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Impact of diabetes on promoting the growth of breast cancer

Cancer Communications 2021年第5期41卷 414-431页

作者： Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan jaehyuk lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong lee Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510020P.R.China Research Institute of Gastroenterology the Sixth Affiliated Hospital of Sun Yat-sen University GuangzhouGuangdong 510020P.R.China Department of Imaging Physics the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Pathology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Emergency Medicine the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast ***,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy ***,the precise diabetic signaling pathways that regulate cancer growth remain *** the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer ***:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)*** administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor *** resonance spectroscopic imaging was employed to analyze the tumor ***:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor ***-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate *** tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate *** decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism ***,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine ***:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast ***,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy.

关键词： diabetes human epidermal growth factor receptor 2 breast cancer metformin metabolism

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文體間的辯證法與詩歌的功能性擴張——張可久“律曲”

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岭南学报 2023年第2期 35-58页

作者：李在赫俄亥俄州立大學

張可久以極爲可觀的散曲数量(全部元散曲的五分之一)以及其獨特的散曲風格,在中國散曲史上佔據舉足輕重的地位,尤其是張可久的散曲風格融合了中國傳統的詩歌元素和當時盛行的散曲形式,自成一派。本文旨在重现具有融合性美學詩歌功能的... 详细信息

張可久以極爲可觀的散曲数量(全部元散曲的五分之一)以及其獨特的散曲風格,在中國散曲史上佔據舉足輕重的地位,尤其是張可久的散曲風格融合了中國傳統的詩歌元素和當時盛行的散曲形式,自成一派。本文旨在重现具有融合性美學詩歌功能的張可久式散曲創作觀。主要包括:第一,本文將對張可久散曲的節奏、對仗、押韻等散曲形式層面的主要構成要素進行詳細考查,以此探討張可久如何通過散曲的形式體現中國古典詩歌的美學特徵。第二,本文將通過對張可久時代的整個文化背景下的集體文學創作活動的分析,證明張可久散曲的融合性特徵並不是文言雅風格與口語俗風格的機械疊加的產物。

关键词：散曲律詩節奏對仗押韻

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糖尿病对促进乳腺癌生长的影响

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癌症 2022年第3期41卷 107-124页

作者： Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan jaehyuk lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong lee Department of Molecular and Cellular Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 结直肠盆底疾病研究重点实验室中山大学第六附属医院广州广东510020 胃肠病学研究所中山大学第六附属医院广州广东510020 Department of Imaging Physics the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 中山大学肿瘤防治中心肿瘤内科广州广东510060 Department of Pathology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Emergency Medicine the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

背景与目的2型糖尿病(typeⅡdiabetes mellitus,DM2)是包括乳腺癌在内的多种癌症的危险因素。目前,尚未建立可用于研究的糖尿病乳腺癌小鼠模型。另外,调节癌症生长的糖尿病信号通路也尚未明确。在本研究中,我们建立了一个糖尿病乳腺癌... 详细信息

背景与目的2型糖尿病(typeⅡdiabetes mellitus,DM2)是包括乳腺癌在内的多种癌症的危险因素。目前,尚未建立可用于研究的糖尿病乳腺癌小鼠模型。另外,调节癌症生长的糖尿病信号通路也尚未明确。在本研究中,我们建立了一个糖尿病乳腺癌小鼠模型,并证实了糖尿病在乳腺癌进展中的影响。方法通过将瘦素受体突变(Lepr^(db/+))小鼠和MMTV-ErbB2/neu小鼠杂交,成功构建了人表皮生长因子受体2阳性(human epidermal growth factor receptor 2,Her2^(+)或ERBB2)的乳腺癌转基因小鼠模型。用抗糖尿病药物治疗该小鼠模型来评价治疗DM2对肿瘤生长的影响。用磁共振波谱成像分析肿瘤代谢情况。结果用二甲双胍/罗格列酮治疗MMTV-ErbB2/Lepr^(db/db)小鼠模型可降低血清胰岛素水平,延长生存,降低肿瘤累积发生率,抑制肿瘤进展。超极化^(13)C标记的丙酮酸/乳酸转换代谢流降低,表明抗胰岛素抵抗治疗抑制了体内实验中肿瘤糖酵解。用二甲双胍处理MMTV-ErbB2/Lepr^(db/db)转基因小鼠来源的肿瘤细胞,降低了耗氧量和乳酸产量,使细胞代谢发生了重新编程。二甲双胍可降低Myc和丙酮酸激酶M2型同工酶(pyruvate kinase isozyme 2,PKM2)的表达,引起代谢重编程。另外,二甲双胍可阻断mTOR/AKT信号通路并改变脂肪因子谱。结论MMTV-ErbB2/Lepr^(db/db)转基因小鼠模型可用于糖尿病HER2^(+)人乳腺癌的研究。本研究明确了糖尿病状态下HER2^(+)人乳腺癌中失调的信号通路,该通路可被抗胰岛素抵抗治疗干预。

关键词：糖尿病人表皮生长因子受体2 乳腺癌二甲双胍代谢

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Functional genomics in the rice blast fungus to unravel the fungal pathogenicity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 747-752页

作者： Junhyun JEON jaehyuk CHOI Jongsun PARK Yong-Hwan lee Department of Agricultural Biotechnology Center for Fungal Genetic Resources and Center for Agricultural BiomaterialsSeoul National UniversitySeoul 151-921Korea Department of Agricultural Biotechnology Center for Fungal Genetic Resourcesand Center for Agricultural BiomaterialsSeoul National UniversitySeoul 151-921Korea

A rapidly growing number of successful genome sequencing projects in plant pathogenic fungi greatly increase the demands for tools and methodologies to study fungal pathogenicity at genomic scale. Magnaporthe oryzae is an economically important plant pathogenic fungus whose genome is fully sequenced. Recently we have reported the development and application of functional genomics platform technologies in M. oryzae. This model approach would have many practical ramifications in design and implementation of upcoming functional genomics studies of filamentous fungi aimed at understanding fungal pathogenicity.

关键词： Functional genomics Magnaporthe oryzae Plant pathogenic fungus Pathogenicity Rice blast

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Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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中医杂志:英文版 2023年第4期43卷 686-694页

作者： Dong-Wook Kang Jae-Gyun Choi Hee Ju Song jaehyuk Kim Miae lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun lee Jin Bong Park Sang Do lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

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