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Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo

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Bone Research 2019年第4期7卷 388-398页

作者： Marietta Landgraf Christoph ALahr Alvaro Sanchez-Herrero Christoph Meinert Ali Shokoohmand Pamela MPollock Dietmar WHutmacher Abbas Shafiee jacqui amcgovern Centre in Regenerative Medicine Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia School of Biomedical Science Institute of Health and Biomedical InnovationTranslational Research InstituteQueensland University of TechnologyBrisbaneAustralia Australian Research Council(ARC)Training Centre in Additive Biomanufacturing Queensland University of TechnologyBrisbaneAustralia UQ Diamantina Institute Translational Research InstituteThe University of QueenslandBrisbaneQLDAustralia

Advanced prostate cancer(PCa)is known for its high prevalence to metastasize to bone,at which point it is considered *** significant effort,there is no animal model capable of recapitulating the complexity of PCa bone *** humanized mouse model for PCa bone metastasis used in this study aims to provide a platform for the assessment of new drugs by recapitulating the human–human cell interactions relevant for disease development and *** humanized tissueengineered bone construct(hTEBC)was created within NOD-scid IL2rgnull(NSG)mice and was used for the study of experimental PC3-Luc bone *** was confirmed that PC3-Luc cells preferentially grew in the hTEBC compared with murine *** translational potential of the humanized mouse model for PCa bone metastasis was evaluated with two clinically approved osteoprotective therapies,the non-species-specific bisphosphonate zoledronic acid(ZA)or the human-specific antibody Denosumab,both targeting Receptor Activator of Nuclear Factor Kappa-Β***,but not Denosumab,significantly decreased metastases in hTEBCs,but not murine *** results highlight the importance of humanized models for the preclinical research on PCa bone metastasis and indicate the potential of the bioengineered mouse model to closely mimic the metastatic cascade of PCa cells to human ***,it will enable the development of new effective antimetastatic treatments.

关键词： metastasis PC3 drugs

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Comparison of research hotspots and trends in long-term care for the elderly between China and Australia: a bibliometric analysis

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Frontiers of Nursing 2022年第4期9卷 421-430页

作者： Mian-Li Li jacqui Allen Virginia Plummer Yan-Ling Dai College of Nursing Fujian University of Traditional Chinese MedicineFuzhouFujian 350122China School of Nursing and Midwifery Monash UniversityMelbourne 3800Australia School of Nursing and Healthcare Professions Federation UniversityMelbourne 859Australia

Objective:To explore the current status and development of long-term care(LTC)research in terms of publications in China and Australia,to identify the major contributing authors and institutions,and to compare the research hotspots and trends between China and Australia in order to encourage informed collaborations and work in ***:We collected bibliometric data on the LTC of the elderly in China and Australia from 2009 to 2020 using Chinese National Knowledge Infrastructure(CNKI)and Web of Science(WOS).Cite Space software was used to analyze co-authorships,co-institutions,and ***:A total of 826 ar ticles in Chinese and 393 in English were included for *** total number of publications showed an upward trend in both *** top 10 productive researchers and institutions in China and Australia were identified,and their collaboration network was ***,the knowledge maps of cooccurring keywords,respectively,showed the hotspots of"LTC insurance,disabled elderly,combination of medical and health care,nursing home"and"nursing home,dementia,quality of life,intervention"in China and *** citation burst keywords illustrated the emerging trends of"combination of medical and health care,healthy aging"in China and"polypharmacy,prevention"in ***:This article provided an insight into LTC of the elderly in China and Australia,and research in this field is developing rapidly and is being increasingly *** findings will be useful for future researchers to facilitate collaboration,identify new topics,and suppor t urgently needed research of LTC in China.

关键词： Australia bibliometric analysis China Cite Space elderly knowledge map long-term care

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英格兰启动2型糖尿病预防项目

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英国医学杂志中文版 2015年第9期18卷 487-488页

作者： jacqui Wise 任倩伦敦北京大学人民医院内分泌科

基于英国国家健康体系（NHS）的糖尿病预防项目已经取得了第一阶段的新证据．英国政府已对此进行了公开发布。该项目旨在阻止高达1万名2型糖尿病高危人群发病。由英格兰的NHS、公共卫生机构及英国糖尿病慈善基金会联合发起的这个项目，... 详细信息

基于英国国家健康体系（NHS）的糖尿病预防项目已经取得了第一阶段的新证据．英国政府已对此进行了公开发布。该项目旨在阻止高达1万名2型糖尿病高危人群发病。由英格兰的NHS、公共卫生机构及英国糖尿病慈善基金会联合发起的这个项目，旨在大幅度降低2025年英格兰2型糖尿病患病人数。如不加干预，该数据可能会达到400万。

关键词： 2型糖尿病预防英国

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NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease

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World Journal of Gastroenterology 2011年第23期17卷 2829-2837页

作者： Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson jacqui I Keenan Judy McKenzie Robert W Bentley Department of Medicine University of ChicagoIL 60637-1470United States Department of Medicine University of OtagoChristchurch8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch8140New Zealand Department of Biochemistry University of OtagoDunedin9054New Zealand Department of Pathology University of OtagoChristchurch8140New Zealand Department of Surgery University of OtagoChristchurch8140New Zealand Department of Haematology University of OtagoChristchurch8140New Zealand Department of Paediatrics University of OtagoChristchurch8140New Zealand

AIM： TO assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis （MAP） survival in monocytes from Crohn＇s disease （CD） patients METHODS： Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1, Monocytes were challenged with MAP and bacterial per- sistence assessed at subsequent time-points. Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines. RESULTS： Monooltes heterozygous for a NOD2 polymorphism （R702W, P268S, or 1007fs） were more permissive for growth of MAP （P = 0.045） than those without. There was no effect of NOD2 genotype on subsequent cytokine expression. The T300A polymorphism of ATG16L1 did not affect growth of MAP in our model （P = 0.175）, but did increase expression of cytokines interleukin （IL）-10 （P = 0.047） and IL-6 （P = 0.019）. CONCLUSION： CD-associated polymorphisms affected the eliminaUon of MAP from ex v/vo monooltes （NOD2）, or expression of certain oltokines （ATG16LI）, implying independent but contributory roles in the pathogenesis of CD.

关键词： Inflammatory bowel disease Mycobacteriumavium subspecies paratuberculosis Cytokine CARD15 Autophagy

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An assessment of African lion Panthera leo sociality via social network analysis： prerelease monitoring for an ex situ reintroduction program

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Current Zoology 2017年第3期63卷 301-311页

作者： Emma J. DUNSTON Jackie ABEL Rebecca E. DOYLE jacqui KIRK Victoria B. HILLEY Andrew FORSYTH Emma JENKINS Rafael FREIRE School of Animal and Veterinary Sciences Charles Sturt University Wagga Wagga NSW 2678 Australia Social and Conservation Psycology Coventry University Coventry CV1 5FB UK African Lion & Environmental Research Trust Melrose Farm Livingstone 23345 Zambia Animal Welfare Science Centre The University of Melbourne Parkville Victoria 3010 Australia African Lion & Environmental Research Trust Antelope Park Gweru Midlands Zimbabwe Siyafunda The Greater Makalali Private Game Reserve Harmony 27 Hoedspruit 0895 South Africa

The wild population of the African lion Panthera leo continues to decline, requiring alternate conservation programs to be considered. One such program is ex situ reintroduction. Prior to release, longterm monitoring and assessment of behavior is required to determine whether prides and coalitions behave naturally and are sufficiently adapted to a wild environment. Social network analysis （SNA） can be used to provide insight into how the pride as a whole and individuals within it, function. Our study was conducted upon 2 captive-origin prides who are part of an ex situ reintroduction program, and 1 wild pride of African lion. Social interactions were collected at all occurrence for each pride and categorized into greet, social grooming, play, and aggression. Betweenness centrality showed that offspring in each pride were central to the play network, whereas degree indicated that adults received （indegree） the greatest number of overall social interactions, and the adult males of each pride were least likely to initiate （outdegree） any interactions. Through the assessment of individual centrality and degree values, a social keystone adult female was identified for each pride. Social network results indicated that the 2 captive-origin prides had formed cohesive social units and possessed relationships and behaviors comparable with the wild pride for the studied behaviors. This study provided the first SNA comparison between captive-bred origin and a wild pride of lions, providing valuable information on individual and pride sociality, critical for determining the success of prides within an ex situ reintroduction program.

关键词： African lion Panthera leo conservation ex situ reintroduction social interactions.

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高龄老人的自评完好及其影响因素

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中国人口科学 2004年第S1期 57-64,177页

作者：李强 Denis Gerstorf jacqui Smith 北京大学人口研究所德国马普人类研究所心理学研究中心

文章应用中国高龄老人健康长寿纵向调查数据考察高龄老人的自评完好及其影响因素。分析表明,高龄老人自评完好的总体水平较高,80岁组老人的积极的自评要高于90岁和100岁组老人,消极的自评低于90岁和100岁组老人,但各年龄组之间的均值水... 详细信息

文章应用中国高龄老人健康长寿纵向调查数据考察高龄老人的自评完好及其影响因素。分析表明,高龄老人自评完好的总体水平较高,80岁组老人的积极的自评要高于90岁和100岁组老人,消极的自评低于90岁和100岁组老人,但各年龄组之间的均值水平差异不大。多元回归模型的研究显示,控制其他影响变量后,年龄对积极的自评有显著影响,对消极的自评没有显著的影响;认知能力、日常活动的参与程度、生理功能以及自评健康都是影响自评完好的关键变量。相比而言,女性和农村高龄老人的消极的自评程度高。

关键词：高龄老人自评完好影响因素

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研究人员说婴儿频繁眼球运动与孤独症有关

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英国医学杂志中文版 2016年第3期19卷 133-134页

作者： jacqui Wise 许桦肖世富不详上海交通大学医学院附属精神卫生中心

一项由英国医学研究理事会资助的研究发现，婴儿频繁的眼球运动与之后的孤独症谱系障碍诊断有关。研究者称该研究还处于早期阶段，仅仅靠眼球运动来预测一个孩子之后可能会诊断为孤独症谱系障碍不是一个可靠的指标。但他们认为，这些发... 详细信息

一项由英国医学研究理事会资助的研究发现，婴儿频繁的眼球运动与之后的孤独症谱系障碍诊断有关。研究者称该研究还处于早期阶段，仅仅靠眼球运动来预测一个孩子之后可能会诊断为孤独症谱系障碍不是一个可靠的指标。但他们认为，这些发现可能有助于用更好的方法在早期发现存在行为障碍的孩子。

关键词：婴儿频繁眼球运动孤独症眼球跟踪技术

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成人慢性心力衰竭:NICE指南更新概要

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英国医学杂志中文版 2019年第4期22卷 232-238页

作者： jacqui Real Emma Cowles Anthony S Vi ierzbicki 王乙茹(译) 周国鹏(校) National Guideline Centre Royal College of Physicians London UK Department of Metabolic Medicine/Chemical Pathology Guy′s & St Thomas′ Hospitals London UK 北京大学第一医院全科

由于人口老龄化和与心力衰竭相关的慢性病生存率的提高,心力衰竭的患病率正在上升。其中包括射血分数降低的(50%)心力衰竭。英国国家健康与临床优选研究所(NICE)关于慢性心力衰竭的指南上次更新是在2010年。从那时起,新兴的和现存的治... 详细信息

由于人口老龄化和与心力衰竭相关的慢性病生存率的提高,心力衰竭的患病率正在上升。其中包括射血分数降低的(50%)心力衰竭。英国国家健康与临床优选研究所(NICE)关于慢性心力衰竭的指南上次更新是在2010年。从那时起,新兴的和现存的治疗方法都出现了更多证据,例如盐皮质激素受体拮抗剂(MRA)的作用已经得到了证实。关于心力衰竭的诊断和心力衰竭的治疗研究进展也已发表,包括监测、康复和多学科合作小组(MDT)的组成。

关键词：慢性心力衰竭 NICE 指南成人治疗方法人口老龄化受体拮抗剂盐皮质激素

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The role of emerging organic contaminants in the development of antimicrobial resistance

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Emerging Contaminants 2021年第1期7卷 160-171页

作者： Izzie Alderton Barry R.Palmer Jack A.Heinemann Isabelle Pattis Louise Weaver Maria J.Gutierrez-Gines jacqui Horswell Louis A.Tremblay Institute of Environmental Science&Research(ESR) New Zealand School of Health Sciences Massey UniversityWellingtonNew Zealand School of Biological Sciences University of CanterburyChristchurchNew Zealand Cawthron Institute NelsonNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

Antimicrobial resistance(AMR)threatens human and ecological health *** major changes occur across the human,animal and environmental sectors,the problem will continue to *** important component of AMR that deserves greater attention is the influence of emerging organic contaminants(EOCs)e ubiquitous compounds found,amongst others,in pharmaceuticals,personal care products,food,industrial and agricultural products,plastics and building *** are widely used and can accumulate in the environment from varied sources,predominantly via waste *** can interact with microbial communities potentially leading to the emergence and spread of *** and pharmaceuticals have been demonstrated to promote AMR *** resistance is a multi-faceted problem that requires input from all sectors,with robust strategies and policies needed to make headway with solving the issues of this important threat.

关键词： Resistance transfer Mechanisms of resistance Antimicrobial pollutants Antibiotics Personal care products Pharmaceuticals

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直肠出血和排便习惯对年轻人疾病的预警

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英国医学杂志中文版 2017年第9期20卷 374-374页

作者： jacqui Wise 齐顺利伦敦北京市二龙路医院病理科

一项研究发现，50岁以下的患者出现直肠出血和排便习惯改变，再加上血液学指标的异常，强烈预示发生结直肠癌和炎性肠病。研究者在British Journal of General Practice杂志上指出，这个发现能帮助全科医生优先定位一些结肠镜检查诊断... 详细信息

一项研究发现，50岁以下的患者出现直肠出血和排便习惯改变，再加上血液学指标的异常，强烈预示发生结直肠癌和炎性肠病。研究者在British Journal of General Practice杂志上指出，这个发现能帮助全科医生优先定位一些结肠镜检查诊断不典型的患者。

关键词：直肠出血排便习惯年轻人疾病

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