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Management of post-gastrectomy anastomosis site obstruction with a self-expandable metallic stent

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World Journal of Gastroenterology 2015年第16期21卷 5110-5114页

作者： Ra Ri Cha Sang Soo Lee Hyunjin Kim Hong Jun Kim Tae-Hyo Kim Woon Tae Jung Ok jae Lee Kyung Soo bae Sang-Ho Jeong Chang Yoon Ha Department of Internal Medicine Gyeongsang National University School of Medicine Department of Radiology Gyeongsang National University School of Medicine Department of Surgery Gyeongsang National University School of Medicine

Post-gastrectomy anastomosis site obstruction is a relatively rare complication after a subtotal *** present a case of a 75-year-old man who underwent a truncal vagotomy, omental patch, gastrojejunostomy, and Braun anastomosis for duodenal ulcer perforation and a gastric outlet *** the 10 th postoperative day, the patient complained of abdominal discomfort and *** diagnosed post-gastrectomy anastomosis site obstruction by an upper gastrointestinal series and an upper endoscopic *** inserted a self-expandable metallic stent(SEMS) at the anastomosis *** stent was fully expanded after *** the day following the stent insertion, the patient began to eat, and his abdominal discomfort was *** paper describes the successful management of post-gastrectomy anastomosis site obstruction with temporary placement of a SEMS.

关键词： Efferent loop syndrome Postgastrectomysyndrome self-expandable metallic stent

An on-line scaling method for improving scalability of a database cluster

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重庆邮电学院学报（自然科学版） 2004年第5期16卷 71-77页

作者： JANG Yong ll LEE Chung ho LEE jae dong bae Hae young Dept. of Computer Science and Engineering Inha UniversitySouth KoreaDept. of Computer Science and Engineering Inha UniversitySouth KoreaDept. of Computer Science Dankook UniversityYonghyun Dong Nam ku Inchon 402 751 KoreaDept. of Computer Science and Engineering Inha UniversitySouth Korea

The explosive growth of the Internet and database applications has driven database to be more scalable and available, and able to support on line scaling without interrupting service. To support more client’s queries without downtime and degrading the response time, more nodes have to be scaled up while the database is running. This paper presents the overview of scalable and available database that satisfies the above characteristics. And we propose a novel on line scaling method. Our method improves the existing on line scaling method for fast response time and higher throughputs. Our proposed method reduces unnecessary network use, i.e., we decrease the number of data copy by reusing the backup data. Also, our on line scaling operation can be processed parallel by selecting adequate nodes as new node. Our performance study shows that our method results in significant reduction in data copy time.

关键词：数据库串在线缩放方法可量测性改进方法

Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis

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World Journal of Gastroenterology 2017年第34期23卷 6306-6314页

作者： Hyungil Seo Seohyun Lee Hoonsub So Donghoi Kim Seon-Ok Kim jae Seung Soh Jung Ho bae Sun-Ho Lee Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-jae Myung Suk-Kyun Yang Byong Duk Ye Department of Gastroenterology University of Ulsan College of MedicineAsan Medical Center Division of Gastroenterology Department of Internal MedicineCenter for Health PromotionSeoul National University Hospital Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical Center Division of Gastroenterology Department of Internal MedicineHallym University College of Medicine Hallym University Sacred Heart Hospital Department of Gastroenterology Seoul National University College of MedicineSeoul National University Hospital Gangnam Center Inflammatory Bowel Disease Center University of Ulsan College of MedicineAsan Medical Center

AIM To investigate the temporal trends in the misdiagnosis rate between Crohn's disease(CD) and intestinal tuberculosis(ITB) in South Korea. METHODS We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB(final CD group) and vice versa(final ITB group). Final diagnostic criteria for ITB and medication for CD before definite diagnosis of TB were also analyzed in final ITB *** In total, 2760 patients were managed for CD and 772 patients for ITB between 1996 and 2014. As well, 494 of the 2760 CD patients(17.9%) were initially misdiagnosed as ITB and 83 of the 772 ITB patients(10.8%) as CD. The temporal trend in misdiagnosing CD as ITB showed a decrease(OR = 0.89, 95%CI: 0.87-0.91, P < 0.001), whereas the temporal trend in misdiagnosing ITB as CD showed an increase(OR = 1.06, 95%CI: 1.01-1.11, P = 0.013). Age at diagnosis, presenting symptoms, and proportion of patients with active/past perianal fistula and active/inactive pulmonary tuberculosis(TB) were significantly different between final CD group and final ITB group. Forty patients(48.2%) in final ITB group were diagnosed by favorable response to empirical anti-TB treatment. Seventeen patients(20.5%) in final ITB group had inappropriately received corticosteroids and/or thiopurines due to misdiagnosis as CD. However, there were no mortalities in both groups. CONCLUSION Cases of CD misdiagnosed as ITB have been decreasing, whereas cases of ITB misdiagnosed as CD have been increasing over the past two decades.

关键词： Crohn’s disease Intestinal tuberculosis Misdiagnosis

Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis

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World Journal of Gastroenterology 2017年第13期23卷 2396-2403页

作者： Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk bae Kim Il Han Song Hee Bok Chae Soon Young Ko jae Dong Lee Division of Hepatology Department of Internal MedicineDaejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea Department of Internal Medicine Chungnam University Hospital Department of Internal Medicine Konyang University Hospital Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung Buk University Hospital Department of Internal Medicine Konkuk University Chungju Hospital

AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients.

关键词： Tenofovir Decompensated liver cirrhosis Compensated liver cirrhosis Virological response Renal safety

Bone marrow stem cells ameliorate brain pathology and rescue memory deficits in Alzheimer's disease mice by modulation of immune responses

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Bone marrow stem cells ameliorate brain pathology and rescue...

The Effect of Surfactant on the Shear-induced Structure and Rheological Properties of SAA/Oil/Fatty Alcohol/Water Quaternary System

第十届中国实验动物科学年会

作者： Jong Kil Lee Hee Kyung Jin jae-sung bae

Objective Alzheimer’s disease(AD) is the most common form of *** increased life expectancy, this number is expected torise in the *** is characterized by progressive memorydeficits,cognitive impairment,and personalitychanges associated with the degeneration of multiple neuronal types andpathologically by the presence of neuritic plaques and neurofibrillary *** of bone marrow stem cells(BMSCs) has been suggested as a potential therapeutic approach to preventneurodegenerativediseases including ***,the actual therapeutic impact of BMSCs and their mechanism of action in AD have not yet been *** aim of this study was therefore to examine the effects of BMSCs therapy in *** one strategy of BMSC therapy is pharmacological-induced recruitment of endogenous BMSCs into an injured site by systemic administration of growth factors or *** examine the effects of endogenous BMSC therapy,we injected granulocyte colony stimulating factor(G-CSF)/AMD3100(CXCR4 antagonist) and stromal cell-derived factor- 1α(SDF-1α) on endogenous BM-hematopoietic progenitor cell(BM-HPC)recruitment into the brain of an AD mouse *** mobilize BM-HPCs,G-CSF was injected intraperitoneally,and boosted by ***, these micereceived an intracerebral injection with SDF-1αto induce migrationof mobilized BM-HPCs into *** found that the memory deficit in the AD micewas significantly improved by these treatments,butamyloidβ(Aβ) deposition was ***,microglial activation was increased with alternative activation of microglia to a neuroprotective ***,by generating anAPP/PS1-GFP chimeric mouse we ascertained that the GFP positive microglia identified in the brain were ***,increased hippocampal neurogenesis and improved memory was observed in mice receivingcombined G-CSF/AMD3100 and SDF-la,but not in controls or animals receiving each treatment *** results suggest

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The Effect of Surfactant on the Shear-induced Structure and ...

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

第八届中国化妆品学术研讨会

作者： Sung-Ho moon Chang Seok Ki Woori bae Pi Bongsoo Heeseon An Chang Man Park Soonae An Byung-guen Chae Sang-Hoon Han Hak-Hee Kang jae Ho Yeon Cosmetics & Personal Care Research Institute Amore-Pacific R&D CenterKorea Amore-Pacific Shanghai R&D Center China

The effect of surfactant on the rheological properties of quaternary systems consisting of surfactant, oil,fatty alcohol and water is studied to improve the stability of O/W *** basic ternary systems show the formation of lamella liquid crystals called∝gel(alpha).On the other hand,the quaternary systems behave lamella liquid crystals including M and D *** is the study of the diverse rheological responses was done by a polarizing microscope,rheometer,differential scanning calorimetry,small angle X-ray scattering(SAXS) and *** the different kinds of surfactant is added,quaternary systems show the diverse rheological *** surfactants are used as emulsifier which is nonionic surfactant,anionic surfactant,cationic surfactant and surfactant mixtures.

关键词： Lamella liquid crystals quaternary systems Rheological Properties

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Neural Regeneration Research 2015年第6期10卷 944-950页

作者： Eun Joo bae Bai Hui Chen Bing Chun Yan Bich Na Shin Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn jae Chul Lee Hyun-Jin Tae Seongkweon Hong Dong Won Kim Jun Hwi Cho Yun Lyul Lee Moo-Ho Won Joon Ha Park Department of Pediatrics Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Institute of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Surgery School of MedicineKangwon National University Department of Emergency Medicine Chuncheon Sacred Heart HospitalCollege of MedicineHallym University Department of Emergency Medicine School of MedicineKangwon National University

The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet. In this study, we first compared ischemia-induced effects on p63 expression in the hippocampal regions （CA1-3） between the young and adult gerbils subjected to 5 minutes of transient global cerebral ischemia. Neuronal death in the hippocampal CA1 region of young gerbils was significantly slow compared with that in the adult gerbils after transient global cerebral ischemia, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons in the sham-operated young group was significantly low compared with that in the sham-operated adult group, p63 immunoreactivity was apparently changed in ischemic hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. In the ischemia-operated adult groups, p63 immunoreactivity in the hippocampal CA1 pyramidal neurons was significantly decreased at 4 days post-ischemia; however, p63 immunoreactivity in the ischemia-operated young group was significantly higher than that in the ischemia-operated adult group. At 7 days post-ischemia, p63 immunoreactivity was decreased in the hippocampal CA1 pyramidal neurons in both ischemia-operated young and adult groups. Change patterns of p63 level in the hippocampal CA1 region of adult and young gerbils after ischemic damage were similar to those observed in the immunohistochemical results. These findings indicate that higher and longer-term expression of p63 in the hippocampal CA1 region of the young gerbils after ischemia/reperfusion may be related to more delayed neuronal death compared to that in the adults.

关键词： p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting neural regeneration

Massive small bowel bleeding caused by scrub typhus in Korea

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World Journal of Gastrointestinal Surgery 2010年第2期2卷 47-50页

作者： Ki Beom bae Won Hwa Youn Youn jae Lee Soo Jin Jung Kwan Hee Hong Department of Surgery Inje University College of MedicineBusan Paik Hospital Department of Internal Medicine Inje University College of MedicineBusan Paik Hospital Department of Pathology Inje University College of MedicineBusan Paik Hospital

A 79-year-old man was diagnosed with scrub typhus based on fever,eschar,skin rash and a markedly elevated serum tsutsugamushi antibody and doxycycline was *** days later,hematochezia developed and multiple small bowel ulcerations with hemorrhage were seen on *** intensive therapy,the massive hematochezia worsened and the distal small bowel was *** ulcerated lesions were identified pathologically as vasculitis caused by scrub *** is the first reported case of pathologically proven small bowel involvement in scrub typhus infection.

关键词： Hematochezia Small bowel bleeding Scrub typhus Vasculitis Multiple small bowel ulcerations

Cyanidine-3-O-Galactoside Enriched <i>Aronia melanocarpa</i>Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells

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Food and Nutrition Sciences 2019年第2期10卷 128-147页

作者： Su-Min Lim jae In Jung Nam Young Kim Jung-Shik bae Hyun Sook Lee Eun Ji Kim Center for Efficacy Assessment and Development of Functional Foods and Drugs Hallym UniversityChuncheonRepublic of Korea R&D Center Wellfine Co.Ltd.ChuncheonRepublic of Korea Department of Food Science&Nutrition Dongseo UniversityBusanRepublic of Korea

Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.

关键词： Obesity Adipocyte Adipogenesis Lipogenesis Transcription Factor Adipocyte Protein 2