检索结果-南通市图书馆

Role of extracellular vesicles in lung diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2022年第15期135卷 1765-1780页

作者： Li Zhou Hong Luo jae woo lee Department of Pulmonary and Critical Care Medicine The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Anesthesiology University of CaliforniaSan FranciscoSan FranciscoCalifornia 94143USA

Extracellular vesicles(EVs)are anuclear particles composed of lipid bilayers that contain nucleic acids,proteins,lipids,and *** act as an important mediator of cell-to-cell communication by transmitting biological signals or components,including lipids,proteins,messenger RNAs,DNA,microRNAs,organelles,etc,to nearby or distant target cells to activate and regulate the function and phenotype of target *** physiological conditions,EVs play an essential role in maintaining the homeostasis of the pulmonary milieu but they can also be involved in promoting the pathogenesis and progression of various respiratory diseases including chronic obstructive pulmonary disease,asthma,acute lung injury/acute respiratory distress syndrome,idiopathic pulmonary fibrosis(IPF),and pulmonary artery *** addition,in multiple preclinical studies,EVs derived from mesenchymal stem cells(EVs)have shown promising therapeutic effects on reducing and repairing lung ***,in recent years,researchers have explored different methods for modifying EVs or enhancing EVs-mediated drug delivery to produce more targeted and beneficial *** article will review the characteristics and biogenesis of EVs and their role in lung homeostasis and various acute and chronic lung diseases and the potential therapeutic application of EVs in the field of clinical medicine.

关键词： Lung diseases Biomarker Lung disease pathogenesis Extracellular vesicles Clinical application

Adaptive data fusion framework for modeling of non-uniform aerodynamic data

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第7期36卷 316-336页

作者： Vinh PHAM Maxim TYAN Tuan Anh NGUYEN Chi-Ho lee L.V.Thang NGUYEN jae-woo lee Department of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea Konkuk Aerospace Design-Airworthiness Institute Konkuk UniversitySeoul 05029Republic of Korea

Multi-fidelity Data Fusion(MDF)frameworks have emerged as a prominent approach to producing economical but accurate surrogate models for aerodynamic data modeling by integrating data with different fidelity ***,most existing MDF frameworks assume a uniform data structure between sampling data sources;thus,producing an accurate solution at the required level,for cases of non-uniform data structures is *** address this challenge,an Adaptive Multi-fidelity Data Fusion(AMDF)framework is proposed to produce a composite surrogate model which can efficiently model multi-fidelity data featuring non-uniform ***,the design space of the input data with non-uniform data structures is decomposed into subdomains containing simplified ***,different MDF frameworks and a rule-based selection process are adopted to construct multiple local models for the subdomain *** the other hand,the Enhanced Local Fidelity Modeling(ELFM)method is proposed to combine the generated local models into a unique and continuous global ***,the resulting model inherits the features of local models and approximates a complete database for the whole design *** validation of the proposed framework is performed to demonstrate its approximation capabilities in(A)four multi-dimensional analytical problems and(B)a practical engineering case study of constructing an F16C fighter aircraft’s aerodynamic *** comparisons of the generated models using the proposed AMDF framework and conventional MDF approaches using a single global modeling algorithm are performed to reveal the adaptability of the proposed approach for fusing multi-fidelity data featuring non-uniform ***,the results indicated that the proposed framework outperforms the state-of-the-art MDF approach in the cases of non-uniform data.

关键词： Aerodynamic modeling Data fusion Diverse data structure Multi-fidelity data Multi-fidelity surrogate modeling

Efficient multi-response adaptive sampling algorithm for construction of variable-fidelity aerodynamic tables

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2019年第3期32卷 547-558页

作者： Maxim TYAN jae-woo lee Department of Aerospace Information Engineering Konkuk University

Adaptive sampling is an iterative process for the construction of a global approximation model. Most of engineering analysis tools computes multiple parameters in a single run. This research proposes a novel multi-response adaptive sampling algorithm for simultaneous construction of multiple surrogate models in a time-efficient and accurate manner. The new algorithm uses the Jackknife cross-validation variance and a minimum distance metric to construct a sampling criterion function. A weighted sum of the function is used to consider the characteristics of multiple surrogate models. The proposed algorithm demonstrates good performance on total 22 numerical problems in comparison with three existing adaptive sampling algorithms. The numerical problems include several two-dimensional and six-dimensional functions which are combined into singleresponse and multi-response systems. Application of the proposed algorithm for construction of aerodynamic tables for 2 D airfoil is demonstrated. Scaling-based variable-fidelity modeling is implemented to enhance the accuracy of surrogate modeling. The algorithm succeeds in constructing a system of three highly nonlinear aerodynamic response surfaces within a reasonable amount of time while preserving high accuracy of approximation.

关键词： Adaptive sampling Aerodynamic database Multi-response system Surrogate modeling Variable fidelity modeling

Aerodynamic design optimization of helicopter rotor blades including airfoil shape for hover performance

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2013年第1期26卷 1-8页

作者： Ngoc Anh Vu jae woo lee Jung Il Shu Department of Aerospace Engineering Ho Chi Minh City University of Technology Department of Aerospace Information Engineering Konkuk University

This study proposes a process to obtain an optimal helicopter rotor blade shape for aerodynamic performance in hover flight. A new geometry representation algorithm which uses the class function/shape function transformation （CST） is employed to generate airfoil coordinates. With this approach, airfoil shape is considered in terms of design variables. The optimization process is constructed by integrating several programs developed by author. The design variables include twist, taper ratio, point of taper initiation, blade root chord, and coefficients of the airfoil distribution function. Aerodynamic constraints consist of limits on power available in hover and forward flight. The trim condition must be attainable. This paper considers rotor blade configuration for the hover flight condition only, so that the required power in hover is chosen as the objective function of the optimization problem. Sensitivity analysis of each design variable shows that airfoil shape has an important role in rotor performance. The optimum rotor blade reduces the required hover power by 7.4% and increases the figure of merit by 6.5%, which is a good improvement for rotor blade design.

关键词： Airfoil Design optimization Helicopter design Hover performance Planforms Rotor blades design

Synergistically coupling of Ni–Fe LDH arrays with hollow Co–Mo sulfide nanotriangles for highly efficient overall water splitting

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 522-532页

作者： Yun jae lee Seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityAnseongGyeonggi-do17546Republic of Korea Department of Intelligent Energy and Industry Chung-Ang University84 Heukseok-ro Dongjak-guSeoul06974Republic of Korea Western Seoul Center Korea Basic Science Institute150 Bugahyeon-roSeodaemun-guSeoul03759Republic of Korea

Developing bifunctional catalysts that can catalyze both oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is pivotal to commercializing large-scale water ***,a novel hollow nanotriangle composed of NiFe LDH-CoMoS_(x) heterojunction(H-CMSx@NiFe LDH)is proposed as a highly efficient bifunctional electrocatalyst for both OER and *** fabricate a heterojunction system,ultra-thin nickel–iron layered double hydroxide(NiFe LDH)nanosheets are uniformly electrodeposited onto a metal–organic framework-derived hollow CoMoS_(x) *** strong coupling of CoMoS_(x) and NiFe LDH catalysts forms the intimate heterojunction interfaces to facilitate interfacial charge transfer,which is favorable to enhance the bifunctional catalytic ***,the large void of CoMoS_(x) nanotriangles and interconnected ultra-thin NiFe LDH nanosheets result in good electrolyte penetration and gas ***,the as-prepared H-CMSx@NiFe LDH on nickel foam(NF)exhibits an impressive catalytic activity and durability for OER and HER activities,delivering a current density of 100 mA·cm^(−2) at the small overpotentials of 214 and 299 mV in OER and HER,***,H-CMSx@NiFe LDH/NF proves to be an effective electrode for an alkaline electrolyzer,as a voltage of only 1.99 V is enough to achieve a current density voltage of only 1.99 V is enough to achieve a current density of 400 mA·cm^(−2) with no degradation in performance over 50 h.

关键词： Overall water splitting Metal-organic framework Molybdenum sulfide Layered double hydroxide Heterojunction

Electrical and Corrosion Properties of Titanium Aluminum Nitride Thin Films Prepared by Plasma-Enhanced Atomic Layer Deposition

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2017年第3期33卷 295-299页

作者： Eun-Young Yun woo-jae lee Qi Min Wang Se-Hun Kwon School of Materials Science and Engineering Pusan National University School of Electromechanical Engineering Guangdong University of Technology

Titanium-aluminum-nitride（TiAlN） films were grown by plasma-enhanced atomic layer deposition（PEALD）on 316 L stainless steel at a deposition temperature of 200 °C. A supercycle, consisting of one AlN and ten TiN subcycles, was used to prepare TiAlN films with a chemical composition of Ti（0.25）Al（0.25）N（0.50）. The addition of AlN to TiN resulted in an increased electrical resistivity of TiAlN films of 2800 μΩ cm, compared with 475 μΩ cm of TiN films, mainly due to the high electrical resistivity of AlN and the amorphous structure of TiAlN. However, potentiostatic polarization measurements showed that amorphous TiAlN films exhibited excellent corrosion resistance with a corrosion current density of 0.12 μA/cm^2, about three times higher than that of TiN films, and about 12.5 times higher than that of 316 L stainless steel.

关键词： Titanium-aluminum nitride Plasma-enhanced atomic layer deposition Corrosion protection Ternary transition metal nitrides

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi jae-Jung Ha Ji-Hyun lee Seong-Beom lee woo-jae Son Soo-Young Yum Won-Wu lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

Process of establishing design requirements and selecting alternative configurations for conceptual design of a VLA

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2017年第2期30卷 738-751页

作者： Bo-Young Bae Sangho Kim jae-woo lee Nhu Van Nguyen Bong-Cheul Chung Department of Aerospaee Information Engineering Konkuk University Seoul 143-701 Republic of Korea Konkuk Aerospace Design Airworthiness Research Institute Konkuk University Seoul 143-701 Republic of Korea

In this study,a process for establishing design requirements and selecting alternative configurations for the conceptual phase of aircraft design has been *** proposed process uses system-engineering-based requirement-analysis techniques such as objective tree,analytic hierarchy process,and quality function deployment to establish logical and quantitative ***,in order to perform a logical selection of alternative aircraft configurations,it uses advanced decision-making methods such as morphological matrix and technique for order preference by similarity to the ideal *** addition,a preliminary sizing tool has been developed to check the feasibility of the established performance requirements and to evaluate the flight performance of the selected *** present process has been applied for a two-seater very light aircraft（VLA）,resulting in a set of tentative design requirements and two families of VLA configurations：a high-wing configuration and a low-wing *** resulting set of design requirements consists of three categories：customer requirements,certification requirements,and performance *** performance requirements include two mission requirements for the flight range and the endurance by reflecting the customer *** flight performances of the two configuration families were evaluated using the sizing tool developed and the low-wing configuration with conventional tails was selected as the best baseline configuration for the VLA.

关键词： Aircraft configuration Conceptional design Design requirements Requirement analysis Very light aircraft (VLA)

A fully automated framework for helicopter rotor blades design and analysis including aerodynamics,structure, and manufacturing

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2016年第6期29卷 1602-1617页

作者： Ngoc Anh Vu jae woo lee Tuan Phuong Nam Le Song Thanh Thao Nguyen Division of Computational Mechatronics Institute for Computational Science Ton Duc Thang University Faculty of Electrical & Electronics Engineering Ton Duc Thang University Department of Aerospace Information Engineering Konkuk University Faculty of Mechanical Engineering Industrial University of Ho Chi Minh City Department of Aerospace Engineering Ho Chi Minh City University of Technology Vietnam National University-Ho Chi Minh City

This study describes an integrated framework in which basic aerospace engineering aspects(performance, aerodynamics, and structure) and practical aspects(configuration visualization and manufacturing) are coupled and considered in one fully automated design optimization of rotor blades. A number of codes are developed to robustly perform estimation of helicopter configuration from sizing, performance analysis, trim analysis, to rotor blades configuration representation. These codes are then integrated with a two-dimensional airfoil analysis tool to fully design rotor blades configuration including rotor planform and airfoil shape for optimal aerodynamics in both hover and forward flights. A modular structure design methodology is developed for realistic composite rotor blades with a sophisticated cross-sectional geometry. A D-spar cross-sectional structure is chosen as a baseline. The framework is able to analyze all realistic inner configurations including thicknesses of D-spar, skin, web, number and ply angles of layers of each composite part,and materials. A number of codes and commercial software(ANSYS, Gridgen, VABS, Pre VABS,etc.) are implemented to automate the structural analysis from aerodynamic data processing to sectional properties and stress analysis. An integrated model for manufacturing cost estimation ofcomposite rotor blades developed at the Aerodynamic Analysis and Design Laboratory(AADL),Aerospace Information Engineering Department, Konkuk University is integrated into the framework to provide a rapid and dynamic feedback to configuration design. The integration of three modules has constructed a framework where the size of a helicopter, aerodynamic performance analysis, structure analysis, and manufacturing cost estimation could be quickly investigated. All aspects of a rotor blade including planform, airfoil shape, and inner structure are considered in a multidisciplinary design optimization without an exception of critical configuration.

关键词： Design optimization Helicopter rotor blades Integrated framework Modular structure design methodology Perform estimation