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Numerical modeling of centrifuge cyclic lateral pile load experiments

Earthquake Engineering and Engineering Vibration 2009年第1期8卷 61-76页

作者： Nikos Gerolymos Sandra Escoffier George Gazetas jacques garnier Civil Engineering National Technical UniversityAthens Greece Laboratoire Central des Ponts et Chaussées Nantes France Lecturer Laboratoire Central des Ponts et Chaussées Nantes France

To gain insight into the inelastic behavior of piles, the response of a vertical pile embedded in dry sand and subjected to cyclic lateral loading was studied experimentally in centrifuge tests conducted in Laboratoire Central des Ponts et Chaussees. Three types of cyclic loading were applied, two asymmetric and one symmetric with respect to the unloaded pile. An approximately square-root variation of soil stiffness with depth was obtained from indirect in-flight density measurements, laboratory tests on reconstituted samples, and well-established empirical correlations. The tests were simulated using a cyclic nonlinear Winkler spring model, which describes the full range of inelastic phenomena, including separation and re-attachment of the pile from and to the soil. The model consists of three mathematical expressions capable of reproducing a wide variety of monotonic and cyclic experimentalp-y curves. The physical meaning of key model parameters is graphically explained and related to soil behavior. Comparisons with the centrifuge test results demonstrate the general validity of the model and its ability to capture several features of pile-soil interaction, including： soil plastification at an early stage of loading, ＂pinching＂ behavior due to the formation of a relaxation zone around the upper part of the pile, and stiffness and strength changes due to cyclic loading. A comparison of the p-y curves derived from the test results and the proposed model, as well as those from the classical curves of Reese et al. （1974） for sand, is also presented.

关键词： centrifuge test Winkler model p-y curves cyclic loading pile-soil separation/gapping nonlinear response experimental validation

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Organ sparing to cure stage IV rectal cancer: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2619-2626页

作者： Hélène Meillat Jonathan garnier Anais Palen jacques Ewald Cécile de Chaisemartin Marguerite Tyran Emmanuel Mitry Bernard Lelong Department of Digestive Surgical Oncology Institut Paoli CalmettesMarseille 13009France Department of Radiotherapy Institut Paoli CalmettesMarseille 13009France

BACKGROUND Rectal sparing is an option for some rectal cancers with complete or good response after chemoradiotherapy(CRT);however,it has never been evaluated in patients with *** assessed long-term outcomes of a rectal-sparing approach in a liver-first strategy for patients with rectal cancer with resectable liver *** SUMMARY We examined patients who underwent an organ-sparing approach for rectal cancer with synchronous liver metastases using a liver-first strategy during 2010-2015(n=8).Patients received primary chemotherapy and pelvic *** surgery was performed during the interval between CRT completion and rectal tumor *** and oncological characteristics and long-term outcomes were *** SUMMARY All patients underwent liver metastatic resection with curative *** R0 rate was 100%.Six and two patients underwent local excision and a watch-and-wait(WW)approach,*** patients had T3N1 tumors at diagnosis and had good clinical response after *** median survival time was 60(range,14-127)*** patients were disease free for 5,8,and 10 years after the *** patients developed metastatic recurrence in the liver(n=5)and/or lungs(n=2).Only one patient developed local recurrence concurrent with metastatic recurrence 24 mo after the WW *** patients died during *** The results suggest good local control in patients undergoing organ-sparing strategies for rectal cancer with synchronous liver *** trials are required to validate these data and identify good candidates for these strategies.

关键词： Colorectal cancer Liver metastasis Rectal sparing Pver-first strategy

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