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Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

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Bioactive Materials 2023年第6期24卷 497-506页

作者： jaehoon kim Hyeji Um Na Hee kim Dokyoung kim Department of Biomedical Science Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute Kyung Hee UniversitySeoul02447Republic of Korea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoul02447Republic of Korea Center for Converging Humanities Kyung Hee UniversitySeoul02447Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul02447Republic of Korea UC San Diego Materials Research Science and Engineering Center 9500 Gilman Drive La JollaCA92093USA

There has been a lot of basic and clinical research on Alzheimer’s disease(AD)over the last 100 years,but its mechanisms and treatments have not been fully *** some controversies,the amyloid-beta hypothesis is one of the most widely accepted causes of *** this study,we disclose a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles(pSiNPs)as a therapeutic nano-platform to overcome *** hypothesized that the negatively charged sulfonic acid functional group could disaggregate plaques and construct a chemical *** a result of the in vitro assay of amyloid plaques and library screening,we confirmed that 6-amino-2-naphthalenesulfonic acid(ANA)showed the highest efficacy for plaque disaggregation as a hit *** confirm the targeted delivery of ANA to the AD brain,a nano-platform was created using porous silicon nanoparticles(pSiNPs)with ANA loaded into the pore of pSiNPs and biotin-polyethylene glycol(PEG)surface *** resulting nano-formulation,named Biotin-CaCl2-ANA-pSiNPs(BCAP),delivered a large amount of ANA to the AD brain and ameliorated memory impairment of the AD mouse model through the disaggregation of amyloid plaques in the *** study presents a new bioactive small molecule for amyloid plaque disaggregation and its promising therapeutic nano-platform for AD brain-targeted delivery.

关键词： Alzheimer’s disease Plaques disaggregation Nanotherapeutics Brain-targeted drug delivery Porous silicon nanoparticles

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Germinant ZnO nanorods as a charge-selective layer in organic solar cells

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Journal of Materials Science & Technology 2020年第20期52卷 89-94页

作者： Kunsik An jaehoon kim Mohammad Afsar Uddin Seunghyun Rhee Hyeok kim Kyung-Tae Kang Han Young Woo Changhee Lee Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea Micro/Nano Process Group Korea Institute of Industrial Technology(KITECH)Sangnok-guAnsan-si 15588Republic of Korea Department of Chemistry College of ScienceKorea UniversitySeoul 02841Republic of Korea Department of Electrical Engineering Engineering Research Institute(ERI)Gyeongsang National UniversityJinju 52828Republic of Korea

A facile method was introduced and demonstrated to synthesize zinc oxide(ZnO) nanorods(NRs) as an electron transporting layer(ETL) for organic solar cells(OSCs).Hydrothermal synthesis of the NRs showed a constant growth rate of 5.5 nm min-1 from germination to sub-micrometer *** properties were characterized using scanning electron microscopy(SEM),transmission electron microscopy(TEM),absorption spectrophotometry and so *** on these measurements,the germinant growth mechanism and its corresponding orientation characteristics were *** an ETL of the OSCs,ZnO NRs enhance the charge extraction from the active layer due to their increased interfacial surface area,but there is an optimal length because of the shunt path formation and UV absorption of long ZnO *** a re sult,the OSC with the ZnO NRs as ETL shows power conversion efficiency(PCE) up to 6.2%.The J-V characteristics and incident photon-to-current conversion efficiency(IPCE) measurement also reveal that the efficiency enhancement is an assembly of individual results from optical,physical and electrical characteristic of the ZnO NRs.

关键词： ZnO nanorods Solar cells Self-assembly Oriented growth mechanism Hydrothermal synthesis

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低温快速制备基于溶液工艺的高性能氧化铟薄膜及晶体管

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物理学报 2024年第9期73卷 236-243页

作者：张雪 kim Bokyung Lee Hyeonju Park jaehoon 山东科技大学海洋科学与工程学院青岛266590 翰林大学春川24252

利用脉冲紫外线辅助热退火在200℃的低温条件下,5 min内制备了基于溶液工艺的氧化铟薄膜及薄膜晶体管.对比传统热退火,研究了脉冲紫外线辅助热退火对氧化铟薄膜的表面形态、化学结构和电学特性的影响.实验结果表明,脉冲紫外线辅助热退... 详细信息

利用脉冲紫外线辅助热退火在200℃的低温条件下,5 min内制备了基于溶液工艺的氧化铟薄膜及薄膜晶体管.对比传统热退火,研究了脉冲紫外线辅助热退火对氧化铟薄膜的表面形态、化学结构和电学特性的影响.实验结果表明,脉冲紫外线辅助热退火方式能够在短时间内实现改善氧化铟薄膜的质量及薄膜晶体管的性能.原子力显微镜和场发射扫描电子显微镜结果显示该薄膜表面较传统热退火制备薄膜表面更为致密平坦.X射线光电能谱测试表明,脉冲紫外线辅助热退火处理后会产生氧空位,从而提高载流子浓度,改善了氧化铟薄膜的导电性.此外,对比研究了紫外线辅助热退火对氧化铟薄膜晶体管电气性能的影响.结果表明器件的电学特性得到了明显改善,亚阈值摆幅降低至0.12 mV/dec,阈值电压为7.4 V,电流开关比高达1.29×107,场效应迁移率提升至1.27 cm^(2)/(V·s).因此,脉冲紫外线辅助热退火是一种简单、快速的退火方式,即使在低温条件下也能快速提高氧化铟薄膜和薄膜晶体管的性能.

关键词：脉冲紫外线辅助热退火氧化铟溶液法薄膜晶体管

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Risk factors for posterior synechiae of the iris after 23-gauge phacovitrectomy

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 843-849页

作者： Jong-Hyun Oh jaehoon Na Seong-Woo kim Jaeryung Oh Kuhl Huh Department of Ophthalmology Dongguk University Ilsan Hospital Department of Ophthalmology Korea University College of Medicine

AIM:To identify risk factors for the development of posterior synechiae of the iris(PSI) after 23-gauge ***:A retrospective chart review was performed in consecutive Asian patients treated with 23-gauge phacovitrectomy with a 3-piece intraocular lens(IOL) or a single-piece 4 haptics ***:A total of 263 eyes from 242 patients were included in the study. Postoperative PSI was identified in16(6.1%) eyes. In multivariate analysis, C3F8 gas tamponade, oil tamponade, and long operation time were significantly associated with PSI formation. There was no difference in the incidence of PSI between the groups using two different types of IOL(P =0.779).·CONLUSION: C3F8 gas or oil tamponade and long operation time increased the incidence of PSI after 23-gauge phacovitrectomy. The single-piece 4 haptics IOL,in lieu of a 3-piece IOL, may be inserted into the capsular bag with a comparable incidence of PSI.

关键词： complication intraocular lens phacoemulsification vitrectomy

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Ternary layered double hydroxide oxygen evolution reaction electrocatalyst for anion exchange membrane alkaline seawater electrolysis

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Journal of Energy Chemistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei Park Jae-Yeop Jeong Myeong Je Jang Chae-Yeon Kwon Geul Han kim jaehoon Jeong Ji-hoon Lee Jooyoung Lee Sung Mook Choi Department of Hydrogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from ***,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this *** this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)*** NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high *** on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.

关键词： Anion exchange membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis Hydrogen production

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Endoscopic and clinicopathologic characteristics of early gastric cancer with high microsatellite instability

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World Journal of Gastroenterology 2012年第27期18卷 3571-3577页

作者： jaehoon Jahng Young Hoon Youn Kwang Hyun kim Junghwan Yu Yong Chan Lee Woo Jin Hyung Sung Hoon Noh Hyunki kim Hoguen kim Hyojin Park Sang In Lee Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 100-753South Korea Department of Surgery Yonsei University College of MedicineSeoul 100-753South Korea Department of Pathology Yonsei University College of MedicineSeoul 100-753South Korea

AIM： To investigate endoscopic and clinicopathologic characteristics of early gastric cancer （EGC） according to microsatellite instability phenotype. METHODS： Data were retrospectively collected from a single tertiary referral center. Of 981 EGC patients surgically treated between December 2003 and October 2007, 73 consecutive EGC patients with two or more microsatellite instability （MSI） mutation [high MSI （MSI-H）] and 146 consecutive EGC patients with one or no MSI mutation （non-MSI-H） were selected. The endoscopic and clinicopathologic features were compared between the MSI-H and non-MSI-H EGC ***： In terms of endoscopic characteristics, MSI-H EGCs more frequently presented with elevated pattern （OR 4.38, 95% Cl： 2.40-8.01, P 〈 0.001）, moderate- to-severe atrophy in the surrounding mucosa （OR 1.91, 95% CI： 1.05-3.47, P = 0.033）, antral location （OR 3.99, 95% CI： 2.12-7.52, P 〈 0.001） and synchronous le- sions, compared to non-MSI-H EGCs （OR 2.65, 95% CI： 1.16-6.07, P = 0.021）. Other significant clinicopatholog- ic characteristics of MSI-H EGC included predominance of female sex （OR 2.77, 95% CI： 1.53-4.99, P 〈 0.001）, older age （〉 70 years）（OR 3.30, 95% CI： 1.57-6.92, P = 0.002）, better histologic differentiation （OR 2.35, 95% Cl： 1.27-4.34, P = 0.007）, intestinal type by Lau- ren classification （OR 2.34, 95% CI： 1.15-4.76, P = 0.019）, absence of a signet ring cell component （OR 2.44, 95% CI： 1.02-5.86, P = 0.046）, presence of mu- cinous component （OR 5.06, 95% Cl： 1.27-20.17, P = 0.022）, moderate-to-severe lymphoid stromal reaction （OR 3.95, 95% CI： 1.59-9.80, P = 0.003）, and co-exist- ing underlying adenoma （OR 2.66, 95% CI： 1.43-4.95, P = 0.002）. CONCLUSION： MSI-H EGC is associated with unique endoscopic and clinicopathologic characteristics includ- ing frequent presentation in protruded type, co-exist- ing underlying adenoma, and synchronous lesions.

关键词： Microsatellite instability Early gastric can-cer Endoscopic characteristic Advanced gastric cancer

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