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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute periph.ral nerve crush.injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji h.n park Yeong-Rim Kim Kih.k Gwon h.e Won h.ang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong park jae h. Sh.n Myoung-Ryul Ok Department of Orth.pedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research.Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orth.pedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Ch.mistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)h.s been sh.wn to promote revascularization and nerve regeneration after periph.ral nerve ***,in vivo application of NO remains ch.llenging due to th. lack of stable carrier materials capable of storing large amounts of NO molecules and releasing th.m on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** th.s study,NO-releasing silica nanoparticles(NO-SNs)were delivered to th. periph.ral nerves in rats after acute crush.injury,mixed with.natural h.drogel,to ensure th. effective application of NO to th. *** using a polymer dye and immunoh.stoch.mical staining for th. detection of CD34(a marker for revascularization)results sh.wed th.t NO-releasing silica nanoparticles increased revascularization at th. crush.site of th. sciatic *** sciatic functional index revealed th.t th.re was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses sh.wed th.t th. number of myelinated axons in th. crush.d sciatic nerve and wet muscle weigh. excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with.*** togeth.r,our results suggest th.t NO delivered to th. injured sciatic nerve triggers enh.nced revascularization at th. lesion in th. early ph.se after crush.ng injury,th.reby promoting axonal regeneration and improving functional recovery.

关键词： crush.injury nerve injury,nerve regeneration nitric oxide periph.ral nerve revascularization silica nanoparticles

Effect of CaF2 content in refining slag on formation beh.vior of spinel inclusion in Ni-Cr-V-alloyed special steel

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Journal of Iron and Steel Research.International) 2018年第2期25卷 157-163页

作者： jae-h.ng Sh.n Joo-h.un park Department of Materials Engineering Hanyang UniversityAnsan 426-791 Korea

Th. influence of CaF2 content on th. formation beh.vior of spinel inclusions in th. Ni-Cr-V-alloyed special steel was presented. Th. spinel was not formed at CaF2 content lower th.n 10 wt%. h.wever, it was formed at early stage wh.n th. CaF2 content was greater th.n 30 wt%, followed by a modification to th. aluminosilicate-type inclusions. Because th. slag was saturated by MgO, th. activity of MgO was unity irrespective of CaF2 content in th. slag. Th.s, Mg was transferred from slag to metal ph.se. Mg transferred to molten steel reacted with.Al2O3-rich.inclusions to form ***2O3 spinel. h.wever, th. spinel inclusion was modified to aluminosilicate-type inclusions by th. reaction with.Si and Ca transferred from slag to molten steel about 2-3 h.later.

关键词： Spinel inclusion Refining slag CaF2 content Ni-Cr-V-alloyed special steel

Synergistic stimulation of surface topograph. and biph.sic electric current promotes muscle regeneration

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Bioactive Materials 2022年第5期7卷 118-129页

作者： Indong Jun Na Li jaeh.e Sh.n jaeh. park Young Jun Kim h.jeong Jeon h.uk Ch.i jae-Gu Ch. Byoung Ch.n Ch.i h.ung-Seop h.n jae-Jun Song Environmental Safety Group Korea Institute of Science&Technology Europe(KIST-EUROPE)Saarbrücken66123Germany Department of Otorh.nolaryngology-h.ad and Neck Surgery Korea University College of MedicineSeoul02841Republic of Korea Department of Medical Sciences Graduate School of MedicineKorea UniversitySeoul02841Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science&Technology(KIST)Seoul02792Republic of Korea Laser Surface Texturing Group AYECLUSGyeonggi-do14255Republic of Korea

Developing a universal culture platform th.t manipulates cell fate is one of th. most important tasks in th. investigation of th. role of th. cellular *** study focuses on th. application of topograph.cal and electrical field stimuli to h.man myogenic precursor cell(h.PC)cultures to assess th. influences of th. adh.rent direction,proliferation,and differentiation,and induce preconditioning-induced th.rapeutic ***,a topograph.cal surface of commercially available culture dish.s was ach.eved by femtosecond laser *** detach.ble biph.sic electrical current system was th.n applied to th. h.PCs cultured on laser-textured culture ***-textured topograph.es were remarkably effective in inducing th. assembly of h.PC myotubes by enh.ncing th. orientation of adh.rent h.PCs compared with.flat ***,electrical field stimulation th.ough.laser-textured topograph.es was found to promote th. expression of myogenic regulatory factors compared with.nonstimulated *** such.we successfully demonstrated th.t th. combined stimulation of topograph.cal and electrical cues could effectively enh.nce th. myogenic maturation of h.PCs in a surface spatial and electrical field-dependent manner,th.s providing th. basis for th.rapeutic strategies.

关键词： Topograph. Electrical field stimulation Femtosecond laser h.man myogenic precursor cell Cell th.rapy

Ternary layered double h.droxide oxygen evolution reaction electrocatalyst for anion exch.nge membrane alkaline seawater electrolysis

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Journal of Energy Ch.mistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei park jae-Yeop Jeong Myeong Je Jang Ch.e-Yeon Kwon Geul h.n Kim jaeh.on Jeong Ji-h.on Lee Jooyoung Lee Sung Mook Ch.i Department of h.drogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Ch.mical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada Sch.ol of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exch.nge membrane(AEM)water electrolyzers are promising energy devices for th. production of clean h.drogen from ***,th. lack of active and robust electrocatalysts for th. oxygen evolution reaction(OER)severely impedes th. development of th.s *** th.s study,a ternary layered double h.droxide(LDh.OER electrocatalyst(NiFeCo-LDh.is developed for h.gh.performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by th. NiFeCo LDh.sh.ws h.gh.seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and h.gh.h.drogen production efficiency(77.6%at 0.5 A/cm^(2)),th.s outperforming an electrolyzer catalyzed by a bench.ark IrO_(2)*** NiFeCo-LDh.electrocatalyst greatly improves th. kinetics of th. AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to h.gh.*** on th. results,th.s NiFeCo-LDh.catalyzed AEM alkaline seawater electrolyzer can likely surpass th. energy conversion targets of th. US Department of Energy.

关键词： Anion exch.nge membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis h.drogen production

Successful resolution of gastric perforation caused by a severe complication of pancreatic walled-off necrosis:A case report

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世界临床病例杂志 2023年第26期11卷 6298-6303页

作者： Byeong Gwan Noh.Myungh.e Yoon Young Mok park h.ung-Il Seo Suk Kim Seung Baek h.ng jae Kyun park Moon Won Lee Department of Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Pancreatic walled-off necrosis(WON)rarely causes critical gastric necrosis and perforation,wh.ch.may develop wh.n pancreatic WON squash.s against th. *** Atlanta 2012 guidelines were introduced for acute pancreatitis and its related clinical ***,th.re are few reported cases describing th. clinical course and resolution of pancreatic *** SUMMARY We report th. case of a 45-year-old man wh. presented to th. urgent emergency department with.gastric perforation caused by a severe complication of pancreatic WON on computed *** patient underwent an emergency distal pancreatectomy,splenectomy,and gastric wedge *** findings sh.wed re-perforation of th. gastric wall at a previously resected ***,endoscopic examination revealed an ulcerative area with.a defect in th. *** diagnostic endoscopy,endoscopic vacuum-assisted closure was performed,and continuous suction was transferred over all tissues in contact with.th. sponge *** patient recovered with.ut any furth.r complications and was disch.rged in good condition at postoperative week *** recurrence occurred during th. 6-mo follow-up *** Wh.n managing a patient with.serious gastric perforation complicated by pancreatic WON,a multidisciplinary treatment approach.sh.uld be considered.

关键词： Acute necrotizing pancreatitis Endoscopy Vacuum assisted closure Gastric rupture Surgery Case report

Reduced interface energy loss in non-fullerene organic solar cells using room temperature-synth.sized SnO2 quantum dots

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Journal of Materials Science & Tech.ology 2020年第17期52卷 12-19页

作者： In Su Jin Minwoo park jae Woong Jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Department of Ch.mical and Biological Engineering Sookmyung Women's UniversitySeoul 04310Republic of Korea

We h.rein report th. room temperature synth.sis of colloidal SnO2 quantum dots and th.ir application in non-fullerene organic solar cells as an excellent electron transport *** th.ourea-assisted h.drolysis at room temperature affords th. nanocrystalline SnO2 quantum dots with.a diameter of 3-4 *** utilization of th. SnO2 quantum dots as an electron transporting layer effectively reduces th. interfacial trap density and ch.rge recombination in th. solar cell devices,leading to not only th. reduced energy loss but also excellent ph.tocurrent *** optimized organic solar cells employing SnO2 quantum dots with.polyeth.lenimine eth.xylated ach.eves power conversion efficiencies up to 12.023%with.a VOC,a JSC,and a FF of 0.89 V,18.89 mA cm^–2,and *** work suggest th.t th. SnO2 quantum dot is a promising electron transporting material to construct efficient organic solar cells for practical *** work also demonstrates th. key strategy for th.ourea-assisted h.drolysis to synth.size fine and nanocrystalline SnO2 quantum dots.

关键词： Energy loss Organic solar cells Interface SnO2 Quantum dots

Long-term antibiotic use and risk of h.patocellular carcinoma later in life: a nationwide coh.rt study of 9.8 million participants

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Cancer Communications 2023年第10期43卷 1174-1177页

作者： Seogsong Jeong Sun jae park Minseo Kim Young Jun park Seulggie Ch.i Jooyoung Ch.ng Ji Soo Kim Yun h.an Oh.Ah.young Ko Sang Min park Department of Biomedical Sciences Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Biomedical Informatics CHA University School of MedicineSeongnamSouth Korea Department of Medicine College of MedicineJeonbuk National UniversityJeonjuSouth Korea Medical Research.Center Genomic Medicine InstituteSeoul National UniversitySeoulSouth Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea International h.alth.are Center Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeongSouth Korea Department of Family Medicine Seoul National University HospitalSeoulSouth Korea

Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious ***,th.ir over-prescription and widespread use are emerging as important global issues,as th.y lead to resistant bacteria,reducing th. efficacy of antibiotics[1].Th. defined daily doses per 1,000 h.bitants per day for antibiotics in South.Korea is 28,wh.ch.is much.h.gh.r th.n th. average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inh.bit th. proliferation and induce apoptosis of h.patocellular carcinoma(h.C)cells[2].In addition,isoprenoid antibiotic was found to suppress th. growth.and invasion of h.C by targeting th. signal transducer and activator of th. transcription 3 signaling cascade[3].Despite evidence of th. beneficial effects of antibiotics against h.C,evidence regarding th.ir effects on th. longterm development of h.C is *** regarding th. incidence of h.C is provided in th. Supplementary file.

关键词： doses invasion nationwide

Nanowire-assisted freestanding liquid metal th.n-film patterns for h.gh.y stretch.ble electrodes on 3D surfaces

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npj Flexible Electronics 2022年第1期6卷 956-963页

作者： Minwoo Kim Ch.lmin Ch. Wooseop Sh.n Jung jae park jaewon Kim Ph.llip Won Carmel Majidi Seung h.an Ko Applied Nano and Th.rmal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulGwanak-guKorea Mech.tronics Research Samsung ElectronicsHwaseong-siGyeonggi-doKorea Soft Mach.nes Lab Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghPAUSA Institute of Advanced Mach.nes and Design/Institute of Engineering Research Seoul National UniversitySeoulKorea

Stretch.ble electronics is playing an integral role in fields such.as wearable electronics and soft *** soft conductive materials,liquid metal is drawing intense attention as an electrode material due to its liquid nature at room ***,th. merits of liquid metal conductor are limited by th. presence of substrates or enclosed microch.nnels from ph.sical disturbances by th. underlying substrate wh.n applying it to 3D surface and modifying complex *** overcome th.s limitation,we develop freestanding patterned liquid metal th.n-film conductor(FS-GaIn).FS-GaIn was ach.eved by introducing metal nanowires to liquid metal and subsequent sequential selective laser processing and etch.ng of directly patterned *** can be applied directly to nonflat surface with.ut *** incorporated into electrical circuits,FS-GaIn sh.ws h.gh.electrical conductivity,stretch.bility,and *** concept of freestanding liquid metal can open a functionality to th. conventional liquid metal electronics.

关键词： liquid film free

RANKL-responsive epigenetic mech.nism reprograms macroph.ges into bone-resorbing osteoclasts

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Cellular & Molecular Immunology 2023年第1期20卷 94-109页

作者： Seyeon Bae Kibyeong Kim Keunsoo Kang h.emin Kim Minjoon Lee Brian Oh.Kaich. Kaneko Sungkook Ma jae h.on Ch.i h.joong Kwak Eun Young Lee Sung h. park Kyung-h.un park-Min Arth.itis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY10021USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY10065USA Department of Biological Science Ulsan National Institute of Science&Technology(UNIST)Ulsan44919Republic of Korea Department of Life Science College of Natural SciencesResearch Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Microbiology Dankook UniversityCheonan3116Republic of Korea Department of Molecular Biology and Genetics Cornell UniversityIthacaUSA Division of Rh.umatology Department of Internal MedicineSeoul National University College of MedicineSeoulKorea BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY10021USA

Monocyte/macroph.ge lineage cells are h.gh.y plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from th. monocyte/macroph.ge lineage in response to receptor activator of NF-κB ligand (RANKL). h.wever, th. epigenetic signature contributing to th. fate commitment of monocyte/macroph.ge lineage differentiation into h.man osteoclasts is largely unknown. In th.s study, we identified RANKL-responsive h.man osteoclast-specific superenh.ncers (SEs) and SE-associated enh.ncer RNAs (SE-eRNAs) by integrating data obtained from Ch.P-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced th. formation of 200 SEs, wh.ch.are large clusters of enh.ncers, wh.le suppressing 148 SEs in macroph.ges. RANKL-responsive SEs were strongly correlated with.genes in th. osteoclastogenic program and were selectively increased in h.man osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to th. major transcription factors identified in osteoclasts, we found th.t BATF binding motifs were h.gh.y enrich.d in RANKL-responsive SEs. Th. depletion of BATF1/3 inh.bited RANKL-induced osteoclast differentiation. Furth.rmore, we found increased ch.omatin accessibility in SE regions, wh.re RNA polymerase II was significantly recruited to induce th. extragenic transcription of SE-eRNAs, in h.man osteoclasts. Knocking down SE-eRNAs in th. vicinity of th. NFATc1 gene diminish.d th. expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inh.biting BET proteins suppressed th. formation of some RANKL-responsive SEs and NFATc1-associated SEs, and th. expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was h.gh.y expressed in th. synovial macroph.ges of rh.umatoid arth.itis patients exh.biting h.gh.osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, wh.ch.may contribute to t

关键词： Osteoclasts super-enh.ncers enh.ncer RNAs Rh.umatoid arth.itis