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Acupoint catgut embedding for simple obesity in animal studies:a systematic review and Meta-analysis

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中医杂志:英文版 2023年第5期43卷 860-867页

作者： ZHAO HuiYan JUN Purumea LEE Chaewon han Chang-hyun Korean Convergence Medical Science University of Science and Technology(UST)School of Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea KM Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea St.Johnsbury Academy Jeju 304Global edu-roDaejeong-eupSeogwipo-si 63644Republic of Kore

OBJECTIVE:To assess the efficacy of acupoint catgut embedding(ACE)for simple obesity in preclinical animal ***:We searched the following 14 electronic databases:PubM ed,Cochrane Library,EMBASE,Oriental Medicine Advanced Searching Integrated System,KoreaMed,Korean Studies Information Service System,Science-on,Research Information Sharing Service,Korea Citation Index,Korea Traditional Knowledge Portal,China Network Knowledge Infrastructure Database,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biology Medicine Database,from inception to November 2021 without language *** assessment was performed according to the guidelines of Animal Research:Reporting of in vivo experiments;and Metaanalysis was performed using Reviewer Manager 5.4.1 ***:Twenty-four studies involving 813 animals were ***-analysis showed that ACE was beneficial for weight control[n=40,MD=-50.63,95%CI(-57.59,-43.67),P<0.00001,I 2=0%]and reduced the Lee index[n=40,MD=-18.79,95%CI(-20.01,-17.57),P<0.00001,I 2=0%].However,when efficacy of ACE was compared with that of manual acupuncture,electroacupuncture,or oilistat therapy,statistical difference was not observed between the two ***:This systematic review suggests that ACE may be efficacious in treating ***,the analyses highlighted the necessity to perform welldesigned,higher-quality experiments.

关键词： obesity acupoint catgut embedding animal study Meta-analysis systematic review

Emission of particulate and gaseous pollutants from household laser processing machine

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Journal of Environmental Sciences 2021年第5期33卷 148-156页

作者： hyun Sik Ko Sang Bin Jeong Sooyeol Phyo Jiwon Lee jae Hee Jung Department of Mechanical Engineering Sejong UniversitySeoul 05006Republic of Korea Center for Environment Healthand Welfare ResearchKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Graduate School of Energy and Environment Korea UniversitySeoul 02841Republic of Korea Department o f Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Indoor air quality(IAQ) directly affects the health of occupants. Household manufacturing equipment(HME) used for hobbies or educational purposes is a new and unexplored source of air pollution. In this study, we evaluated the characteristics of particulate and gaseous pollutants produced by a household laser processing equipment(HLPE). Various target materials were tested using a commercial HLPE under various operating conditions of laser power and sheath air flow rate. The mode diameters of the emitted particles gradually decreased as laser power increased, while the particle number concentration(PNC) and particle emission rate(PER) increased. In addition, as the sheath air flow rate quadrupled from 10 to 40 L/min, the mode diameter of the emitted particles decreased by nearly 25%, but the effect on the PNC was insignificant. When the laser induced the target materials at 53 m W, the mode diameters of particles were 2.0 × 10^(4) particles/cm^(3). Particularly, analyses of sampled aerosols indicated that harmful substances such as sulfur and barium were present in particles emitted from leather. The carcinogenic gaseous pollutants such as acrylonitrile, acetaldehyde, 1,3-butadiene, benzene, and C 8 aromatics(ethylbenzene) were emitted from all target materials. In an actual indoor environment, the PNC of inhalable ultrafine particles(UFPs) was > 5 × 10^(4) particles/cm^(3) during 30 min of HLPE operation. Our results suggest that more meticulous control methods are needed, including the use of less harmful target materials along with filters or adsorbents that prevent emission of pollutants.

关键词： Indoor air quality(IAQ) Emission Laser processing Ultrafine particles(UFPs) Volatile organic compounds(VOCs)

Hepatic artery pseudoaneurysm caused by acute idiopathic pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2291-2294页

作者： Yeon Hwa Yu Joo hyun Sohn Tae Yeob Kim jae Yoon Jeong Dong Soo han Yong Cheol Jeon Min Young Kim Department of Internal Medicine Hanyang University College of MedicineGuriGyunggi-Do 471-701South Korea Department of Radiology Hanyang University College of MedicineGuri 471-701South Korea

Hepatic artery pseudoaneurysm(HAP) is a very rare disease but in cases of complication,there is a very high *** most common cause of HAP is iatrogenic trauma such as liver biopsy,transhepatic biliary drainage,cholecystectomy and *** may also occur with complications such as infections or inflammation associated with septic *** has been reported rarely in patients with acute *** far as we are aware,there is no report of a case caused by acute idiopathic pancreatitis,*** report a case of HAP caused by acute idiopathic pancreatitis which developed in a 61-year-old *** woman initially presented with acute pancreatitis due to unknown *** conservative management,her symptoms seemed to have *** eight days after admission,abdominal pain abruptly became worse *** computed tomography(CT) was rechecked and it detected a new HAP that was not seen in a previous abdominal *** retrograde cholangiopancreatography(ERCP) was performed because of a suspicion of hemobilia as a cause of aggravated abdominal *** confirmed hemobilia by observing fresh blood clots at the opening of the ampulla and several filling defects in the distal common bile duct on *** any particular treatment such as embolization or surgical ligation,HAP thrombosed *** months after discharge,abdominal CT demonstrated that HAP in the left lateral segment had disappeared.

关键词： Hepatic artery Pseudoaneurysm Pancreatitis Acute Hemobilia

Vertical graphene on flexible substrate,overcoming limits of crack-based resistive strain sensors

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npj Flexible Electronics 2022年第1期6卷 28-35页

作者： Hong Ryeol Na hyun Joo Lee jae Ho Jeon han-Jin Kim Sahng-Kyoon Jerng Sanjib Baran Roy Seung-hyun Chun Sunghun Lee Yong Ju Yun Department of Physics and Astronomy Sejong UniversitySeoul 05006Korea Graduate School of Energy and Environment(KU-KIST Green School) Korea UniversitySeoul 02841Korea Center for Energy Materials Research Korea Institute of Science and TechnologySeoul 02792Korea Graphene Research Institute Sejong UniversitySeoul 05006Korea

Resistive strain sensors(RSS)with ultrasensitivity have attracted much attention as multifunctional ***,since most ultrasensitive RSS are designed by cracked conductive metals,the sensing performance is severely degraded due to accumulated structural deformation with consecutive *** overcome such limitation,newly designed structures have been suggested,but the development of mechanosensors exhibiting superior stability and ultrasensitivity still remains a ***,we demonstrate that vertical graphene(VG)RSS with high sensitivity(gauge factor greater than 5000),remarkable durability(>10,000 cycles),and extraordinary resilience can serve multifunctional *** find that well-defined cracks on tufted network structure result in highly reversible resistance variation,especially revivable status even after broken current path,confirmed by microscopic in situ *** VG integrated with a wireless sensing system exhibits excellent timbre recognition *** findings provide inspirable insights for mechanosensing system,making VG a promising component for future practicable flexible sensor technologies.

关键词： strain durability Vertical

Unilateral pleuroparenchymal fibroelastosis as a rare form of idiopathic interstitial pneumonia:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4186-4192页

作者： jae-Ha Lee hang-Jea Jang Jin-han Park hyun-Kuk Kim Sunggun Lee Ji-Yeon Kim Seong-Ho Kim Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Pathology Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea

BACKGROUND Pleuroparenchymal fibroelastosis(PPFE)is a rare idiopathic interstitial pneumonia characterized by predominantly upper lobe involvement with pleural fibrosis and subjacent parenchymal ***,there have been increasing reports of PPFE,and PPFE might coexist with other interstitial lung diseases in the lower lobe and upper ***,cases of unilateral PPFE are *** SUMMARY A 75-year-old Korean male presented to our hospital with chronic dry cough and exertional *** patient’s symptoms started 6 mo previously and had been gradually *** the time of presentation,he felt dyspnea when walking at his own *** findings suggested PPFE,but the lesion was localized in the upper lobe of the right *** multidisciplinary discussion,a transbronchial lung biopsy in the right upper lobe revealed collapsed alveoli with parenchymal fibroelastosis,and elastic van Gieson staining demonstrated septal elastosis with intra-alveolar collagenosis,which met the histopathologic criteria of definite *** multidisciplinary discussion in an experienced interstitial lung disease center,we confirmed the diagnosis of unilateral ***,we confirmed the progression of PPFE on radiologic findings during the followup *** Clinicians should consider PPFE,even in cases with unilateral,predominantly upper lung involvement in interstitial lung disease patients through multidisciplinary discussion.

关键词： Interstitial lung disease Pleuroparenchymal fibroelastosis Progression Unilateral Multidisciplinary discussion Case report

Diagnostic performance of the current risk-stratified approach with computed tomography for suspected choledocholithiasis and its options when negative finding

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 366-372页

作者： hyun Woo Lee Tae Jun Song Do hyun Park Sang Soo Lee Dong-Wan Seo Sung Koo Lee Myung-Hwan Kim jae Hyuck Jun Ji Eun Moon Yeon han Song Digestive Disease Center and Research Institute Department of Internal MedicineSoonchunhyang University School of MedicineBucheonKorea Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoulKorea Division of Gastroenterology Department of Internal MedicineUniversity of Eulji College of MedicineEulji Medical CenterDaejeonKorea Department of Biostatistics Clinical trial centerSoonchunhyang University Bucheon HospitalBucheonKorea

Background:Several studies evaluated the current guideline of the American Society for Gastrointestinal Endoscopy(ASGE)and reported only suboptimal *** study evaluated the diagnostic performance of the ASGE guideline based on computed tomography(CT)and role of endoscopic ultrasonography(EUS)and magnetic resonance cholangiopancreatography(MRCP)in patients with suspected choledocholithiasis but negative CT ***:Patients with suspected choledocholithiasis undergoing ERCP between January 2016 and January 2017 were retrospectively *** patients underwent CT to detect *** or MRCP was performed when the CT scan showed negative *** were classified into the high and intermediate-risk groups,based on predictors from the ASGE ***:Of 583 patients with suspected choledocholithiasis,340(58.3%)had stones on ERCP(65.9%in the high-risk group and 40.6%in the intermediate-risk group).The accuracy of ASGE guideline for CT was 63.98%(79.12%sensitivity,42.80%specificity)and 36.02%(20.88%sensitivity,57.20%specificity)in the high-risk and intermediate-risk groups,*** 103 patients in the high-risk group underwent both CT and US,the accuracy of CT was higher than that of US for detecting choledocholithiasis(78.64%vs.53.40%),with a significant difference in area under the curve(AUC)(0.78 vs.0.59,Phan that of MRCP(90.91%vs.82.76%),but with no significant difference in AUC(0.91 vs.0.83,P=0.347).Conclusions:CT-based ASGE guideline showed superior diagnostic performance than US for predicting *** diagnostic options,EUS or MRCP,with negative CT finding showed comparable ***,the diagnostic modality should be selected based on availability,experience,cost,and contraindications.

关键词： Choledocholithiasis ASGE guideline Accuracy Endoscopic ultrasound Magnetic resonance cholangiopancreatography

Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network

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Journal of Animal Science and Biotechnology 2018年第3期9卷 574-584页

作者： jae Yong han Hyo Gun Lee Young hyun Park Young Sun Hwang Sang Kyung Kim Deivendran Rengaraj Byung Wook Cho Jeong Mook Lim Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University Department of Animal Science and Technology Chung-Ang University Department of Animal Science College of Natural Resources and Life Sciences Pusan National University

Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well ***: We found that chicken NANOG(c NANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I(EGK.I) to X. However, c POUV was not expressed during fol iculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, c SOX2 could not be detected during fol iculogenesis and intrauterine embryonic development. Instead of c SOX2, c SOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as c ENS-1, c KIT, c LIN28 A, c MYC, c PRDM14, and c SALL4 began to be dramatical y upregulated between *** and ***: These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and c SOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around *** to VI I.

关键词： Avian Embryonic development NANOG Pluripotency Transcriptional factor

Germline-competent stem cell in avian species and its application

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Asian Journal of Andrology 2015年第3期17卷 421-426页

作者： jae Yong han hyung Chul Lee Tae Sub Park Department of Agricultural Biotechnology College of Agriculture and Life Sciences and Research Institute of Agriculture and Life Sciences Seoul National University Seoul 151-921 Korea Graduate School of International Agricultural Technology and Institute of Green-Bio Science and Technology Seoul National University Pyeongchang-gun Gangwon-do 232-916 Korea

Germ cells are the only cell type in the body that can transfer genetic information to the next generation. Germline-competent stem cells can self-renew and contribute to the germ cell lineage giving rise to pluripotent stem cells under specific conditions. Hence far, studies on germline-competent stem cells have contributed to,the generation of avian model systems and the conservation of avian genetic resources. In this review, we focus on previous studies on germline-competent stem cells from avian species, mainly chicken germline-competent stem cells, which have been well established and characterized. We discuss different sources of germline-competent stem cells and recent advances for the future applications in birds.

关键词： birds germline-competent stem cells primordial germ cells spermatogonial stem cells

Microstructure and Mechanical Properties of Mg-Al-Ca-Nd Alloys Fabricated by Gravity Casting

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Journal of Materials Science & Technology 2008年第1期24卷 85-88页

作者： Hyeon-Taek Son jae-Seol Lee Ik-hyun Oh Chang-Seog Kang Korea Institute of Industrial Technology 1110-90ryong-dong Buk-gu Gwangju 500-480 South Korea

The aims of this study are to investigate the effects of Nd addition in the Mg-Al-Ca alloys on microstructure and mechanical *** of as-cast Mg-5Al-3Ca alloy containing Nd consists ofα-Mg matrix, eutectic phase and Al-Nd rich intermetallic *** Nd addition was increased,α-Mg matrix morphology was changed from dendritic to equiaxed grains and average value of grain size was *** addition to Mg-5Al-3Ca based alloys resulted in the formation of Al-Nd rich intermetallic compounds at grain boundary andα-Mg matrix *** these Al-Nd rich intermetallic compounds were dispersed *** these alloys,two kinds of eutectic phases were observed,*** irregular-shape structure at grain boundary and fine needle-shape structure in theα-Mg matrix *** is found that the ultimate strength showed the maximum value of 271 MPa at Mg-5Al-3Ca-2Nd alloy and elongation was decreased as the addition of Nd was increased.

关键词： Mg-AI-Ca alloy Neodymium (Nd) Rare earth element