检索结果-南通市图书馆

Proportion and clinical features of never-smokers with non-small cell lung cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第2期36卷 81-87页

作者： jaeyoung Cho Sun Mi Choi Jinwoo Lee Chang-hoon Lee sang-Min Lee dong-Wan kim jae-Joon Yim young Tae kim Chul-Gyu Yoo young whan kim Sung Koo han young Sik park Department of Internal Medicine Seoul National University HospitalSeoul 110-744Republic of Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul 110-744Republic of Korea

Background: The proportion of never?smokers with non?small cell lung cancer(NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never?smokers with NSCLC in a large single ***: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December ***: Of the 1860 NSCLC patients, 707(38.0%) were never?smokers. The proportions of women(83.7% vs. 5.6%) and adenocarcinoma(89.8% vs. 44.9%) were higher among never?smokers than among ever?smokers. Significantly more never?smokers were diagnosed at a younger median age(65 vs. 68 years, P homa kinase rearrangements(7.8% vs. 2.8%, P homolog mutations(5.8% vs. 9.6%, P ntly encountered in never?smokers than in ever?smokers. Never?smokers showed longer su= 0.021) were less frequervival after adjust?ing for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations(hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003).Conclusions: More than one?third of the Korean patients with NSCLC were never?smokers. NSCLC in never?smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever?smokers.

关键词： Non-small cell lung carcinoma Never-smoker Epidermal growth factor receptor KRAS Prognosis

PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer： a retrospective study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第4期19卷 458-462页

作者： Sung han kim Weon Seo park Bo Ram park Jungnam Joo jae young Joung ho Kyung Seo Jinsoo Chung Kang Hyun Lee Department of Urology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Pathology Center for Prostate Cancer Research Institute and Hospital of National Cancer Center Goyang Korea Department of Statistics Biometric Research Branch Clinical Research Coordination Center Research Institute and Hospital of National Cancer Center Goyang Korea.

Prostate cancer is the second most common male cancer, with half of all patients going on to develop metastases. To better identify patients at high risk for prostate cancer progression and reduce prostate cancer-related mortality, improved prognostic factors are required. In this study, we used immunohistochemistry （IHC） to determine the prognostic values of multiple tissue biomarkers in hormone-na＇l＇ve prostatectomy specimens of prostate cancer. Using 510 prostatectomy specimens collected between 2002 and 2012, IHC analysis was performed for Cerb-2, Cyclin D1, VEGF, EGFR, Rb, PSCA, p53, Bcl-2, Cox-2, PMS2, and Ki-67 on formalin-fixed paraffin-embedded sections. The Cox proportional hazard model was used to determine the predictive risk factors for biochemical recurrence （BCR） of prostate cancer. During a median 44-month follow-up, 128 （25.1%） patients developed BCR. A multivariate regression analysis revealed that Ki-67 （hazard ratio [HR]. 1.60, P = 0.033）, PSCA （HR： 0.42, P 〈 0.001）, and Cox-2 （HR： 2.05, P = 0.003） were the only significant prognostic tissue markers of BCR. Resection margin status （HR： 1.67, P = 0.010）, pathologic pTO/l/2 stage （vs pT3/4; HR： 0.20, P = 0.002）, preoperative PSA levels （HR.. 1.03, P 〈 0.001）, biopsied （HR： 1.30, P = 0.022） and pathologic （HR： 1.42, P = 0.005） Gleason scores, and prostate size （HR： 0.97, P = 0.003） were significant clinicopathologic factors. The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for BCR in patients with clinically localized prostate cancer following radical prostatectomy.

关键词： biomarker immunohistochemistry prostatectomy recurrence tissue microarray

Undiagnosed Borrmann type Ⅱ gastric cancer due to necrosis and regenerative epithelium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第28期20卷 9621-9625页

作者： Joon Hur jae Hyuck Chang Byung Kee kim hoon young Ko Jong Hwan Lee Soo Jeong kim Mi Ae Song Tae ho kim Chang whan kim Sok Won han Division of Gastroenterology Department of Internal MedicineBucheon St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Department of Clinical Pathology Bucheon St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine

Endoscopic biopsy is essential to the proper diagnosis and treatment of gastric ***,the results of endoscopic biopsy are not always the same as what is expected based on gross endoscopic *** results of endoscopic biopsy can be negative for malignancy in Borrmann typeⅣadvanced gastric cancer(AGCa)or gastric ***,in the case of typeⅡAGCa,repeated biopsies negative for malignancy have not been reported.A 49-year-old male patient underwent esophagogastroduodenoscopy three times due to large gastric ulcer suspected to be Borrmann typeⅡ***,three repeat endoscopic biopsies with multiple specimens showed necrosis and superficial regenerative epithelium without malignant *** patient underwent laparoscopic distal gastrectomy with D2 lymph node *** surgical specimen revealed that the mucosal layer was completely replaced with regenerative epithelium without cancer cells.

关键词： Endoscopy Biopsy Stomach neoplasm Stomach ulcer Regeneration

Spontaneous rupture of hepatic metastasis from a thymoma: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第44期22卷 9860-9864页

作者： ho jae kim Yong Eun park Min Seo Ki Se Ju Lee Seung Hun Beom Dai hoon han young Nyun park Jun Yong park Department of Internal Medicine Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine Department of Pathology Yonsei University College of Medicine

Bleeding resulting from spontaneous rupture of the liver is an infrequent but potentially life threatening complication that may be associated with an underlying liver disease. A hepatocellular carcinoma or hepatic adenoma is frequently reported is such cases. however, hemoperitoneum resulting from a hepatic metastatic thymoma is extremely rare. Here, we present a case of a 62-year-old man with hypovolemic shock induced by ruptured hepatic metastasis from a thymoma. At the first hospital admission, the patient had a 45-mm anterior mediastinal mass that was eventually diagnosed as a type A thymoma. The mass was excised, and the patient was disease-free for 6 years. He experienced sudden-onset right upper quadrant pain and was again admitted to our hospital. We noted large hemoperitoneum with a 10-cm encapsulated mass in S5/8 and a 2.3-cm nodular lesion in the right upper quadrant of the abdomen. He was diagnosed with hepatic metastasis from the thymoma, and he underwent chemotherapy and surgical excision.

关键词： Spontaneous rupture Hemoperitoneum Transarterial chemoembolization Hepatic metastasis Thymoma

Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第3期8卷 211-218页

作者： jae Seung Kang Taesung park youngmin han Seungyeon Lee jae Ri kim hongbeom kim Wooil Kwon Sun-Whe kim Jin Seok Heo Seong ho Choi dong Wook Choi Song Cheol kim Tae ho hong dong Sup Yoon Joon Seong park sang jae park Sung-Sik han Sae-Byeol Choi Joo Seop kim Chang-Sup Lim Jin-young Jang Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Statistics and Interdisciplinary Program in Biostatistics Seoul National UniversitySeoulRepublic of Korea Department of Mathematics and Statistics Sejung UniversitySeoulRepublic of Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryUlsan University College of Medicine and Asan Medical CenterSeoulRepublic of Korea Department of Surgery Seoul St.Mary’s HospitalThe Catholic University of KoreaCollege of MedicineSeoulRepublic of Korea Pancreatobiliary Cancer Clinic Department of SurgeryGangnam Severance HospitalYonsei University College of MedicineSeoulRepublic of Korea Center for Liver Cancer National Cancer CenterGyeonggidoRepublic of Korea Department of Surgery Korea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Department of Surgery Kangdong Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Surgery Seoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoul National University College of MedicineSeoulRepublic of Korea

Background:Although several prediction models for the occurrence of postoperative pancreatic fistula(POPF)after pancreatoduodenectomy(PD)exist,all were established using Western ***-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index(BMI)are *** purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean ***:Nine tertiary university hospitals in the Republic of Korea ***'preoperative characteristics,intraoperative factors,and pathologic findings were *** grades were determined according to the 2016 International Study Group on Pancreatic Surgery *** POPF risk models(Callery,Roberts,and Mungroop)were selected for external ***:A total of 1,898 PD patients were enrolled.A non-pancreatic disease diagnosis[hazard ratio(HR),1.856;95%confidence interval(CI),1.223–2.817;P=0.004),higher preoperative BMI(HR,1.069;95%CI,1.019–1.121;P=0.006),and soft pancreatic texture(HR,1.859;95%CI,1.264–2.735;P=0.002)were independent risk factors for clinically relevant POPF(CR-POPF).The area under the receiver operating characteristic curve(AUC)values were 0.61,0.64,and 0.63 on the Callery,Roberts,and Mungroop models,respectively;all were lower than those published in each external validation ***:Western POPF prediction models performed less well when applied to Korean ***,a large-scale Eastern-specific and externally validated POPF prediction model is needed.

关键词： Pancreatic fistula pancreatoduodenectomy(PD) predictive score

Clinical outcomes and predictive factors in oral corticosteroid-refractory active ulcerative colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第2期19卷 265-273页

作者： han ho Jeon Hyun Jung Lee Hui Won Jang Jin young Yoon Yoon Suk Jung Soo Jung park Sung Pil hong Tae Il kim Won ho kim jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Brain Korea 21 Project for Medical Science Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To evaluate the clinical outcomes and prognostic factors after intravenous corticosteroids following oral corticosteroid failure in active ulcerative colitis ***:Consecutive patients with moderate to severe ulcerative colitis who had been treated with a course of intravenous corticosteroids after oral corticosteroid therapy failure between January 1996 and July 2010 were recruited at Severance hospital,Seoul,South *** disease activity was measured by the Mayo score,which consists of stool frequency,rectal bleeding,mucosal appearance at flexible sigmoidoscopy,and Physician Global *** retrospectively evaluated clinical outcomes at two weeks,one month,three months,and one year after the initiation of intravenous corticosteroid *** weeks outcomes were classified as responders or *** month,three month and one year outcomes were classified into prolonged response,steroid dependency,and ***:Our study included a total of 67 eligible *** two weeks,56(83.6%) patients responded to intravenous *** one month,complete remission was documented in 18(32.1%) patients and partial remission in 26(46.4%).Eleven patients(19.7%) were refractory to the *** three months and one year,we found 37(67.3%) and 25(46.3%) patients in prolonged response,ten(18.2%) and 23(42.6%) patients in corticosteroid dependency,8(14.5%) and 6(11.1%) patients with no response,*** 9 patients were underwent elective proctocolectomy within 1 *** duration of oral corticosteroid therapy(> 14 d vs ≤ 14 d,P = 0.049) and lower hemoglobin level(≤ 11.0 mg/dL vs >11.0 mg/dL,P = 0.02) were found to be poor prognostic factors for response at two *** one year outcome,univariate analysis revealed that only a partial Mayo score(≥ 6 vs <6,P = 0.057) was found to be associated with a poor ***:The duration of oral corticosteroid therapy and lower hemoglobin level were strongly associ

关键词： Clinical outcome Prognosis Corticosteroid Ulcerative colitis

Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第1期12卷 146-149页

作者： Ki-jae park hong-Jo Choi Sung-Heun kim sang-young han Sook-Hee hong Jin-han Cho Hyung-ho kim Department of Surgery Dong-A University College of MedicinePusanSouth Korea Department of Internal Medicine Dong-A University College of Medicine.PusanSouth Korea Department of Pathology Dong-A University College of MedicinePusanSouth Korea Department of Radiology Dong-A University College of MedicinePusanSouth Korea Department of Surgery Seoul National University Bundang HospitalBundangKyunggi-DoSouth Korea

We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp. The patient was a 56-year-old man who suffered from rectal bleeding for one day. He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge. Several hours after admission to our coloproctology clinic, he suddenly presented with lower abdominal cramping pain with rectal bleeding during his bowel preparation using polyethylene glycol electrolyte solution. An emergency colonoscopy revealed that the invaginated colon with polypoid mass was protruded to the lower rectum. Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge. CT scan showed the typical finding of intussusception. We performed laparoscopic anterior resection and anastomosis after the sponge-on-the-stickassisted manual reduction. The permanent pathologic finding showed villotubular adenoma of the sigmoid colon.

关键词： Sigmoidorectal intussusception Adenomatouspolyp Laparoscopic resection

Design of Korean Standard Modular Buoy Body Using Polyethylene Polymer Material for Ship Safety

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2016年第1期4卷 65-73页

作者： young whan park Tae Wan kim jae Sub Kwak In Kwan kim Ji Eon park Kyong ho Ha Department of Mechanical Engineering Pukyong National University Busan Korea Department of R & D Newmarine Engineering co. Ltd. Busan Korea Department of Electric Energy Dongwon Science and Technology University Busan Korea

Buoy is the structure which is floated on sea surface in order to indicate the presenting obstacle such as reef and shallow sea and to show the direction of sea route to ship during sailing. Generally, the conventional material of buoy is steel and it has some problems. Firstly this steel light buoy has safety risk in case of collision between ship and steel buoy. Secondly steel buoy revealed high corrosion environment of salted water and oxide and corrosion of steel can lead to marine pollution. Thirdly it needs too much maintain cost because of its heavy weight. In this study, in order to overcome these problems we changed the buoy material from conventional steel body to polyethylene body. Polymer buoy body was designed with module type part and it can reduce total weight up to 43.12%. To evaluate the strength of that part, the structure analysis simulation was carried out with respect to stress, displacement, and strain. Maximum stress was 1.667 × 107 N/m2 and it was 25% of yielding stress of base material. Maximum displacement and strain were 3.164 mm and 0.00433353 and they are too small value and in safe range with comparing to total length of body. The stability of polymer buoy body was compared with conventional buoy with respect to center of gravity, center of buoyancy, metacenter, oscillation period, and tilt angle by wind, tidal current, and wave. Every value was improved comparing conventional one and we can get more stable buoy. Therefore the new polymer buoy body could prove its safety and stability.

关键词： Polymer Buoy Polyethylene Float Weight Reduction Structure Analysis Stability Evaluation

Newly developed autoimmune cholangitis without relapse of autoimmune pancreatitis after discontinuing prednisolone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第41期18卷 5990-5993页

作者： Ji Hun kim jae Hyuck Chang Sung Min Nam Mi Jeong Lee Il ho Maeng Jin young park Yun Sun Im Tae ho kim Chang whan kim Sok Won han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

A 57-year-old man presented with a 2-wk history of painless jaundice and weight Iossl He had a large ill- defined enhancing mass-like lesion in the uncinate pro- cess of the pancreas with stricture of the distal common bile duct. Aspiration cytology of the pancreatic mass demonstrated inflammatory cells without evidence of malignancy. Total serum immunoglobulin G level was slightly elevated, but IgG4 level was normal. After the 2-wk 40 mg prednisolone trial, the patient＇s symptoms and bilirubin level improved significantly. A follow-up computed tomography （CT） scan showed a dramatic resolution of the pancreatic lesion. A low dose steroid was continued. After six months he self-discontinued prednisolone for 3 wk, and was presented with jaundice again. ACT scan showed newly developed intrahepatic biliary dilatation and marked concentric wall thickening of the common hepatic duct and the proximal common bile duct without pancreatic aggravation. The patient＇ s IgG4 level was elevated to 2.51 g/L. Prednisolone was started again, after which his serum bilirubin level became normal and the thickening of the bile duct was resolved. This case suggests that autoimmune pancre- atitis can progress to other organs that are not involved at the initial diagnosis, even with sustained pancreatic remission.

关键词： Autoimmune disease Pancreatitis Cholan-gitis Prednisolone