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Utilization of biomarkers for the prognostic prediction of cardiac arrest survivors using a multi-modal approach

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World Journal of Emergency Medicine 2024年第2期15卷 131-134页

作者： Changshin Kang Yeonho You Jung soo Park Byeong Kwon Park jae Kwang Lee Byung Kook Lee Department of Emergency Medicine College of MedicineChungnam National UniversityDaejeon 35015Republic of Korea Department of Emergency Medicine Chungnam National University HospitalDaejoen 35015Republic of Korea Department of Emergency Medicine Konyang University HospitalCollege of MedicineDaejeon 35015Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolChonnam National University HospitalGwangju 61469Republic of Korea

International guidelines for post-cardiac arrest care recommend using multi-modal strategies to avoid the withdrawal of life-sustaining therapy(WLST)in patients with the potential for neurological recovery.[1]However,a clear methodology for multi-modal approaches has yet to be ***-specific enolase(NSE)is currently the only recommended biomarker,and the European Resuscitation Council(ERC)and the European SocietyofIntensiveCareMedicine(ESICM)have proposed a cutoff value of 60μg/L at 48 and/or 72 h after the return of spontaneous circulation(ROSC)as a multimodal prognostic tool for predicting poor neurological outcomes.

关键词： cardiac modal return

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-jae Son soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal Byungkwon yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad Naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar soo Yeong Cho Seunghwan Jeong jaewoo Kim Jung Min Oh Sangwoon Park Youngjin Jeong Chong Min Koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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黄海大海洋生态系滨海湿地保护:进展与建议

国家公园（中英文） 2024年第4期2卷 272-280页

作者：曲方圆 jae-Won yoo 王守强自然资源部第一海洋研究所渤海海峡生态通道野外科学观测研究站青岛266061 Korea Institute of Coastal Ecology Inc. Bucheon 14449

黄海大海洋生态系(YSLME)滨海湿地是东亚—澳大利西亚候鸟的中转站和越冬栖息地,对东亚-澳大利西亚迁徙路线的候鸟至关重要。由于过去几十年的经济发展,中国和韩国都开垦了大量的滨海湿地,因此生境丧失被确定为是对YSLME的一个重大跨界... 详细信息

黄海大海洋生态系(YSLME)滨海湿地是东亚—澳大利西亚候鸟的中转站和越冬栖息地,对东亚-澳大利西亚迁徙路线的候鸟至关重要。由于过去几十年的经济发展,中国和韩国都开垦了大量的滨海湿地,因此生境丧失被确定为是对YSLME的一个重大跨界威胁。为缓解这一跨界威胁,YSLME二期项目在其战略行动计划中提出数项管理行动计划,同时,旨在2030年前保护30%海洋的全球生物多样性保护目标(3030目标)也得到了通过。因此,重点介绍了中国和韩国在湿地保护法律法规、滨海湿地保护地建设、公众意识以及国际合作等方面的进展,并简要介绍了朝鲜的滨海湿地保护情况,为更好地解决滨海湿地丧失这一跨界威胁和实现3030目标提供了建议。YSLME滨海湿地保护主要进展为:中韩两国逐渐完善其湿地保护法律法规体系、早期滨海湿地面积急剧丧失的趋势在近年来得到缓解、两国都建立了越来越多的滨海湿地保护地、提升公众意识已经体现在各级法律法规中、中韩之间有持续的滨海湿地国际合作交流活动。对于未来的保护工作,提出了四点建议:扩大滨海湿地保护地面积、保护迁徙动物的生态廊道、加强YSLME滨海湿地保护地网络建设以及增强保护地信息的可获得性。

关键词：黄海大海洋生态系滨海湿地保护进展建议

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Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

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Journal of Magnesium and Alloys 2022年第9期10卷 2516-2533页

作者： Man soo Joun Mohd Kaswandee Razali jae Dong yoo Min Cheol Kim Jeong Muk Choi ReCAFT Gyeongsang National UniversityGraduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea Gyeongsang National University Graduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea MFRC Research CenterJinju 52818South Korea Jinhap Daejeon 34302South Korea

Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated *** traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain *** coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural ***,metallurgy-related values can be calculated directly from the flow stress *** the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range.

关键词： Flow stress Power law model Piecewise bilinear function Numerical analysis Microstructural prediction Peak strain

Real-Time Demand Response Management for Controlling Load Using Deep Reinforcement Learning

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Computers, Materials & Continua 2022年第12期73卷 5671-5686页

作者： Yongjiang Zhao jae Hung yoo Chang Gyoon Lim Department of Computer Engineering Chonnam National UniversityYeosu59626Korea

With the rapid economic growth and improved living standards,electricity has become an indispensable energy source in our ***,the stability of the grid power supply and the conservation of electricity is *** following are some of the problems facing now:1)During the peak power consumption period,it will pose a threat to the power *** and improving the power distribution infrastructure requires high maintenance costs.2)The user’s electricity schedule is unreasonable due to personal behavior,which will cause a waste of *** load as a vital part of incentive demand response(DR)can achieve rapid response and improve demand-side *** load by manually formulating rules,some devices are selective to be adjusted during peak power ***,it is challenging to optimize methods based on manual *** paper uses SoftActor-Critic(SAC)as a control algorithm to optimize the control *** results show that through the coordination of the SAC to control load in CityLearn,realizes the goal of reducing both the peak load demand and the operation costs on the premise of regulating voltage to the safe limit.

关键词： Demand response controlling load SAC CityLearn

Defect-rich spinel ferrites with improved charge collection properties for efficient solar water splitting

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Journal of Advanced Ceramics 2023年第3期12卷 612-624页

作者： Runfa Tan yoo jae Jeong Qu Li Minje Kang In Sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea

Spinel zinc ferrite(ZnFe_(2)O_(4),ZFO)is a potential photoanode material for photoelectrochemical(PEC)water splitting because of its ideal bandgap(1.9–2.1 eV)and superior chemical stability in aqueous ***,the low charge collection efficiency significantly hinders the improvement in PEC ***,we report an ultrafast and effective flame activation route to enhance the charge collection properties of ***,high-temperature flame(>1300℃)facilitated surface and grain boundary diffusions,increasing the grain size and connectivity of the ZFO ***,the reducing atmosphere of the flame enabled the formation of surface defects(oxygen vacancy and Fe^(2+)),thereby increasing the charge carrier density and surface adsorption ***,these two factors promoted charge transport and transfer kinetics,resulting in a 10-fold increase in the photocurrent density over the unactivated ***,we deposited a thin Al_(2)O_(3)overlayer to passivate the ZFO surface and then the NiFeOx oxygen evolution catalyst(OEC)to expedite hole injection into the *** surface passivation and OEC deposition led to a remarkable photocurrent density of~1 mA/cm^(2)at 1.23 V versus the reversible hydrogen electrode,which is the highest value among all reported ZFO ***,the NiFeOx/Al_(2)O_(3)/F-ZFO photoanode achieved excellent photocurrent stability over 55 h(96%retention)and superior faradaic efficiency(FE>94%).Our flame activation method is also effective in improving the photocurrent densities of other spinel ferrites:CuFe_(2)O_(4)(93 times),MgFe_(2)O_(4)(16 times),and NiFe_(2)O_(4)(12 times).

关键词： spinel ferrites flame activation defect-rich surface charge collection photoelectrochemical(PEC) water splitting

Computed tomography coronary angiography after excluding myocardial infarction:high-sensitivity troponin versus risk score-guided approach

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World Journal of Emergency Medicine 2023年第6期14卷 428-433页

作者： Won jae yoo Shin Ahn Bora Chae Won Young Kim Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republicof Korea

BACKGROUND:Patients with suspected acute coronary syndrome (ACS) in whom myocardial infarction has been ruled out are still at risk of having obstructive coronary artery disease (CAD).This rate is higher among patients with intermediate high-sensitivity troponin I (hsTnI) concentrations (5 ng/L to 99th percentile) than low concentrations (<5 ng/L).Therefore,an intermediate concentration has been suggested as a candidate for downstream investigation with computed tomography coronary angiography(CTCA).We tried to compare the HEART score-guided ***-guided approach for identifying obstructive ***:From a prospective cohort study of patients presenting to the emergency department with suspected ACS,433 patients without elevated hsTnI who also underwent CTCA were selected and *** performances of hsTnI concentration and HEART score were compared using sensitivity,specificity,positive predictive value (PPV),and negative predictive value (NPV).RESULTS:Overall,120 (27.7%) patients had obstructive *** with intermediate hsTnI concentrations were more likely to have obstructive CAD than those with low hsTnI concentrations(40.0%vs.18.1%);patients with non-low-risk HEART scores (≥4 points) were also more likely to have obstructive CAD than those with low-risk scores (0 to 3 points)(41.0%vs.7.6%).The HEART score had higher sensitivity and NPV for detecting obstructive CAD in each classification than hsTnI concentration (sensitivity:89.2%vs.63.3%;NPV:92.4%vs.81.9%,respectively).CONCLUSION:After excluding myocardial infarction in patients with suspected ACS,adding the HEART score for selecting candidates for CTCA could improve patient risk stratification more accurately than relying on hsTnI concentration.

关键词： Chest pain Coronary artery disease Acute coronary syndrome Troponin HEART score

Extracorporeal membrane oxygenation for lung cancer-related life-threatening hypoxia:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8974-8979页

作者： Seung soo yoo Shin Yup Lee Sun Ha Choi Department of Internal Medicine Kyungpook National UniversityDaegu 41404South Korea Lung Cancer Center Kyungpook National University Chilgok HospitalDaegu 41404South Korea

BACKGROUND Life-threatening hypoxia can occur in patients with lung cancer due to bronchial *** membrane oxygenation(ECMO)can be used as a bridge therapy for patients with severe hypoxia not relieved by conventional mechanical ***,the usefulness of chemotherapy in patients with lung cancer receiving ECMO therapy is not well *** SUMMARY A 53-year-old man visited the emergency room with worsening dyspnea for 1 mo.A series of imaging and diagnostic tests were performed,and stageⅢB(cT4N2M0)lung cancer was eventually *** hospital day 3,he experienced dyspnea and hypoxia that was not relieved with oxygen support via a high-flow nasal *** was initiated because his respiratory condition did not improve even with mechanical *** patient then underwent gemcitabine/cisplatin chemotherapy without dose reduction while on *** two cycles of chemotherapy,there was a decrease in the size of the primary tumor in the right main *** the completion of concurrent chemoradiotherapy,a computed tomography scan revealed further improvement in the right main bronchus *** months after a lung cancer diagnosis,the patient did well without any *** ECMO is a potential bridge therapy for respiratory failure in patients with central airway obstruction secondary to lung cancer.

关键词： Extracorporeal membrane oxygen Lung cancer Hypoxia Respiratory failure Chemoradiotherapy Case report