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Pancreatic pseudocystocolonic fistula treated without surgical or endoscopic intervention

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World Journal of Gastroenterology 2014年第7期20卷 1882-1886页

作者： jae Choon Kwon Bo Yean Kim Ah Lim Kim Tae Hoon Kim Myung Il Park Ho Jin jung Jang Hwan Lim jae Kwon jung Hyun Soo Kim Dong Wook Lee Division of Gastroenterology and Hepatology Department of Internal MedicineDaegu Fatima HospitalDong-gu Daegu701-600South Korea

We report here a case of pancreatic pseudocystocolic fistula that was treated without surgical or endoscopic intervention.A 76-year-old woman,presenting with a fever and epigastric pain,was referred to our *** months prior to this admission,the patient had been admitted to the hospital for acute *** computerized tomography(CT)revealed a 9 cm pseudocyst containing air,and a fistular opening was observed via *** colonoscopy,the abdominal pain was slightly improved,the fever subsided and laboratory results showed decreased C-reactive protein *** observed improvement was likely due to the cleansing of the bowel,which induced spontaneous drainage from the pseudocyst into the *** therapy was administered and daily bowel cleansing was performed using a polyethylene glycol *** three weeks,a follow-up CT revealed that the size of the pseudocyst had decreased significantly from 9 to 5.3 *** addition,laboratory tests were *** patient was able to resume a normal diet and was discharged in good overall health from the hospital,without aggravation of the symptoms.A colonoscopy performed 3 mo later and a follow-up CT performed 6 mo later confirmed that both the fistula and pseudocyst had completely disappeared.

关键词： Acute pancreatitis Pseudocyst Pseudocystocolic fistula

Dual in-situ observation of tribochemical and morphological evolution of single-layer WS_(2)and multi-layer WS_(2)/C coatings

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Friction 2024年第7期12卷 1580-1598页

作者： Yuzhen LIU jae-Ho HAN Shusheng XU Young Chan jung Dae-Eun KIM State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Department of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264000China

The outstanding tribological performance of transition metal dichalcogenides(TMDs)is attributed to their unique sandwich microstructure and low interlayer shear *** advantageous structure allows TMDs to demonstrate exceptional friction reduction ***,the incorporation of TMDs and amorphous carbon(a-C)in multi-layer structures shows excellent potential for further enhancing tribological and anti-oxidation *** carbon,known for its high ductility,chemical inertness,and excellent wear resistance,significantly contributes to the overall performance of these multi-layer *** gain an in-depth understanding of the tribological mechanism and evolution of TMDs’multi-layer coatings,a dual in-situ analysis was carried out using a tribometer equipped with a 3D laser microscope and a Raman *** innovative approach allowed for a comprehensive evolution of the tribological,topographical,and tribochemical characteristics of both single-layer WS_(2)and multi-layer WS_(2)/C coatings in real *** findings from the dual in-situ tribotest revealed distinct failure characteristics between the single-layer WS_(2)coating and the multi-layer WS_(2)/C *** single-layer WS_(2)coating predominantly experienced failure due to mechanical removal,whereas a combination of mechanical removal and tribochemistry primarily influenced the failure of the multi-layer WS_(2)/C *** tribological evolution process of these two coatings can be classified into four stages on the basis of their tribological behavior:the running-in stage,stable friction stage,re-deposition stage,and lubrication failure *** stage represents a distinct phase in the tribological behavior of the coatings and contributes to our understanding of their behavior during sliding.

关键词： In-situ analysis multi-layer coating tribology tribochemistry

Induction of vascular endothelial growth factor receptor expression in human umbilical vein endothelial cells after repeated bevacizumab treatment in vitro

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1064-1068页

作者： Ji Eun Lee Jin Young Kim jae Ho jung Dong Hoon Shin Sung Who Park Department of Ophthalmology School of MedicinePusan National University Medical Research Institute Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Pathology School of MedicinePusan National University

AIM： To investigate the mechanism underlying the loss of responsiveness to anti-vascular endothelial growth factor（VEGF） treatment after repeated injections for choroidal neovascularization, VEGF and VEGF receptor（VEGFR） expressions were evaluated following repeated bevacizumab treatments in hypoxic human umbilical vein endothelial cells（HUVECs） in ***： HUVECs were incubated under hypoxic conditions in two media of different bevacizumab concentrations（1.0 or 2.5 mg/m L） for 17 h, and then in a new medium without bevacizumab for 7h. This procedure was repeated twice more. A culture with an identical volume of excipients served as the control. Cytotoxicity and cell proliferation were assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and Ki-67 assays, respectively. Levels of VEGF and VEGFR were assessed using enzyme-linked immunosorbent assay and Western blot ***： Cytotoxic effects were not reported for either bevacizumab concentration. Cell proliferation was not reduced after anti-VEGF treatments. VEGF level after single treatment was significantly higher than that of the control and after repeated treatments. Phosphorylated VEGFR-2 expression increased significantly after singleand repeated bevacizumab treatments compared with the control. The 1.0 mg/m L bevacizumab induced significantly higher expressions of VEGFR-2 than the 2.5 mg/m L in single and repeated treatment ***： Bevacizumab treatment of HUVECs elevated VEGFR expression in both single and repeated treatments, indicating a mechanism for the reduced efficacy of anti-VEGF therapy in ocular neovascular disorders.

关键词： vascular endothelial growth factor vascular endothelial growth factor receptor choroidal neovascularization bevacizumab repeated treatments

The Influence of Ceramic Surface Treatments on the Microtensile Bond Strength of Resin Cements to Y-TZP Ceramic

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 996-1000页

作者：朴美姬朴珠美 Seung-Geun Ahn Kwang-Yeob Song Tae-Sung Bae jae-Youn jung Department of Prosthodontics and Institute of Oral Bioscience School of DentistryChonbuk National University Department of Dental Biomaterials and Institute of Oral Bioscience School of DentistryChonbuk National University Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University

The effects of surface conditioning methods on the microtensile bond strength of Y-TZP ceramic were studied based on airborne particle abrasion and resin *** square-shaped（φ12 mm×5 mm high） Y-TZP ceramic were studied blocks（LAVATM,3M ESPE,USA） and flat occlusal dentin blocks were fabricated,pre-treated（airborne abrasion with 125μm Al2O3 particles,tribochemical silica coating with 110 μm Al2O3 particles modified by silica oxide）,and bonded to each other using resin cements（Panavia F 2.0,RelyX Unicem）.Thereafter the trilayer specimens were cut into microbar specimens with a bonding area of approximately 1.0±0.1 mm2 and then microtensile bond strength tests were *** Y-TZP ceramic following airborne particle abrasion with 125μm Al2O3 and silicoating,the surface roughness of Y-TZP and its surface silica content were confirmed to ***,the Y-TZP ceramic surface treatment with a tribochemical silica coating showed the highest microtensile bond strength of the phosphate monomer-based resin cement to Y-TZP ceramic（mean MPa=18.11±0.27（Panavia F 2.0）,17.45±0.39（Rely X Unicem）.In cases in which a silica coating was applied,there was no significant difference in the bonding strength depending on resin cements（P0.05）.

关键词： Y-TZP ceramic resin cement microtensile bond strength

Exploring treatment options for biliary tract cancers:moving beyond the era of gemcitabine and platinum doublet

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 562-565页

作者： jung Sun Kim Hong jae Chon Department of Medical Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnamRepublic of Korea

Biliary tract cancers(BTCs)refer to invasive adenocarcinomas arising from the bile duct(intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma)and gallbladder(gallbladder cancer).Patients with BTCs typically present at an advanced stage due to a lack of early detection methods and non-specific symptoms;systemic chemotherapy is the cornerstone of treatment for these advanced *** plus cisplatin(GC)has been the standard treatment since the pivotal ABC-02 randomized phase 3 trial conducted in 2010(1).Moving beyond the era of GC,several triplet combination regimens have been proposed in recent years(Table 1).The combination of nab-paclitaxel(nab-P)and GC showed promising survival outcomes in a phase 2 trial(2),although it eventually failed to meet the primary endpoint of overall survival(OS)in a randomized phase 3 trial(3).Around the same time,TOPAZ-1(5)demonstrated that the programmed death ligand 1(PD-L1)inhibitor durvalumab combined with GC significantly improved the median OS[11.5 vs.12.8 months;hazard ratio(HR),0.80;95%confidence interval(CI):0.66–0.97;P=0.021]and median progression-free survival(PFS)(5.7 vs.7.2 months;HR,0.75;95%CI:0.63–0.89;P=0.001),with an objective response rate(ORR)of 26.7%.Moreover,KEYNOTE-966(6)found that the addition of programmed death-1(PD-1)inhibitor pembrolizumab also improved median OS(10.9 vs.12.7 months;HR,0.83;95%CI:0.72–0.95;P=0.0034),whereas the median PFS only showed numerical improvements(5.6 vs.6.5 months;HR,0.86;95%CI:0.75–1.00;P=0.023),with an ORR of 29%.Consequently,the combination of PD-1/PD-L1 inhibitors and GC has become the new standard of care for first-line treatment of patients with BTCs,establishing the new era of triplet combinations.

关键词： Biliary tract cancer cholangiocarcinoma gallbladder cancer

Self-assembly of tau fragments as a key pathologic event in tauopathies

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Neural Regeneration Research 2024年第12期19卷 2565-2566页

作者： Ly Thi Huong Luu Le jung Hoon Lee Min jae Lee Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea

Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the *** has unique biophysical properties that make it both highly water-soluble and positively *** tau is an intrinsically disordered protein lacking defined secondary structures,it can acquire highly organized-sheet structures and stack into a filamentous inclusion such as a paired helical filament(PHF).

关键词： tau pathologic assembly

Comparative Study of Visual and Instrumental Analyses of Shade Selection

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Journal of Wuhan University of Technology(Materials Science) 2010年第1期25卷 62-67页

作者： Jee-Ha Choi Ju-Mi Park Seung-Geun Ahn Kwang-Yeob Song Min-Ho Lee jae-Youn jung Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The difference between visual and instrumental analyses of a shade selection on natural teeth was investigated. With visual analysis, five prosthodontist examined the middle third of the unrestored maxillary right central incisor of a patient using VITAPEN classical and Vita Toothguide 3D-MASTER tooth shade guide. In instrumental analysis, one prosthodontist examined the same teeth using a spectrophotometer （ShadepilotTM, Degudent, Hanau-Wolfgang, Germany, software 2.40）. Overall, instrumental analysis is more accurate and reproducible than a visual assessment. However, the difference is clinically acceptable.

关键词： shade selection visual analysis instrumental analysis spectrophotometer

Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 1019-1020页

作者： Seung Min Lee jae Woo jung Sung Who Park Ji Eun Lee Ik Soo Byon Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 Korea Department of Ophthalmology College of Medicine Pusan National University Yangsan 50612 Korea Biomedical Research Institute Pusan National University Hospital Busan 49241 Korea

Lee SM, jung JW, Park SW, Lee JE, Byon IS. Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye. Int J Ophthalmo12017; 10（6）： 1019-1020

关键词： ME Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye

Nanowire-assisted freestanding liquid metal thin-film patterns for highly stretchable electrodes on 3D surfaces

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npj Flexible Electronics 2022年第1期6卷 956-963页

作者： Minwoo Kim Chulmin Cho Wooseop Shin jung jae Park jaewon Kim Phillip Won Carmel Majidi Seung Hwan Ko Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoulGwanak-guKorea Mechatronics Research Samsung ElectronicsHwaseong-siGyeonggi-doKorea Soft Machines Lab Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghPAUSA Institute of Advanced Machines and Design/Institute of Engineering Research Seoul National UniversitySeoulKorea

Stretchable electronics is playing an integral role in fields such as wearable electronics and soft *** soft conductive materials,liquid metal is drawing intense attention as an electrode material due to its liquid nature at room ***,the merits of liquid metal conductor are limited by the presence of substrates or enclosed microchannels from physical disturbances by the underlying substrate when applying it to 3D surface and modifying complex *** overcome this limitation,we develop freestanding patterned liquid metal thin-film conductor(FS-GaIn).FS-GaIn was achieved by introducing metal nanowires to liquid metal and subsequent sequential selective laser processing and etching of directly patterned *** can be applied directly to nonflat surface without *** incorporated into electrical circuits,FS-GaIn shows high electrical conductivity,stretchability,and *** concept of freestanding liquid metal can open a functionality to the conventional liquid metal electronics.

关键词： liquid film free