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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik kim Soyeon kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Luminescent metal-halide perovskites:fundamentals,synthesis,and light-emitting devices

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Science China Chemistry 2024年第6期67卷 1776-1838页

作者： Kang Wang Jeong hui kim Jie Yang Xiaoke Liu Yixuan Dou Yuxuan Li Weijian Tao Haiyun Dong Haiming Zhu Kaifeng Wu Li Na Quan Feng Gao Jianpu Wang Letian Dou Yong Sheng Zhao Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Physics Linköping UniversityLinköping58183Sweden Department of Chemistry Virginia TechBlacksburgVA24060USA State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Chemistry Zhejiang UniversityHangzhou310058China Changzhou University Changzhou213164China Department of Chemistry Purdue UniversityWest LafayetteIN47907USA

Metal-halide perovskites have garnered considerable research attention as highly efficient light emitters in recent years due to their outstanding optoelectronic properties with remarkable tunability and excellent solution *** advancements have been achieved in the development of novel halide perovskites,and the exploitations of these materials in lightemitting *** review comprehensively outlines recent breakthroughs in metal-halide perovskites,encompassing the rational design of perovskite materials with tunable light emission properties,the controllable growth of single crystal for a deeper understanding of their structure-property relationships,as well as the fundamental insights into the photophysics and carrier dynamics in perovskite ***,it provides an overview of recent applications of perovskite materials in high-performance light-emitting diodes(LEDs)and lasers.

关键词： metal-halide perovskites perovskite luminescent materials perovskite synthesis excited-state processes perovskite light-emitting diodes perovskite lasers

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乡镇学校体育教学现状及对策分析

黑河学院学报 2024年第3期15卷 78-80,125页

作者：万传琦 In jae-kim 黑河学院黑龙江黑河164300 韩国湖西大学忠清南道牙山31499

我国拥有14亿多人口,其中将近4.77亿是农村人口,乡镇学校的体育教学是实现中国体育强国的关键所在,黑河市乡镇学校体育教学现状是各项目不均衡,极大限制了体育教学的全面性。影响体育教学不均衡的主要因素是教育政策、财政支持、师资力... 详细信息

我国拥有14亿多人口,其中将近4.77亿是农村人口,乡镇学校的体育教学是实现中国体育强国的关键所在,黑河市乡镇学校体育教学现状是各项目不均衡,极大限制了体育教学的全面性。影响体育教学不均衡的主要因素是教育政策、财政支持、师资力量及学生兴趣等,需要从管理、教师队伍、硬件设施等方面,贯彻全民健身下的学校体育教育,促进乡镇学校发展体育教育全面发展。

关键词：黑河市乡镇学校农村体育教学

Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian Seong Hoon Goh Yundeok kim Cheol-Su kim Doo-Sup kim Kyu-jae Lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

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Oncology Research 2024年第2期32卷 421-432页

作者： SEUNG-HEE GWAK JUHYUN LEE EUNJI OH DOHYUN LEE WONSHIK HAN JONGMIN kim KYONG-TAI kim Department of Life Sciences Pohang University of Science and TechnologyPohang37673Korea R&D Center NovMetaPharma Co.Ltd.Pohang37668Korea Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoul03080Korea Generative Genomics Research Center Global Green Research&Development CenterHandong Global UniversityPohang37554Korea

Genetic information is transcribed from genomic DNA to mRNA,which is then translated into threedimensional *** can undergo various post-transcriptional modifications,including RNA editing that alters mRNA sequences,ultimately affecting protein *** this study,RNA editing was identified at the 499th base(c.499)of human vaccinia-related kinase 2(VRK2).This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine(with adenine base)to valine(with guanine base).Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2,which leads to an increase in tumor cell *** we reported that VRK2 directly interacts with dystrobrevin-binding protein(dysbindin)and results in reducing its ***,we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valinecontaining *** interacts with cyclin D and thereby regulates its expression and *** reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression,resulting in increased tumor growth and reduction in survival *** has also been observed that in patient samples,VRK2 level was elevated in breast cancer tissue compared to normal breast ***,the isoleucine form of VRK2 exhibited a greater increase in breast cancer ***,it is concluded that VRK2,especially dependent on the 167th variant amino acid,can be one of the indexes of tumor progression and proliferation.

关键词： VRK2 Kinase activity Breast cancer Tumor RNA editing Cell proliferation Cell growth

Infrared-harvesting colloidal quantum dot inks for efficient photovoltaics: Impact of surface chemistry and device engineering

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Journal of Materials Science & Technology 2023年第16期147卷 224-240页

作者： Younghoon kim Min-jae Choi Jongmin Choi Department of Chemistry Kookmin UniversitySeoul02707Republic of Korea Department of Chemical and Biochemical Engineering Dongguk UniversitySeoul04620Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu42988Republic of Korea

Colloidal quantum dots(CQDs)are promising semiconducting materials,which can be used as a photoactive layer in various optoelectronic applications,because of their size-tunable bandgap energy,solution processability,and excellent optical and optoelectronic *** particular,these features have generated great interest in the development of CQD solar cells and led to a rapid increase in their power conversion *** improvements were enabled by many innovative approaches in terms of CQD’s surface chemistry and device architecture *** this review,a critical overview of the research progress in CQD solar cells is presented with a focus on the strategies adopted for achieving record efficiency in CQD solar *** strategies include the use of organic/inorganic surface ligands,pre-and post-treatment of CQDs,and solid-state/solution-phase ligand ***,we provide an understanding of the research history to inspire the rational design of next-generation CQD optoelectronic devices,such as solar cells,light-emitting diodes,and *** research on the development of infrared CQD solar cells as complementary platforms to other solar cell technologies is also critically discussed to provide another perspective on CQD technologies.

关键词： Quantum dot Lead sulfide Ligand exchange Colloidal ink Infrared light Solar cell

Comparison of mesophilic and thermophilic anaerobic digestions of thermal hydrolysis pretreated swine manure: Process performance,microbial communities and energy balance

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Journal of Environmental Sciences 2023年第4期126卷 222-233页

作者： Xiaohui Liu Changmin Lee jae Young kim Department of Civil and Environmental Engineering Seoul National UniversitySeoul 08826Korea

Anaerobic digestion (AD) of swine manure (SM) commonly shows low biogas output and unsatisfactory economic performance. In this study, thermophilic AD (TAD, 50±1℃) was combined with thermal hydrolysis pretreatment (THP, 170℃/10 bar), to investigate its potential for maximizing biogas yield, securing successful digestion and microbial diversity, as well as improving energy balance. Four lab-scale continuously stirred tank reactors were operated for 300 days and compared with each other, i.e., reactor 1 (raw SM fed in mesophilic AD:RSM-MAD), reactor 2 (THP-treated SM fed in MAD:TSM-MAD), reactor 3 (RSM-TAD),and reactor 4 (TSM-TAD). The results showed that THP was efficient to increase methane production of SM, TSM-TAD mode led to the highest methane yield (129.8±40.5 mL-CH_(4)/gVS/day) among the tests (p 700 mg/L) or volatile fatty acids (> 6000 mg/L) accumulation compared with MAD in start-up phase, TSM-TAD treatment mode behaved a sustainable digestion process in a long-term operation. For TSM-TAD scenario, higher Shannon–Weaver (3.873) and lower Simpson index (0.061) indicated this mode ensured and enlarged the diversity of bacteria communities. Phylum Bathyarchaeota was dominant (59.3%-90.0%) in archaea community,followed by Euryarchaeota in the four reactors. RSM-MAD treatment mode achieved the highest energy output (4.65 GJ/day), TSM-TAD was less effective (-17.38 GJ/day) due to increased energy demands. Thus improving the energetic efficiency of THP units is recommended for the development of TSM-TAD treatment mode.

关键词： Thermal hydrolysis pretreatment Digestion temperature Process performances Microbial communities Energy balance

基于rs-fMRI探讨杨氏絮刺火罐对湿疹瘙痒的影响

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中国针灸 2024年第1期44卷 19-24页

作者：魏翔宇于立新 Taeeun kim Larissa Tao 沈嫱徐慧慧王辉沈卫东上海中医药大学附属曙光医院针灸科上海201203 上海中医药大学附属曙光医院针刺与麻醉研究所上海201203 中国人民解放军联勤保障部队第963医院放射科上海中医药大学国际教育学院上海中医药大学附属曙光医院放射科上海201203

目的:采用静息态功能磁共振成像(rs-f MRI)技术探究杨氏絮刺火罐治疗湿疹瘙痒的临床疗效和中枢机制。方法:50例湿疹瘙痒患者纳入观察组,50名健康受试者纳入对照组。对照组不行任何干预;观察组于大椎及双侧曲池、血海、三阴交行杨氏絮刺... 详细信息

目的:采用静息态功能磁共振成像(rs-f MRI)技术探究杨氏絮刺火罐治疗湿疹瘙痒的临床疗效和中枢机制。方法:50例湿疹瘙痒患者纳入观察组,50名健康受试者纳入对照组。对照组不行任何干预;观察组于大椎及双侧曲池、血海、三阴交行杨氏絮刺火罐治疗,每周1次,共治疗6周。比较观察组治疗前后12项瘙痒严重程度评估量表(12-PSS)、湿疹面积及严重程度(EASI)、皮肤病生活质量指数(DLQI)、匹兹堡睡眠质量指数(PSQI)和焦虑自评量表(SAS)评分。观察组治疗前后及对照组入组时均接受rs-fMRI扫描并进行局部一致性(ReHo)分析,将差异脑区ReHo值与上述量表评分进行相关性分析。结果:与治疗前比较,观察组治疗后12-PSS、EASI、DLQI、PSQI、SAS评分均降低(P<0.01,P<0.05)。与对照组比较,观察组治疗前右侧尾状核、右侧颞中回、右侧眶部额上回、右侧丘脑、左侧角回ReHo值增高(P<0.001);与治疗前比较,观察组治疗后上述脑区ReHo值下降(P<0.001)。与对照组比较,观察组治疗前左侧颞中回、左侧顶上小叶、左侧补充运动区ReHo值下降(P<0.001);与治疗前比较,观察组治疗后上述脑区ReHo值增高(P<0.001)。治疗前,观察组左侧补充运动区ReHo值与12-PSS评分呈正相关(r=0.432,P=0.004);右侧眶部额上回ReHo值与PSQI评分呈负相关(r=-0.318, P=0.04)。治疗后,观察组左侧顶上小叶ReHo值与12-PSS评分呈正相关(r=0.384,P=0.012)。结论:湿疹瘙痒患者多个参与刺激反应、情绪调节、行为控制、注意力等功能的脑区存在活动异常。杨氏絮刺火罐能有效改善湿疹患者瘙痒症状和皮肤损害,其作用机制可能和逆转瘙痒所导致的脑区功能活动异常有关。

关键词：湿疹瘙痒絮刺火罐局部一致性静息态功能磁共振成像

Adsorption properties of polycarboxylate ether-based superplasticizer on cement particles and their resultant dispersion

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 506-514页

作者： Jinyoung YOON Byoung Il CHOI jae Hong kim Department of Structural Engineering Research Korea Institute of Civil Engineering and Building Technology(KICT)Goyang 10223Republic of Korea System Safety Research Department Korea Shipbuilding and Offshore EngineeringSeongnam 13591Republic of Korea Department of Civil and Environmental Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

The cement dispersion performance of a polycarboxylate(PCE)-based superplasticizer is highly related to their adsorption behaviors as a function of *** study evaluated effects of PCEs on rheological properties of cementitious ***,characteristics of PCEs were characterized via permeation chromatography(GPC)and Fourier-transform infrared spectrometry(FT-IR).The adsorption behavior of single and blended PCEs on cementitious composites was identified using total organic carbon analyzer(TOC).Based on the measurement of PCE adsorption,the changes of rheological properties of cementitious materials as well as the number of dispersed cement particles were characterized using a rheometer and laser spectroscopy,*** experimental results support the systematic mechanism of PCE adsorption,cement dispersion,and the decrease in viscosity of cementitious materials.

关键词： adsorption polycarboxylate superplasticizer rheology dispersion