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Frequency of Hypovitaminosis D in 6 - 59 Month Children with Severe Malaria in the Pediatrics Unit of the Teaching Hospital of Parakou (CHUD/BA) in Benin in 2016

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Open Journal of Pediatrics 2018年第1期8卷 66-73页

作者： Alphonse Noudamadjo Julien Didier Adédémy Joseph Agossou Gratien Godonou Sagbo Falilatou Agbeille Gérard Kpanidja jacques assoklé Simon Akpona Faculty of Medicine University of Parakou CHUD/BA Parakou Benin Faculty of Health Sciences of Cotonou Cotonou Benin

Introduction: Vitamin D’s action outside of bone, especially on immunity, is widely reported in the international scientific literature over the last years. Objective: Calculate the frequency of hypovitaminosis D in children aged 6 to 59 months suffering from severe malaria in the CHUD-P pediatric unit in 2016. Setting and Methods: This research work is a cross-sectional study with descriptive and analytical purposes. Data gathering was prospective. The study involved children aged 6 to 59 months hospitalized for severe malaria in the CHUD-P pediatric unit. The said children were HIV-uninfected, eutrophic and had not received vitamin D supplementation during the last 6 months. Vitamin D dose was measured using the High Performance Liquid Chromatography (HPLC) technique. Results: A total of 80 subjects were involved in the survey. Mean age was 26.08 months, sex ratio was 0.8 and average weight was 10.80 kg. Hypovitaminosis D frequency was 83.8% (67 cases out of 80 children investigated during the survey) with an average plasma concentration of vitamin D estimated at 21.57 ng/ml ± 7.34 with two extremes (11.24 - 42.32) ng/ml. The minimum parasitaemia was 202 P/μl and the maximum was 580,000 P/μl. Conclusion: Hypovitaminosis D is common in children suffering from severe malaria;this result suggests conducting a large-scale community-based study to decide on vitamin D inclusion in national supplementation policies and severe malaria management.

关键词： Hypovitaminosis D Severe Malaria Children Benin

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Two hits are better than one:rational dual strategy efficiently fights neuroblastoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1802-1804页

作者： jacques Zimmer Camille Rolin Markus Ollert Department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Department of Dermatology and Allergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published landmark paper by Bergaggio et *** Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer *** important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.

关键词： neuroblastoma Cancer

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Intermittent fasting-a double edged sword for atherosclerosis

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Life Metabolism 2024年第3期3卷 9-11页

作者： jacques Togo Hoon-Ki Sung Translational Medicine Program The Hospital for Sick ChildrenTorontoOntario M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada

The impact of alternate-day fasting(ADF)on atherosclerosis remains poorly understood,particularly in high-risk popula*** a recent paper published in Life Metabolism,Deng et *** that ADF exacerbated both early and advanced atherosclerotic lesion development in Apoe^(-/-)mice through suppression of hepatic activating transcription factor 3(ATF3)and consequent dysregulation of cholesterol metabolism.

关键词： fasting atherosclerosis

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Application of in-situ characterization techniques in modern aqueous batteries

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Rare Metals 2024年第8期43卷 3553-3575页

作者： Jia-Hao Wu Hong-Wei Cai Zhao-Hui Deng Jean-jacques Gaumet Yu Bao Wen Luo Department of Physics State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingSchool of Materials Science and EngineeringWuhan University of TechnologyWuhan430070China Laboratoire de Chimie Et Physique:Approche Multi-Echelles Des Milieux Complexes(LCP-A2MC)Institut Jean BarriolUniversitéde Lorraine57070MetzFrance Department of Medicinal Chemistry Hubei College of Chinese MedicineJingzhou 434020China

The development of high-performance aqueous batteries calls for an in-depth knowledge of their chargedischarge redox and failure mechanism,as well as a systematic understanding of the dynamic evolution of microstructure,phase composition,chemical composition,and local chemical environment of the materials for ***-situ characterization technology is expected to understand and reveal the problems faced by aqueous rechargeable batteries,such as the dissolution of electrode materials,the growth of metal negative electrode dendrites,passivation,corrosion,side reactions and a series of *** on this,typical in-situ characterization techniques and their basic mechanisms are summarized,including in-situ optical visualization,in-situ microscopy techniques(in-situ scanning electron microscopy(SEM),in-situ transmission electron microscopy(TEM)),in-situ X-ray techniques(in-situ X-ray diffraction(XRD),in-situ X-ray photoelectron spectroscopy(XPS),in-situ near-edge structural X-ray absorption spectroscopy(XANES)),and in-situ spectroscopy techniques(in-situ Raman spectroscopy,in-situ Fourier transform infrared(FTIR)).Moreover,some emerging techniques concerning aqueous battery research,especially gas evolution and materials dissolution issues,such as in-situ electrochemical quartz crystal microbalance(EQCM).in-situ fiber-optic sensing,in-situ gas chromatography(GC) are *** last,the applications of advanced in-situ characterizations in future research of aqueous batteries are emphasized and discussed,along with some of the remaining challenges and possible solutions.

关键词： Aqueous battery In-situ characterization Phase transformation Solid electrolyte interphase Zinc dendrite growth

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Measures of Relative and Absolute Convergence and Pro-poor Growth with an Illustration based on China(2010–2018)

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China & World Economy 2024年第2期32卷 1-41页

作者： Elena Bárcena-Martin jacques Silber Yuan Zhang Facultad de Ciencias Económicas y Empresariales Universidad de MálagaSpain Department of Economics Bar-Ilan UniversityIsrael China Center for Economic Studies Fudan UniversityChina

Income mobility is a key issue for understanding the process of economic growth and distributional *** economists have used the concept of“pro-poor growth”to examine,with individual-level panel data,whether the poor benefit more than the rich from economic growth by tracking the extent of income mobility among different population *** is also literature in macroeconomics on the measurement of *** paper introduces population-weighted relative and absolute indices of mobility,convergence,and pro-poor growth;it also distinguishes between anonymous and nonanonymous approaches to these *** empirical analysis is based on Chinese panel data for the period 2010–*** both absolute and relative terms,income growth in China was greater for individuals with an initially lower income but only for lower income deciles in relative *** was also an overall increase in individual welfare from anonymous and nonanonymous perspectives,which was higher among younger *** welfare of the poor did not increase more than that of the *** results shed light on the evolution of income distribution in China during the past decade's rapid economic growth.

关键词： anonymous and nonanonymous approach convergence exchange and structural mobility pro-poor growth

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Comparative Study on Microstructure and Mechanical Properties of Coarse-grained WC-based Cemented Carbides Sintered with Ultrafine WC or (W+C) as Additives

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 399-409页

作者：于淞百闵凡路 LI De NOUDEM Guillaume jacques ZHANG Hailong MA Jichang ZHAO Kui YAO Zhanhu 张建峰 College of Mechanics and Materials Hohai UniversityNanjing 210098China Key Laboratory of Geomechanics and Embankment Engineering Hohai UniversityMinistry of EducationNanjing 210098China CRISMAT-ENSICAEN(UMR-CNRS 6508) Universitéde Caen-Basse-NormandieF-14050 CaenFrance Shaanxi Aeronautic Carbide Tool Co.Ltd. Hanzhong 724200China CCCC Tunnel Engineering Co.Ltd. Beijing 100102China

The effects of ultrafine WC(WC_(UF),0.5μm) or W(1μm) and C(0.3μm)(W+C)_(UF) additives on the densification,microstructure and mechanical properties of coarse-grained cemented carbides were compared ***,the cemented carbides with WC_(UF)/(W+C)_(UF) additives are almost fully densification to be higher than 99%,and the average grain size is kept above 2.8μ*** WC_(UF) additive assists grains to(truncated)trigonal prism shape by two dimensional(2D) growth,whereas the(W+C)_(UF) additive assists grains to rounded shape by three dimensional(3D) growth,lowers WC contiguity and increases face-centered-cubic *** hardness and bending strength of(75WC_(C)-15WC_(UF))-10Co are 86.6 HRA and 2 272 MPa,respectively,both higher than those of(75WC_(C)-15(W+C)_(UF))-10Co,which could be ascribed to the enhanced densification and unblemished ***,the fracture toughness of the(75WC_(C)-15(W+C)_(UF))-10Co is 23.5 MPa·m^(1/2),higher than that of the(75WC_(C)-15WC_(UF))-10Co due to the uniform WC-Co structure and flexible binder phase.

关键词： coarse-grained WC-based cemented carbide ultrafine WC ultrafine(W+C) microstructure mechanical properties

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The Sword of Damocles behind the Curtain of the Earth’s Global Warming: A Review

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International Journal of Geosciences 2024年第2期15卷 119-136页

作者： jacques Bourgois Institut des Sciences de la Terre Paris (iSTeP) Unité Mixte de Recherche (UMR) 7193 Université Pierre et Marie Curie (UPMC)/Université Paris 06 Paris France iSTeP UMR 7193 Centre National de la Recherche Scientifique (CNRS) Paris France

The “mainstream” climatology (MSC)—i.e. which includes the Intergovernmental Panel on Climate Change (IPCC) community—considers the present day massive release of greenhouse gases into the atmosphere as the main cause of the current global warming trend. The main inference from this stance is that the increase in temperature must occur after the release of greenhouse gases originating from the anthropic activities. However, no scientific evidence has been provided for this basic notion. Earth paleoclimatic records document the antecedence of temperature over CO2 levels. For the past 65 Ma, the temperature parameter has controlled the subsequent increase in CO2. This includes the three rapid aberrant shifts and extreme climate transients at 55 Ma, 34 Ma, and 23 Ma REF _Ref159913672 \r \h \* MERGEFORMAT [1]. The simple fact of their existence points to the potential for highly nonlinear responses in climate forcing. Whatever these shifts and transients are, CO2 remains a second order parameter in their evolution through time. Confronted with the past, a suitable response must therefore be given to the unresolved question of whether the CO2 trends precede the temperature trends in the current period, or not. The assertion that the current global warming is anthropogenic in origin implicitly presupposes a change of paradigm, with the consequence (the increase in CO2 levels) that occurred in Earth’s past being positioned as the cause of the warming for its present day climatic evolution. The compulsory assumption regarding the antecedence of CO2 levels over the temperature trends is associated with the haziness of the methodological framework—i.e. the paradigm—and tightens the research fields on the likely origins of global warming. The possible involvement of an “aberrant” natural event, hidden behind the massive release of greenhouse gases, has not been considered by the MSC.

关键词： Climate CO2 Temperature Paleoclimate Warming

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Mimotope peptide modified pompon mum-like magnetic microparticles for precise recognition,capture and biotransformation analysis of rituximab in biological fluids

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1317-1328页

作者： Jiawen Yang Aixuan Zhou Minyi Li Qiaoxian He Jingwei Zhou jacques Crommen Wentao Wang Zhengjin Jiang Qiqin Wang Institute of Pharmaceutical Analysis College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China Laboratory for the Analysis of Medicines Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium SCIEX Shanghai 200050China

Due to low immobilized ligand density,limited binding capacity,and severe interference from serum proteins,developing ideal peptide-based biomaterials for precise recognition and in vivo analysis of biopharmaceuticals remains a huge *** this study,mimotope peptide modified pompon mum-like biomimetic magnetic microparticles(MMPs,3.8μm)that mimic the specific functionalities of CD20 on malignant B cells were developed for the first *** from the numerous ligand binding sites(Ni^(2+))on the pompon mum-like MMPs,these novel materials achieved≥10 times higher peptide ligand densities(>2300 mg/g)and antibody binding capacities(1380 mg/g)compared to previous reported *** the high specificity of the mimotope peptide,rituximab can be precisely recognized and enriched from cell culture media or serum *** also established an LC-MS/MS method using the MMPs for tracking rituximab biotransformation in patient ***,deamidation of Asn55 and Asn33,as well as oxidation of Met81 and Met34 were observed at the key complementarity determining regions of rituximab,which could potentially influence antibody function and require careful ***,these versatile biomimetic MMPs demonstrate superior recognition and enrichment capabilities for target antibodies,offering interesting possibilities for biotransformation analysis of biopharmaceuticals in patient serum.

关键词： Therapeutic monoclonal antibody Mimotope peptide Precise recognition Peptide-based biomaterials Biotransformation Patient serum

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High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1772-1786页

作者： Yu Fan Jincai Wang Jingyi Jian Yalei Wen Jiahao Li Hao Tian jacques Crommen Wei Bi Tingting Zhang Zhengjin Jiang Institute of Pharmaceutical Analysis/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China/College of Pharmacy Jinan UniversityGuangzhou 510632China KU Leuven-University of Leuven Pharmaceutical AnalysisDepartment of Pharmaceutical and Pharmacological SciencesLeuven 3000Belgium Laboratory of Analytical Pharmaceutical Chemistry Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium Department of Neurology the First Affiliated Hospital of Jinan University/Clinical Neuroscience Institutethe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's *** to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversible hMAO-B inhibitors with good blood-brain barrier *** this study,a high-throughput at-line nanofractionation screening platform was established with extracts from Chuanxiong Rhizoma,which resulted in the discovery of 75 active compounds,including phenolic acids,volatile oils,and phthalides,two of which were highly selective novel natural phthalide hMAO-B inhibitors that were potent,selective,reversible and had good blood‒brain *** docking and molecular dynamics simulations elucidated the inhibition ***(IC_(50)=103 nmol/L;SI=645)and neocnidilide(IC_(50)=131 nmol/L;SI=207)demonstrated their excellent potential as hMAO-B *** offset the limitations of deactivating enzymes associated with irreversible hMAO-B inhibitors such as *** SH-SY5Y cell assays,sedanolide(EC_(50)=0.962μmol/L)and neocnidilide(EC_(50)=1.161μmol/L)exhibited significant neuroprotective effects,comparable to the positive drugs rasagiline(EC_(50)=0.896μmol/L)and safinamide(EC_(50)=1.079μmol/L).These findings underscore the potential of sedanolide as a novel natural hMAO-B inhibitor that warrants further development as a promising drug candidate.

关键词： Human monoamine oxidase B inhibitors High-throughput screening At-linenanofractionation Parkinson's disease Cellular neuroprotection Traditional Chinese medicines(TCMs)

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Infant’s Sigh Breathing Matters—The Role of the Hering-Breuer Deflation Reflex in Bronchial Decongestion

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 197-212页

作者： Karine Truflandier Kevin Albert Jean-jacques Moraine Department of Cardio-Pulmonary Physiotherapy Hpital de La Tour Meyrin Switzerland Paediatric Intensive Care Unit Centre Hospitalier Universitaire Sainte-Justine Montral Canada Laboratoire des Sciences de la Motricit Universit Libre de Bruxelles Brussel Belgium

Background: The prolonged slow expiratory (PSE) technique can induce sigh breaths related to the Hering-Breuer reflex in *** is a specific chest physiotherapy technique often used in children to help with the clearance of secretions, reduce pulmonary obstruction and decrease ventilatory effort. Purpose: The main objective of this review was to synthesize and clarify the existing knowledge of the physiological mechanism behind the Hering-Breuer reflex and its utility in the PSE technique. The secondary objective was to provide an overview of PSE which is probably the main mechanical feature for mucus clearance in infants and to identify gaps and any further research required. Method: A comprehensive literature search was performed using PubMed/MEDLINE and Ovid EMBASE, from 1968 to January 2024, using search terms relating to “Interaction of Hering-Breuer reflex and chest physiotherapy therapy, sigh breath in infants and prolonged slow expiration technique” to create an overview of the advances and gaps in current knowledge of PSE. Result: The data obtained following treatment with PSE maneuvers in infants with histories of recurrent wheezing shows that the presence of sighs could be the main active principle of treatment. Conclusion: Changes in volume induced by PSE technique and, effects from crying may stimulate the Hering-Breuer deflation reflex and sighs in turn improving alveolar ventilation as well as lung volume in infants.

关键词： Hering-Breuer (HB) Reflex Sigh Breath Infants Prolonged Slow Expiration Technique Large Volume Chest Physiotherapy

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