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Impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy

World Journal of Gastroenterology 2012年第31期18卷 4175-4181页

作者： Chul-Gyu kim sungho Jo jae sun kim Department of Nursing Cheongju UniversityCheongjuChungbuk 360-764South Korea Department of Surgery Dankook University College of MedicineCheoanChungnam 330-714South Korea Health Insurance Review and Assessment Service Seoul 137-706South Korea

AIM:To evaluate the impact of surgical volume on nationwide hospital mortality after pancreaticoduodenectomy(PD) for periampullary tumors in South ***:Periampullary cancer patients who underwent PD between 2005 and 2008 were analyzed from the database of the Health Insurance Review and Assessment Service of South Korea.A total of 126 hospitals were divided into 5 categories,each similar in terms of surgical volume for each *** used hospital mortality as a quality indicator,which was defined as death during the hospital stay for PD,and calculated adjusted mortality through multivariate logistic models using several confounder ***:A total of eligible 4975 patients were enrolled in this *** annual surgical volume of hospitals was markedly varied,ranging from 215 PDs in the very-high-volume hospital to < 10 PDs in the verylow-volume *** route,type of medical security,and type of operation were significantly different by surgical *** overall hospital mortality was 2.1% and the observed hospital mortality by surgical volume showed statistical *** volume,age,and type of operation were independent risk factors for hospital death,and adjusted hospital mortality showed a similar difference between hospitals with observed *** result of the HosmerLemeshow test was 5.76(P = 0.674),indicating an acceptable appropriateness of our regression ***:The higher-volume hospitals showed lower hospital mortality than the lower-volume hospitals after PD in South Korea,which were clarified through the nationwide database.

关键词： Hospital mortality Pancreaticoduodenecto-my South Korea Databases Factual Logistic models Risk factors

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： jae-Hong kim Ruqayya Afridi Il-sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji Hyun Song Su-Yeon Choi Young sun kim sun Young Yang Kyung-Do Han Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using ***,even in participants without diabetes,a higher CV risk was associated with an increased CRC *** Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： Han-Ning Xuan Yuan Hyun sung kim Gye Ryeol Park jae Eun Ryu Ji Eun kim In Young Kang Hye Young kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease

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Effects of monoglyceride blend on systemic and intestinal immune responses,and gut health of weaned pigs experimentally infected with a pathogenic Escherichia coli

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Journal of Animal Science and Biotechnology 2025年第1期16卷 345-363页

作者： Sangwoo Park Shuhan sun Lauren Kovanda Adebayo O.Sokale Adriana Barri Kwangwook kim Xunde Li Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA BASF Corporation Florham Park 07932USA BASF SE LampertheimGermany Department of Animal Science Michigan State UniversityEast LansingMI 48824USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA

Background Monoglycerides have emerged as a promising alternative to conventional practices due to their biolog-ical activities,including antimicrobial ***,few studies have assessed the efficacy of monoglyceride blend on weaned pigs and their impacts on performance,immune response,and gut health using a disease chal-lenge ***,this study aimed to investigate the effects of dietary monoglycerides of short-and medium-chain fatty acids on the immunity and gut health of weaned pigs experimentally infected with an enterotoxigenic Escherichia coli *** Pigs supplemented with high-dose zinc oxide(ZNO)had greater(P<0.05)growth performance than other treatments,but no difference was observed in average daily feed intake between ZNO and monoglycerides groups during the post-challenge *** in ZNO and antibiotic groups had lower(P<0.05)severity of diarrhea than control,but the severity of diarrhea was not different between antibiotic and monoglycerides *** fed with monoglycerides or ZNO had lower(P<0.05)serum haptoglobin on d 2 or 5 post-inoculation than *** in ZNO had greater(P<0.05)goblet cell numbers per villus,villus area and height,and villus height:crypt depth ratio(VH:CD)in duodenum on d 5 post-inoculation than pigs in other *** supplemented with monoglyc-erides,ZNO,or antibiotics had reduced(P<0.05)ileal crypt depth compared with control on d 5 post-inoculation,contributing to the increase(P=0.06)in VH:***,pigs in ZNO expressed the lowest(P<0.05)TNFa,IL6,IL10,IL12,IL1A,IL1B,and PTGS2 in ileal mucosa on d 5 post-inoculation,and no difference was observed in the expres-sion of those genes between ZNO and *** of ZNO and antibiotic had significant impacts on metabolic pathways in the serum compared with control,particularly on carbohydrate and amino acid metabolism,while limited impacts on serum metabolites were observed in monoglycerides group when compared with cont

关键词： Diarrhea Enterotoxigenic Escherichia coli Gut health Monoglycerides Systemic immunity Weaned pigs

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Confined metal-acid units for boosting benzene hydroalkylation via efficient activation of key intermediate

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Nano Research 2025年第2期18卷 193-205页

作者： Jianpeng Li Kaihang sun Jinyu Huang Yongheng Jia Shufang Zhao Young Dok kim Li Han Baojun Li Jie Feng Zhongyi Liu Zhikun Peng College of Chemistry Henan Institutes of Advanced TechnologyCollege of Ecology and EnvironmentState Key Laboratory of Coking Coal Resources Green ExploitationZhengzhou UniversityZhengzhou 450001China Department of Chemistry Sungkyunkwan UniversitySuwon 16419Republic of Korea

Precisely *** micro-nanoscale characteristics and synergistic effect of metal-acid sites to regulate the distribution of hydroconversion products are significant but *** protonated carbocation intermediates triggered by tandem reaction on metal-acid region hinder target product formation due to their high reactivity and *** M/Zeolite hydroconversion catalysts,which often excel in simple synthesis,ease of separation and ***,they usually consist of sterically unconstrained metal centers which are isolated from acid sites,only providing limited coupling-selectivity to target ***,metal nanoparticles enveloped in acidic zeolite frameworks were developed and used for investigating the process of hydroalkylation of benzene to *** show that appropriate metal encapsulation comprising adequate efficient metal-acid units successfully avoids the more thermodynamically favorable hydrogenation of cyclohexene to cyclohexane,but steers to alkylation of cyclohexene with benzene to *** resulted in the highest cyclohexylbenzene yield of 47.7%among the reported work,and surpassed the performance of all supported M/Zeolite *** and theoretical results supported that the abundant bifunctional metal-acid units enhance the activation frequency and probability of intermediate *** work might provide insights for the integration strategy of dual active site and guidance for the construction of efficient"metal-acid balance"in tandem reactions.

关键词： tandem reaction benzene hydroalkylation metal-acid balance metal encapsulation intermediate transformation

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Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 163-176页

作者： Shin, Yu-Bin Ham, Su Been kim, Ha-Neul kim, Mi-Ju Ko, jae-Woong Lee, jae-Wook Park, Young-Jo kim, Jung-Hyung Lee, Hyo-Chang Jung, Young Hwa Lee, Jung Woo Ma, Ho Jin Korea Inst Mat Sci Nano Mat Res Div Chang Won 51508 Gyeongsangnam South Korea Pusan Natl Univ Dept Mat Sci & Engn Pusan 46241 South Korea Korea Res Inst Stand & Sci Semicond Integrated Metrol Team Daejeon 34113 South Korea Korea Aerosp Univ Dept Semicond Sci Engn & Technol Goyang 10540 South Korea Korea Aerosp Univ Sch Elect & Informat Engn Goyang 10540 South Korea Pohang Accelerator Lab PLS II Beamline Div Pohang 37673 South Korea

High-entropy ceramics exhibit novel intrinsic properties. Hence, they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical components. Recently, the semiconductor industry has faced a demand for higher-performance chips, necessitating higher aspect ratios in wafer fabrication and further miniaturization of linewidths. Therefore, novel materials with high plasma etching resistance and minimal contaminant generation are needed. The plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging challenge. In this study, we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency, dense microstructure, and minimal residual pores. A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase homogeneity. An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. These comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications, such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

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Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2025年第1期14卷 203-211页

作者： Dae-Hyun kim Seong-Eun Park Eun-Ju kim Seung-Ho Seo Kwang-Moon Cho sun-jae Kwon Hong-Seok Son Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841Korea Sonlab Inc. Seoul 02841Korea AccuGene Inc. Incheon 21999Korea

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy *** of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 *** complex bacterial community was simplified to two genera,Tetragenococcus and Halanaerobium,after approximately 0.55 years of *** genera,such as Saccharomyces,Cladosporium,Candida,and Aspergillus,were relatively dominant,no clear pattern was identified in fungal community *** longitudinal metabolite profile demonstrated that approximately half(55.8%)of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid *** the static microbial community,the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy *** study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

关键词： Fish sauce Salted anchovy Long-term fermentation Microbiome Metabolite

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Estimation of deformed laser heat sources and thermal analysis on laser assisted turning of square member

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Journal of Central South University 2012年第2期19卷 402-407页

作者： kim jae-hyun kim Kwang-sun CHOI Jun-young LEE Choon-man Department of Mechanical Design and Manufacturing Engineering Changwon National University

Laser assisted machining （LAM） has difficulties in estimating temperature after applying a LAM process due to its very small heat input area, large energy and movement. In particular, in the case of laser assisted turning （LAT） process, it is more difficult to estimate the temperature after preheating because it has a shape of ellipse when a laser heat source is rotated. A prediction method and thermal analysis method for heat source shapes were proposed as a square shaped member was preheated. The temperature distribution was calculated according to the rotation of the member. Compared with the results of the former study, the maximum temperature of the calculation results, 1 407.1 ℃, is 8.5 ℃ higher than that of the square member, which is 1 398.6 ℃. In a LAT process for a square member, the maximum temperature is 1 850.8 ℃. It is recognized that a laser power control process is required because square members show a maximum temperature that exceeds a melting temperature at around a vertex of the member according to the rotation.

关键词： laser assisted machining laser assisted turning laser preheating laser power control

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Rational strategy for power doubling of monolithic multijunction Ⅲ-Ⅴ photovoltaics by accommodating attachable scattering waveguides

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Light(Science & Applications) 2024年第11期13卷 2734-2744页

作者： Shin Hyung Lee Hyo Jin kim jae-Hyun kim Gwang Yeol Park sun-Kyung kim sung-Min Lee School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Optoelectronic Convergence Research Center Korea Photonics Technology InstituteGwangju 61007Republic of Korea Department of Applied Physics Kyung Hee UniversityYongin 17104Republic of Korea Department of Electrical Engineering Hanyang UniversitySeoul 04763Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea

While waveguide-based light concentrators offer significant advantages,their application has not been considered an interesting option for assisting multijunction or other two-terminal tandem solar *** this study,we present a simple yet effective approach to enhancing the output power of transfer-printed multijunction InGaP/GaAs solar *** utilizing a simply combinable waveguide concentrator featuring a coplanar waveguide with BaSO4 Mie scattering elements,we enable the simultaneous absorption of directly illuminated solar flux and indirectly waveguided *** deployment of cells is optimized for front-surface photon collection in monofacial *** systematic comparisons across various waveguide parameters,supported by both experimental and theoretical quantifications,we demonstrate a remarkable improvement in the maximum output power of a 26%-efficient cell,achieving an enhancement of~93%with the integration of the optimal scattering ***,a series of supplementary tests are conducted to explore the effective waveguide size,validate enhancements in arrayed cell module performance,and assess the drawbacks associated with rear *** findings provide a comprehensive understanding of our proposed approach towards advancing multi-junction photovoltaics.

关键词： waveguide scattering power

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