检索结果-南通市图书馆

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young park Chulhwan Kwak Yoonji Lee Dae-Geun Song jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

儒学人性教育效果分析之研究

国际儒学（中英文） 2024年第2期4卷 140-149,193页

作者：曹在衡高在锡成均馆大学社会福利研究所韩国首尔01623 成均馆大学成均人文东洋学院韩国首尔03063

开发由客观指标构成的人性评价标准是检验人性教育效果、设定系统性目标、改善内容和方法的必由之路。特别是此评价标准能够检验以儒学为基础的人性教育成效,除了能诊断教育效果,更能够实际推动教育课程的设计和编制。但目前关于儒学经... 详细信息

开发由客观指标构成的人性评价标准是检验人性教育效果、设定系统性目标、改善内容和方法的必由之路。特别是此评价标准能够检验以儒学为基础的人性教育成效,除了能诊断教育效果,更能够实际推动教育课程的设计和编制。但目前关于儒学经典是否影响大学生人性变化的统计依据还远远不够。在大数据社会中,这成为论证《论语》教育必要性方面的不足。通过对成均馆大学2022年第二学期7门人性教育课程的142名修课学生的调查,可以发现,在15周的有限时间内修课学生的“人性分数”有所增加,证明了人性教育课程对人性变化有效。另外,推动知、仁、勇的价值尺度化,引导平均值的变化也是非常积极的结果。

关键词：人性教育儒学《论语》教育效果

维普期刊数据库

用连续振动阻抗法进行预应力钢筋混凝土梁桥的混合健康监测

在线全文

学校读者我要写书评

暂无评论

钢结构(中英文) 2010年第2期 87-87页

作者： Jeong-Tae Kim jae-hyung park Dong-Soo Hong Woo-Sun park

提出连续振动阻抗法,对预应力钢筋混凝土桥梁的两种破坏形式(即预应力筋破坏或梁破坏)进行混合健康监测。监测包括3个步骤:第一步,通过监测加速信号的变化,对整体破坏进行预警。第二步,通过振动和阻抗识别模式,将破坏类型分为预应力筋... 详细信息

提出连续振动阻抗法,对预应力钢筋混凝土桥梁的两种破坏形式(即预应力筋破坏或梁破坏)进行混合健康监测。监测包括3个步骤:第一步,通过监测加速信号的变化,对整体破坏进行预警。第二步,通过振动和阻抗识别模式,将破坏类型分为预应力筋破坏或梁破坏。第三,基于形状模式和频率方法,通过测量试验室中几个预应力筋和梁的加速响应和电子-机械阻抗,对所提系统的可行性进行评估。

关键词：混合法健康监测破坏检测 PSC梁加速信号阻抗信号损伤指标法

Segmental artery injury during transforaminal percutaneous endoscopic lumbar discectomy:Two case reports

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第33期10卷 12345-12351页

作者： Wan-jae Cho Ki-Won Kim hyung-Youl park Bo-Hyoung Kim Jun-Seok Lee Department of Orthopedic Surgery Yeouido St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 07345South Korea Department of Orthopedic Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 03312South Korea

BACKGROUND Since Kambin experimentally induced arthroscopy to treat herniated nucleus pulposus,percutaneous endoscopic lumbar discectomy(PELD)has been *** branch of the segmental artery around the neural foramen may be damaged during PELD using the transforaminal *** report 2 rare cases in which segmental artery injury that occurred during PELD was treated with emergency *** SUMMARY In case 1,a 31-year-old man was transferred to our emergency department with left lower quadrant abdominal pain after PELD at a local *** spine magnetic resonance imaging after the surgery showed a hematoma of the left retroperitoneal area and the psoas muscle *** suspicion of vascular injury,arteriography was *** and blood leakage from the left 4th lumbar segmental artery into the abdominal cavity were *** transarterial embolization was performed using fibered microcoils for bleeding of the segmental *** case 2,a 75-year-old woman was transferred to our emergency department with low blood pressure,right flank pain,and drowsy mental status after PELD at a local *** the patient arrived at the emergency room,the blood pressure decreased from 107/55 mmHg to 72/47 *** blood pressure *** suspicion of vessel injury,arteriography was performed,and the right 4th lumbar segmental artery rupture was *** transarterial embolization was performed for bleeding of segmental *** We were able to find the bleeding focus by angiography and treat the injury of the segmental artery successfully through emergency transarterial embolization.

关键词： Percutaneous endoscopic lumbar discectomy Segmental artery injury Transarterial embolization Angiography Case report

Variations in dynamic recrystallization behavior and mechanical properties of AZ31 alloy with extrusion temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

镁合金学报(英文) 2023年第7期11卷 2351-2365页

作者： jae Won Cha Sung Hyuk park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigates the effects of extrusion temperature on the dynamic recrystallization(DRX)behavior of a Mg-3Al-1Zn-0.3Mn(AZ31,wt%)alloy during hot extrusion and on the microstructural characteristics and mechanical properties of materials extruded at 350 and 450℃.An increase in the extrusion temperature causes a decrease in the amount of strain energy accumulated in the material during extrusion,because of promoted activation of pyramidalslip and dynamic *** reduced strain energy weakens the DRX behavior during extrusion,which eventually results in a decrease in the area fraction of recrystallized grains of the extruded *** material extruded at 450℃has coarser grains and a stronger basal fiber texture than that extruded at 350℃.As the extrusion temperature increases from 350 to 450℃,the tensile yield strength(TYS)of the extruded material increases from 191.8 to 201.5 MPa,whereas its compressive yield strength(CYS)decreases from 122.5 to 111.0 MPa;consequently,its tension-compression yield stress ratio(CYS/TYS)decreases from 0.64 to *** increase in the TYS is attributed mainly to the stronger texture hardening and strain hardening effects of the extruded material,and the decrease in the CYS is attributed to the reduced twinning stress resulting from grain coarsening and texture *** microstructural and textural evolutions of the materials during extrusion and the deformation and hardening mechanisms of the extruded materials are discussed in detail.

关键词： Mg-Al-Zn alloy Extrusion Dynamic recrystallization Microstructure Yield asymmetry

维普期刊数据库

Effects of homogenization temperature on microstructure and mechanical properties of high-speed-extruded Mg–5Bi–3Al alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第10期10卷 2833-2846页

作者： jae Won Cha Sang-Cheol Jin jae-Gil Jung Sung Hyuk park School of Materials Science and Engineering Kyungpook National University80 DaehakroDaegu 41566Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

This study investigates the effects of billet homogenization temperature on the dynamic recrystallization behavior during high-speed extrusion and resultant microstructure and tensile properties of the Mg–5Bi–3Al(BA53,wt%)*** billets homogenized at 350 and450℃(350H and 450H billets)are extruded at a high speed of 69 m/*** 350H billet has a relatively smaller grain size and a higher abundance of fine Mg3Bi2particles compared to the 450H *** extrusion of the 350H billet,enhanced dynamic recrystallization occurs as a result of its finer grains and abundance of particles,while the growth of recrystallized grains is suppressed by the grain-boundary pinning effect of ***,the extruded 350H material is characterized by smaller grains,relatively greater number of Mg3Bi2particles,and a higher internal strain energy than the extruded 450H *** tensile strength of the extruded 350H material is higher than that of the extruded 450H material owing to stronger grain-boundary hardening,particle hardening,and strain hardening *** extruded 350H material also exhibits a higher tensile elongation as its smaller grains inhibit the formation of crack-inducing undesirable twins during *** results from this study demonstrate that a decrease in the homogenization temperature from 450 to 350℃leads to improved strength and ductility in the high-speed-extruded BA53 material.

关键词： Mg–Bi–Al alloy High-speed extrusion Homogenization Dynamic recrystallization Tensile properties

维普期刊数据库

Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第2期7卷 35-48页

作者： hyung Shik Kim Seung jae Lee Dong Yun Lee Department of Bioengineering College of Engineeringand BK FOUR Biopharmaceutical Innovation Leader for Education and Research GroupHanyang UniversitySeoul04763Republic of Korea Institute of Nano Science and Technology Hanyang UniversitySeoul04763Republic of Korea

Orally absorbable gold nanoparticles(AuNP)having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme(GBM)for patients with its highest incidence ***,we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin(Lf)and lactoferrin receptor(LfR)that is highly expressed in the intestine,blood-brain barrier and *** stability and long circulation of AuNP,glutathione and polyethylene glycol(PEG)is introduced,which is called to *** Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice,11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain,respectively,compared with ***,orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor ***,we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption,and that its efficient photothermal therapy is possible.

关键词： intestine absorption gastrointestinal

Successful resolution of gastric perforation caused by a severe complication of pancreatic walled-off necrosis:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界临床病例杂志 2023年第26期11卷 6298-6303页

作者： Byeong Gwan Noh Myunghee Yoon Young Mok park hyung-Il Seo Suk Kim Seung Baek Hong jae Kyun park Moon Won Lee Department of Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Pancreatic walled-off necrosis(WON)rarely causes critical gastric necrosis and perforation,which may develop when pancreatic WON squashes against the *** Atlanta 2012 guidelines were introduced for acute pancreatitis and its related clinical ***,there are few reported cases describing the clinical course and resolution of pancreatic *** SUMMARY We report the case of a 45-year-old man who presented to the urgent emergency department with gastric perforation caused by a severe complication of pancreatic WON on computed *** patient underwent an emergency distal pancreatectomy,splenectomy,and gastric wedge *** findings showed re-perforation of the gastric wall at a previously resected ***,endoscopic examination revealed an ulcerative area with a defect in the *** diagnostic endoscopy,endoscopic vacuum-assisted closure was performed,and continuous suction was transferred over all tissues in contact with the sponge *** patient recovered without any further complications and was discharged in good condition at postoperative week *** recurrence occurred during the 6-mo follow-up *** When managing a patient with serious gastric perforation complicated by pancreatic WON,a multidisciplinary treatment approach should be considered.

关键词： Acute necrotizing pancreatitis Endoscopy Vacuum assisted closure Gastric rupture Surgery Case report

Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第5期7卷 118-129页

作者： Indong Jun Na Li jaehee Shin jaeho park Young Jun Kim Hojeong Jeon Hyuk Choi jae-Gu Cho Byoung Chan Choi hyung-Seop Han jae-Jun Song Environmental Safety Group Korea Institute of Science&Technology Europe(KIST-EUROPE)Saarbrücken66123Germany Department of Otorhinolaryngology-Head and Neck Surgery Korea University College of MedicineSeoul02841Republic of Korea Department of Medical Sciences Graduate School of MedicineKorea UniversitySeoul02841Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science&Technology(KIST)Seoul02792Republic of Korea Laser Surface Texturing Group AYECLUSGyeonggi-do14255Republic of Korea

Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular *** study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell(hMPC)cultures to assess the influences of the adherent direction,proliferation,and differentiation,and induce preconditioning-induced therapeutic ***,a topographical surface of commercially available culture dishes was achieved by femtosecond laser *** detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture ***-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat ***,electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated *** such,we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner,thus providing the basis for therapeutic strategies.

关键词： Topography Electrical field stimulation Femtosecond laser Human myogenic precursor cell Cell therapy