with *** comparative studies have shown that LLR is better than open liver resection in patients with liver cirrhosis in terms of a lower incidence of postoperative liver failure and similar patient *** conclusion,LLR is a promising treatment modality for HCC in patients with liver cirrhosis.

关键词： Laparoscopy hepatectomy cirrhosis portal hypertension

Immunotherapy for hepatocellular carcinoma:A promising therapeutic option for advanced disease

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World Journal of Hepatology 2022年第10期14卷 1862-1874页

作者： Gianluca Cassese Ho-Seong Han Boram Lee Hae Won Lee jai young cho Fabrizio Panaro Roberto Ivan Troisi Department of Clinical Medicine and Surgery Division of Minimally Invasive and Robotic HPB SurgeryFederico II UniversityNaples 80131Italy Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Division of HBP Surgery and TransplantationMontpellier University Hospital-School of MedicineMontpellier 34000France

Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide,and its incidence continues to *** improvements in both medical and surgical therapies,HCC remains associated with poor outcomes due to its high rates of recurrence and *** 50% of patients require systemic therapies that traditionally consist of tyrosine kinase ***,however,immune checkpoint inhibitors have revolutionized HCC management,providing new therapeutic *** these major advances,the different factors involved in poor clinical responses and molecular pathways leading to resistance following use of these therapies remain *** strategies,such as adoptive T cell transfer,vaccination,and virotherapy,are currently under *** of immunotherapies with other systemic or local treatments are also being investigated and may be the most promising opportunities for HCC *** aim of this review is to provide updated information on currently available immunotherapies for HCC as well as future perspectives.

关键词： Hepatocellular Carcinoma Immunotherapy Hepatocellular Carcinoma management Hepatocellular Carcinoma therapy Molecular targeted therapy

Laparoscopic anatomical versus non-anatomical liver resection for hepatocellular carcinoma in the posterosuperior segments:a propensity score matched analysis

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 824-834,I0001页

作者： Boram Lee jai young cho Ho-Seong Han Yoo-Seok Yoon Hae Won Lee Jun Suh Lee Moonhwan Kim Yeongsoo Jo Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnamKorea

Background:Since laparoscopic anatomical resection(LAR)for tumors,especially located in the posterosuperior(PS)segments of the liver remains difficult,laparoscopic non-anatomical resection(LNAR)are generally *** compare the clinical outcomes between LAR and LNAR for hepatocellular carcinoma(HCC)located in the PS ***:We retrospectively reviewed the data for 1,029 patients who underwent hepatectomy for HCC between 2004 and *** 167 patients who underwent laparoscopic hepatectomy for HCC in PS segments,64 underwent LNAR and 103 underwent *** were matched one-to-one using propensity score matching(46:46).Results:LNAR was associated with significantly shorter operation time(P=0.001),lower estimated blood loss(P=0.001),lower transfusion rate(P=0.006)and shorter hospital stay(P=0.012)than *** respective 1-,3-,and 5-year overall survival rates(LAR:95.3%,87.1%,and 77.8%;LNAR:96.7%,91.6%,and 85.0%;P=0.262)and recurrence-free survival rates(LAR:75.7%,70.3%,and 68.9%;LNAR:81.8%,58.3%,and 55.3%;P=0.879)were *** intrahepatic recurrence rate was significantly higher in LNAR group than in LAR group(78.6%vs.57.1%,P=0.023),but the post-recurrence treatments differed significantly between the two groups(P=0.016);the re-resection rate was much greater in the LNAR group(45.0%vs.0%)*** respective 1-,3-,and 5-year post-recurrence survival rates were similar in the LAR and LNAR groups(P=0.212).After recurrence,survival in re-resection group was significantly greater than not(P=0.026).Conclusions:LNAR is safe and feasible for HCC located in PS segments,and provided acceptable oncologic outcomes that are comparable to those of *** can be considered for patient with tumor located in PS segment when LAR is not feasible.

关键词： Laparoscopy hepatectomy carcinoma,hepatocellular recurrence

Intra-arterial lipo-prostaglandin E1 infusion for arterial spasm in liver transplantation:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8153-8157页

作者： Moonhwan Kim Hae Won Lee Chang Jin Yoon Boram Lee Yeongsoo Jo jai young cho Yoo-Seok Yoon Jun Suh Lee Ho-Seong Han Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-si 13620Gyeonggi-doSouth Korea Department of Radiology Seoul National UniversitySeongnam 463-707South Korea

BACKGROUND Hepatic artery obstruction is a critical consideration in graft outcomes after living donor liver *** report a case of diffuse arterial vasospasm that developed immediately after anastomosis and was managed with an intra-arterial infusion of lipo-prostaglandin E1(PGE1).CASE SUMMARY A 57-year-old male with hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma underwent ABO-incompatible living donor liver *** grafted hepatic artery was first anastomosed to the recipient’s right hepatic artery ***,the arterial pulse immediately *** a new anastomosis was performed using the right gastroepiploic artery,the patient’s arterial pulse rate remained *** attempted angiographic intervention immediately after the operation;it showed diffuse arterial vasospasms like‘beads on a string’.We attempted continuous infusion of lipo-PGE1 overnight via an intra-arterial *** next day,arterial flow improved without any spasms or *** patient had no additional arterial complications or related sequelae at the time of writing,1-year post-liver *** Angiographic evaluation is helpful in cases of repetitive arterial obstruction,and intra-arterial infusion of lipo-PGE1 may be effective in treating diffuse arterial spasms.

关键词： Liver transplantation Hepatic artery Vasospasm Prostaglandin E1 Intervention Case report

Tidal effects based on a GUP-induced effective metric

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Communications in Theoretical Physics 2024年第9期76卷 63-72页

作者： Soon-Tae Hong Yong-Wan Kim young-jai Park Center for Quantum Spacetime and Department of Physics Sogang UniversitySeoul 04107Republic of Korea Department of Physics and Research Institute of Physics and Chemistry Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Physics Sogang UniversitySeoul 04107Republic of Korea

In this paper,we study tidal forces in the Schwarzschild black hole,whose metric explicitly includes a generalized uncertainty principle(GUP)*** also investigate interesting features of the geodesic equations and tidal effects that are dependent on the GUP parameterαrelated to a minimum ***,by solving the geodesic deviation equations explicitly with appropriate boundary conditions,we show thatαin the effective metric affects both the radial and angular components of the geodesic equation,particularly near the singularities.

关键词： generalized uncertainty principle geodesic deviation equation effective metric

Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo young cho Dong Hae Ho Sae Byeok Jo Jeong Ho cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics