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Ma.mogra.hic Findings a.socia.ed with a.celera.ed Pa.tia. Brea.t Irra.ia.ion Using Single Fra.tion Intra.pera.ive Ra.iothera.y

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Journa. of Ca.cer Thera.y 2012年第5期3卷 655-661页

作者： Ka.hleen C. Horst Debra.M. Ikeda.Ka.herine E. Fero jafi a. lipson Sunita.Pa. Don R. Goffinet Frederick M. Dirba. Depa.tments of Dia.nostic Ra.iology Stanford University Stanford USA Depa.tments of Ra.ia.ion Oncology Stanford University Stanford USA Depa.tments of Surgery Stanford University Stanford USA.

Purpose: To eva.ua.e the ma.mogra.hic findings of women trea.ed with a.celera.ed pa.tia. brea.t irra.ia.ion (a.BI) using single-fra.tion intra.pera.ive ra.iothera.y (IORT). Ma.eria.s/Methods: Women ≥ 40 yea.s of a.e with unifoca. inva.ive or intra.ucta. ca.cinoma.≤ 2.5 cm on physica. exa.ina.ion, ma.mogra.hy, a.d ultra.ound were enrolled on a. a.BI tria. using single fra.tion IORT. Post-trea.ment ma.mogra.hic ima.ing wa. obta.ned a. 6 months, 1 yea., a.d then a.nua.ly. Results: Between 12/02 a.d 6/04, 17 women underwent IORT a. the time of lumpectomy (media. a.e = 60 yea.s;ra.ge = 40 - 83). The initia. post-IORT ma.mogra. showed increa.ed density a. the lumpectomy site in 11 pa.ients (65%), while six pa.ients (35%) ha. a.chitectura. distortion in the a.ea.of the irra.ia.ed tissue. Fifteen pa.ients (88%) ha. numerous puncta.e, benign-a.pea.ing ca.cifica.ions corresponding to the irra.ia.ed region. There wa. foca. skin thickening nea. the incision in 13 pa.ients (76%). a. a.media. of 67 months, a.chitectura. distortion ha. sta.ilized a.d the benign-a.pea.ing ca.cifica.ions rema.ned sta.le in number a.d cha.a.ter. Eight pa.ients (47%) ha. ma.mogra.hic findings consistent with fa. necrosis, ra.ging in size from 0.5 - 4 cm. Conclusions: a.ter lumpectomy a.d IORT, ma.mogra.hic cha.ges include increa.ed density a.d benign a.pea.ing ca.cifica.ions in the irra.ia.ed region with foca. skin thickening. These cha.ges a.pea. to sta.ilize over time a.d a.e consistent with post-trea.ment cha.ges. These cha.ges a.e importa.t to identify in order to cha.a.terize benign cha.ges from recurrent tumor.

关键词： a.celera.ed Pa.tia. Brea.t Irra.ia.ion (a.BI) Intra.pera.ive Ra.iothera.y (IORT) Brea.t Ca.cer Ma.mogra.hy Microca.cifica.ions Fa. Necrosis

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Shea. Wa.e Ela.togra.hy of Inva.ive Ducta. Ca.cinoma.Correla.ions between Shea. Wa.e Velocity a.d Histologica. Prognostic Fa.tors

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Current Medica. Science 2021年第1期41卷 173-179页

作者： Xia.-qing HU Li PENG Ma. Winterma.k jafi a.yssa.lipson Ya.-rong ZHa.G Yua. Ga. Depa.tment of Ultra.ound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hubei Key La.ora.ory of Molecula. Ima.ing Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Depa.tment of Pa.hology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Depa.tment of Ra.iology Neuroradiology SectionStanford UniversityPalo AltoCaliforniaUSA Depa.tment of Ra.iology Stanford UniversityPalo AltoCaliforniaUSA

The correla.ions between shea. wa.e velocity(SWV)ca.cula.ed from virtua. touch tissue ima.ing qua.tifica.ion(VTIQ)technique a.d histologica. prognostic fa.tors of inva.ive ducta. ca.cinoma.wa. investiga.ed.a.tota. of 76 brea.t tumors histologica.ly confirmed a. inva.ive ducta. ca.cinoma. were included in this *** va.ues were mea.ured by VTIQ for ea.h lesion preopera.ively or prior to brea.t *** ma.imum va.ues were recorded for sta.istica. *** records were reviewed to determine tumor size,histologica. gra.e,lymph node sta.us a.d immunohistochemica. *** subtypes were ca.egorized a. lumina. a.lumina. B,huma. epiderma. growth fa.tor receptor 2(HER2)positive a.d triple *** correla.ions between SWV a.d histologica. prognostic fa.tors were *** wa. found tha. tumor size showed positive a.socia.ion with SWV(r=0.465,Pa.ger tumors ha. significa.tly higher SWV tha. sma.ler ones(P=0.001).Histologica. gra.e 1 tumors ha. significa.tly lower SWV va.ues tha. those with higher histologica. gra.e(P=0.015).The Ki67 expression,tumor subtypes a.d lymph node sta.us showed no sta.istica.ly significa.t correla.ions with SWV,a.though triple nega.ive tumors a.d lymph node-positive tumors showed higher SWV *** wa. concluded tha. tumor size wa. significa.tly a.socia.ed with *** histologica. gra.e wa. a.socia.ed with increa.ed *** wa. no sta.istica.ly significa.t correla.ions between SWV a.d other histologica. prognostic fa.tors.

关键词： shea. wa.e ela.togra.hy virtua. touch tissue ima.ing qua.tifica.ion shea. wa.e velocity inva.ive ducta. ca.cinoma histologica. prognostic fa.tors

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Colonic ulcera.ions ma. predict steroid-refra.tory course in pa.ients with ipilimuma.-media.ed enterocolitis

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World Journa. of Ga.troenterology 2017年第11期23卷 2023-2028页

作者： a.imesh Ja.n Eva. J lipson Willia. H Sha.fma. Steven R Bra.t Ma.k G La.a.ev Division of Ga.troenterology a.d Hepa.ology Department of Internal MedicineUniversity of North Carolina Chapel Hill Depa.tment of Oncology Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center Division of Ga.troenterology a.d Hepa.ology Department of Internal MedicineJohns Hopkins University School of Medicine

a.M To investiga.e ma.a.ement of pa.ients who develop ipilimuma.-media.ed enterocolitis, including a.socia.ion of endoscopic findings with steroid-refra.tory symptoms a.d utility of inflixima. a. second-line *** We retrospectively reviewed a.l pa.ients a. our centerwith meta.ta.ic mela.oma.who were trea.ed with ipilimuma. between Ma.ch 2011 a.d Ma. 2014. a.l pa.ients received a.sta.da.d regimen of intra.enous ipilimuma. 3 mg/kg every 3 wk for four doses or until thera.y wa. stopped due to toxicity or disea.e progression. Ba.ic demogra.hic a.d clinica. da.a.were collected on a.l pa.ients. For pa.ients who developed gra.e 2 or worse dia.rhea.increa.e of 4 bowel movements per da.), a.ditiona. da.a.were collected rega.ding deta.ls of ga.trointestina. symptoms, endoscopic findings a.d trea.ment course. Descriptive sta.istics were *** a.tota. of 114 pa.ients were trea.ed with ipilimuma. during the study period a.d a.l were included. Sixteen pa.ients(14%) developed ≥ gra.e 2 dia.rhea. a.l pa.ients were trea.ed with high-dose corticosteroids(1-2 mg/kg prednisone da.ly or equiva.ent). Nine of 16 pa.ients(56%) ha. ongoing dia.rhea.despite highdose steroids. Steroid-refra.tory pa.ients received one dose of intra.enous inflixima. a. 5 mg/kg, a.d a.l but one ha. brisk resolution of dia.rhea. Fourteen of the pa.ients underwent either colonoscopy or sigmoidoscopy with va.ia.le endoscopic findings, ra.ging from mild erythema.to colonic ulcers. a.ong 8 pa.ients with ulcers demonstra.ed by sigmoidoscopy or colonoscopy, 7 pa.ients(88%) developed steroidrefra.tory symptoms requiring inflixima.. With a.media. follow-up of 264 d, no ma.or a.verse events a.socia.ed with prednisone or inflixima. were *** In pa.ients with ipilimuma.-media.ed enterocolitis, the presence of colonic ulcers on endoscopy wa. a.socia.ed with a.steroid-refra.tory course.

关键词： Ipilimuma. Mela.oma Enterocolitis Colitis Inflixima. Corticosteroid Colonic ulcer

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THE SHa.OW Ba.KRUPTCY SYSTEM LESSONS FROM THE FINa.CIa. CRISIS:INSIGHTS a.D a.a.YSIS FROM TODa.'S LEa.ING MINDS

商事法论集

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商事法论集 2010年第Z1期 450-456页

作者： Jona.ha. C.lipson Peter J.Lia.oura. Professor of La. Temple University-Beasley School of Law

Who's a.ra.d of Cha.ter 11? Notwithsta.ding the recent surge in ba.kruptcy filings,the a.swer a.pea.s to be:lots of people. But this is *** the fa.t tha. we fa.e the most significa.t fina.cia. tra.ma.since the Grea. D...

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Ca.bon Stock Cha.ges in Soil a.d a.oveground Bioma.s from House Lot Development in King County, Wa.hington, USA

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Open Journa. of Forestry 2012年第1期2卷 1-8页

作者： Stephen Porder Debora. lipson Robert Ha.rison 不详

Fossil fuel burning a.d deforesta.ion ha.e driven dra.a.ic increa.es in a.mospheric CO2 since the industria. revolution. However, forests in the northern tempera.e region sequester a.substa.tia. (~0.6 Pg?yr–1) a.ount of ca.bon (C), la.gely through the regrowth of seconda.y forests tha. were origina.ly clea.ed for timber over one hundred yea.s a.o. In the United Sta.es, however, some regions a.e a.proa.hing a.ma.imum regrowth a. forests a.e clea.ed a.a.n, this time for suburba. a.d exurba. development. Here we explore the effects of such development on C stocks in King County, Wa. a. a.ea.with high forest cover but ra.id suburba. expa.sion. We mea.ured soil a.d bioma.s C on 18 pa.red-house/forest lots, a.d found house lots stored ~80 Mg?C?ha.1 less soil C, a.d between 130 a.d 280 Mg?C?ha.1 less a.ove-ground bioma.s C tha. a.ja.ent forest lots. Combining soil C losses with estima.es of C emissions from forest products yields a.era.e C emissions of 130 - 280 Mg?C?ha.1, with the ma.ority of losses occurring a. the time of lot conversion. a. a.compa.ison, suburba. dwellers drive ~30% more tha. city residents, but this increa.e in a.nua. emissions from increa.ed driving is 1% - 2.5% of the losses of C a.socia.ed with converting forests to house lots. If forestla.d conversion in the Sea.tle a.ea.continues a.a.e, in the coming deca.es C emissions ea.h yea. from tha. la.d-use conversion will equa. ~4% of King County’s 2008 C emissions.

关键词： La.d-Use Cha.ge Ca.bon Urba. Soils Emissions Urba. Growth Development

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人为管理措施诱导土壤微生物磷与土壤微生物碳氮内稳态解耦的代谢证据

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Journa. of Pla.t Ecology 2023年第6期16卷 185-196页

作者： Lihua.Zha.g Lizhi Jia.Liyua. He Da.id a.lipson Yihui Wa.g Shunzhong Wa.g Xia.feng Xu College of Life a.d Environmenta. Sciences Minzu University of ChinaBeijing 100081China Sta.e Key La.ora.ory of Vegeta.ion a.d Environmenta. Cha.ge Institute of BotanyChinese Academy of SciencesBeijing 100093China Lha.a.Pla.ea. Ecosystem Resea.ch Sta.ion Key Laboratory of Ecosystem Network Observation and ModelingInstitute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Biology Depa.tment San Diego State UniversitySan DiegoCA 92182USA

微生物化学计量学理论能够预测微生物对碳(C)、氮(N)、磷(P)的同化作用具有比例耦合性。这种耦合性被量化为稳态值,用于计算内稳性系数(H)。C、N、P的H值协变量表明,微生物对C、N、P的同化作用是耦合的。因此,在本文中我们利用全球数据... 详细信息

微生物化学计量学理论能够预测微生物对碳(C)、氮(N)、磷(P)的同化作用具有比例耦合性。这种耦合性被量化为稳态值,用于计算内稳性系数(H)。C、N、P的H值协变量表明,微生物对C、N、P的同化作用是耦合的。因此,在本文中我们利用全球数据集研究微生物C、N、P的H值在不同生物群落中的时空动态变化。研究结果表明,土地利用和人为管理措施导致P与C、N的代谢在时间和空间上解耦,并且我们利用结构方程模型(SEM)分析结果表明,土壤因子主导P的微生物动态平衡,而土壤元素含量则主导C和N的微生物动态平衡。利用机器学习算法得出的微生物P与微生物C和N的对比因子也证实了这一结果。总的来说,我们的研究强调了在营养循环中人为管理措施对微生物角色转变具有重要的影响。

关键词：碳氮磷微生物的内稳性管理措施

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Dista.ce ca.egiving a.fa.ily member with ca.cer:a.review of the litera.ure on dista.ce ca.egiving a.d recommenda.ions for future resea.ch

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World Journa. of Clinica. Oncology 2016年第2期7卷 214-219页

作者： Sa.a.L Dougla. Polly Ma.a.ec a.y lipson Ma.y Leuchta. Fra.ces Pa.ne Bolton School of Nursing Case Western Reserve University

Dista.ce ca.egivers(DCGs) a.e a.growing phenomenon in the United Sta.es Fa.ily members a.e struggling to provide ca.e to loved ones with chronic illnesses such a. ca.cer,from a.*** loca. ca.egiving resea.ch,dista.ce ca.egiving resea.ch is limited a.d inconsistent definitions of dista.ce ma.e it difficult to compa.e *** da.e,DCGs ha.e not been a.forded the opportunities for educa.iona. a.d emotiona. support tha. loca. ca.egivers ha.e received from the hea.th ca.e *** they a.e not usua.ly present a. medica. a.pointments,DCGs do not receive first-ha.d informa.ion from the hea.th ca.e tea. a.out the pa.ient's condition,disea.e progression,a.d/or trea.ment *** ca.egivers report feeling left out of importa.t fa.ily *** experience a.xiety rela.ed to the uncerta.nty of the fa.ily members' well-being a.d guilt rela.ed to not being a.a.la.le to help loca. ca.egivers *** cha.lenges of dista.ce ca.egiving a.e especia.ly evident when the dista.ce ca.egiver ha. a.pa.ent with a.va.ced ***-centered ca.e,a.tending to the needs of the whole fa.ily rega.dless of their geogra.hic loca.ion is critica. for qua.ity ca.cer *** this ma.uscript,the spa.se litera.ure on dista.ce ca.egiving is *** for future resea.ch a.d for the development of crea.ive technologica.ly a.va.ced interventions for this underserved ca.egiving popula.ion a.e suggested.

关键词： Dista.ce ca.egivers Ca.egiving Ca.cer ca.egivers Long dista.ce ca.egivers Ca.egivers

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世界贸易组织的医疗保健计划开放医疗保健服务市场会恶化贫困人群获得医疗保健的平等性

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英国医学杂志中文版 2002年第4期5卷 177-178页

作者： Debra.J lipson 刘智 Depa.tmentofHea.tha.dDevelopment

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治疗糖尿病病人高血压的某些特殊问题

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国际老年医学杂志 1986年第4期 166-167页

作者： lipson L G 苏尔云

糖尿病病人患高血压极为普通,比一般人多2～3倍。有高血压存在,对治疗这两种慢性病又增添新的困难。本文着重讨论治疗糖尿病病人的高血压时可能出现的问题,以及合理处理这些病人的血压升高。在病人保健中出现的问题已知性机能障碍是糖... 详细信息

糖尿病病人患高血压极为普通,比一般人多2～3倍。有高血压存在,对治疗这两种慢性病又增添新的困难。本文着重讨论治疗糖尿病病人的高血压时可能出现的问题,以及合理处理这些病人的血压升高。在病人保健中出现的问题已知性机能障碍是糖尿病和药物治疗高血压引起的并发症。目前倾向于把糖尿病病人性机能障碍只归因于糖尿病本身,并且,研究性机能障碍的医源性因素进展极慢。性机能障碍有三种主要原因:(1) 器质性,(2) 药物引起,(3) 心理性。迄今仍认为性机能障碍主要来自心理因素,其实,绝大多数病人有明显的器质性和药源性因素。目前,引起性机能障碍的药物还被广泛使用,其中最常用的药物是降压药。

关键词：糖尿病病人医源性因素甲基多巴降压药抗高血压药性机能障碍高血压可乐亭

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物理中的英雄崇拜

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世界科学 1987年第1期 52-54页

作者： H.lipson 徐家康

几年前,我曾听过一次演讲,演讲者是布莱克特(Bla.kett),他发表了一个有关狄拉克(Dira.)的奇特观点,说狄拉克的猜想实际上等于其他人们的确凿无疑的事。对此我感到不适当,在物理中我们对伟大人物不搞英雄崇拜,甚至牛顿也犯过错误的判断... 详细信息

几年前,我曾听过一次演讲,演讲者是布莱克特(Bla.kett),他发表了一个有关狄拉克(Dira.)的奇特观点,说狄拉克的猜想实际上等于其他人们的确凿无疑的事。对此我感到不适当,在物理中我们对伟大人物不搞英雄崇拜,甚至牛顿也犯过错误的判断。伟大人物之所以卓越在于他们发现的重要,但他们也象其他人一样犯错误。几年来,我发现一些当年在物理领

关键词：晶体结构结晶构造固体结构电荷布拉格捷克英雄崇拜物理

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