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Investigating the adaptability and implementation of computational design methods in concept design taking plasterboard opportunities for dimensional coordination and waste reduction as a case study

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Frontiers of Architectural Research 2023年第5期12卷 1011-1029页

作者： Omar Majzoub M.hank Haeusler Sisi Zlatanova University of New South Wales SydneyNSW 2052Australia

Construction material offcuts is a data problem that can largely be avoided by dimensional coordination during concept *** the environmental benefits,early phase coordination is beneficial to the overall design process as it integrates information not typically considered until later in the design ***,taking reality-changing actions is often challenged by uncertainty,time constraints,and lack of integration of available *** the potential of computational design in enabling architects to manage design and coordination complexities and taking plasterboard opportunities for dimensional coordination,the paper presents a review and assessment of the existing methods to interrogate what,when,and how are these adaptable to the *** study shows that ML-based methods outperform other methods and concludes that leveraging computational design powers to reduce offcuts is not a question of a tool,but one of a ***,the future steps to achieving such a strategy are discussed.

关键词： Computational design Plasterboard dimensional coordination Conceptdesign

An absolutely remarkable thing

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An absolutely remarkable thing

Experimental and computational correlation and prediction on herbicide resistance for acetohydroxyacid synthase mutants to Bispyribac

作者： hank Green.

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Science China Chemistry 2013年第3期56卷 286-405页

作者： HE YinWu NIU CongWei LI hank WEN Xin XI Zhen State Key Laboratory of Elemento-Organic Chemistry

Bispyribac is a widely used herbicide that targets the acetohydroxyacid synthase(AHAS) *** in AHAS have caused serious herbicide resistance that threatened the continued use of the *** far,a unified model to decipher herbicide resistance in molecular level with good prediction is still *** this paper,we have established a new QSAR method to construct a prediction model for AHAS mutation resistance to herbicide Bispyribac.A series of AHAS mutants concerned with the herbicide resistance were constructed,and the inhibitory properties of Bispyribac against these mutants were *** 3D-QSAR method has been transformed to process the AHAS mutants and proposed as mutation-dependent biomacromolecular QSAR(MB-QSAR).The excellent correlation between experimental and computational data gave the MB-QSAR/CoMFA model(q2=0.615,r2=0.921,r2 pred=0.598) and the MB-QSAR/CoMSIA model(q2=0.446,r2=0.929,r2 pred=0.612),which showed good prediction for the inhibition properties of Bispyribac against AHAS *** MB-QSAR models,containing the three-dimensional molecular interaction diagram,not only disclose to us for the first time the detailed three-dimensional information about the structure-resistance relationships,but may also provide further guidance to resistance mutation ***,the molecular interaction diagram derived from MB-QSAR models may aid the resistance-evading herbicide design.

关键词： MB-QSAR resistance prediction herbicide resistance Bispyribac-sodium acetohydroxyacid synthase

Progressive loss of striatal dopamine terminals in MPTP-induced acute parkinsonism in cynomolgus monkeys using vesicular monoamine transporter type 2 PET imaging([^(18)F]AV-133)

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Neuroscience Bulletin 2014年第3期30卷 409-416页

作者： Yajing Liu Feng Yue Rongping Tang Guoxian Tao Xiaomei Pan Lin Zhu hank F.Kung Piu Chan Department of Neurobiology Xuanwu Hospital of Capital Medical University Key Laboratory of Neurodegenerative Diseases Ministry of Education Xuanwu Hospital of Capital Medical University Beijing Key Laboratory on Parkinson's Disease Wincon Theracells Biotechnologies Inc. Key Laboratory of Radiopharmaceuticals Beijing Normal University Department of Radiology University of Pennsylvania

The 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine （MPTP）-induced parkinsonism model, particularly in non-human primates, remains the gold-standard for studying the pathogenesis and assessing novel therapies for Parkinson＇s disease. However, whether the loss of dopaminergic neurons in this model is progressive remains controversial, mostly due to the lack of objective in vivo assessment of changes in the integrity of these neurons. In the present study, parkinsonism was induced in cynomolgus monkeys by intravenous administration of MPTP （0.2 mg/kg） for 15 days; stable parkinsonism developed over 90 days, when the symptoms were stable. Noninvasive positron emission tomographic neuroimaging of vesicular monoamine transporter 2 with 9-[18F] fluoropropyl-（＋）-dihydrotetrabenazine （[18F]AV-133） was used before, and 15 and 90 days after the beginning of acute MPTP treatment. The imaging showed evident progressive loss of striatal uptake of [18SF]AV-133. The dopaminergic denervation severity had a significant linear correlation with the clinical rating scores and the bradykinesia subscores. These findings demonstrated that [18F]AV-133 PET imaging is a useful tool to noninvasively evaluate the evolution of monoaminergic terminal loss in a monkey model of MPTP-induced parkinsonism.

关键词： Parkinson's disease non-human primate [18F]AV-133 VMAT2 positron emission tomography

Net energy,energy utilization,and nitrogen and energy balance affected by dietary pea supplementation in broilers

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Animal Nutrition 2021年第2期7卷 506-511页

作者： Nishchal K.Sharma Zhibin Ban hank L.Classen Huaming Yang Xiaogang Yan Mingan Choct Shu-Biao Wu School of Environmental and Rural Science University of New EnglandArmidaleNSW 2351Australia Laboratory of Animal Nutrition Metabolism Jilin Academy of Agricultural SciencesGongzhulingJilin 136100China Department of Animal and Poultry Science University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Office of the Pro Vice-Chancellor External Relations University of New EnglandArmidaleNSW 2351Australia

Pea starch consists predominantly of C-type of amylopectin chain which is more resistant to digestive enzymes than A-type of starch thus slowly digested in *** was hypothesized that the presence of slowly digested pea starch in broiler diets will increase net energy and the efficiency of energy utilization in *** experiments were performed to investigate starch digestibility of pea at different in-cubation times(in vitro study)and the effect of dietary pea on heat increment and net energy in broilers using an open-circuit respiratory calorimetry system(in vivo study).One-day-old Ross 308 male broilers were fed a common starter crumble from d 1 to 10 and standard grower diets *** d 21,birds were transferred to the chambers each housing 2 *** treatment was replicated 6 times with 2 identical runs of 3 replicates per treatment.A wheat-soybean meal-based diet was used as a control and the treatment diet contained 500 g of pea/kg *** vitro study showed that pellet processing increased(P0.05)FCR compared to those offered the wheat-based *** energy(NE)and apparent metabolizable energy(AME)values were higher in the pea-based diet than in the wheat-based diet(P-0.037 for NE and P-0.018 for AME).Heat production,respiratory quotient,heat increment of feed,efficiency of utilization of gross energy for AME,and efficiency of utilization of AME for NE did not differ(P>0.05)between the 2 *** was no effect(P>0.05)of pea on the total tract di-gestibilities of dry matter,crude protein and ash,but the total tract digestibility of starch was higher(P-0.022)in the pea-based diet compared to the wheat-based *** study provides insight into the energy metabolism of broilers offered a pea-based diet and indicates that dieta

关键词： Slowly digested starch Pea Heat increment Net energy Broiler

Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 38-45页

作者： Edward Hsi Yung-Song Wang Chia-Wei Huang Ming-Lung Yu Suh-Hang hank Juo Chung-Ling Liang Centre for Myopia and Eye Disease Department of Medical ResearchChina Medical University(Taiwan) Hospital Department of Genome Medicine Kaohsiung Medical University Institute of Fisheries Science National Taiwan University Department of Biotechnology Kaohsiung Medical University Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University Hospital Faculty of Medicine College of Medicine Kaohsiung Medical University Centre for Myopia and Eye Disease Department of Medical Research China Medical University(Taiwan) Hospital Graduate Institute of Biomedical Sciences China Medical University(Taiwan) Institute of New Drug Development China Medical University(Taiwan) Drug Development Center China Medical University(Taiwan) Department of Ophthalmology Asia University Hospital Department of Optometry College of Medical and Health ScienceAsia University

AIM: To test for the association between genome-wide methylation and myopia in human and mice. METHODS: Long interspersed nucleotide element 1(LINE-1) methylation levels were used to surrogate genome-wide methylation level. We first tested for the association between high myopia(<-6 D) and LINE-1 methylation in leukocytes in 220 cases and 220 control subjects. Secondly, we validated the results of LINE-1 methylation in eyes from the form deprivation myopia(FDM) mice. Furthermore,we calculated the correlation of LINE-1 methylation levels between leukocyte DNA and ocular DNA in the mice. We also tested whether dopamine can alter LINE-1 methylation levels. RESULTS: The LINE-1 methylation level was significantly higher in the myopic human subjects than controls. The upper and middle tertiles of the methylation levels increased an approximately 2-fold(P≤0.002) risk for myopia than the lower tertile. Similarly, FDM mice had high LINE-1 methylation levels in the leukocyte, retina and sclera, and furthermore the methylation levels detected from these three tissues were significantly correlated. Immunohistochemical staining revealed higher levels of homocysteine and methionine in the rodent myopic eyes than normal eyes. Dopamine treatment to the cells reduced both LINE-1 methylation and DNA methyltransferase levels. CONCLUSION: LINE-1 hypermethylation may be associated with high myopia in human and mice. Homocysteine and methionine are accumulated in myopic eyes, which may provide excess methyl group for genome-wide methylation.

关键词： methylation myopia LINE-1 homocysteine dopamine

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How I Work

国际经济合作 2006年第9期 1-1页

作者： hank Paulson Chairman and CEO Goldman Sachs

G-Quadruplex(G4) Motifs in the Maize(Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status,Hypoxia,Low Sugar,and Nutrient Deprivation

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Journal of Genetics and Genomics 2014年第12期41卷 627-647页

作者： Carson M.Andorf Mykhailo Kopylov Drena Dobbs Karen E.Koch M.Elizabeth Stroupe Carolyn J.Lawrence hank W.Bass USDA-ARS Corn Insects and Crop Genetics Research Unit Iowa State University Department of Computer Science Iowa State University Institute of Molecular Biophysics Florida State University Department of Genetics Development and Cell BiologyIowa State University Plant Molecular and Cellular Biology Program Horticultural Sciences DepartmentGenetics InstituteUniversity of Florida Department of Biological Science Florida State University Department of Agronomy Iowa State University

The G-quadruplex （G4） elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix. This （34 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA. The reversibility and structural diversity of G4s make them highly versatile genetic structures, as demonstrated by their roles in various functions including telomere metabolism, genome maintenance, immunoglobulin gene diversification, transcription, and translation. Sequence motifs capable of forming G4 DNA are typically located in telomere repeat DNA and other non-telomeric genomic loci. To investigate their potential roles in a large-genome model plant species, we computationaily identified 149,988 non-telomeric G4 motifs in maize （Zea mays L., B73 AGPv2）, 29% of which were in non-repetitive genomic regions. G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand, one in the 5~ UTR and the other at the 5~ end of the first intron. Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures in vitro. The G4 motifs were prevalent in key regulatory genes associated with hypoxia （group VII ERFs）, oxidative stress （D J-1/GATasel）, and energy status （AMPK/ SnRK） pathways. They also showed statistical enrichment for genes in metabolic pathways that function in glycolysis, sugar degradation, inositol metabolism, and base excision repair. Collectively, the maize G4 motifs may represent conditional regulatory elements that can aid in energy status gene responses. Such a network of elements could provide a mechanistic basis for linking energy status signals to gene regulation in maize, a model genetic system and major world crop species for feed, food, and fuel.

关键词： Maize G-quadruplex G4 Hypoxia Sucrose synthase

A Hyperbolic Eulerian Model for Dilute Two-Phase Suspensions

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Journal of Modern Physics 2011年第9期2卷 997-1011页

作者： Sarah hank Richard Saurel Olivier Le Metayer 不详

Conventional modeling of two-phase dilute suspensions is achieved with the Euler equations for the gas phase and gas dynamics pressureless equations for the dispersed phase, the two systems being coupled by various relaxation terms. The gas phase equations form a hyperbolic system but the particle phase corresponds to a hyperbolic degenerated one. Numerical difficulties are thus present when dealing with the dilute phase system. In the present work, we consider the addition of turbulent effects in both phases in a thermodynamically consistent way. It results in two strictly hyperbolic systems describing phase’s dynamics. Another important feature is that the new model has improved physical capabilities. It is able, for example, to predict particle dispersion, while the conventional approach fails. These features are highlighted on several test problems involving particles jets dispersion and are compared against experimental data. With the help of a single parameter (a turbulent viscosity), excellent agreement is obtained for various experimental configurations studied by different

关键词： Turbulence Riemann Solver Pressureless Gas Dynamics