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World Journal of Gastroenterology 2014年第11期20卷 2760-2764页

作者： jae young jang Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee UniversitySeoul 136-705South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

Helicobacter pylori(***)plays an important role in gastric carcinogenesis,as the majority of gastric cancers develop from ***-infected gastric *** rate of early gastric cancer diagnosis has increased in Japan and Korea,where *** infection and gastric cancer are highly *** intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic *** metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric *** efficacy of *** eradication for the prevention of metachronous gastric cancer remains ***,in patients who undergo endoscopic resection of early gastric cancer,*** eradication is recommended to suppress or delay metachronous gastric *** and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.

关键词： Helicobacter pylori Gastric cancer Endoscopic resection Metachronous cancer

Bowel preparations as quality indicators for colonoscopy

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World Journal of Gastroenterology 2014年第11期20卷 2746-2750页

作者： jae young jang Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee UniversitySeoul 130-701South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

Colonoscopy is the principal investigative procedure for colorectal neoplasms because it can detect and remove most precancerous *** effectiveness of colonoscopy depends on the quality of the *** preparation is an essential part of high-quality colonoscopies because only an optimal colonic cleansing allows the colonoscopist to clearly view the entire colonic mucosa and to identify any polyps or other *** bowel preparation not only prolongs the overall procedure time,decreases the cecal intubation rate,and increases the costs associated with colonoscopy but also increases the risk of missing polyps or adenomas during the ***,a repeat examination or a shorter colonoscopy follow-up interval may be suitable strategies for a patient with suboptimal bowel preparation.

关键词： Colonoscopy Colorectal neoplasm Bower preparation Quality

Clinical features of second primary cancers arising in earlygastric cancer patients after endoscopic resection

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World Journal of Gastroenterology 2015年第27期21卷 8358-8365页

作者： Jung-Wook Kim jae-young jang young Woon Chang Yong Ho Kim Department of Internal Medicine College of Medicine Kyung Hee University Department of Surgery College of Medicine Kyung Hee University

AIM: To investigate the incidence and distribution of second primary cancers(SPCs) in early gastric cancer(EGC) patients who underwent endoscopic resection(ER), compared to advanced gastric cancer(AGC) patients who underwent ***: The medical records of 1021 gastric cancer(GC) patients were retrospectively reviewed from January 2006 to December 2010. The characteristics and incidence of SPCs were investigated in those with EGC that underwent curative ER(the EGC group) and those with AGC who underwent curative surgical resection(the AGC group).RESULTS: We ultimately enrolled 184 patients in the EGC group and 229 patients in the AGC group. A total of 38 of the 413(9.2%) GC patients had SPCs; the rate was identical in both groups. Of these 38 patients, 18 had synchronous and 20 had metachronous cancers. The most common SPC was lung cancer(18.4%), followed by colorectal cancer(13.2%) and esophageal cancer(13.2%). No significant risk factors were identified for the development of ***: Endoscopists should provide close surveillance and establish follow-up programs to ensure SPC detection in GC patients undergoing curativeresection regardless of their clinical characteristics.

关键词： Second primary cancers Early gastric cancer Endoscopic resection Advanced gastric cancer

Outcome after endoscopic submucosal dissection for early gastric cancer in Korea

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World Journal of Gastroenterology 2011年第31期17卷 3591-3595页

作者： Jun Haeng Lee Su Jin Hong jae young jang Seong Eun Kim Sang young Seol Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Department of Internal Medicine Digestive Disease CenterInstitute for Digestive ResearchSoon Chun Hyang University College of Medicine Department of Internal Medicine Kyung Hee University College of Medicine Department of Internal Medicine Ewha Womans University School of MedicineEwha Medical Research Institute Division of Gastroenterology and Hepatology Department of Internal MedicineInje University College of Medicine

Endoscopic treatment,such as endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD),has been established as one of the treatment options for selected cases with early gastric cancer(EGC).Most studies on this topic have been carried out by researchers in ***,the experience in EMR/ESD for EGC outside Japan is increasingly *** Korea,gastric cancer is the most common malignant disease,and the second leading cause of cancer ***,EMR for EGC is widely performed in many centers in *** results with a shortterm follow-up period are very promising in *** resection rate of EMR was 37.8%-94.3%,and that of ESD was 77.4%-93.1%.In this review,we will provide an overview of the outcomes of endoscopic treatments in Korea.

关键词： Early gastric cancer Endoscopic mucosal resection Endoscopic submucosal dissection Outcome

Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report

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World Journal of Gastroenterology 2015年第16期21卷 5099-5104页

作者： Tae-In Lee jae-young jang Seungmin Kim Jung-Wook Kim young-Woon Chang Youn-Wha Kim Division of Gastroenterology Department of Internal MedicineCollege of MedicineKyung Hee University Department of Pathology College of MedicineKyung Hee University

Gastric adenocarcinoma is one of the most common malignancies *** and immunohistologic analyses classify the phenotypes of gastric adenocarcinoma into several groups based on the variable clinical and pathologic features.A new and rare variant of gastric adenocarcinoma with chief cell differentiation(GA-CCD)has recently been *** reporting the distinct clinicopathologic characteristics proposed the term oxyntic gland polyp/adenoma because of the benign nature of the ***,GA-CCD is a solitary mucosal lesion that develops either in the gastric cardia or ***,this lesion is characterized by tightly clustered glands and anastomosing cords of chief ***,GA-CCD is diffusely positive for mucin(MUC)6 and negative for MUC2and ***,other gastric tumors such as a gastric neuroendocrine tumor or fundic gland polyp have been difficult to *** GA-CCD tends to be endoscopically misdiagnosed as a neuroendocrine tumor or fundic gland polyp,comprehensive assessment and observation by an endoscopist are strongly ***,we report a rare case of oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor that was successfully removed by endoscopic mucosal resection.

关键词： Chief cell differentiation Gastric carcinoma Mucin 6 Neuroendocrine tumor Oxyntic gland adenoma

Usefulness of magnifying endoscopy for iodine-unstained lesions in a high-risk esophageal cancer population

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World Journal of Gastroenterology 2010年第37期16卷 4709-4715页

作者： Ik Seong Choi jae young jang Won young Cho Tae Hee Lee Hyun Gun Kim Bo young Lee Soung Won Jeong Joo young Cho Joon Seong Lee So young Jin Institute for Digestive Research SoonChunHyang University College of Medicine

AIM: To investigate the usefulness of magnified observations of iodine-unstained esophageal lesions in the histological diagnosis of esophageal mucosa abnormalities, in high-risk esophageal cancer groups. METHODS: The subjects included 38 patients who had at least one of the four criteria known to be highrisk factors for esophageal cancer. Following endoscopic observation, magnified observations were performed on iodine-unstained lesions of the esophagus. The total number of lesions was 43. These lesions were classified as type A (clear papilla), type B (fused papilla), and type C (non-visible papilla) according to the findings. Tissue biopsy was then carried out. Finally the histological findings were graded in terms of histological factors, and their relationships were compared. RESULTS: Of the 43 lesions, 11 were type A, 17 were type B, and 15 were type C under magnifying endoscopy. Histological findings such as inflammatory cell infiltration and basal cell hyperplasia were significantly increased in type B and type C lesions compared with type A lesions (P < 0.05). Low-grade esophageal dysplasia was apparent in 1 (9%) of 11 type A lesions, in 3 (18%) of 17 type B lesions, and in 6 (40%) of 15 type C lesions, with the highest rate in type C. CONCLUSION: Magnified observations of the esophagus, classified by papillary aspects using magnifying endoscopy of iodine-unstained lesions in high-risk esophageal cancer groups, are considered useful in estimating dysplasia and inflammation of esophageal mucosa.

关键词： Esophageal cancer Iodine Magnifying endoscopy

Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography

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World Journal of Gastroenterology 2009年第41期15卷 5232-5235页

作者： jaejun Shim jae young jang young Hwangbo Seok Ho Dong Joo Hyeong Oh Hyo Jong Kim Byung-Ho Kim young Woon Chang Rin Chang Department of Internal Medicine Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoongu Seoul 130-702 South Korea Department of Diagnostic Radiology Kyung Hee University School of Medicine Hoegi-dong 1 Dongdaemoon-gu Seoul 130-702 South Korea

Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery.

关键词： Esophagus Intramural hematoma Therapeutic angiography

Recurrent gastric neuroendocrine tumors treated with total gastrectomy

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World Journal of Gastroenterology 2015年第46期21卷 13195-13200页

作者： Myounghwa Jung Jung-Wook Kim jae-young jang young Woon Chang Sun Hee Park Yong Ho Kim Youn Wha Kim Department of Internal Medicine College of MedicineKyung Hee University Department of Surgery College of MedicineKyung Hee University Department of Pathology College of MedicineKyung Hee University

Gastric neuroendocrine tumors are rare; however,the incidence has recently increased due to the increasing use of upper endoscopy. Neuroendocrine tumors arise from the excess proliferation of enterochromaffinlike(ECL) cells. The proliferative changes of enterochromaffin cells evolve through a hyperplasiadysplasia-neoplasia sequence that is believed to underlie the pathogenesis of gastric neuroendocrine tumors. Endoscopic resection is recommended as the initial treatment if the tumor is not in an advanced stage. However,there is no definite guideline for the treatment of recurrent gastric neuroendocrine tumors following endoscopic resection. Here,we report a rare case of gastric neuroendocrine tumors in a 56-yearold male who experienced two recurrences within 11 years after endoscopic resection. The patient finally underwent a total gastrectomy. The pathological features of the resected stomach exhibited the full hyperplasia-dysplasia-neoplasia sequence of the ECL cells in a single specimen.

关键词： Neuroendocrine tumor Hyperplasia of neuroendocrine

Comparison of hepatic venous pressure gradient and endoscopic grading of esophageal varices

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World Journal of Gastroenterology 2016年第11期22卷 3212-3219页

作者： Eun Ji Lee Yong jae Kim Dong Erk Goo Seung Boo Yang Hyun-Joo Kim jae young jang Soung Won Jeong Department of Radiology Soonchunhyang University Seoul Hospital Department of Radiology Soonchunhyang University Gumi Hospital Department of Gastroenterology Soonchunhyang University Seoul Hospital

AIM: To determine the correlation between the hepatic venous pressure gradient and the endoscopic grade of esophageal ***: From September 2009 to March 2013, a total of 176 measurements of hepatic venous pressure gradient (HVPG) were done in 146 patients. Each transjugular HVPG was measured twice, first using an end whole catheter (EH-HVPG), and then using a balloon catheter (B-HVPG). The HVPG was compared with the endoscopic grade of esophageal varices (according to the general rules for recording endoscopic findings of esophagogastric varices), which was recorded within a month of the measurement of ***: The study included 110 men and 36 women, with a mean age of 56.1 years (range, 43-76 years). The technical success rate of the pressure measurements was 100% and there were no complication related to the procedures. Mean HVPG was 15.3 mmHg as measured using the end hole catheter method and 16.5 mmHg as measured using the balloon catheter method. Mean HVPG (both EH-HVPG and B-HVPG) was not significantly different among patients with different characteristics, including sex and comorbid factors, except for cases with hepatocellular carcinoma (B-HVPG, P = 0.01; EH-HVPG, P = 0.02). Portal hypertension (> 12 mmHg HVPG) occurred in 66% of patients according to EH-HVPG and 83% of patients according to B-HVGP, and significantly correlated with Child’s status (B-HVPG, P < 0.000; EH-HVGP, P < 0.000) and esophageal varies observed upon endoscopy (EH-HVGP, P = 0.003; B-HVGP, P = 0.006). One hundred and thirty-five endoscopies were performed, of which 15 showed normal findings, 27 showed grade 1 endoscopic esophageal varices, 49 showed grade 2 varices, and 44 showed grade 3 varices. When comparing endoscopic esophageal variceal grades and HVPG using univariate analysis, the P value was 0.004 for EH-HVPG and 0.002 for ***: Both EH-HVPG and B-HVPG showed a positive correlation with the endoscopic grade of esophag

关键词： Hepatic venous pressure gradient Liver cirrhosis Esophageal varices Endoscopic grade of esophageal varices Balloon catheter measurement End hole catheter measurement

3D image reconstruction with controllable spatial filtering based on correlation of multiple periodic functions in computational integral imaging

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Chinese Optics Letters 2015年第3期13卷 22-26页

作者： jae-young jang Myungjin Cho Eun-Soo Kim Department of Optometry Eulji University 553 Sanseong-daero Sujeong-guSeongnam-si Gyonggi-do South Korea Department of Electrical Electronic and Control Engineering Hankyong National University

We propose a novel method of slice image reconstruction with controllable spatial filtering by using the correlation of periodic delta-function arrays （PDFAs） with elemental images in computational integral imaging. The multiple PDFAs, whose spatial periods correspond to object＇s depths with the elemental image array （EIA）, can generate a set of spatially filtered EIAs for multiple object depths compared with the conventional method for the depth of a single object. We analyze a controllable spatial filtering effect by the proposed method. To show the feasibility of the proposed method, we carry out preliminary experiments for multiple objects and present the results.

关键词： image reconstruction with controllable spatial filtering based on correlation of multiple periodic functions in computational integral imaging EIA