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Tuberculosis in kidney transplant candidates and recipients

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World Journal of Transplantation 2024年第3期14卷 59-69页

作者： Pallavi prasad Sourabh Sharma Subashri Mohanasundaram Anupam agarwal Himanshu Verma Department of Nephrology Vardhman Mahavir Medical College and Safdarjung HospitalNew Delhi 110029DelhiIndia Department of Nephrology Prashanth HospitalChennai 600042Tamil NāduIndia

Tuberculosis(TB)is the leading cause of infectious mortality and morbidity in the world,second only to coronavirus disease *** with chronic kidney disease and kidney transplant recipients are at a higher risk of developing TB than the general *** TB is difficult to diagnose in this population due to close *** transplant candidates should be screened for latent TB infection and given TB *** who develop active TB pre-or post-trans-plantation should receive multidrug combination therapy of antitubercular therapy for the recommended duration with optimal dose modification as per glomerular filtration rate.

关键词： Tuberculosis Latent Antitubercular therapy Kidney transplantation Donor Interferon-gamma release assays Tuberculin Rifampicin Isoniazid

Support pressure for circular tunnels in two layered undrained clay

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第1期12卷 135-148页

作者： Bibhash Kumar jagdish prasad Sahoo Department of Civil Engineering National Institute of TechnologyUttarakhand246174India Department of Civil Engineering Indian Institute of TechnologyRoorkee247667India

To estimate the required support pressure for stability of circular tunnels in two layered clay under undrained condition,numerical solutions are developed by performing finite element lower bound limit analysis in conjunction with second-order cone *** support system is assumed to offer uniform internal compressive pressure on its *** the literature,it is known that the stability of tunnels depends on the overburden pressure acting over it,which is a function of undrained cohesion and unit weight of soil,and cover of *** a tunnel is constructed in layered undrained clay,the stability depends on the undrained shear strength,unit weight,and thickness of one layer relative to the other *** the present study,the solutions are presented in a form of dimensionless charts which can be used for design of tunnel support systems for different combinations of ratios of unit weight and undrained shear strength of upper layer to those of lower layer,thickness of both layers,and total soil cover depth.

关键词： Finite elements Layered clay Limit analysis Stability of tunnels

Rutting prediction models for flexible pavement structures: A review of historical and recent developments

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第3期8卷 315-338页

作者： Auinash Kumar Singh jagdish prasad Sahoo Department of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

Rutting is the major distress mode in flexible pavements occurring due to the repeated movement of traffic loading. Deformation in the pavements comprise of both recoverable(elastic) and irrecoverable(plastic) part. Overall deformation occurring in the flexible pavement system due to continuous vehicular movement is contributed from all the components of pavement. A number of empirical models have been proposed by several researchers for analysis and prediction of accumulated rutting in different components of pavement. The accumulated permanent strain has been expressed as the function of the number of load applications and deviator stress applications in most of the models proposed;however, factors such as stress state, moisture content, material type and environmental conditions also impose a significant influence on the permanent deformation characteristics of pavement materials under cyclic loading. In this article, a comprehensive review has been carried out covering every aspect of deformation related to distress occurring in pavements. Important rut models, modeling approaches and modern concepts in the rutting analysis of pavement structures have been presented. In addition to review, fallacy existing in the current design practices related to adaptation of stiffness parameters and negligence of shear strength aspect of subgrade soil has been also presented with the support of literatures.

关键词： Road engineering Permanent deformation Rutting models Resilient modulus Shear strength

Bianchi type V universe with bulk viscous matter and time varying gravitational and cosmological constants

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Research in Astronomy and Astrophysics 2012年第11期12卷 1457-1466页

作者： Prashant Singh Baghel jagdish prasad Singh Department of Mathematical Sciences A. P. S. University

We consider spatially homogeneous and anisotropic Bianchi type V space- time with a bulk viscous fluid source, and time varying gravitational constant G and cosmological term A. The coefficient of bulk viscosity ζ is assumed to be a simple linear function of the Hubble parameter H （i.e. ζ = ζ0 ＋ ζ1H, where ζ0 and ζ1 are constants）. The Einstein field equations are solved explicitly by using a law of varia- tion for the Hubble parameter, which yields a constant value of the deceleration pa- rameter. Physical and kinematical parameters of the models are discussed. The models are found to be compatible with the results of astronomical observations.

关键词： bulk viscosity -- Bianchi V -- relativity: equation of state -- cosmology:cosmological parameters -- miscellaneous

Vulnerability assessment of the Satluj catchment for sustainable development of hydroelectric projects in the northwestern Himalaya

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Journal of Mountain Science 2019年第12期16卷 2714-2738页

作者： jagdish Chandra KUNIYAL Amit JAMWAL Nidhi KANWAR Bhim CHAND Kireet KUMAR Pitamber prasad DHYANI G.B.Pant National Institute of Himalayan Environment and Sustainable Development Kosi-KatarmalAlmora-263643UttarakhandIndia G.B.Pant National Institute of Himalayan Environment and Sustainable Development Himachal Regional CentreMohal-Kullu-175126Himachal PradeshIndia Sri Dev Suman Uttarakhand University BadshahitholTehriUttarakhandIndia

Hydropower if scientifically developed is considered to be one of the clean and non-polluted renewable energy *** its impacts always exist on physical and social environment of the *** present study was conducted in the River Satluj basin which is well known for its hydropower *** main objective of the study was to understand the vulnerability of the Satluj basin and to develop a strategy for the development of hydropower *** basin has been facing many problems relating to construction of haphazard development of hydropower *** has led multi-hazards like landslides,floods,earthquakes,***,vulnerability assessment index was assessed quantitatively and *** Information System and people’s perception were used to study these aspects in the *** parameters considered for vulnerability assessment were slope,slope profile,relative relief,curvature,slope aspect,soil texture,lithology,river morphometry,precipitation,hydroelectric projects,land use and land cover,mass-movement,flood,geological elements and earthquake *** highest vulnerability was found in the middle zone,and finally on the basis of parameters analyzed;the hydropower’s development strategy was developed.

关键词： Hazards Vulnerability assessment Hydroelectric projects Sustainable development Satluj basin

Performance evaluation of NeuMoDx 96 system for hepatitis B and C viral load

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World Journal of Virology 2023年第4期12卷 233-241页

作者： Gagan Chooramani Jasmine Samal Nitiksha Rani Gaurav Singh Reshu agarwal Meenu Bajpai Manoj Kumar Manya prasad Ekta Gupta Department of Clinical Virology Institute of Liver&Biliary SciencesNew Delhi 110070India Department Transfusion Medicine Institute of Liver&Biliary SciencesNew Delhi 110070India Department of Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Epidemiology and Clinical Research Institute of Liver and Biliary SciencesNew Delhi 110070India

BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV *** to a longer turnaround time for VL estimation,many patients drop out from the cascade of *** achieve the global goals of reducing morbidity and mortality due to HBV/HCV and moving towards their elimination by 2030,molecular diagnostic platforms with faster and random(*** sample)access are *** To evaluate the performance of the recently launched NeuMoDx 96 random access system with the conventional COBAS^(■)AmpliPrep/COBAS TaqMan system for HBV and HCV VL *** Archived once-thawed plasma samples were retrieved and tested on both *** between the assays was determined by linear regression and Bland-Altman *** study included samples from 186 patients,99 for HBV of which 49 were true infected HBV cases(hepatitis B surface antigen,antihepatitis B core antibody,and HBV DNA-positive)and 87 for HCV assay in which 39 were true positives for HCV infection(anti-HCV and HCV RNA-positive).RESULTS The median VL detected by NeuMoDx for HBV was 2.9(interquartile range[IQR]:2.0-4.3)log_(10)IU/mL and by COBAS it was 3.70(IQR:2.28-4.56)log_(10)IU/mL,with excellent correlation(R2=0.98).In HCV,the median VL detected by NeuMoDx was 4.9(IQR:4.2-5.4)log_(10)IU/mL and by COBAS it was 5.10(IQR:4.07-5.80)log_(10)IU/mL with good correlation(R2=0.96).CONCLUSION The overall concordance between both the systems was 100%for both HBV and HCV VL ***,no genotype-specific bias for HBV/HCV VL quantification was seen in both the *** findings reveal that NeuMoDx HBV and HCV quantitative assays have shown overall good clinical performance and provide faster results with 100%sensitivity and specificity compared to the COBAS AmpliPrep/COBAS TaqMan system.

关键词： Hepatitis B Hepatitis C NeuMoDx Random access Viral load COBAS AmpliPrep

Performance Analysis of Unbalance Radial Feeder with Time Varying Composite Load

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Journal of Power and Energy Engineering 2015年第5期3卷 56-70页

作者： jagdish prasad Sharma H. Ravishankar Kamath Mewar University Chittorgarh India Malwa Institute of Technology Indore India

The focus of this paper is to present performance indices for unbalance radial feeder having different characteristic and composition of time varying static ZIP load models. These provide a framework for benchmarking of distribution automation projects. 15 minutes characteristics time interval for load flow and load modeling are considered to meet smart grid implementation criterion. A forward-backward sweep method is employed for load flow solution. Developed performance indices were illustrated on modified IEEE 37 node test feeder. Performance indices are useful for analysis, operational, planning and integration of stochastic renewable sources.

关键词： Voltage sensitive load Performance Indices Unbalance load flow Radial distribution feeder Stochastic load modeling Modeling

A New Spectrophotometric Method for the Determination of Hydrochlorothiazide Based on the Redox Reaction

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材料科学与工程（中英文A版） 2011年第5X期1卷 725-730页

作者： Neeti Nema Sandeep Kumar Shukla Ramprakash Aharwal jagdish prasad Malviya Archna Pandey Department of Chemistry Dr. Hari Singh Gout Central University Sagar 470 003 M.P. India

Hydrochlorothiazide (HCTZ) is widely prescribed diuretic, used in congestive heart failure and hypertension. In healthy fasting volunteers the gastrointestinal uptake of the compound approximates 70% and it is linear over the dose range 5-75 mg. In this work a validated spectrophotometric method has been described for the assay of HCTZ in bulk and commercial dosage forms. The method is based on the oxidation of drug by ammonium metavanadate [V(V)]. The V(V) is reduced so the solution becomes green colored complex which absorbs maximally at 365 nm. Beer’s law obeyed in the concentration range with molar absorbtivity and Sandell’s sensitivity in absorbance unit respectively. The various experimental parameters were optimized. The proposed method has advantages concerning to simplicity, low cost and rapidly, fulfilling the requirements for the routine quality control.

关键词：分光光度法测定氧化还原反应氢氯噻嗪肠道吸收偏钒酸铵比尔定律浓度范围实验参数

Atypical Olfactory Neuroblastoma Presenting as Sinonasal Polyposis with Nasopharyngeal Extension: A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 394-400页

作者： jagdish prasad Purohit Chandra Bhan Bhoopendra Singh Ajay Pratap Singh Siva Selvaraj Manish Pandey Vijay Krishna Sharma Department of ENT Head and Neck Surgery MLB Medical College Jhansi India

Background: Olfactory neuroblastoma also known as Esthesioneuroblastoma (ENB) is a tumor arising from the basal layer of olfactory epithelium in the superior recess of the nasal cavity in the region of cribriform plate. Incidence peaks once in 11 - 20 years of age and again in 50 - 60 years of age. It is equally found in men and women. Aim: The main aim of this case report is to characterize the clinical features of ENB showing nasopharyngeal involvement and its importance in the differential diagnosis of sinonasal neuroendocrine malignancies. Case presentation: Two cases are reported. The first case was a 21-year-old male with symptoms of nasal obstruction, recurrent epistaxis, nasal discharge, headache and paresthesia over the face with an evolution of 1 year with no previous history of trauma. Diagnostic nasal endoscopy revealed reddish gray mass filling bilateral nasal cavities. Posterior rhinoscopy revealed mass coming through choanae and filling the nasopharynx. Endoscopic resection of tumor was done and postoperatively all the symptoms of the patient resolved. The second case was a 62-year-old male with complaints of nasal obstruction, nasal discharge, recurrent epistaxis, anosmia and difficulty in swallowing. On computed tomography, anteriorly, the mass was extending up to external nares and posteriorly up to the nasopharynx, superiorly up to nasal roof and inferiorly up to hard palate. No obvious erosion of floor of anterior cranial fossa was seen. No intracranial extension was seen. Surgery was advised but patient refused to undergo any treatment. Conclusion: This study highlights the characteristics and clinical features of ENB showing nasopharyngeal involvement and their importance in the differential diagnosis of sinonasal neuroendocrine malignancies.

关键词： Esthesioneuroblastoma Cribriform Plate Neuroectodermal