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Plant-derived nanovesicles: Current understanding and applications for cancer therapy

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Bioactive Materials 2023年第4期22卷 365-383页

作者： Ngoc Phung Ly Hwa Seung Han Myungsuk Kim jae hyung park Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea School of Chemical Engineering College of EngineeringSungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Sciences and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Biomedical Institute for Convergence at SKKU Sungkyunkwan UniversitySuwon16419Republic of Korea

Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological *** the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer ***,much remains unknown about these vesicles,and current research remains *** review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.

关键词： Plant-derived vesicles Extracellular vesicles Cancer therapy Anti-cancer Drug delivery

Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus

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World Journal of Gastroenterology 2016年第46期22卷 10131-10139页

作者： Kyung Sik park Kwang Bum Cho Il Seon Hwang jae hyung park Byung Ik Jang Kyeong Ok Kim Sung Woo Jeon Eun Soo Kim Chang Sik park Joong Goo Kwon Department of Internal Medicine Keimyung University School of Medicine Department of Pathology Keimyung University School of Medicine Department of Physiology Keimyung University School of Medicine Department of Internal Medicine Youngnam University College of Medicine Department of Internal Medicine Kyungpook National University School of Medicine Department of Advanced Materials Convergence Korea Institute of Ceramic Engineering and Technology Department of Internal Medicine Catholic University of Daegu School of Medicine

AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also *** Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P < 0.01). On immunohistochemical staining, c-Kit- and PDGFRα-positive immunoreactivity were significantly decreased in the DM group compared with the control group(P < 0.05). There were no statistically significant differences in PGP9.5, n NOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal(ICC) was observed to decrease with increasing duration of *** Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM.

关键词： Diabetes mellitus Interstitial cells of Cajal Fibroblast-like cell Gastroparesis Enteric nerve system

Elucidating the impact of the ionomer equivalent weight on a platinum group metal-free PEMFC cathode via oxygen limiting current

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SusMat 2023年第1期3卷 72-90页

作者： HaoWang Luigi Osmieri Haoran Yu Michael J.Zachman jae hyung park Nancy N.Kariuki Firat C.Cetinbas Sunilkumar Khandavalli Scott Mauger Deborah J.Myers David A.Cullen Kenneth C.Neyerlin Chemistry and Nanoscience Center National Renewable Energy LaboratoryGoldenColoradoUSA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTennesseeUSA Chemical Sciences and Engineering Division Argonne National LaboratoryLemontIllinoisUSA Nuclear Science and Engineering Division Argonne National LaboratoryLemontIllinoisUSA

Leveraging the interactions between ionomer and catalyst can increase the performance of proton exchangemembrane fuel *** impacts of the equivalent weight(EW)of perfluorosulfonic acid-based ionomers on the platinum group metal-free electrode structure and fuel cell performance have not been fully *** membrane electrode assemblies(MEAs)were prepared by using a commercial Fe-N-C catalyst,two perfluorosulfonic acid ionomers with different EWs,that is,Aquivion 720(A720)and Nafion 1100(N1100),and two ionomer-tocatalyst(I/C)*** four MEAswere characterized to understand the impact of the ionomer EW and content on the capacitance,proton conductivity,and mass transport on the *** mass transport resistance was measured for the first time using a new oxygen reduction reaction limiting current method enabling to couple the effects of oxygen diffusion with liquid water *** EW ionomer combined with a moderate I/C results in improved performance due to its enhanced proton ***,when used at high I/C,it can cause severewater flooding at high current density due to the enhanced liquid water uptake,especially at high relative humidity,resulting in lower catalyst utilization and higher mass transport resistance.

关键词： ionomer equivalent weight limiting current mass transport oxygen reduction reaction PGMfree catalyst proton exchange membrane fuel cell

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam Kim Jun Su park En hyung Kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

Germline-competent stem cell in avian species and its application

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Asian Journal of Andrology 2015年第3期17卷 421-426页

作者： jae Yong Han hyung Chul Lee Tae Sub park Department of Agricultural Biotechnology College of Agriculture and Life Sciences and Research Institute of Agriculture and Life Sciences Seoul National University Seoul 151-921 Korea Graduate School of International Agricultural Technology and Institute of Green-Bio Science and Technology Seoul National University Pyeongchang-gun Gangwon-do 232-916 Korea

Germ cells are the only cell type in the body that can transfer genetic information to the next generation. Germline-competent stem cells can self-renew and contribute to the germ cell lineage giving rise to pluripotent stem cells under specific conditions. Hence far, studies on germline-competent stem cells have contributed to,the generation of avian model systems and the conservation of avian genetic resources. In this review, we focus on previous studies on germline-competent stem cells from avian species, mainly chicken germline-competent stem cells, which have been well established and characterized. We discuss different sources of germline-competent stem cells and recent advances for the future applications in birds.

关键词： birds germline-competent stem cells primordial germ cells spermatogonial stem cells

Chorioretinal response to intravitreal aflibercept injection in acute central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1865-1871页

作者： Byung Ju Jung Kook Lee Jin hyung park jae hyung Lee Department of Ophthalmology and Visual Science Seoul St.Mary’s Hospital College of Medicine the Catholic University of Korea

AIM: To evaluate chorioretinal responses to intravitreal aflibercept injection(IAI) in patients with acute central serous chorioretinopathy(CSC). METHODS: Seventy-one eyes from 71 patients with symptomatic CSC for less than six months were included. Thirty-five eyes received a single IAI and 36 eyes were observed without treatment. Best-corrected visual acuity(BCVA), central subfield foveal thickness(CSFT), and subfoveal choroidal thickness(SFCT) were assessed at baseline and at 1, 2, and 3 mo. RESULTS: The mean SFCT in the IAI group decreased at 1 mo, rebounded at 2 mo and remained stable at 3 mo compared to the baseline, while significant change was not noted in the observation group. The mean CSFT decreased significantly during the 3-month study period in both groups, and was significantly lower in the IAI group at 1 mo(P<0.001). A rebound of CSFT between 1 and 2 mo was noted in 14 eyes(40.0%) in the IAI group and in 1 eye(2.8%) in the observation group(P<0.001). The significant visual improvement was achieved from 1 mo in the IAI group, and from 2 mo in the observation group. The rate of complete absorption of subretinal fluid at 3 mo did not differ between the two groups.(45.7% vs 41.7%, P=0.813). CONCLUSION: A single IAI for acute CSC induce a transient decrease in SFCT and CSFT, which implies that IAI may have a pharmacological effect on the underlying hyperpermeable choroid in acute CSC.

关键词： aflibercept acute central serous chorioretinopathy anti-vascular endothelial growth factor choroidal hyperpermeability choroidal thickness

Application of signal processing techniques to the detection of tip vortex cavitation noise in marine propeller

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Journal of Hydrodynamics 2013年第3期25卷 440-449页

作者： LEE Jeung-Hoon HAN jae-Moon park hyung-Gil SEO Jong-Soo Samsung Ship Model Basin (SSMB) Marine Research Institute Samsung Heavy Industries Science TownDaejeon 305-380 Korea

The tip vortex cavitation and its relevant noise has been the subject of extensive researches up to now. In most cases of experimental approaches, the accurate and objective decision of cavitation inception is primary, which is the main topic of this paper. Although the conventional power spectrum is normally adopted as a signal processing tool for the analysis of cavitation noise, a faithful exploration cannot be made especially for the cavitation inception. Alternatively, the periodic occurrence of bursting noise induced from tip vortex cavitation gives a diagnostic proof that the repeating frequency of the bursting contents can be exploited as an indication of the inception. This study, hence, employed the Short-Time Fourier Transform （STFT） analysis and the Detection of Envelope Modulation On Noise （DEMON） specmma analysis, both which are appropriate for finding such a repeating frequency. Through the acoustical measurement in a water tunnel, the two signal processing techniques show a satisfactory result in detecting the inception of tip vortex cavitation.

关键词： tip vortex cavitation inception Short-Time Fourier Transform (STFT) Detection of Envelope Modulation On Noise(DEMON)

Improvements of model-test method for cavitation-induced pressure fluctuation in marine propeller

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Journal of Hydrodynamics 2013年第4期25卷 599-605页

作者： LEE Jeung-Hoon HAN jae-Moon park hyung-Gil SEO Jong-Soo Samsung Ship Model Basin (SSMB) Marine Research Institute Samsung Heavy Industries Science Town

Although the prediction of propeller cavitation-induced pressure fluctuation strongly depends on the model-scalemeasure- ment in a cavitation tunnel, there is still a lack of correlation with full-scale data. This paper deals with the enhancement of such a correlation deficiency by improving the conventional model-test technique, two majors of which are in the following. One is to take into account the boundary layer effect of wooden fairing plate at the ceiling of water cavitation tunnel. The other is to avoid the reso- nance frequency range of model-ship via adjusting the revolution speed of model propeller. Through a case study, for which both model and full-scale test data are available, the improved method in this study shows its validness, and furthermore a close correla- tion with full scale measurement.

关键词： cavitation boundary layer resonance

用连续振动阻抗法进行预应力钢筋混凝土梁桥的混合健康监测

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钢结构(中英文) 2010年第2期 87-87页

作者： Jeong-Tae Kim jae-hyung park Dong-Soo Hong Woo-Sun park

提出连续振动阻抗法,对预应力钢筋混凝土桥梁的两种破坏形式(即预应力筋破坏或梁破坏)进行混合健康监测。监测包括3个步骤:第一步,通过监测加速信号的变化,对整体破坏进行预警。第二步,通过振动和阻抗识别模式,将破坏类型分为预应力筋... 详细信息

提出连续振动阻抗法,对预应力钢筋混凝土桥梁的两种破坏形式(即预应力筋破坏或梁破坏)进行混合健康监测。监测包括3个步骤:第一步,通过监测加速信号的变化,对整体破坏进行预警。第二步,通过振动和阻抗识别模式,将破坏类型分为预应力筋破坏或梁破坏。第三,基于形状模式和频率方法,通过测量试验室中几个预应力筋和梁的加速响应和电子-机械阻抗,对所提系统的可行性进行评估。

关键词：混合法健康监测破坏检测 PSC梁加速信号阻抗信号损伤指标法