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Prevalence and prognosis of acute pancreatitis in critically ill patients with COVID-19

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 399-402页

作者： Dongju Kang SuHo park Changkyo Oh YuJin Kim JinBae Kim SangHoon park myung Seok Lee jaeKeun park Department of Internal Medicine Kangnam Sacred Heart HospitalHallym University College of MedicineSeoul 07441Korea

Background:Coronavirus disease 2019(COVID-19)is a global pandemic *** addition to the well-known respiratory and fever symptoms,gastrointestinal symptoms have also been *** study aimed to evaluate the prevalence and prognosis of patients with COVID-19 infection complicated with acute pancreatitis in intensive care unit(ICU).Methods:This was a retrospective observational cohort study,and patients aged 18 years or older,ad-mitted into the ICU in a single tertiary center from January 1,2020,to April 30,2022 were *** were identified by electronic medical records and reviewed *** primary outcome was the prevalence of acute pancreatitis among ICU patients with *** secondary outcomes were the length of hospital stay,need for mechanical ventilation(MV),need for continuous renal replacement therapy(CRRT),and in-hospital ***:A total of 4133 patients,admitted into the ICU,were *** these patients,389 were infected by COVID-19,and 86 were diagnosed with acute ***-19 positive patients were more likely to present with acute pancreatitis than COVID-19 negative patients(odds ratio=5.42,95%confidence interval:2.35-6.58,P<0.01).However,the length of hospital stay,need for MV,need for CRRT,and in-hospital mortality were not significantly different between acute pancreatitis patients with and without COVID-19 ***:Severe COVID-19 infections may cause acute pancreas damage in critically ill ***-ever,the prognosis may not differ between acute pancreatitis patients with and without COVID-19 infec-tion.

关键词： Acute pancreatitis COVID-19 Coronavirus infections Intensive care unit

Reduced interface energy loss in non-fullerene organic solar cells using room temperature-synthesized SnO2 quantum dots

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Journal of Materials Science & Technology 2020年第17期52卷 12-19页

作者： In Su Jin Minwoo park jae Woong Jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea Department of Chemical and Biological Engineering Sookmyung Women's UniversitySeoul 04310Republic of Korea

We herein report the room temperature synthesis of colloidal SnO2 quantum dots and their application in non-fullerene organic solar cells as an excellent electron transport *** thiourea-assisted hydrolysis at room temperature affords the nanocrystalline SnO2 quantum dots with a diameter of 3-4 *** utilization of the SnO2 quantum dots as an electron transporting layer effectively reduces the interfacial trap density and charge recombination in the solar cell devices,leading to not only the reduced energy loss but also excellent photocurrent *** optimized organic solar cells employing SnO2 quantum dots with polyethylenimine ethoxylated achieves power conversion efficiencies up to 12.023%with a VOC,a JSC,and a FF of 0.89 V,18.89 mA cm^–2,and *** work suggest that the SnO2 quantum dot is a promising electron transporting material to construct efficient organic solar cells for practical *** work also demonstrates the key strategy for thiourea-assisted hydrolysis to synthesize fine and nanocrystalline SnO2 quantum dots.

关键词： Energy loss Organic solar cells Interface SnO2 Quantum dots

Dendrite Spacing Selection during Directional Solidification of Pivalic Acid-Ethanol System

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Journal of Materials Science & Technology 2008年第3期24卷 340-342页

作者： myung-Jin Suk Young-Min park Youn-Che Kim Department of Materials and-Metallurgical Engineering Kangwon National University

Unidirectional solidification of pivalic acid （PVA）-ethanol （Eth） mixture was performed to examine whether an allowable range of primary dendrite spacing definitely exists at a given growth velocity and how the range is history-dependent. PVA-0.59 wt pct Eth was unidirectionally solidified in the range of growth velocity 0.5-64 μm/s at the temperature gradient of 2.3 K/ram. Sequential change in growth velocity was imposed to determine the upper and lower limits for the allowable range of stable spacing. An allowable range of the steady state primary spacing was observed at a given growth velocity, and the extent of the range seems to be dependent on the degree to which step-increase or step-decrease in growth velocity is accomplished. As the degree of sequential change in growth velocity increases, the history-dependence of the selection for the primary dendrite spacing tends to disappear.

关键词： Dendrite spacing History-dependent Spacing selection Pivalic acid-ethanol

Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1026-1039页

作者： Yoo-Jin park Won-Ki Pang myung-Geol Pang Department of Animal Science&Technology and BET Research Institute Chung-Ang UniversityAnseongGyeonggi‑do17546Republic of Korea

Background Comparative and comprehensive omics studies have recently been conducted to provide a comprehensive understanding of the biological mechanisms underlying ***,because these huge omics datasets often contain irrelevant information,editing strategies for summarizing and filtering the data are necessary prerequisite steps for identifying biomarkers of male ***,we attempted to integrate omics data from spermatozoa with normal and below-normal fertility from boars and bulls,including transcriptomic,proteomic,and metabolomic *** enrichment analysis was conducted and visualized using g:Profiler,Cytoscape,EnrichmentMap,and AutoAnnotation to determine fertility-related biological functions according to *** In particular,gamete production and protein biogenesis-associated pathways were enriched in bull spermatozoa with below-normal fertility,whereas mitochondrial-associated metabolic pathways were enriched in boar spermatozoa with normal *** results indicate that below-normal fertility may be determined by aberrant regulation of protein synthesis during spermatogenesis,and the modulation of reactive oxygen species generation to maintain capacitation and the acrosome reaction governs boar sperm *** Overall,this approach demonstrated that distinct molecular pathways drive sperm fertility in mammals in a species-dependent ***,we anticipate that searching for species-specific signaling pathways may aid in the discovery of fertility-related biomarkers within large omics datasets.

关键词： Integrated signaling pathways Male fertility Metabolomics Proteomics Spermatozoa transcriptomics

Histogram equalization using a reduced feature set of background speakers' utterances for speaker recognition

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Frontiers of Information Technology & Electronic Engineering 2017年第5期18卷 738-750页

作者： myung-jae KIM Il-ho YANG Min-seok KIM Ha-jin YU School of Computer Science University of Seoul

We propose a method for histogram equalization using supplement sets to improve the performance of speaker recognition when the training and test utterances are very short. The supplement sets are derived using outputs of selection or clustering algorithms from the background speakers' utterances. The proposed approach is used as a feature normalization method for building histograms when there are insufficient input utterance *** addition, the proposed method is used as an i-vector normalization method in an i-vector-based probabilistic linear discriminant analysis(PLDA) system, which is the current state-of-the-art for speaker verification. The ranks of sample values for histogram equalization are estimated in ascending order from both the input utterances and the supplement set. New ranks are obtained by computing the sum of different kinds of ranks. Subsequently, the proposed method determines the cumulative distribution function of the test utterance using the newly defined ranks. The proposed method is compared with conventional feature normalization methods, such as cepstral mean normalization(CMN), cepstral mean and variance normalization(MVN), histogram equalization(HEQ), and the European Telecommunications Standards Institute(ETSI) advanced front-end methods. In addition, performance is compared for a case in which the greedy selection algorithm is used with fuzzy C-means and K-means *** YOHO and Electronics and Telecommunications Research Institute(ETRI) databases are used in an evaluation in the feature space. The test sets are simulated by the Opus Vo IP codec. We also use the 2008 National Institute of Standards and Technology(NIST) speaker recognition evaluation(SRE) corpus for the i-vector system. The results of the experimental evaluation demonstrate that the average system performance is improved when the proposed method is used, compared to the conventional feature normalization methods.

关键词： Speaker recognition Histogram equalization i-vector

Comparison of excyclotorsion following graded inferior oblique recession for primary versus secondary inferior oblique overaction

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1281-1286页

作者： Donghun Lee Won jae Kim myung Mi Kim Department of Ophthalmology Catholic University of Daegu School of MedicineDaegu 42472Republic of Korea Department of Ophthalmology Yeungnam University Medical CenterDaegu 42415Republic of Korea Nune Eye Hospital Daegu 2179Republic of Korea

AIM:To compare the changes in excyclotorsion after inferior oblique(IO)recession in patients with primary and secondary inferior oblique overaction(IOOA).METHODS:We retrospectively analyzed the data obtained from patients with IOOA who underwent graded IO *** patients were followed up for at least 3 mo after *** photographs were taken preand postoperatively,and the sum of the angles of torsion in both eyes was used to analyze changes in *** were divided into two groups:those diagnosed with primary IOOA were enrolled in the 1’IOOA group,and those diagnosed with secondary IOOA caused by superior oblique palsy(SOP)were enrolled in the 2’IOOA *** before and after surgery were compared between the two ***:A total of 78 patients were enrolled in this study:34 eyes in the 1’IOOA group and 44 eyes in the 2’IOOA *** the 78 patients,torsional angle significantly decreased from 15.31°±7.40°to 12.11°±6.53°after IO recession(P<0.001).Mean preoperative torsional angle was larger in the 2’IOOA group than in the 1’IOOA group(P=0.03).In both groups,excyclotorsion significantly decreased after IO recession(P=0.001 and P<0.001,respectively);however,there was no significant difference in the amounts of changes in excyclotorsion between the two ***:Excyclotorsion is significantly larger in secondary IOOA than in primary IOOA,and a significant decrease in the torsional angle occurs after IO recession in both types of IOOA.

关键词： inferior oblique overaction inferior oblique recession ocular excyclotorsion strabismus

Primordial germ cell-mediated transgenesis and genome editing in birds

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Journal of Animal Science and Biotechnology 2018年第2期9卷 257-267页

作者： jae Yong Han Young Hyun park Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University

Transgenesis and genome editing in birds are based on a unique germline transmission system using primordial germ cells(PGCs), which is quite different from the mammalian transgenic and genome editing system. PGCs are progenitor cells of gametes that can deliver genetic information to the next generation. Since avian PGCs were first discovered in nineteenth century, there have been numerous efforts to reveal their origin, specification, and unique migration pattern, and to improve germline transmission efficiency. Recent advances in the isolation and in vitro culture of avian PGCs with genetic manipulation and genome editing tools enable the development of valuable avian models that were unavailable before. However, many challenges remain in the production of transgenic and genome-edited birds,including the precise control of germline transmission, introduction of exogenous genes, and genome editing in ***, establishing reliable germline-competent PGCs and applying precise genome editing systems are critical current issues in the production of avian models. Here, we introduce a historical overview of avian PGCs and their application, including improved techniques and methodologies in the production of transgenic and genome-edited birds, and we discuss the future potential applications of transgenic and genome-edited birds to provide opportunities and benefits for humans.

关键词： Avian Genome editing Primordial germ cell Transgenesis

Effects of homogenization temperature on microstructure and mechanical properties of high-speed-extruded Mg–5Bi–3Al alloy

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Journal of Magnesium and Alloys 2022年第10期10卷 2833-2846页

作者： jae Won Cha Sang-Cheol Jin jae-Gil Jung Sung Hyuk park School of Materials Science and Engineering Kyungpook National University80 DaehakroDaegu 41566Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

This study investigates the effects of billet homogenization temperature on the dynamic recrystallization behavior during high-speed extrusion and resultant microstructure and tensile properties of the Mg–5Bi–3Al(BA53,wt%)*** billets homogenized at 350 and450℃(350H and 450H billets)are extruded at a high speed of 69 m/*** 350H billet has a relatively smaller grain size and a higher abundance of fine Mg3Bi2particles compared to the 450H *** extrusion of the 350H billet,enhanced dynamic recrystallization occurs as a result of its finer grains and abundance of particles,while the growth of recrystallized grains is suppressed by the grain-boundary pinning effect of ***,the extruded 350H material is characterized by smaller grains,relatively greater number of Mg3Bi2particles,and a higher internal strain energy than the extruded 450H *** tensile strength of the extruded 350H material is higher than that of the extruded 450H material owing to stronger grain-boundary hardening,particle hardening,and strain hardening *** extruded 350H material also exhibits a higher tensile elongation as its smaller grains inhibit the formation of crack-inducing undesirable twins during *** results from this study demonstrate that a decrease in the homogenization temperature from 450 to 350℃leads to improved strength and ductility in the high-speed-extruded BA53 material.

关键词： Mg–Bi–Al alloy High-speed extrusion Homogenization Dynamic recrystallization Tensile properties

Semantic Segmentation by Using Down-Sampling and Subpixel Convolution: DSSC-UNet

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Computers, Materials & Continua 2023年第4期75卷 683-696页

作者： Young-Man Kwon Sunghoon Bae Dong-Keun Chung myung-jae Lim Department of Medical IT Eulji University553Sanseong-daeroSujeong-guSeongnam-siGyeonggi-do13135Korea

Recently, semantic segmentation has been widely applied toimage processing, scene understanding, and many others. Especially, indeep learning-based semantic segmentation, the U-Net with convolutionalencoder-decoder architecture is a representative model which is proposed forimage segmentation in the biomedical field. It used max pooling operationfor reducing the size of image and making noise robust. However, instead ofreducing the complexity of the model, max pooling has the disadvantageof omitting some information about the image in reducing it. So, thispaper used two diagonal elements of down-sampling operation instead ofit. We think that the down-sampling feature maps have more informationintrinsically than max pooling feature maps because of keeping the Nyquisttheorem and extracting the latent information from them. In addition,this paper used two other diagonal elements for the skip connection. Indecoding, we used Subpixel Convolution rather than transposed convolutionto efficiently decode the encoded feature maps. Including all the ideas, thispaper proposed the new encoder-decoder model called Down-Sampling andSubpixel Convolution U-Net (DSSC-UNet). To prove the better performanceof the proposed model, this paper measured the performance of the UNetand DSSC-UNet on the Cityscapes. As a result, DSSC-UNet achieved89.6% Mean Intersection OverUnion (Mean-IoU) andU-Net achieved 85.6%Mean-IoU, confirming that DSSC-UNet achieved better performance.

关键词： Semantic segmentation encoder-decoder U-Net DSSC-UNet subpixel convolution down-sampling