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Application of Integrated Multiple Criteria Data Envelopment Analysis to Humanitarian Logistics Network Design

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Journal of Systems Science and Systems Engineering 2020年第6期29卷 709-729页

作者： jae-dong hong Industrial Engineering Program South Carolina State UniversityOrangeburgSCUSA

This paper considers a humanitarian logistics network(HTLN)design problem,including the emergency relief facilities(ERFs)location-allocation decision for the efficient distribution of emergency supplies from the ERFs to the affected areas.A goal programming(GP)approach is applied to consider the multiple objectives *** the GP model with a given weight assigned to each goal yields a single HTLN scheme,so there will be various schemes available by solving the GP with multiple values of the *** evaluating these schemes and identifying the most efficient one,we apply the data envelopment analysis(DEA)methods considering each scheme as a decision-making unit(DMU).Since the classical DEA(C-DEA)intrinsically aims to identify efficient DMUs and the efficient frontier,the use of C-DEA may not lead to a full ranking in many *** are several independent evaluation approaches to increasing discriminating *** them,this study integrates the multiple criteria DEA(MC-DEA)with the following three DEA methods,(i)stratification DEA(S^DEA),(ii)cross-efficiency DEA(CE-DEA),and(iii)super-efficiency DEA(SE-DEA),to make the most use of each method's *** a case study of designing the HTLN system for South Carolina,the procedure of implementing the integrated multiple criteria DEA(IMC-DEA)method is *** is observed that the IMCDEA method performs well in terms of designing the HTLN system and would help the decision-makers consider more efficient options and make a final decision.

关键词： Humanitarian logistics network goal programming decision-making unit data envelopment analysis(DEA) stratification DEA cross efficiency DEA super-efficiency DEA multiple-criteria DEA

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

Removal of particulate matter and dissolved organic matter from sedimentation sludge water during pre-sedimentation process:Performances and mechanisms

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Journal of Environmental Sciences 2025年第2期148卷 409-419页

作者： Shule Duan Huiyu dong Caifang Jiang hong Liang Ling Jiang Qian Xu Xiaoyu Cheng Zhimin Qiang Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Guangxi Nanning Water Co. Ltd.Nanning 530029China

Sedimentation sludge water(SSW),a prominent constituent of wastewater from drinking water treatment plants,has received limited attention in terms of its treatment and utilization likely due to the perceived difficulties associated with managing SSW *** study comprehensively evaluated the water quality of SSW by comparing it to a well-documented wastewater(filter backwash water(FBW)).Furthermore,it investigated the pollutant variations in the SSW during pre-sedimentation process,probed the underlying reaction mechanism,and explored the feasibility of employing a pilot-scale coagulation-sedimentation process for SSW *** levels of most water quality parameters were generally comparable between SSW and *** the pre-sedimentation of SSW,significant removal of turbidity,bacterial counts,and dissolved organic matter(DOM)was *** characterization of DOM components,molecular weight distributions,and optical properties revealed that the macromolecular proteinaceous biopolymers and humic acids were preferentially *** characterization of particulates indicated that high surface energy,zeta potential,and bridging/adsorption/sedimentation/coagulation capacities in aluminum residuals of SSW,underscoring its potential as a coagulant and promoting the generation and sedimentation of inorganic-organic *** coagulation-sedimentation process could effectively remove pollutants from low-turbidity SSW([turbidity]0<15 NTU).These findings provide valuable insights into the water quality dynamics of SSW during the pre-sedimentation process,facilitating the development of SSW quality management and enhancing its reuse rate.

关键词： Sedimentation sludge water Filter backwash water Reuse Health risk Coagulation-sedimentation

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen Xiong hong Ling Yingdan Huang Hanzhi dong Bangxiang Xie Qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

CoPSe nanoparticles confined in nitrogen-doped dual carbon network towards high-performance lithium/potassium ion batteries

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Chinese Chemical Letters 2025年第1期36卷 568-573页

作者： Zhong-Hui Sun Yu-Qi Zhang Zhen-Yi Gu dong-Yang Qu hong-Yu Guan Xing-Long Wu Guangdong Engineering Technology Research Center for Photoelectric Sensing Materials and Devices c/o School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchun 130024China

The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling *** the advanced anode materials is significant for next generation energy storage ***,severe electrode volume changes and sluggish redox kinetics are the critical problems for lithium/potassium ion batteries(LIBs/PIBs)towards large-scale ***,we prepare a novel anode material,which consists of reduced graphene oxide wrapping one-dimensional(1D)N-doped porous carbon nanotube with cobalt phosphoselenide(CoPSe)nanoparticles embedded inside them(r GO@Co PSe/NC).Benefited from the dual carbon decorations and ultrafine nanoparticles structure,it achieves a reversible capacity of 245 mAh/g at 5 A/g after 2000 cycles for LIBs and 215 mAh/g at 1 A/g after 500 cycles for *** pseudocapacitance and GITT measurements are used to investigate the electrochemical kinetics of r GO@Co PSe/NC for *** addition,the lithium ion full cell also shows good electrochemical performance when paired with high capacity LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) *** work provides a feasible electrode design strategy for high-efficiency metal ion batteries based on multidimensional nanoarchitecture engineering and composition tailoring.

关键词： Cobalt phosphoselenide Lithium-ion batteries Potassium-ion batteries Reduced graphene oxide Structural stability Full cell

Machine learning-based grayscale analyses for lithofacies identification of the Shahejie formation, Bohai Bay Basin, China

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Petroleum Science 2025年第1期22卷 42-54页

作者： Yu-Fan Wang Shang Xu Fang Hao Hui-Min Liu Qin-hong Hu Ke-Lai Xi dong Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Shengli Oilfield Branch Company SINOPEC

It is of great significance to accurately and rapidly identify shale lithofacies in relation to the evaluation and prediction of sweet spots for shale oil and gas reservoirs. To address the problem of low resolution in logging curves, this study establishes a grayscale-phase model based on high-resolution grayscale curves using clustering analysis algorithms for shale lithofacies identification, working with the Shahejie Formation, Bohai Bay Basin, China. The grayscale phase is defined as the sum of absolute grayscale and relative amplitude as well as their features. The absolute grayscale is the absolute magnitude of the gray values and is utilized for evaluating the material composition(mineral composition + total organic carbon) of shale, while the relative amplitude is the difference between adjacent gray values and is used to identify the shale structure type. The research results show that the grayscale phase model can identify shale lithofacies well, and the accuracy and applicability of this model were verified by the fitting relationship between absolute grayscale and shale mineral composition, as well as corresponding relationships between relative amplitudes and laminae development in shales. Four lithofacies are identified in the target layer of the study area: massive mixed shale, laminated mixed shale, massive calcareous shale and laminated calcareous shale. This method can not only effectively characterize the material composition of shale, but also numerically characterize the development degree of shale laminae, and solve the problem that difficult to identify millimeter-scale laminae based on logging curves, which can provide technical support for shale lithofacies identification, sweet spot evaluation and prediction of complex continental lacustrine basins.

关键词： Shale Machine learning Absolute grayscale Relative amplitude Grayscale phase model Lithofacies identification

Enhancement of bending toughness for Fe-based amorphous nanocrystalline alloy with deep cryogenic-cycling treatment

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China Foundry 2025年第1期22卷 99-107页

作者： Yi-ran Zhang dong Yang Qing-chun Xiang hong-yu Liu Jing Pang Ying-lei Ren Xiao-yu Li Ke-qiang Qiu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China Qingdao Yunlu Advanced Material Technology Co. Ltd.Qingdao 266232ShandongChina

The effects of deep cryogenic-cycling treatment(DCT)on the mechanical properties,soft magnetic properties,and atomic scale structure of the Fe_(73.5)Si_(13.5)B_(9)Nb_(3)Cu_(1)amorphous nanocrystalline alloy were *** DCT samples were obtained by subjecting the as-annealed samples to a thermal cycling process between the temperature of the supercooled liquid zone and the temperature of liquid *** flat plate bending testing,hardness measurements,and nanoindentation experiment,it is found that the bending toughness of the DCT samples is improved and the soft magnetic properties are also slightly *** are attributed to the rejuvenation behavior of the DCT samples,which demonstrate a higher enthalpy of ***,DCT is an effective method to enhance the bending toughness of Fe-based amorphous nanocrystalline alloys without degrading the soft magnetic properties.

关键词： deep cryogenic-cycling treatment Fe-based amorphous nanocrystalline alloy bending toughness rejuvenation

Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

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Chinese Journal of Integrative Medicine 2025年第1期31卷 39-48页

作者： WU Wen-bin GAO Fan TANG Yue-heng WANG hong-zhan dong Hui LU Fu-er YUAN Fen Institution of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(GLP-1)/GLP-1 receptor(GLP-1R) in both islet and intestine. Methods: The db/db mice were divided into the model(distilled water), low-dose HRD(LHRD, 3 g/kg), high-dose HRD(HHRD, 6 g/kg), and liraglutide(400 μg/kg) groups using a random number table, 8 mice in each group. The db/m mice were used as the control group(n=8, distilled water). The entire treatment of mice lasted for 6 weeks. Blood insulin, glucose, and GLP-1levels were quantified using enzyme-linked immunosorbent assay kits. The proliferation and apoptosis factors of islet cells were determined by immunohistochemistry(IHC) and immunofluorescence(IF) staining. Then,GLP-1, GLP-1R, prohormone convertase 1/3(PC1/3), PC2, v-maf musculoaponeurotic fibrosarcoma oncogene homologue A(MafA), and pancreatic and duodenal homeobox 1(PDX1) were detected by Western blot, IHC,IF, and real-time quantitative polymerase chain reaction, respectively. Results: HRD reduced the weight and blood glucose of the db/db mice, and improved insulin sensitivity at the same time(P<0.05 or P<0.01). HRD also promoted mice to secrete more insulin and less glucagon(P<0.05 or P<0.01). Moreover, it also increased the number of islet β cell and decreased islet α cell mass(P<0.01). After HRD treatment, the levels of GLP-1,GLP-1R, PC1/3, PC2, MafA, and PDX1 in the pancreas and intestine significantly increased(P<0.05 or P<0.01).Conclusion: HRD can maintain the normal function and identity of islet β cell, and the underlying mechanism is related to promoting the paracrine and endocrine activation of GLP-1 in pancreas and intestine.

关键词： type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine

Stretchable All-Small-Molecule Organic Solar Cells Enabled by Polymer Elastomer Confinement

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 271-277页

作者： Zhang, Chen-Yi Liu, Yu-Qiang Li, hong-Xiang Cui, Xin-Yue Wei, Zheng-dong Liu, Yue-Heng Li, Ming-Hua Zhang, An-dong Cheng, Pei Bo, Zhi-Shan Qingdao Univ Coll Text & Clothing State Key Lab Biofibers & Ecotext Qingdao 266071 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China Qingdao Univ Coll Mat Sci & Engn Qingdao 266071 Peoples R China Beijing Normal Univ Coll Chem Beijing Key Lab Energy Convers & Storage Mat Beijing 100875 Peoples R China

Intrinsic stretchability is a promising attribute of polymer organic solar cells (OSCs). However, rigid molecular blocks typically exhibit poor tensile properties, rendering polymers vulnerable to mechanical stress. In this study, we introduce a different approach utilizing all-small-molecule donors and acceptors to fabricate stretchable OSCs. An elastomer, styrene-b-ethylene-butylene-styrene (SEBS), was embedded to modulate film crystallization and stretchability. SEBS effectively confines the growth process of donors and acceptors, leading to enhancement of the crystallization quality, thus contributing to enhanced device efficiencies. Meanwhile, SEBS can absorb and release mechanical stress during stretching, thereby preventing mechanical degradation of donors and acceptors. The mechanical properties of the OSCs were significantly improved by the incorporation of SEBS. Notably, the crack-onset strain increased from 1.03% to 5.99% with SEBS embedding. These findings present a straightforward strategy for achieving stretchable OSCs using all small molecules, offering a different perspective for realizing stretchable devices.

关键词： All-small-molecule Organic solar cells Elastomer Stretchability Flexibility