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Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration

Bioactive Materials 2022年第5期7卷 118-129页

作者： Indong Jun Na Li jaehee Shin jaeho Park Young Jun Kim Hojeong Jeon Hyuk choi jae-gu cho Byoung Chan choi Hyung-Seop Han jae-Jun Song Environmental Safety Group Korea Institute of Science&Technology Europe(KIST-EUROPE)Saarbrücken66123Germany Department of Otorhinolaryngology-Head and Neck Surgery Korea University College of MedicineSeoul02841Republic of Korea Department of Medical Sciences Graduate School of MedicineKorea UniversitySeoul02841Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science&Technology(KIST)Seoul02792Republic of Korea Laser Surface Texturing Group AYECLUSGyeonggi-do14255Republic of Korea

Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular *** study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell(hMPC)cultures to assess the influences of the adherent direction,proliferation,and differentiation,and induce preconditioning-induced therapeutic ***,a topographical surface of commercially available culture dishes was achieved by femtosecond laser *** detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture ***-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat ***,electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated *** such,we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner,thus providing the basis for therapeutic strategies.

关键词： Topography Electrical field stimulation Femtosecond laser Human myogenic precursor cell Cell therapy

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A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong cho Byeori Kim Haehyun cho Taek-Young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

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Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.Robert Singh Gyanendra Prasad Joshi Woong cho School of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*cho and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Study on adhesively-bonded surface of tapered double cantilever specimen made of aluminum foam affected with shear force

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Journal of Central South University 2015年第12期22卷 4521-4527页

作者：孙洪鹏 cho jae-ung Division of Mechanical Engineering Graduate School Kongju National University Division of Mechanical and Automotive Engineering Kongju National University

Aluminum foam is widely used in diverse areas to minimize the weight and maximize the absorption of shock energy in lightweight structures and various *** presents a number of advantages,such as low density,incombustibility,non-rigidity,excellent energy absorptivity,sound absorptivity and low heat *** aluminum foam with an air cell structure was placed under the TDCB Mode II tensile load by using Landmark equipment manufactured by MTS to examine the shear failure *** angle of the tapered adhesively-bonded surfaces of specimens was designated as a variable,and three models were developed with the inclined angles differing from one another at 6°,8° and 10°.The specimens with the inclined angles of 6°,8° and 10° have the maximum reaction forces of 168 N,194 N when the forced displacements are 6,5 and 4.2 mm *** are three specimens with the inclined angles of 10°,8° and 6° in the order of maximum reaction *** the analysis result,the maximum equivalent stresses of 0.813 MPa and 0.895 MPa happened when the forced displacements of 6 mm and 5 mm proceeded at the models of 6° and 8°,respectively.A simulation was carried out on the basis of finite element method and the experimental *** results of the experiment and the simulation analysis are shown not different from each other ***,only a simulation could be confirmed to be performed in substitution of an experiment,which is costly and time-consuming in order to determine the shearing properties of materials made of aluminum foam with artificial data.

关键词： adhesive displacement force reaction shearing fracture characteristic tapered double cantilever beam(TDCB)

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Survival analysis based on human epidermal growth factor 2 status in stage Ⅱ-Ⅲ gastric cancer

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World Journal of Gastroenterology 2017年第41期23卷 7407-7414页

作者： Jang Ho cho jae Yun Lim jae Yong cho Division of Medical Oncology Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To investigate human epidermal growth factor 2(HER2) overexpression and validate its prognostic effect in stage Ⅱ-Ⅲ gastric *** We reviewed the data of patients who were diagnosed with gastric cancer between March 2008 and October 2013 at the Yonsei University Medical Center. Among these patients, 384 patients who met the inclusion criteria were analyzed retrospectively. RESULTS Thirty-two(8.3%) of the 384 stage Ⅱ-Ⅲ gastric cancer patients exhibited HER2 overexpression. The median follow-up duration was 26.0 mo. HER2-negative patients had superior recurrence-free survival(RFS) compared to HER2-positive patients(HR = 0.52, 95%CI: 0.30-0.89; P = 0.015). The median overall survival(OS) was significantly prolonged in the HER2-negative group compared with the HER2-positive group(55.0 mo vs 38.0 mo, HR = 0.43, 95%CI: 0.21-0.88, P = 0.021). OS was also prolonged in HER2-negative patients who received adjuvant chemotherapy compared to HER2-positive patients(55.0 vs 38.0mo, HR = 0.42, 95%CI: 0.18-1.00, P = 0.051). In patients who did not receive adjuvant chemotherapy,the median RFS was prolonged in the HER2-negative group compared to the HER2-positive group(not reached vs 12.0 mo, HR = 0.17, 95%CI: 0.06-0.49, P= 0.001). In a multivariate analysis, HER2 status(HR= 0.421, 95%CI: 0.206-0.861, P = 0.018) and Eastern Cooperative Oncology Group performance status(HR = 2.002, 95%CI: 1.530-2.618, P < 0.001) were independent predictors of *** Our findings showed that HER2-positive patients had inferior OS and RFS. Stage Ⅱ-Ⅲ HER2-positive patients might be potential candidates for targeted therapies involving trastuzumab.

关键词： Trastuzumab Gastric neoplasm Human epidermal growth factor 2

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Porous Microspheres Comprising CoSe2 Nanorods Coated with N-Doped Graphitic C and Polydopamine-Derived C as Anodes for Long-Lived Na-Ion Batteries

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Nano-Micro Letters 2022年第7期14卷 118-139页

作者： jae Seob Lee Rakesh Saroha Jung Sang cho Department of Engineering Chemistry Chungbuk National UniversityCheongjuChungbuk 361-763Republic of Korea

Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte *** microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume ***,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life *** instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively.

关键词： Spray pyrolysis Sodium-ion batteries Cobalt selenide nanorods Porous microspheres Dual carbon coating

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin cho Xuelian Jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Simple method for extracting the seasonal signals of photochemical reflectance index and normalized difference vegetation index measured using a spectral reflectance sensor

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Journal of Integrative Agriculture 2021年第7期20卷 1969-1986页

作者： jae-Hyun RYU Dohyeok OH jaeil cho Department of Applied Plant Science Chonnam National UniversityGwangju 61186Republic of Korea

A spectral reflectance sensor(SRS)fixed on the near-surface ground was developed to support the continuous monitoring of vegetation indices such as the normalized difference vegetation index(NDVI)and photochemical reflectance index(PRI).NDVI is useful for indicating crop growth/phenology,whereas PRI was developed for observing physiological ***,the seasonal change patterns of NDVI and PRI are two valuable pieces of information in a crop-monitoring ***,capturing the seasonal patterns is considered challenging because the vegetation index values estimated by the reflection from vegetation are often governed by meteorological conditions,such as solar irradiance and ***,unlike growth/phenology,the physiological condition has diurnal changes as well as seasonal *** study proposed a novel filtering method for extracting the seasonal signals of SRS-based NDVI and PRI in paddy rice,barley,and ***,the measurement accuracy of SRSs was compared with handheld spectrometers,and the R^(2)values between the two devices were 0.96 and 0.81 for NDVI and PRI,***,the experimental study of threshold criteria with respect to meteorological variables(i.e.,insolation,cloudiness,sunshine duration,and precipitation)was conducted,and sunshine duration was the most useful one for excluding distorted values of the vegetation *** data processing based on sunshine duration,the R^(2)values between the measured vegetation indices and the extracted seasonal signals of vegetation indices increased by approximately 0.002–0.004(NDVI)and 0.065–0.298(PRI)on the three crops,and the seasonal signals of vegetation indices became noticeably *** method will contribute to an agricultural monitoring system by identifying the seasonal changes in crop growth and physiological conditions.

关键词： photochemical reflectance index normalized difference vegetation index vegetation remote sensing spectral reflectance sensor

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Microstructure comparison of ZK60 alloy under casting,twin roll casting and hot compression

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Transactions of Nonferrous Metals Society of China 2010年第5期20卷 763-768页

作者：王守仁王敏 KANG Suk-bong cho jae-hyung School of Mechanical Engineering University of Ji'nan School of Materials Science and Engineering Shandong University Korea Institute of Materials Science 66 Sangnam-dongChangwon 641010Korea

The microstructures of ZK60 alloy under conventional direct as-casting (DC),twin roll casting (TRC) and twin roll casting followed by hot compression (TRC-HC) were analyzed by optical morphology (OM),electron backscatter diffraction (EBSD) and X-ray diffraction (XRD).The deformation condition of hot compression is 350 ℃,0.1 s?*** microstructural evolution under TRC-HC deformation followed by annealing at different temperatures and time was *** results show that TRC provides more modified microstructure compared with *** are found in TRC processing;dynamic recrystallization (DRX),shear bands and twins are found in TRC-HC.A short annealing time has little effect on hardness,while during a long time annealing,it is found that low annealing temperatures increase the micro-hardness and high temperature decreases it.

关键词： microstructural evolution anneal dynamic recrystallization static recrystallization twin-roll casting hot compression magnesium alloy ZK60

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