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World Journal of Gastroenterology 2006年第26期12卷 4185-4190页

作者： Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot jacques-henri jacob Pierre Michel Digestive Oncology Unit Hepatogastroenterology Department Rouen University HospitalFrance Digestive Oncology unit Francois Baclesse Centre CaenFrance Radiotherapy Department henri Becquerel Centre RouenFrance

瞄准：学习的目的是与食道的癌(LASCOC ) 与权威的 chemoradiotherapy (CRT ) 对待的局部地先进的有鳞的房间在病人评估幸存的预兆的因素政体基于 5FU/CDDP 联合。方法：有用在 1994 和 2000 之间的 5FU/CDDP 联合与权威的 CRT 对待的 L... 详细信息

瞄准：学习的目的是与食道的癌(LASCOC ) 与权威的 chemoradiotherapy (CRT ) 对待的局部地先进的有鳞的房间在病人评估幸存的预兆的因素政体基于 5FU/CDDP 联合。方法：有用在 1994 和 2000 之间的 5FU/CDDP 联合与权威的 CRT 对待的 LASCOC 的所有病人回顾地被包括。对 CRT 的临床的完全的反应(CCR ) 被食道的内视镜检查法和 CT 扫描估计在 CRT 结束以后的 2 瞬间。幸存的预示的因素用 univariate 被估计，多，由艇长回归的变量分析当模特儿。结果：116 个病人的一个总数在学习被包括。到 CRT 的 CCR 在 86/116 (74.1%) 被观察。中部的幸存是 20 瞬间(范围 2-114 ) ， 5 年的幸存是 9.4% 。到 CRT 的应答者病人的中部的幸存在非应答者病人作为与 9 瞬间(范围 2-81 ) 相比是 25 瞬间(范围 3-114 )(P < 0.001 ) 。在 univariate 分析，幸存与 CCR 被联系(P < 0.001 ) ，表演地位 < 2 (P = 0.01 ) ，瘤长度 < 6 厘米(P = 0.045 ) 并且 10% 在意义的限制的重量损失 <(P = 0.053 ) 。在里面多变量分析，幸存对 CCR 依赖(P < 0.0001 ) ，重量损失 <10%(P = 0.034 ) 并且表演 < 2 (P = 0.046 ) 。结论：我们的结果建议在有与权威的 CRT 对待的 LASCOC 的病人的那幸存被相关到 CCR，重量损失并且表演地位。

关键词：发病因素鳞状细胞食管癌临床治疗

APOBEC3G Role on HIV Infection in Africa: A Systematic Review

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American Journal of Molecular Biology 2024年第1期14卷 25-42页

作者： Tegwinde Rebeca Compaore Abdoul Karim Ouattara Adama Baguiya Lassina Traore Abdou Azaque Zoure henri Gautier Ouedraogo Seni Kouanda jacques Simpore Biomedical and Public Health Department Institut de Recherche en Sciences de la Santé (IRSS)/CNRST Ouagadougou Burkina Faso Laboratoire de Biologie et de Génétique Moléculaire (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Université Norbert Zongo (UNZ) Centre Universitaire de Manga Koudougou Burkina Faso

The highly active antiretroviral treatment (HAART) has allowed people living with HIV to live longer with a better quality of life. However, toxicity and the emergence of drug resistance arise from HAART use. Therefore, new antiretroviral therapy is needed since no cure or vaccine is available against HIV. Virus-host interaction has been proven to be important in the last decade. Host factors such as the C-C chemokine receptor type 5 (CCR5), a receptor used by HIV to penetrate host cells, have led to the discovery of the Maraviroc, which is an antiretroviral medication used in the United States. In contrast, other factors like C-X-C Motif Chemokine Receptor 4 (CXCR4) and the Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G), a potent host defense factor against HIV, is under investigation. APOBEC3G antiviral activity remains a possible therapeutic target against HIV. This systematic review aimed to synthesize the available evidence on the role of APOBEC3G polymorphisms and their expression on HIV infection disease progression in Africa. We used Web of Science, PubMed, Embase, and Google Scholar and searched for relevant publications in French or English reporting on APOBEC3G polymorphisms association with HIV infection in African populations from January 2009 to May 2023. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyzes) was used to process for reporting systematic review. Fifteen studies were included, of which seven were on APOBEC3G polymorphisms and eight were on APOBEC3G expression. Among the APOBEC3G polymorphisms, the most studied was H186R or rs8177832. The average of the minor allele frequency of H186R of APOBEC3G available for the studies included in this study was 0.29 with a 95% CI (0.172;0.401) and varied from 0.108 reported in Uganda to 0.47 recorded from Burkina Faso. The polymorphism H186R was not associated with HIV status in Southern Africa. However, the referent allele of H186R was protectiv

关键词： APOBEC3G HIV Genetic Variation Therapeutic Target African Populations

A unified plasticity methodology for rate-and temperature-sensitive alloys exhibiting a non-linear kinematic hardening behavior

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Acta Mechanica Solida Sinica 2017年第1期30卷 27-37页

作者： jacques Luk-Cyr Daniel Paquet jacques Lanteigne henri Champliaud Aurelian Vadean Department of Mechanical Engineering Ecole Polyechnique de Montreal 2900 Blvd Edouard-Montpetit MontrealQC H3T 1J4 Institut de recherche d'Hydro-Quebec 1800 Blvd Lionel-Boulet Varennes QC J3X 1S1 Department of Mechanical Engineering Ecole de technologie superieure 1100 Rue Notre-Dame O Montreal QCH3C 1K3

In this paper, a novel unified plasticity methodology is proposed to allow the coupling of rate-and temperature-sensitivity of engineering alloys as well as the non-linear kinematic hardening behavior often observed during cyclic loading. The proposed methodology is general in the sense that an arbitrary constitutive model may be chosen for the viscoplastic part, as well as the cyclic part. We adapt our model with a physically-motivated viscoplasticity flow rule and a nonlinear kinematic hardening model. In contrast with other unified plasticity models, the simplified theory involves few material parameters that can be readily calibrated from standard mechanical tests. The capabilities of the proposed theory are demonstrated for a hot rolled annealed 304 L stainless steel supplied by Vimetal Peckover. The model is tested with stress–strain curves obtained from standard tensile and cyclic uniaxial tests at various strain amplitudes and strain-rates, and good accuracy of the response is obtained for strains up to 15%, within a temperature range of 293–673 K. We note that the cyclic plasticity model in our adapted theory can be readily enhanced with ratchetting, mean stress relaxation, strain amplitude history, Masing effects or other complex capabilities.

关键词： Unified plasticity Constitutive behavior Viscoplasticity Non-linear kinematic hardening Stainless steels

雅克·亨利·拉蒂格一个具有摄影天赋的“富二代”

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旅游世界 2022年第8期 40-57页

作者：崔霁云 jacques henri Lartigue(摄) 不详

雅克•享利•拉蒂格,出生于1894年巴黎郊外的一个小城,家境富裕,父亲是个银行家。所以在他孩童年代,父亲就给他添置了一台相机,开始拍照。我想这位父亲绝对没有想到,儿子的照片最终会出现在美术馆和摄影画册中。雅克•享利•拉蒂格的童年正... 详细信息

雅克•享利•拉蒂格,出生于1894年巴黎郊外的一个小城,家境富裕,父亲是个银行家。所以在他孩童年代,父亲就给他添置了一台相机,开始拍照。我想这位父亲绝对没有想到,儿子的照片最终会出现在美术馆和摄影画册中。雅克•享利•拉蒂格的童年正逢一战之前法国的"美好年代"(Belle fipoque).

关键词：雅克富二代蒂格美术馆孩童

Generalized Blaze Flash,a“Flashover”Behavior for Forest Fires—Analysis from the Firefighter’s Point of View

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Open Journal of Forestry 2014年第5期4卷 547-557页

作者： Francois-Joseph Chatelon Sophie Sauvagnargues Gilles Dusserre jacques-henri Balbi Universita di Corsica UMR CNRS 6134 SPECorteFrance Ecole des Mines d’Ales Institut des Sciences et des RisquesAlesFrance

The phenomenon called “flashover” or “eruptive fire” in forest fires is characterized by a sudden change in fire behavior: everything seems to burst into flames instantly and firefighters are overwhelmed by a sort of eruption, spreading at a speed at far several meters per second. Unfortunately it has cost several lives in the past. The reasons for such an accident always create controversy in the research field. Different theories are highlighted and especially two major axes are currently subject to discussion because they are very popular among people involved in fire-fighting. The one with regard to VOCs emissions is the best-known among firemen. Under great heat, during summer or with a fire approaching, plants emit VOCs and the more the temperature grows, the more the amount of VOCs emitted grows. Under specific conditions (essentially topographical, meteorological and atmospheric), the cloud of gas can accumulate in an appropriate zone. The concentration of VOCs may therefore reach the Lower Explosive Limit, triggering the burst of the cloud when in contact with the fire. The second theory depends on physical considerations. An example is based on a convective flow created by the fire itself. When a fire spreads on a slope, it creates an aspiration phenomenon in a way to supply the fire with oxygen. The more this phenomenon is important, the more the flames tilt and increase the rate of speed, needing even more oxygen and thus induced flow. This vicious circle can stabilize or have an erratic behavior to trigger off a fire eruption. This article presents these two theories, and especially the new advances on this research subject.

关键词： Fire Behavior Flashover Blow up Induced Wind VOC

Rapid HPLC Method for Determination of Parachloroaniline in Chlorhexidine Antiseptic Agent in Mouthrinses, Ophthalmic and Skin Solution

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American Journal of Analytical Chemistry 2011年第4期2卷 422-428页

作者： Alain Nicolay Estelle Wolff Marie-France Vergnes jacques Kaloustian henri Portugal 不详

We described a simple and rapid method to quantify simultaneously chlorhexidine (CHD) and its major metabolite, para Chloroaniline (pCA) by HPLC with UV detection without the additional need of mobile-phase amine modifiers or ion-pairing reagents, with good resolution between pCA and CHD, symmetry peak of the compound and short run time. HPLC-UV analyses were performed using a Dionex? Summit liquid chromatograph (Dionex Corp, Sunnyvale, CA, USA). Chromatographic separations were carried out on a Luna? 150 mm×3 mm i.d. column packed with 3 μm CN (cyano) particles (Phenomenex?), guarded by an on-line filter. Mobile phase consist of methanol:water with sodium chloride with 0.02% of formic acid (55:45). Wavelengths for pCA and for CHD are 238 and 255 nm respectively. Influence of methanol and of sodium chloride content in the eluant has been studied. Linearity of CHD is very good, from 0.5 up to 21.2 μg/l while linearity of pCA is in the range of 0.05 to 10 μg/l with correlation coefficients above 0.999. Resolution between the components is above 4, asymmetry is about 1.3 and 1.7 for pCA and CHD respectively and the run time is less than 5 minutes. This method has been applied to CHD solution of different medical devices. No interference has been reported, and the analysis of direct injection of solution, without any treatment is achieved in less than five *** conclusion, we present a validated method for dosage of CHD and its major impurity pCA, known to be carcinogen, available into medical products or medicinal device for in-vitro diagnostic.

关键词： Chlorhexidine Chloroaniline HPLC

严重上肢创伤的修复重建计划:患者需求及所需检查

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中华显微外科杂志 2021年第3期44卷 241-244页

作者：雅克·亨利·哈克波德 Hansjörg Wyss整形外科中心矫形外科纽约大学医学院朗格骨科医院手外科贝尔维尤医疗中心手外科纽约10016

我本次讲座内容是治疗方案的制定而不在手术本身。之前几位讲者的发言非常有趣和重要,但我要讲的却不一样。我所讲的不是介绍一些具体技术、诀窍或者如何通过某种治疗来解决问题,而是更侧重于治疗方案的制定阶段,这个内容似乎没那么有趣... 详细信息

我本次讲座内容是治疗方案的制定而不在手术本身。之前几位讲者的发言非常有趣和重要,但我要讲的却不一样。我所讲的不是介绍一些具体技术、诀窍或者如何通过某种治疗来解决问题,而是更侧重于治疗方案的制定阶段,这个内容似乎没那么有趣,但却非常重要,特别是对于有更多慢性症状的来诊患者。

关键词：修复重建患者需求慢性症状讲座内容解决问题有趣

Helicobacter pylori Virulence Genes cagA, babA2, and vacA Detection in Dyspeptic Patients from Burkina Faso

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American Journal of Molecular Biology 2023年第3期13卷 141-155页

作者： Tegwinde Rebeca Compaore Kalifou Traore Nômawendé Ines Compaore Lassina Traore Sylvie Zida Serge Theophile Soubeiga Dinanibe Kambire Jean Claude R. P. Ouedraogo Aminata Dickel Sidibe Yasmine Astrid Sana Tani Sagna Wendkuuni Florencia Djigma henri Gautier Ouedraogo jacques Simpore Département Biomédical et Santee Publique Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Laboratoire de Biologie et de Génétique Moléculaire (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Clinique El Fateh-Suka Service de médecine et de spécialités médicales Ouagadougou Burkina Faso Département de Médecine et de Pharmacopée Traditionnelle Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso

The diverse clinical presentation of Helicobacter pylori (H. pylori) infection results from the interaction between bacterial virulence, host genetics, socio-demographic and environmental factors. This study aimed to characterize Helicobacter pylori virulence genes and the associated behavioral factors among dyspeptic patients in Burkina Faso. Two hundred and fifty (250) stool samples were collected from patients with dyspepsia seen at health centers in Ouagadougou, Burkina Faso. Bacterial deoxyribonucleic acid (DNA) was extracted using a commercial kit. Virulence genes were detected using conventional multiplex Polymerase Chain Reaction with specific primers. The overall prevalence of Helicobacter pylori of the 250 participants was 91.20%. CagA virulence gene was present among 20.19% of individuals, while babA2 and vacA were detected respectively among 9.65% and 67.54% of the population positive for Helicobacter pylori. Among vacA subtypes, vacAs1 was the most frequent, with 39.04%, followed by vacAi1 (19.74%), vacAi2 (17.54%), and vacAs2 with 10.96%. Regarding vacAm1 and vacAm2, they were less frequent at 6.14% each. “Handwashing three times or less per day” significantly increased the risk of having vacAi2 allele and H. pylori rRNA16s, with p-values of 0.013 and 0.020, respectively. The consumption of non-tap water increases the risk of carrying the cagA virulence gene. Additionally, H. pylori-positive patients living with more than four (4) people in their household had about two times the risk of having the vacAs1 allele. The present study shows the detection of Helicobacter pylori cagA, vacA subtypes, and babA2 by stool a PCR method in Burkina Faso. The strong association between sanitary habits and virulence factors depicts the composite interaction between ecological factors, gastric mucosa, and bacteria. Therefore, the synergic action of these factors should be considered when aiming for bacterial eradication and gastric pathology cure.

关键词： Helicobacter pylori Stool cagA babA2 vacA

Effect of Farming Practices on Honey Production in Boundary of Gishwati Forest National Park

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Journal of Geoscience and Environment Protection 2020年第5期8卷 107-119页

作者： Nsabimana Prince Alexandre Nsanzumukiza Martin Vincent Uwayo Pacifique Maniragaba Abias Segatashya Alexis Mukasekuru Francoise Ngirinshuti henri jacques Department of Environmental Economics and Natural Resources Management Faculty of Environmental Studies University of Lay Adventists of Kigali Kigali Rwanda

Pesticides and inorganic fertilizers applied in agriculture are key factors which affect biodiversity, especially bees, butterfly and other pollinators. Therefore, this study assessed the effects of farming practices on honey production in boundary of Gishwati Forest National Park in Rwanda. Survey was conducted to collect data from 2000 year to 2018 year from 51 members grouped in UNICOAPIGI beekeeping and 73 members of JYAMBERE agricultural cooperatives to establish the impact of agriculture practice on honey production. The results showed that the change in agricultural inputs from 2000 to 2018 (R2 = 0.901) resulted in high corn yield and consequently induced honey reduction (R2 = 0.75). The correlation coefficients for pesticides and inorganic fertilizers used in corn production had strong negative effects on honey production {γ3 = -0.06 for chemical fertilizers (X3) and γ4 = -0.42 for pesticides (X4)}. JYAMBERE Agricultural cooperative with 75.78% of farmers reported that they used pesticides and inorganic fertilizers in corn production. However, 51 beekeepers grouped in UNICOAPIGI cooperative reported a serious decline of honey production from 27 Kg to 6 Kg of honey per hive after the 2008 year, which is suspected to be mainly the effect from applications of pesticides and fertilizers in corn production. The findings illustrated that the roles of honeybees as pollinator exposed them to toxic, especially pesticides applied in agriculture in boundary of Gishwati national forest reserve, therefore, beekeepers proposed that protection of forests and park is not only sufficient to reach sustainable conservation of bee biodiversity but also requires determining the land use pattern and socio-political factors around the Gishwati forest reserve.

关键词： Biodiversity Ecosystem Agricultural System Gishwati Forest National Park Honey Production

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Fas型敞车

智慧轨道交通 1979年第1期 11-12页

作者： Jean-jacques henri 王其利

法国设计制造了一种有效长度为18,500毫米,有效容积为101米3,有效载重为51吨的废铁运输敞车。这种新型敞车共有三种方案:一种为两个货仓,另一种为一个货仓两个车门,第三种为一个货仓4个车门。设计图纸上要求车体侧墙向内倾斜,侧墙上带... 详细信息

法国设计制造了一种有效长度为18,500毫米,有效容积为101米3,有效载重为51吨的废铁运输敞车。这种新型敞车共有三种方案:一种为两个货仓,另一种为一个货仓两个车门,第三种为一个货仓4个车门。设计图纸上要求车体侧墙向内倾斜,侧墙上带有工字形断面的加强立柱,立柱根部嵌入车底架内。侧墙根部和地板接触部位,带有倾斜45°的补强板,从而使侧墙与地板牢固地连为一体。车底架带有一根鱼腹形中梁,以便安装

关键词：敞车车门有效容积有效长度货车 Fas 货仓