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Changes on optical coherence tomography angiography and fluorescein angiography in eyes with neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1837-1844页

作者： So Min Ahn Mihyun Choi Cheolmin Yun Seong-Woo Kim jaeryung oh Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or not.By combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions simultaneously.Tiny capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly decreased.CONCLUSION:Leakage on FA is associated with CNV morphology in OCTA and remained so after IAls.Therefore,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

关键词： choroidal neovascularization fluorescein angiography leakage neovascular age-related macular degeneration optical coherence tomography angiography

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Comparison of ring 1 parameters in 37-segment multifocal electroretinography between onset and offset conditions of ring 2 to 4 in normal subjects

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 73-78页

作者： Jun Ho Yoo Cheolmin Yun jaeryung oh Seong-Woo Kim Department of Ophthalmology Korea University College of Medicine

AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. METHODS: Prospective, observational study. Thirty healthy subjects were included in this study. mfERG recordings were performed according to two protocols: stimulus with 37 hexagonal elements(protocol 1), and stimulus with a single central element created by deactivating the other 36 hexagonal elements(protocol 2). We compared differences between ring 1 parameters in each protocol. RESULTS: In protocol 1, the first positive component(P1) implicit time and P1 amplitude were 37.8±1.8 ms and 6.3±2.7 μV. After single element stimulation(protocol 2), double positive waves appeared. The implicit time and amplitude of P1 were 40.7±2.4 ms(P<0.001) and 9.1±3.3 μV(P=0.001), respectively. The implicit time and amplitude of the second positive component(P2) were 68.0±4.5 ms(P<0.001, compared with P1 in protocol 1) and 12.3±4.7 μV(P<0.001, compared with P1 in protocol 1), respectively. The amplitude of P2 in protocol 2 was about two times higher than that of P1 in protocol 1. CONCLUSION: mfERG responses of a central hexagonal element in a single element stimulation protocol are different from those of multiple element stimulation. The positive wave is more enhanced compared to that of the conventional protocol and it elongated into two wavelets.

关键词： multifocal electroretinography focal electroretinography macular function single element stimulation stray light effect

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Risk factors for posterior synechiae of the iris after 23-gauge phacovitrectomy

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 843-849页

作者： Jong-Hyun oh Jaehoon Na Seong-Woo Kim jaeryung oh Kuhl Huh Department of Ophthalmology Dongguk University Ilsan Hospital Department of Ophthalmology Korea University College of Medicine

AIM:To identify risk factors for the development of posterior synechiae of the iris(PSI) after 23-gauge phacovitrectomy.METHODS:A retrospective chart review was performed in consecutive Asian patients treated with 23-gauge phacovitrectomy with a 3-piece intraocular lens(IOL) or a single-piece 4 haptics IOL.RESULTS:A total of 263 eyes from 242 patients were included in the study. Postoperative PSI was identified in16(6.1%) eyes. In multivariate analysis, C3F8 gas tamponade, oil tamponade, and long operation time were significantly associated with PSI formation. There was no difference in the incidence of PSI between the groups using two different types of IOL(P =0.779).·CONLUSION: C3F8 gas or oil tamponade and long operation time increased the incidence of PSI after 23-gauge phacovitrectomy. The single-piece 4 haptics IOL,in lieu of a 3-piece IOL, may be inserted into the capsular bag with a comparable incidence of PSI.

关键词： complication intraocular lens phacoemulsification vitrectomy

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Macular hole closure following anti-vascular endothelial growth factor injection in an eye with myopic choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1364-1366页

作者： Cheolmin Yun Seong-Woo Kim Kuhl Huh jaeryung oh Department of Ophthalmology Korea University College of Medicine

Dear Editor,I am Cheolmin Yun,from the Department of Ophthalmology,Korea University College of Medicine.I write to present a case report of a female patient with a myopic patient suffering from atrophic choroidal neovascularization（CNV）and a full thickness macular hole（FTMH）,who was treated with an intravitreal anti-vascular endothelial growth factor （VEGF） injection without vitrectomy.

关键词： CNV Macular hole closure following anti-vascular endothelial growth factor injection in an eye with myopic choroidal neovascularization

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Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 170-172页

作者： Kyung Ho Lee Seong-Woo Kim Soon-Sun Kwon jaeryung oh Kuhl Huh Department of Ophthalmology Korea University College of Medicine Biomedical Research Institute Seoul National University Bundang Hospital

Dear Sir,I write to present the correlation between microperimetric （MP） values and the density of myelinated retinal nerve fibers （MNFs） in optical coherence tomography （OCT） imaging.

关键词： Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers OS Figure line

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