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A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

Journal of Innovative Optical Health Sciences 2021年第3期4卷 77-87页

作者： Jiawei Ge Justin D.Opfermann Hamed Saeidi Katherine A.Huenerberg Christopher D.Badger jaepyeong cha Martin J.Schnermann Arjun S.Joshi Axel Krieger Department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Mechanical Engineering University of Maryland College Park MD 20742USA Sheikh Zayed Institute for Pediatric Surgical Innovation Children's National Hospital WashingtonDC 20010USA Department of Pathology George Washington University WashingtonDC 20052USA Division of Otolaryngology-Head and Neck Surgery George Washington University Washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

Surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(SNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and SNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

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