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Right hepatectomy in living donors with previous abdominal surgery

Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 33-38页

作者： Seong hoon Kim Seung Duk Lee Young Kyu Kim Sang-jae Park Center for Liver Cancer National Cancer Center 111 Jungbalsan-ro Ilsandong-gu Goyang-si Gyeonggi-do 410-769 Korea

BACKGROUND： Few studies have evaluated the impact of previous abdominal surgery （PAS） on living donor right hepatectomy （LDRH）. The aim of this study was to investigate the outcomes of liver transplantation using right lobe grafts of living donors with PAS. METHODS： Data were reviewed from LDRH patients at the authors＇ institution between March 2008 and November 2014. LDRH patients with PAS were divided into two groups according to upper PAS （group 1） or lower PAS （group 2）, and they were compared to those without PAS （group 3） who were matched 1：1 based on age, gender, and body mass index. Periop- erative data, complications by the Clavien classification, and the outcomes with more than 14 months follow-up were compared. RESULTS： Twenty-three （4.9%） of a total of 471 LDRH donors had PAS. Eleven donors were assigned to group 1, 12 to group 2, and 23 to group 3. Intraperitoneal adhesions were found in 20 （87.0%） of 23 donors with PAS, of whom 5 （21.7%） had adhesiolysis-related injuries that happened more commonly in group 1 than in group 2 （P=0.025）. LDRH was successfully completed under upper midline laparotomy in all donors. No donors received perioperative blood transfusion. The peak postoperative AST, ALT, INR, and total bilirubin levels made no difference between the three groups. Compared with group 3, groups 1 and 2 had a longer operative time （P=0.012） and a higher grade I complication rate （P=0.047）. All donors recovered fully to their routine activities. The 23 recipients of grafts from donors with PAS showed good liver function with 1-year graft and patient survivals of 100%. CONCLUSION： A history of PAS is not a contraindication to LDRH in the current era of advanced surgical techniques.

关键词： living donor liver transplantation liver surgery liver function

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Spatial distribution and comparative evaluation of phosphorus release rate in benthic sediments of an estuary dam

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International Journal of Sediment Research 2022年第3期37卷 355-369页

作者： Yongsik Song Yong-hoon jeong Chang-Min Shin Dong-Heui Kwak Geosystem Research Corporation Department of Civil Engineering Jeonbuk National University Department of Bio-Convergence Science Jeonbuk National University Water Quality Assessment Research Division National Institute of Environmental Research Department of Bioactive Materials Science Jeonbuk National University

A series of experiments and simulations were performed to ascertain the rate at which phosphorus is released using a water quality model in Saemangeum Lake, an artificially constructed lake located in an estuary. The general inflow of seawater once a day contributed to the formation of a halocline in the lake water, which caused variation in the vertical concentration of dissolved oxygen. The halocline was mainly observed in the deep downstream regions of Saemangeum Lake that are close to the open sea. In contrast, the shallower regions upstream, which are under the influence of pollutant-loading from upstream rivers, exhibited high concentrations of chemical oxygen demand, total phosphorus, and Chl-a,resulting in lower water quality than the downstream regions. Laboratory experiments investigating the release of phosphorus at five representative locations showed that the upstream release flux, where the halocline was weaker, was higher than that downstream, where the initial level of phosphorus sedimentation was high. In particular, a need for an accurate evaluation method for the release of phosphorus at each site was suggested as slight differences were obtained depending on the estimation method used at each representative location. The results of the phosphorus release experiments led to the use of time-weighted integration(TWI), terminated time evaluation, and statistical mean value; the Environmental Fluid Dynamics Code-National Institute of Environment Research model, a widely used water quality model for studying retention watersheds, was applied to the simulation of hydraulic and water quality characteristics for the Saemangeum Lake and its surrounding waters. The result of the water quality simulation indicated the highest reproducibility for release-time TWI so that TWI values were more useful in predicting phosphorus concentrations and the subsequent management of water quality.

关键词： Eutrophication Phosphorus release Salinity Sediments Water quality simulation Environmental Fluid Dynamics Code–National Institute of Environment Research model (EFDC-NIER)

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Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

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World Journal of Gastroenterology 2018年第34期24卷 3849-3860页

作者： jae Yoon jeong Young Seo Cho Joo Hyun Sohn Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Department of Radiology Hanyang University Guri Hospital Hanyang University College of Medicine

Liver biopsy is the gold standard for evaluating the degree of liver fibrosis in patients with chronic liver disease. However, due to the many limitations of liver biopsy, there has been much interest in the use of noninvasive techniques for this purpose. Among these techniques real-time two-dimensional shear wave elastography(2D-SWE) has the advantage of measuring tissue elasticity with the guidance of B-mode images. Recently, many studies have been conducted on the application of 2D-SWE in patients with various liver diseases, and their validity has been confirmed. Here, we briefly discuss the role of 2D-SWE in patients with chronic liver diseases, particularly aspects of the examination techniques and clinical applications.

关键词： Shear wave elastography Liver disease Liver fibrosis Portal hypertension Hepatocelluar carcinoma

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Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection

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World Journal of Gastroenterology 2010年第36期16卷 4589-4593页

作者： Dong Yup Ryu Gwang Ha Kim Do Youn Park Bong Eun Lee jae hoon Cheong Dong Uk Kim Hyun Young Woo jeong Heo Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Medical Research InstitutePusan National University HospitalBusan 602-739South Korea Department of Pathology Pusan National University School of MedicineBusan 602-739South Korea

AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic ***:A total of eight patients with ectopic pancreas were *** of them underwent endoscopic ultrasonography before endoscopic ***-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four *** the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by *** four cases,we performed ESD and removed the lesions without any ***:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal.

关键词： Ectopic pancreas Endoscopic resection Endoscopic ultrasonography

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Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 287-304页

作者： Prakash Thapa Du Hyung Choi Min Soo Kim Seong hoon jeong College of Pharmacy Dongguk UniversityGyeonggi10326Republic of Korea Department of Pharmaceutical Engineering Inje UniversityGyeongnam50834Republic of Korea College of Pharmacy Pusan National UniversityBusan46241Republic of Korea

The current study was to understand how process variables of high shear wet granulations affect physical properties of granules and tablets. The knowledge gained was intended to be used for Quality-by-Design based process design and optimization. The variables were selected based on the risk assessment as impeller speed, liquid addition rate, and wet massing time. Formulation compositions were kept constant to minimize their influence on granules properties. Multiple linear regression models were built providing understanding of the impact of each variable on granule hardness, Carr’s index, tablet tensile strength, surface mean diameter of granules, and compression behavior. The experimental results showed that the impact of impeller speed was more dominant compared to wet massing time and water addition rate. The results also revealed that quality of granules and tablets could be optimized by adjusting specific process variables(impeller speed 1193 rpm, water spray rate 3.7 ml/min, and wet massing time 2.84 min). Overall desirability was 0.84 suggesting that the response values were closer to the target one. The SEM image of granules showed that spherical and smooth granules produced at higher impeller speed, whereas rough and irregular shape granules at lower speed. Moreover, multivariate data analysis demonstrated that impeller speed and massing time had strong correlation with the granule and tablet properties. In overall, the combined experimental design and principal component analysis approach allowed to better understand the correlation between process variables and granules and tablet attributes.

关键词： Experimental design Principal component analysis High shear granulation Process parameter

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra Jeon Muhammad Irfan Seung Eun Lee jeong hoon Lee Man Hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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Prediction of Coastal Fecal Indicator Bacteria Concentrations Using Multivariate Data Analysis

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 440-447页

作者： Ki Beom Kim jae hoon Kim Youngsul jeong Young Seon jeong Sung-jae Chung Walt Whitman High School Bethesda MD 20817 USA Washington Baptist University Annandale VA 22003 USA College of Engineering Khalifa University of Science Technology and Research Abu Dhabi UAE Marymount University Arlington VA 22207 USA

The application of multivariate data analysis, a method for coping with multi-colinearity among independent variables in analyzing coastal water quality data, is presented. This study investigates the statistical regression modeling of FIB （fecal indicator bacteria） concentrations at the outlet of Talbert Marsh in Orange County, California. The multivariate data modeling utilized FIB and physical variables measurements （n = 5,580） collected during a series of longitudinal study of the Talbert Marsh. For the statistical prediction modeling in predicting the FIB concentrations at the outlet of the Talbert Marsh, multivariate analysis techniques such as PCR （principal components regression）, PLS （partial least-squares） regression and SVM （support vector machine） regression were adopted. Statistical modeling results suggest that the statistical modeling predictions are all fell within the reasonable range of actual measurement data. In addition, it is indicated that the accuracy of SVM regression for predicting FIB concentrations at the Talbert Marsh outlet is better than that of other models.

关键词： Multivariate statistical analysis fecal pollution coastal saltwater marsh.

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Electrostabilized homogeneous dispersion of boron nitride nanotubes in wide-range of solvents achieved by surface polarity modulation through pyridine attachment

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Nano Research 2020年第2期13卷 344-352页

作者： Mi Se Chang Min-Sun Jang Sangsun Yang Jihun Yu Taehoon Kim Sedong Kim Hyomin jeong Chong Rae Park jae Won jeong Powder/Ceramic Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan.guChangwon 51508Republic of Korea Research Institute of Advanced Materials and Department of Materials Science and Engineering Seoul National University Seoul 08826Republic of Korea Composites Research Division Korea Institute of Materials Science797 Changwondae-roSeongsan-guChangwon 51508Republic of Korea Dept.of Energy and Mech.Eng Gyeongsang National UniversityCheondaegukchi-Gil 38Tongyeong 53064Republic of Korea

Boron nitride nanotubes(BNNTs)show exceptional physical properties including high mechanical strength and thermal conductivity;however,their applications have been restricted due to limited dispersibility in processing ***,a novel BNNT dispersion method with exceptional dispersibility in a wide range of solvents has been demonstrated by surtace polarity modulation through short-molecule pyridine *** atoms in pyridine are selectively bonded to electron-deficient boron atoms of the BNNT surface through Lewis acid-base reaction,which changes the surface polarity of BNNTs from neutral to ***-dispersing pyridine-attached BNNTs(Py-BNNTs)create a thick and stable electronic double layer(EDL),resulting in uniform dispersion of BNNTs in solvents with an exceptional solubility parameter range of 18.5-48 MPa^1/*** uniform dispersion of BNNTs is maintained even after the mixing with diverse ***,composites incorporating uniformly-distributed BNNTs have been realized,and extraordinary property enhancements have been *** thermal conductivity of 20 wt.%Py-BNNT/epoxy composite has been significantly improved by 69.6%and the tensile strength of 2 wt.%Py-BNNT/PVA has been dramatically improved by 75.3%.Our work demonstrates a simple and facile route to dispersing BNNTs in diverse solvents,consequently leading to selective utlization of BNNT dispersed solvents in various application fields.

关键词： boron nitride nanotube one-dimensional nanomaterials surface polarity modulation electrostabilization boron nitride nanotube composite

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Approaching 18% efficiency of ternary organic photovoltaics with wide bandgap polymer donor and well compatible Y6 : Y6-1O as acceptor

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National Science Review 2021年第8期8卷 20-29页

作者： Xiaoling Ma Anping Zeng Jinhua Gao Zhenghao Hu Chunyu Xu jae hoon Son Sang Young jeong Caixia Zhang Mengyang Li Kai Wang He Yan Zaifei Ma Yongsheng Wang Han Young Woo Fujun Zhang Key Laboratory of Luminescence and Optical Information Ministry of EducationBeijing Jiaotong University Organic Optoelectronic Materials Laboratory Department of ChemistryCollege of ScienceKorea University Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology Department of Chemistry The Hong Kong University of Science and Technology Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua University

A series of ternary organic photovoltaics(OPVs) are fabricated with one wide bandgap polymer D18-Cl as donor, and well compatible Y6 and Y6-1O as acceptor. The open-circuit-voltage(V)of ternary OPVs is monotonously increased along with the incorporation of Y6-1O, indicating that the alloy state should be formed between Y6 and Y6-1O due to their excellent compatibility. The energy loss can be minimized by incorporating Y6-1 O, leading to the VOC improvement of ternary OPVs. By finely adjusting the Y6-1O content, a power conversion efficiency of 17.91% is achieved in the optimal ternary OPVs with 30 wt% Y6-1O in acceptors, resulting from synchronously improved short-circuit-current density(JSC) of 25.87 mA cm, fill factor(FF) of 76.92% and VOC of 0.900 V in comparison with those of D18-Cl : Y6 binary OPVs. The JSC and FF improvement of ternary OPVs should be ascribed to comprehensively optimal photon harvesting, exciton dissociation and charge transport in ternary active layers. The more efficient charge separation and transport process in ternary active layers can be confirmed by the magnetophotocurrent and impedance spectroscopy experimental results, respectively. This work provides new insight into constructing highly efficient ternary OPVs with well compatible Y6 and its derivative as acceptor.

关键词： organic photovoltaics power conversion efficiency ternary strategy photon harvesting morphology regulation

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How good is cola for dissolution of gastric phytobezoars?

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World Journal of Gastroenterology 2009年第18期15卷 2265-2269页

作者： Beom jae Lee Jong-jae Park hoon Jai Chun Ji hoon Kim Jong Eun Yeon Yoon Tae Jeen jae Seon Kim Kwan Soo Byun Sang Woo Lee jae Hyun Choi Chang Duck Kim Ho Sang Ryu Young-Tae Bak Division of Gastroenterology Department of Internal MedicineKorea University College of MedicineSeoul 152-703South Korea

AIM:To evaluate the efficacy of cola treatment for gastric phytobezoars,including ***:A total of 17 patients(range:48 to 78 years) with symptomatic gastric phytobezoars treated with cola and adjuvant endoscopic therapy were *** liters of cola lavage(10 cases) or drink(7 cases) were initially used,and then endoscopic fragmentation was done for the remnant bezoars by using a lithotripsy basket or a polypectomy *** overall success of dissolving a gastric phytobezoars with using three liters of cola and the clinical and endoscopic findings were compared retrospectively between four cases of complete dissolution by using only cola and 13 cases of partial dissolution with ***:After 3 L of cola lavage or drinking,a complete dissolution of bezoars was achieved in four patients(23.5%),while 13 cases(76.5%) were only partially ***(4 of 6 cases) were observed more frequently than diospyrobezoars(0 of 11) in the group that underwent complete dissolution(P = 0.006).Gender,symptom duration,size of bezoar and method of cola administration were not significantly different between the two *** of 13 patients with residual bezoars were completely treated with a combination of cola and endoscopic ***:The rate of complete dissolution with three liters of cola was 23.5%,but no case of diospyrobezoar was completely dissolved using this ***,pretreatment with cola may be helpful and facilitate endoscopic fragmentation of gastric phytobezoars.

关键词： Gastric phytobezoars Diospyrobezoars Cola Dissolution Clinical efficacy

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