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科学通报 1993年第22期38卷 2057-2062页

作者：穆穆 jacques Simon 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室 Mathématioues Appliquées Université Blaise PascalClermont-Ferrand63177 AUB IERE CEDEXFrance

文献[1]对于水平区域为β-平面上有界区域的三维准地转运动,首次建立了只需确定两维 Laplace 算子最小特征值的非线性稳定性判据,它对应于 Arnold 第二定理.本文通过更加精细的分析、估计,给出了一个新的判据,它优于文献[1]中的结果.在... 详细信息

文献[1]对于水平区域为β-平面上有界区域的三维准地转运动,首次建立了只需确定两维 Laplace 算子最小特征值的非线性稳定性判据,它对应于 Arnold 第二定理.本文通过更加精细的分析、估计,给出了一个新的判据,它优于文献[1]中的结果.在β-平面近似下,三维准地转模式如下:

关键词：三维准地转运动非线性稳定性

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Efficacy of 2LPAPI^®, a Micro-Immunotherapy Drug, in Patients with High-Risk Papillomavirus Genital Infection

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Advances in Infectious Diseases 2016年第1期6卷 7-14页

作者： Gilles Thomas Hélène Cluzel Jacqueline Lafon jacques Bruhwyler Béatrice Lejeune Private Gynecology Practice Perpignan France Labo’Life France sarl Pescalis Les Magny France ECSOR sa/nv Blanmont Belgium Labo’Life Belgium sprl Les Isnes Belgium

Human papillomaviruses (HPVs) are well known for being linked to the development of cervical cancers, most of them being caused by the high-risk (HR) oncogenic genotypes, mainly 16 and 18. The efficacy of 2LPAPI® (Labo’Life), a micro-immunotherapy homeopathic drug, has been evaluated in HR-HPV infected women (n = 18), in a private gynecology practice, by comparing them to an untreated control group (n = 18). Patients were 20 to 45 years old and had cytology with Atypical Squamous Cells of Undetermined Significance (ASCUS) or Low grade Superficial Intra Lesions/ Cervical Intraepithelial Neoplasia Grade I (LSIL/CINI). Patients freely chose to be treated with the drug or not. Those deciding not to take the drug remained untreated and were followed as a control group. The drug was taken at the regimen of one capsule per day during 6 months. HR-HPV and cytology were evaluated at 6 and 12 months. After 12 months, HR-HPV was cleared in 78% of the patients taking the drug versus 44% in those not taking it (p = 0.086). In patients over 25 years, HR-HPV clearance in the treated group was significantly higher (81.3%) than in the control group (20%) (p = 0.004). The difference in the regression of the lesion grades almost reached statistical significance (p = 0.053). This follow-up confirms that the micro-immunotherapy drug 2LPAPI® is a safe and effective therapeutic approach to treat HR-HPV cervical lesions in women over 25 years.

关键词： High-Risk Human Papillomavirus Micro-Immunotherapy Genital Infection Homeopathy 2LPAPI®

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Distribution of High-Risk Human Papillomavirus Genotypes in Precancerous Cervical Lesions in Ouagadougou, Burkina Faso

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Open Journal of Obstetrics and Gynecology 2016年第4期6卷 196-204页

作者： Charlemagne Ouédraogo Théodora Mahoukèdè Zohoncon Esther M. A. Traoré Souleymane Ouattara Prosper Bado Clarisse T. Ouedraogo Florencia W. Djigma Djénéba Ouermi Dorcas Obiri-Yeboah Olga Lompo Simon A. Akpona jacques Simpore Pietro Annigoni Biomolecular Research Center (CERBA) Ouagadougou Burkina Faso UFR/SDS University of Ouagadougou Ouagadougou Burkina Faso Laboratory of Molecular Biology and Genetics (LABIOGENE) University of Ouagadougou Ouagadougo Burkina Faso Teaching and Research Unit in Biochemistry and Molecular Biology Faculty of Medicine University of Parakou Parakou Republic of Benin Faculty of Medicine Université Saint Thomas d’Aquin Ouagadougou Burkina Faso University of Cape Coast School of Medical Sciences Microbiology Department University Post Office Cape Coast Ghana Yalgado Ouédraogo University Hospital (CHU/YO) Ouagadougou Burkina Faso

Aims: We aimed at identifying the high-risk HPV genotypes associated with high-grade dysplastic cervical lesions in Burkina Faso. The available vaccines to Burkina Faso only protect against two high risk HPV genotypes: HPV 16 and 18. Are the genotypes identified in the high-grade precan-cerous lesions in this survey covered by the available vaccines? Methods: The detection and genotyping of high-risk HPV have been conducted based on 118 formalin-fixed and paraffin-embedded archived tissues using the “HPV Genotypes 14 Real-TM Quant” (Sacace biotechnologies®, Italy) kit allowing for the detection of fourteen high-risk HPV genotypes: HPV 16, 31, 18, 39, 45, 59, 33, 35, 56, 68, 51, 52, 58 and 66. Results: The prevalence of high-risk HPV infections was 48.8% based on the appropriate PCR results (21/43). The most common HPV genotypes were HPV 39 (21.7%), HPV 35 (13.0%) and HPV 45 (13.0%). Two cases of multiple infections between HPV 39 - 45 and HPV 39 - 59 have been observed. HPV 16 was not detected in this study. Conclusions: We noted a high prevalence rate for HPV 39, HPV 35 and HPV 45, which are not covered by the commercial vaccines. We also found that the prevalence of HPV 18 was very low in this study and HPV 16 was not detected.

关键词： HPV Cancer CIN Cervix Burkina Faso

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