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Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-Jin Park jae-yong shim yong-jae Lee Jung-Hyun Lee Hye-Ree Lee Department of Family Medicine Yonsei University College of Medicine Seou1135-720 Korea Department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

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A comparison of desensitization methods: Rituximab with/without plasmapheresis in ABO-incompatible living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 119-125页

作者： Eung Chang Lee Seong Hoon Kim jae Ryong shim Sang-jae Park Center for Liver Cancer National Cancer Center

Background: Plasmapheresis is a desensitization method used prior to ABO-incompatible(ABO-I) living donor liver transplantation. However, studies on its usefulness in the rituximab era are ***: Fifty-six adult patients underwent ABO-I living donor liver transplantation between January2012 and October 2015. A single dose of rituximab(300 mg/m~2) was administered 2 weeks before surgery with plasmapheresis in all patients until February 2014(RP group, n = 26). Patients were administered rituximab only, without plasmapheresis between March 2014 and October 2015(RO group, n = 30).Results: The 6-, 12-and 18-month overall survival rates were 92.3%, 80.8% and 76.9% in the RP group and 96.6%, 85.4% and 85.4% in the RO group, respectively(P = 0.574). When the initial isoagglutinin titers < 16, neither group showed a rebound rise of isoagglutinin titers. For patients with initial isoagglutinin titers ≥ 16, the rebound rise of isoagglutinin titers was more prominent in the RP group. There was no difference in time-dependent changes in B cell subpopulations and ABO-I-related ***: Sufficient desensitization for ABO-I living donor liver transplantation can be achieved using rituximab alone. This desensitization strategy does not affect the isoagglutinin titers, ABO-I-related complications and patient survival.

关键词： Desensitization Rituximab Plasmapheresis ABO-incompatibility Living donor Liver transplantation

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Friction stir welding of 5052 aluminum alloy plates

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中国有色金属学会会刊：英文版 2009年第B9期19卷 23-27页

作者： yong-Jai KWON Seong-Beom shim Dong-Hwan PARK School of Materials Science and Engineering University of Ulsan Institute of E-Vehicle Technology University of Ulsan

Friction stir welding between 5052 aluminum alloy plates with a thickness of 2 mm was performed. The tool for welding was rotated at speeds ranging from 500 to 3000 r/min under a constant traverse speed of 100 mm/min. The results show that at all tool rotation speeds, defect-free welds are successfully obtained. Especially at 1000, 2000 and 3000 r/min, the welds exhibit very smooth surface morphologies. At 500, 1000, and 2000 r/min, onion ring structure is clearly observed in the friction-stir-welded zone (SZ). In addition, the onion ring structure region becomes wider as the tool rotation speed is increased. The gain size in the SZ is smaller than that in the base metal, and is decreased with a decrease of the tool rotation speed. In all tool rotation speeds, the SZ exhibits higher average hardness than the base metal. Especially at 500 r/min, the average hardness of the SZ reaches a level about 33% greater than that of the base metal. At 500, 1 000 and 2 000 r/min, the tensile strength of the friction stir welded (FSWed) plates is similar to that of the base metal (about 204 MPa). The elongation of the FSWed plates is lower than that of the base metal (about 22%). However, it is noticeable that the maximum elongation of about 21% is obtained at 1 000 r/min.

关键词：搅拌摩擦焊接铝合金板旋转速度焊接工具表面形貌环形结构抗拉强度伸长率

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Small-cell neuroendocrine carcinoma arising from an extra-hepatic bile duct:a case report

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Gastroenterology Report 2021年第4期9卷 380-382,I0003页

作者： jae Ryong shim jae Ri Kim Youngmok Park Hyung-Il Seo Division of HBP Surgery and Transplantation Pusan National University Yangsan HospitalYangsanKorea Department of Surgery Biomedical Research InstitutePusan National University HospitalGudeok-roSeoguBusanKorea

Introduction Neuroendocrine tumors(NETs)are neoplasms with variable malignant potential that may arise from neuroendocrine *** gastrointestinal tract is a common site for primary NETs and annually 1.3 for every 100,000 persons are newly detected[1,2].Although gastrointestinal NETs are common in the small bowel,appendix,rectum,and stomach,those that arise from the extra-hepatic bile duct are extremely rare(0.1%–0.4%)[3-5].

关键词：肝外胆管小细胞神经内分泌癌 neoplasms 病例报告

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Key Considerations on the Industrial Application of Lignocellulosic Biomass Pyrolysis Toward Carbon Neutrality

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Engineering 2023年第10期29卷 35-38页

作者： Shu Zhang Kan Zou Bin Li Hojae shim yong Huang Joint International Research Laboratory of Biomass Energy and Materials Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China Department of Civil and Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao 999078China

*** importance of biomass in carbon neutrality With the increasing urgency to mitigate climate change,over 100 countries have committed to net-zero carbon emissions by the mid-21st century[1].For example,China has announced that it will reach a carbon peak and carbon neutrality,with the rapid development of renewable energy undoubtedly playing a key role in achieving these *** with other renewable energy sources,such as wind energy,solar energy.

关键词： doubt Biomass neutral

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Fully rubbery synaptic transistors made out of all-organic materials for elastic neurological electronic skin

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Nano Research 2022年第2期15卷 758-764页

作者： Hyunseok shim Seonmin Jang jae Gyu Jang Zhoulyu Rao Jong-ln Hong Kyoseung Sim Cunjiang Yu Materials Science and Engineering Program University of HoustonHoustonTX 77204 USA Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Mechanical Engineering University of HoustonHoustonTX 77204 USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204 USA Texas Center for Superconductivity University of HoustonHoustonTX 77204USA

Neurologic function implemented soft organic electronic skin holds promise for wide range of applications,such as skin prosthetics,neurorobot,bioelectronics,human-robotic interaction(HRI),***,we report the development of a fully rubbery synaptic transistor which consists of all-organic materials,which shows unique synaptic characteristics existing in biological *** synaptic characteristics retained even under mechanical stretch by 30%.We further developed a neurological electronic skin in a fully rubbery format based on two mechanoreceptors(for synaptic potentiation or depression)of pressure-sensitive rubber and an all-organic synaptic *** converting tactile signals into Morse Code,potentiation and depression of excitatory postsynaptic current(EPSC)signals allow the neurological electronic skin on a human forearm to communicate with a robotic *** collective studies on the materials,devices,and their characteristics revealed the fundamental aspects and applicability of the all-organic synaptic transistor and the neurological electronic skin.

关键词： synaptic transistor stretchable electronic skin all-organic

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Associations of non-high-density lipoprotein cholesterol with metabolic syndrome and its components in Korean children and adolescents: the Korea National Health and Nutrition Examination Surveys 2008–2014

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World Journal of Pediatrics 2018年第5期14卷 461-469页

作者： yong Min Kim So Hyun Kim Young Suk shim Department of Pediatrics Hallym University Dongtan Sacred Heart HospitalHallym University College of Medicine7Keunjaebong-gilHwaseong-siGyeonggi-doSeoul 18450Republic of Korea

Background In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood. Methods A total of 5742 Korean children aged 10–18 years who participated in a national survey were included. The sub-jects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dL (desirable), ≥120 and <150 mg/dL (borderline high), and ≥150 mg/dL (high). Results Males in the borderline high non-HDL-C group had odds ratios (ORs) of 2.86 (95% confidence interval, 2.30–3.56) for elevated triglycerides (TG), 1.73 (1.08–1.79) for reduced high-density lipoprotein cholesterol (HDL-C) and 1.73 (1.08–2.78) for MetS compared with males in the desirable non-HDL-C group after adjusting for covariates. Males in the high non-HDL-C group had ORs of 1.65 (1.14–2.41) for elevated blood pressure (BP), 6.21 (4.27–9.05) for elevated TG, and 3.29 (1.49–7.26) for MetS compared with males in the desirable non-HDL-C group. Females in the borderline high non-HDL-C group had ORs of 3.03 (2.43–3.76) for elevated TG, 1.63 (1.13–2.35) for reduced HDL-C, and 4.53 (2.47–8.31) for MetS compared with females in the desirable non-HDL-C group. Females in the high non-HDL-C group had ORs of 1.43 (1.00–2.04) for elevated BP, 6.36 (4.45–9.08) for elevated TG, and 7.64 (3.65–15.96) for MetS compared with females in the desirable non-HDL-C group. Conclusion Our results suggest that, in a Korean population, a non-HDL-C level of 120 mg/dL for males and 150 mg/dL for females is the threshold between borderline high and high risk for MetS.

关键词： Adolescents Cardiovascular risk Children Metabolic syndrome Non-high-density lipoprotein cholesterol

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Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea

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Acta Oceanologica Sinica 2013年第9期32卷 50-61页

作者： LIM Hak-Soo KIM Chang S PARK Kwang-Soon shim jae Seol CHUN Insik Korea Institute of Ocean Science and Technology Konkuk University

A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a re- gional ocean modeling system （ROMS）. The operational oceanographic modeling system consists of at- mospheric and hydrodynamic models. The hydrodynamic model, ROMS, is coupled with wave, sediment transport, and water quality modules. The system forecasts the predicted results twice a day on a 72 h basis, including sea surface elevation, currents, temperature, salinity, storm surge height, and wave information for the coastal waters of Korea. The predicted results are exported to the web-GIS-based coastal informa- tion system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies. The ROMS is two-way coupled with a simulating waves nearshore model, SWAN, for the hydrodynamics and waves, nested with the meteorological model, WRE for the atmospheric surface forcing, and externally nested with the eutrophication model, CE-QUAL-ICM, for the water quality. The op- erational model, ROMS, was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea. To validate the predicted results, we used real-time monitoring data derived from remote buoy system, HF-radar, and geostationary ocean color imager （GOCI）. This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system （KOOS） with other operational oceanographic systems.

关键词： down-scaled operational oceanographic system regional ocean modeling system wave coupledmodel real-time monitoring system

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High-power and long-life supercapacitive performance of hierarchical, 3-D urchin-like W18049 nanostructure electrodes

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Nano Research 2016年第3期9卷 633-643页

作者： Sangbaek Park Hyun-Woo shim Chan Woo Lee Hee Jo Song jae-Chan Kim Dong-Wan Kim Department of Materials Science and Engineering Seoul National University Seoul 151-744 Republic of Korea School of Civil Environmental and Architectural Engineering Korea University Seou1136-713 Republic of Korea

We report the facile, one-pot synthesis of 3-D urchin-like W18O49 nanostructures （U-WO） via a simple solvothermal approach. An excellent supercapacitive performance was achieved by the U-WO because of its large Brunauer-Emmett- Teller （BET） specific surface area （ca. 123 m2.g-1） and unique morphological and structural features. The U-WO electrodes not only exhibit a high rate-capability with a specific capacitance （Csp） of -235 F·g-1 at a current density of 20 A.g-1, but also superior long-life performance for 1,000 cycles, and even up to 7,000 cycles, showing -176 F·g-1 at a high current density of 40 A.g-1.

关键词： hierarchical structure W18O49 high-power long cycle life supercapacitor

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Anesthetics management of a renal angiomyolipoma using pulse pressure variation and non-invasive cardiac output monitoring: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8656-8661页

作者： Woo jae Jeon Woo Jong Shin Young Joon Yoon Chan Woo Park jae Hang shim Sang Yun Cho Department of Anesthesiolgy and Pain Medicine Hanyang University Guri HospitalGuri-si 471-701Gyeonggi-doSouth Korea

BACKGROUND Hypovolemic shock can lead to life-threatening organ dysfunction,and adequate fluid administration is a fundamental ***,parameters such as vital signs,central venous pressure,and urine output have been used to estimate intravascular ***,pulse pressure variation(PPV)and non-invasive cardiac monitoring devices have been *** this case report,we introduce a patient with massive active bleeding from giant renal angiomyolipoma(AML).During emergent nephrectomy,we used non-invasive cardiac monitoring with CSN-1901(Nihon Kohden,Tokyo,Japan)and PPV to evaluate the patient's intravascular volume status to achieve optimal fluid *** SUMMARY A 30-year-old male patient with giant AML with active bleeding was referred to the emergency room complaining of severe abdominal pain and spontaneous abdominal *** was diagnosed by computed tomography,and emergent nephrectomy was *** bleeding was expected so we decided to use non-invasive cardiac monitoring and PPV to assist fluid therapy because they are relatively easy and fast compared to invasive cardiac *** the surgery,6000 mL of estimated blood loss *** with the patient's vital signs and laboratory results,we monitored cardiac output,cardiac output,stroke volume,stroke volume index with a non-invasive cardiac monitoring device,and PPV using an intra-arterial catheter to evaluate intravascular volume status of the patient to compensate for massive *** In addition to traditional parameters,non-invasive cardiac monitoring and PPV are useful methods to evaluate patient's intravascular volume status and provideguidance for intraoperative management of hypovolemic shock patients.

关键词： Renal angiomyolipoma Pulse pressure variation Cardiac output Case report

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