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Cancer Communications 2022年第6期42卷 572-575页

作者： Ji-Yong Sung jae-ho cheong Department of Laboratory Medicine Yonsei University College of MedicineSeoul 03722Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Korea Yonsei Biomedical Research Institute Yonsei University College of MedicineSeoul 03722Korea Department of Biochemistry&Molecular Biology Yonsei University College of MedicineSeoul 03722Korea

Dear Editor,Immune-directed therapeutic approaches have changed the paradigm of cancer *** tumor-immune microenvironment[1]is a dynamic milieu consisting of heterogeneous metabolic conditions such as low oxygen,nutrient deficiency,acidity,and interactions between multiple cell *** particular,immune cells in the tumor microenvironment are vulnerable to cellular dysfunctions(because of metabolic reprogramming[2])and engage in intercellular communications with neighboring cells.

关键词： cancer programming immunotherapy

Outcome after gastrectomy in gastric cancer patients with type 2 diabetes

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World Journal of Gastroenterology 2012年第1期18卷 49-54页

作者： Jong Won Kim jae-ho cheong Woo Jin Hyung Seung-ho Choi Sung hoon Noh Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Surgery Severance Hospital Yonsei University College of Medicine

AIM: To evaluate the prognosis of type Ⅱ diabetes mellitus (T2DM) after gastrectomy and related factors in gastric cancer patients. METhoDS: 403 gastric cancer patients with T2DM were studied, who underwent gastrectomy between May 2003 and September 2009. A review of medica records and telephone interviews was performed in this cross-sectional study. The factors included in the statistical analysis were as follows: gender, age, type of surgery, preoperative body mass index (BMI), current BMI, BMI reduction ratio, preoperative insulin or oral diabetic medicine requirement, follow-up duration, and current state of diabetes. Assessment of diabetes status after surgery was classified into four categories according to the change in hypoglycemic agents after surgery and present status of T2DM: resolution, improvement, same, and worse.(± 20.6 mo), preoperative BMI was 24.7 kg/m2 (± 3.0 kg/m2), and BMI reduction ratio was 9.8% (± 8.6%). After surgery, T2DM was cured in 58 patients (15.1%) and was improved in 117 patients (30.4%). According to the type of surgery, the BMI reduction ratio was signif icantly higher in the total gastrectomy and Roux-en-Y reconstruction group [14.2% ± 9.2% vs 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001] and signif icantly lower in the subtotal gastrectomy and Billroth Ⅰ reconstruction group [7.6% ± 8.0%, 9.2% ± 7.7% (Billroth Ⅱ group), P < 0.001]. The BMI reduction ratio, follow-up duration after surgery, type of surgery, extent of gastrectomy, and performance of duodenal bypass were signif icantly correlated to the course of T2DM (P < 0.05). The BMI reduction ratio was the most influential factor on T2DM status. In a subgroup analysis of patients with a BMI reduction ratio of 10% or less (n = 206), T2DM was cured in 15 (7.6%) patients and was improved in 57 (28.8%) patients after surgery, and only the duration of surgery was signif icantly correlated to T2DM status (P = 0.022).

关键词： Gastric cancer Diabetes mellitus Metabolic surgery Bariatric surgery

Gastric cancer surgery in cirrhotic patients: Result of gastrectomy with D2 lymph node dissection

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World Journal of Gastroenterology 2005年第30期11卷 4623-4627页

作者： Jun ho Lee Junuk Kim jae ho cheong Woo Jin Hyung Seung ho Choi Sung hoon Noh Research Institute and hospital Department of Surgery

AIM： To explore the feasibility of performing gastrectomy with D2 lymphadenectomy in gastric cancer patients with liver cirrhosis. METhoDS： A total of 7 178 patients were admitted with a diagnosis of liver cirrhosis from January 1993 to December 2003. We reviewed the records of 142 patients who were diagnosed with liver cirrhosis and gastric adenocarcinoma during the same period. Gastrectomy with D2 lymph node dissection for carcinoma of the stomach was performed in 94 patients with histologically proven hepatic cirrhosis. RESULTS： All but 12 patients were dassified as Child＇s class A. Only 35 patients （37.2%） were diagnosed with cirrhosis before operation. Seventy-three patients underwent a subtotal gastrectomy （77.7%） and 21 patients （22.3%） underwent a total gastrectomy, each with D2 or more lymph node dissection. Two patients （3.8%） who had prophylactic intra-operative drain placement, died of postoperative complications from hepatorenal failure with intractable ascites. Thirty-seven patients （39.4%） experienced postoperative complications. The extent of gastric resection did not influence the morbidity whereas serum aspartate aminotransferase level （P = 0.011） and transfusion did （P = 0.008）. The most common postoperative complication was ascites （13.9%） followed by wound infection （10.6%）. CONCLUSION： We concluded that the presence of compensated cirrhosis, i.e. Child class A, is not a contraindication against gastrectomy with D2 or more lymph node dissection, when curative resection for gastric cancer is possible. Hepatic reserve and meticulous hemostasis are the likely determinants of operative prognosis.

关键词： Gastric cancer Liver cirrhosis D2 lymph nodedissection Morbidity Mortality

Influence of a microscopic positive proximal margin in the treatment of gastric adenocarcinoma of the cardia

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World Journal of Gastroenterology 2006年第24期12卷 3883-3886页

作者： Jian-Guo Shen jae-ho cheong Woo-Jin Hyung Junuk Kim Seung-ho Choi Sung-hoon Noh Department of Surgery Yonsei University College ot'Medicine Seoul- 120-752 Korea ' Department of Surgical Oncology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou 310016 China

AIM： To investigate the influence of a positive proximal margin in total gastrectorny patients with gastric adenocarcinorna of the cardia. METhoDS： Medical records of 191 patients with total gastrectornies for adenocarcinorna of the cardia between 1995 and 2000 were reviewed. The clinicopathologic features associated with a positive margin were determined, and the predictors for survival were analyzed. RESULTS： The incidence of positive proximal margin was 8.4% （16/191）. The positive margins were associated with advanced diseases. The tumor size and the depth of tumor invasion were independent risk factors for a positive margin. The mean survival in the positive margin group was 33.9 mo as *** 62.4 mo in the negative group （P 〈 0.001）. however, the difference in survival lost significance in subgroup analysis according to stage. Multivariate analysis identified that a positive margin was not an independent prognostic factor for survival. CONCLUSION： A positive margin is more of an indication of advanced disease in patients with gastric adenocarcinoma of the cardia rather than an independent prognostic factor for survival.

关键词： Resection margin Gastric cancer Totalgastrectomy Outcome

Deciphering metastatic route-specific signals and their microenvironment interactions in peritoneal metastasis of gastric cancer

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Cancer Communications 2024年第4期44卷 514-517页

作者： Ki Tae Kim jae Eun Lee jae-ho cheong In Cho Yoon Young Choi Department of Molecular Genetics&Dental Pharmacology School of DentistrySeoul National UniversitySeoulRepublic of Korea Dental Research Institute and Dental Multi-omics Center Seoul National UniversitySeoulRepublic of Korea Portrai Inc. SeoulRepublic of Korea Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoulRepublic of Korea Department of Surgery Soonchunhyang Bucheon HospitalSoonchunhyang University College of MedicineBucheonRepublic of Korea

Gastric cancer(GC)is a pervasive global malignancy with high mortality rates due to distant metastasis[1].GC metastasis can occur via hematogenous route,peri-toneal route,and specifically through ovarian spread in females[2].Among these,peritoneal metastasis is the most prevalent and challenging condition to treat[3].The Cancer Genome Atlas(TCGA)has uncovered four molec-ular subtypes of GC:microsatellite instability,Epstein-Barr virus-related,chromosomal instability,and genomically stable[4].

关键词： metastasis peritoneal cancer

Single patient classifier as a prognostic biomarker in pT1N1 gastric cancer:Results from two large Korean cohorts

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Chinese Journal of Cancer Research 2021年第5期33卷 583-591页

作者： Yoon Young Choi Eunji Jang Hyunki Kim Kyoung-Mee Kim Sung hoon Noh Tae Sung Sohn Yong-Min Huh Ji Yeong An jae-ho cheong Department of Surgery CHA Ilsan Medical CenterCHA University School of MedicineGoyang-si 1205Korea Department of Surgery Yonsei University Health SystemSeoul 03722Korea Department of Radiology Yonsei University Health SystemSeoul 03722Korea Department of Pathology Yonsei University Health SystemSeoul 03722Korea Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea YUHS-KRIBB Medical Convergence Research Institute Seoul 03722Korea Brain Korea 21 PLUS Project for Medical Science Yonsei University College of MedicineSeoul 03722Korea

Objective:Benefits of adjuvant treatment in pT1 N1 gastric cancer(GC)remain ***,an effective biomarker for early GC is the need of the *** prognostic and predictive roles of single patient classifier(SPC)were validated in stageⅡ/Ⅲ*** this study,we aimed to elucidate the role of SPC as a biomarker for pT1 N1 ***:The present retrospective biomarker study(NCT03485105)enrolled patients treated for pT1 N1 GC between 1996 and 2012 from two large hospitals(the Y cohort and S cohort).For SPC,mRNA expression of four classifier genes(GZMB,WARS,SFRP4 and CDX1)were evaluated by real-time reverse transcription-polymerase chain reaction *** SPC was revised targeting pT1 stages and the prognosis was stratified as high-and lowrisk group by the expression of SFRP4,a representative epithelial-mesenchymal transition ***:SPC was evaluated in 875 patients(n=391 and 484 in the Y and S cohorts,respectively).Among 864 patients whose SPC result was available,41(4.7%)patients experience GC *** to revised SPC,254(29.4%)patients were classified as high risk[123(31.5%)and 131(27.1%)in the Y and S cohorts,respectively].The high risk was related to frequent recurrence in both Y and S cohort(log-rank P=0.023,Phort confirmed the high risk of revised SPC as a significant prognostic factor[hazard ratio(HR):4.402(2.293-8.449),P<0.001]of GC.A significant difference was not detected by SPC in the prognosis of patients in the presence and absence of adjuvant treatment(log-rank P=0.670).Conclusions:The present study revealed the revised SPC as a prognostic biomarker of pT1 N1 GC and suggested the use of the revised SPC for early-stage GC as like stageⅡ/Ⅲ.

关键词： Gastric cancer biomarker prognosis chemotherapy

Current practice of gastric cancer treatment

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Chinese Medical Journal 2014年第3期127卷 547-553页

作者： Yoon Young Choi Ji Yeong An Hyung-Il Kim jae-ho cheong Woo Jin Hyung Sung hoon Noh Department of Surgery Yonsei University Health System Yonsei University College of Medicine Seoul Republic of Korea

Objective The aim of this review was to overview the current practice of gastric cancer treatment including surgery and other adjuvant *** sources The review was based on data obtained from the published articles and main guidelines in the East and *** selection Articles with high level of evidence or current best evidence in each issue were selected to be *** Although varied adjuvant modalities have been proved to be benefit for treating gastric cancer,surgery is still the most important treatment strategy against gastric *** adapting to new technology is important but it should be balanced with an effort to establish sound scientific rationale that adheres to oncologic *** Future treatment of gastric cancer will be focused on tailored,personalized *** achieving it,collaboration across disciplines is *** the philosophy of caring for the patients with gastric cancer should be rooted in the realization of true patient benefit regardless of who is providing the *** these philosophies,we can shift the scientific and technological advances toward triumph over gastric cancer.

关键词： gastric cancer treatment oncology

Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials

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Cancer Communications 2022年第2期42卷 179-183页

作者： Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn ho Kyoung Hwang Gi hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee jae-ho cheong Hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee Department of Systems Biology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Republic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryCHA Bundang Medical CenterCHA UniversitySeongnam 13496Republic of Korea Department of GI Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoul 03722Republic of Korea Division of Thoracic Surgery Michael E.DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030USA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902USA Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841Republic of Korea Department of Surgery The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)*** two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes.

关键词： therapeutic subtypes prognosis

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进展期胃癌的外科治疗

中华消化外科杂志 2011年第6期10卷 409-418页

作者： Kyung Min Kim 胡彦锋 Ji Yeong An Hyoung LI Kim jae ho cheong Woo Jin Hyung Sung hoon Noh 首尔韩国延世大学医学院外科部首尔120752 广州南方医科大学南方医院普通外科广州510515

全球每年约有800000例胃癌新发病例，居于最常见的恶性肿瘤第4位，肿瘤相关死亡原因第2位。虽然胃癌发病率在西方国家持续下降，但是在亚洲、拉丁美洲和东欧依旧保持较高水平。据报道，全球大约42％的胃癌患者在中国。随着手术技术的改... 详细信息

全球每年约有800000例胃癌新发病例，居于最常见的恶性肿瘤第4位，肿瘤相关死亡原因第2位。虽然胃癌发病率在西方国家持续下降，但是在亚洲、拉丁美洲和东欧依旧保持较高水平。据报道，全球大约42％的胃癌患者在中国。随着手术技术的改进、综合治疗方法的进步以及早期诊断能力的提高，最近几十年胃癌的总体生存率得到逐步提升。

关键词：胃肿瘤手术治疗进展期

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes