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Drug therapy for heart failure in older patients —what do they want？

Journal of Geriatric Cardiology 2015年第2期12卷 165-173页

作者： Donah Zachariah jacqueline taylor Nigel Rowell Clare Spooner Paul R Kalra Portsmouth Hospitals NHS Trust Portsmouth P06 3L Y UK Glasgow Royal Infirmary Glasgow G40SF UK South Tees Hospitals NHS Foundation Trust TS4 3BW UK Servier Laboratories Ltd SL3 6P J UK

长期的心失败(CHF ) 主要在更老的病人被看见，因此真实的生活药经常从在年轻得多的人口进行的试用要求调查结果的推测。规定模式和潜力受益在老被 polypharmacy 和 co 疾病的病理重重地影响。增加的长寿可以变得不太相关在脆弱老，而... 详细信息

长期的心失败(CHF ) 主要在更老的病人被看见，因此真实的生活药经常从在年轻得多的人口进行的试用要求调查结果的推测。规定模式和潜力受益在老被 polypharmacy 和 co 疾病的病理重重地影响。增加的长寿可以变得不太相关在脆弱老，而改善，生活(QoL ) 的质量经常成为优先级；在改进幸福上的义务，维持独立为更长，并且推迟 institutionalisation。与 CHF 评估老病人的特定的研究正在缺乏，很少关于 tolerability 和证据的副作用侧面被知道在这张人口的基于的药治疗。在有征兆的 CHF 的病人的心率的影响上有最近的兴趣。与降低能力的选择心率， Ivabradine 在湾穴节奏具有在有 CHF 和左室的收缩机能障碍的病人的利益，导致心失败 hospitalisation 和心血管的死亡的减小。这张手稿将集中于 CHF 和更老的病人并且将讨论心率，药治疗和 tolerability 的影响。它将也为集中于描述很治疗学的审判的集中病人的学习结束点而非死亡目标的特定的研究加亮未满足的需要。在介绍一个唯一的机会评估 tolerability 并且确定的治疗影响大量真实生活的 QoL 上评估 ivabradine 的影响的进行中的研究，有 CHF 的更老的病人将被讨论。

关键词：中老年人药物治疗心力衰竭患者心脏生活质量治疗试验 CHF

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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Risk factors for clinical coronary events in patients with SLE:a multicentre case-control study

Risk factors for clinical coronary events in patients with S...

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The 8th International Congress on SLE

作者： Sahena Haque Donna taylor-Fesler Caroline Gordon Veronica Toescu David Isenberg Anisur Rahman Aubrey Bell Peter Lanyon Neil McHugh David GI Scott Paul Emery Lee Suan Teh jacqueline Andrews Hazem Youssef Bridget Griffiths John McLaren Ian Bruce The University of Manchester Oxford RoadManchesterMI3 910 The University of Manchester Oxford RoadManchesterMI3 910 British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group The University of Manchester Oxford RoadManchesterM139HJ British Isles Lupus Assessment Group BSR Lupus Special Interest Group

＜正＞Purpose:To identify risk factors（RF）for clinical coronary heart disease（CHD）in SLE and to study the role of traditional RF,SLE disease distribution,serology and therapy. Methods:This was a multicentre case,control *** recruited 48 SLE patients with verified clinical CHD （myocardial infarction or angina pectoris）and 78 SLE

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